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Volumn 72, Issue 9, 2013, Pages 867-872

Intracellular targets: Current data on effectiveness and safety profile;Intrazelluläre Targets: Aktuelle Datenlage zu Wirksamkeit und Sicherheitsprofil

Author keywords

Intracellular targets; Janus kinases; Protein kinase inhibitors; Rheumatoid arthritis; Safety

Indexed keywords

TOFACITINIB;

EID: 84888599553     PISSN: 03401855     EISSN: 14351250     Source Type: Journal    
DOI: 10.1007/s00393-013-1139-4     Document Type: Article
Times cited : (4)

References (24)
  • 1
    • 84878936389 scopus 로고    scopus 로고
    • Meta-analysis of mailignancies, serious infections, and serious adverse events with tofacitinib or biologic treatment in rheumatoid arthritis clinical trials
    • Ahadieh S, Checchio T, Tensfeldt T et al (2012) Meta-analysis of mailignancies, serious infections, and serious adverse events with tofacitinib or biologic treatment in rheumatoid arthritis clinical trials. Arthritis Rheum 64(10/Suppl):S726
    • (2012) Arthritis Rheum , vol.64 , Issue.10 SUPPL.
    • Ahadieh, S.1    Checchio, T.2    Tensfeldt, T.3
  • 2
    • 78751685797 scopus 로고    scopus 로고
    • Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: Meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data
    • Askling J, Fahrbach K, Nordstrom B et al (2011) Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data. Pharmacoepidemiol Drug Saf 20:119-130
    • (2011) Pharmacoepidemiol Drug Saf , vol.20 , pp. 119-130
    • Askling, J.1    Fahrbach, K.2    Nordstrom, B.3
  • 3
    • 84873707288 scopus 로고    scopus 로고
    • Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
    • Burmester GR, Blanco R, Charles-Schoeman C et al (2013) Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 381:451-460
    • (2013) Lancet , vol.381 , pp. 451-460
    • Burmester, G.R.1    Blanco, R.2    Charles-Schoeman, C.3
  • 4
    • 0028346563 scopus 로고
    • Signal transduction by the B cell antigen receptor and its coreceptors
    • Cambier JC, Pleiman CM, Clark MR (1994) Signal transduction by the B cell antigen receptor and its coreceptors. Annu Rev Immunol 12:457-486
    • (1994) Annu Rev Immunol , vol.12 , pp. 457-486
    • Cambier, J.C.1    Pleiman, C.M.2    Clark, M.R.3
  • 5
    • 84857761516 scopus 로고    scopus 로고
    • Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690, 550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs
    • Fleischmann R, Cutolo M, Genovese MC et al (2012) Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690, 550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum 64:617-629
    • (2012) Arthritis Rheum , vol.64 , pp. 617-629
    • Fleischmann, R.1    Cutolo, M.2    Genovese, M.C.3
  • 6
    • 84859270131 scopus 로고    scopus 로고
    • Dose ranging study of VX-509, an oral selective JAK3 inhibitor, as monotherapy in patients with active rheumatoid arthritis (RA)
    • Fleischmann R, Spencer-Green G, Fan F et al (2011) Dose ranging study of VX-509, an oral selective JAK3 inhibitor, as monotherapy in patients with active rheumatoid arthritis (RA). Arthritis Rheum:LB3
    • (2011) Arthritis Rheum
    • Fleischmann, R.1    Spencer-Green, G.2    Fan, F.3
  • 7
    • 79955027327 scopus 로고    scopus 로고
    • Modulation of Innate and adaptive immune responses by tofacitinib (CP-690, 550)
    • Ghoreschi K, Jesson MI, Li X et al (2011) Modulation of Innate and adaptive immune responses by tofacitinib (CP-690, 550). J Immunol 186:4234-4243
    • (2011) J Immunol , vol.186 , pp. 4234-4243
    • Ghoreschi, K.1    Jesson, M.I.2    Li, X.3
  • 8
    • 84885311733 scopus 로고    scopus 로고
    • The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: A systematic review and meta-analysis
    • Kawalec P, Mikrut A, Wisniewska N et al (2013) The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol
    • (2013) Clin Rheumatol
    • Kawalec, P.1    Mikrut, A.2    Wisniewska, N.3
  • 9
    • 67650093218 scopus 로고    scopus 로고
    • The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690, 550 versus placebo
    • Kremer JM, Bloom BJ, Breedveld FC et al (2009) The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690, 550 versus placebo. Arthritis Rheum 60:1895-1905
    • (2009) Arthritis Rheum , vol.60 , pp. 1895-1905
    • Kremer, J.M.1    Bloom, B.J.2    Breedveld, F.C.3
  • 10
    • 84872011053 scopus 로고    scopus 로고
    • Kinase inhibitors: A new class of antirheumatic drugs
    • Kyttaris VC (2012) Kinase inhibitors: a new class of antirheumatic drugs. Drug Des Devel Ther 6:245-250
    • (2012) Drug des Devel Ther , vol.6 , pp. 245-250
    • Kyttaris, V.C.1
  • 11
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard WJ, O'shea JJ (1998) Jaks and STATs: biological implications. Ann Rev Immunol 16:293-322
    • (1998) Ann Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 12
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • O'shea JJ, Holland SM, Staudt LM (2013) JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med 368:161-170
    • (2013) N Engl J Med , vol.368 , pp. 161-170
    • O'Shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 13
    • 84876222093 scopus 로고    scopus 로고
    • Janus kinase inhibitors in autoimmune diseases
    • O'shea JJ, Kontzias A, Yamaoka K et al (2013) Janus kinase inhibitors in autoimmune diseases. Ann Rheum Dis 72(Suppl 2):ii111-ii115
    • (2013) Ann Rheum Dis , vol.72 , Issue.SUPPL. 2
    • O'Shea, J.J.1    Kontzias, A.2    Yamaoka, K.3
  • 14
    • 84874658901 scopus 로고    scopus 로고
    • Back to the future: Oral targeted therapy for RA and other autoimmune diseases
    • O'shea JJ, Laurence A, Mcinnes IB (2013) Back to the future: oral targeted therapy for RA and other autoimmune diseases. Nat Rev Rheumatol 9:173-182
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 173-182
    • O'Shea, J.J.1    Laurence, A.2    McInnes, I.B.3
  • 15
    • 84888609785 scopus 로고    scopus 로고
    • XELJANZ® (tofacitinib) tablets for oral administration
    • Pfizer
    • Pfizer (2012) XELJANZ® (tofacitinib) tablets for oral administration. In: US prescribing information. http://labeling.pfizer.com/ShowLabeling.aspx? id=959
    • (2012) US Prescribing Information
  • 16
    • 84898005731 scopus 로고    scopus 로고
    • Safety profile of protein kinase inhibitors in rheumatoid arthritis: Systematic review and meta-analysis
    • Salgado E, Maneiro JR, Carmona L et al (2013) Safety profile of protein kinase inhibitors in rheumatoid arthritis: systematic review and meta-analysis. Ann Rheum Dis
    • (2013) Ann Rheum Dis
    • Salgado, E.1    Maneiro, J.R.2    Carmona, L.3
  • 17
    • 84878946619 scopus 로고    scopus 로고
    • Tofacitinib: A review of its use in adult patients with rheumatoid arthritis
    • Scott LJ (2013) Tofacitinib: a review of its use in adult patients with rheumatoid arthritis. Drugs 73:857-874
    • (2013) Drugs , vol.73 , pp. 857-874
    • Scott, L.J.1
  • 18
    • 84864703156 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
    • Van Vollenhoven RF, Fleischmann R, Cohen S et al (2012) Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med 367:508-519
    • (2012) N Engl J Med , vol.367 , pp. 508-519
    • Van Vollenhoven, R.F.1    Fleischmann, R.2    Cohen, S.3
  • 19
    • 84874267946 scopus 로고    scopus 로고
    • Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; Results of a phase IIa trial
    • Vanhoutte F, Mazur M, Namour F et al (2012) Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIa trial. Ann Rheum Dis 145
    • (2012) Ann Rheum Dis , pp. 145
    • Vanhoutte, F.1    Mazur, M.2    Namour, F.3
  • 20
    • 84875845688 scopus 로고    scopus 로고
    • Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: Analyses of patient-reported outcomes from a randomized, double-blind, placebo-controlled trial
    • Weinblatt ME, Kavanaugh A, Genovese MC et al (2013) Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: analyses of patient-reported outcomes from a randomized, double-blind, placebo-controlled trial. J Rheumatol 40:369-378
    • (2013) J Rheumatol , vol.40 , pp. 369-378
    • Weinblatt, M.E.1    Kavanaugh, A.2    Genovese, M.C.3
  • 21
    • 84857480858 scopus 로고    scopus 로고
    • Strategies for the management of rheumatoid arthritis
    • Wilkie WS, Schwieterman P (2012) Strategies for the management of rheumatoid arthritis. Orthopedics 35:125-130
    • (2012) Orthopedics , vol.35 , pp. 125-130
    • Wilkie, W.S.1    Schwieterman, P.2
  • 22
    • 84878901567 scopus 로고    scopus 로고
    • Tuberculosis and tofacitinib therapy in patients with rheumatoid arthritis
    • Winthrop K, Park SH, Gul A et al (2012) Tuberculosis and tofacitinib therapy in patients with rheumatoid arthritis. Arthritis Rheum 64(10 Suppl):S547
    • (2012) Arthritis Rheum , vol.64 , Issue.10 SUPPL.
    • Winthrop, K.1    Park, S.H.2    Gul, A.3
  • 23
    • 84877861892 scopus 로고    scopus 로고
    • Herpes zoster and tofacitinib therapiy in patients with rheumatoid arhritis
    • Winthrop K, Valdez H, Mortensen E et al (2012) Herpes zoster and tofacitinib therapiy in patients with rheumatoid arhritis. Arthritis Rheum 64(10 Suppl):S1051
    • (2012) Arthritis Rheum , vol.64 , Issue.10 SUPPL.
    • Winthrop, K.1    Valdez, H.2    Mortensen, E.3
  • 24
    • 77957257774 scopus 로고    scopus 로고
    • Rheumatoid arthritis and herpes zoster: Risk and prevention in those treated with anti-tumour necrosis factor therapy
    • Winthrop KL, Furst DE (2010) Rheumatoid arthritis and herpes zoster: risk and prevention in those treated with anti-tumour necrosis factor therapy. Ann Rheum Dis 69:1735-1737
    • (2010) Ann Rheum Dis , vol.69 , pp. 1735-1737
    • Winthrop, K.L.1    Furst, D.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.