Fighting blindness with microelectronics

Science Translational Medicine

Volumn 5, Issue 210, 2013, Pages

  Zrenner, Eberhart ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; EYE PROTEIN; PROTEIN RPE65; RETINOID; UNCLASSIFIED DRUG;

BINOCULAR VISION; BLINDNESS; CELL ENCAPSULATION; COLOR VISION; COMPUTER SYSTEM; CORNEAL ELECTRODE; ELECTRODE IMPLANT; ELECTRONICS; ELECTROSTIMULATION; EMBRYONIC STEM CELL; EYE HAND COORDINATION; GENE REPLACEMENT THERAPY; HUMAN; IMAGE QUALITY; LEBER CONGENITAL AMAUROSIS; LUMINANCE; MICROELECTRONICS; NEUROLOGICAL EQUIPMENT; NEUROPROTECTION; NONHUMAN; OPTOGENETICS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PHOTORECEPTOR CELL; PRIORITY JOURNAL; RETINA FOVEA; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA DEGENERATION; RETINAL IMPLANT; RETINITIS PIGMENTOSA; REVIEW; SAFETY; STEM CELL TRANSPLANTATION; TONGUE STIMULATOR; VISUAL ACUITY; VISUAL FIELD;

ANIMALS; BLINDNESS; ELECTRONICS; HUMANS; MINIATURIZATION; VISUAL PROSTHESIS;

EID: 84888585469     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3007399     Document Type: Review

References (38)

1. A. T. Fahim, S. P. Daiger, R. G. Weleber, Retinitis Pigmentosa Overview. In R. A. Pagon, M. P. Adam, T. D. Bird et al., Eds. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2013 (2000, Updated 2013, Mar. 21). http://www.ncbi.nlm.nih.gov/books/NBK1417/.
2. A. Santos, M. S. Humayun, E. De Juan Jr., R. J. Greenburg, M. J. Marsh, I. B. Klock, A. H. Milam, Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch. Ophthalmol. 115, 511-515 (1997).
3. G. S. Brindley, W. S. Lewin. The sensations produced by electrical stimulation of the visual cortex. J. Physiol. (Lond.), 196, 479-493 (1968).
4. E. M. Maynard, Visual prostheses. Annu. Rev. Biomed. Eng. 3, 145-168 (2001).
5. J. Delbeke, M. Oozeer, C. Veraart, Position, size and luminosity of phosphenes generated by direct optic nerve stimulation. Vision Res. 43, 1091-1102 (2003).
6. E. Zrenner, Will retinal implants restore vision? Science 295, 1022-1025 (2002).
7. J. F. Rizzo 3rd, J. Wyatt, J. Loewenstein, S. Kelly, D. Shire, Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. Invest. Ophthalmol. Vis. Sci. 44, 5362-5369 (2003).
8. J. D. Weiland, W. Liu, M. S. Humayun, Retinal prosthesis. Annu. Rev. Biomed. Eng. 7, 361-401 (2005).
9. J. D. Weiland, A. K. Cho, M. S. Humayun, Retinal prostheses: Current clinical results and future needs. Ophthalmology 118, 2227-2237 (2011).
10. T. Guenther, N. H. Lovell, G. J. Suaning, Bionic vision: System architectures: A review. Expert Rev. Med. Devices 9, 33-48 (2012).
11. E. Zrenner, Artificial vision: Solar cells for the blind. Nat. Photonics 6, 344-345 (2012).
12. A. Y. Chow, V. Y. Chow, K. H. Packo, J. S. Pollack, G. A. Peyman, R. Schuchard, The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa. Arch. Ophthalmol. 122, 460-469 (2004).
13. K. Mathieson, J. Loudin, G. Goetz, P. Huie, L. Wang, T. I. Kamins, L. Galambos, R. Smith, J. S. Harris, A. Sher, D. Palanker, Photovoltaic retinal prosthesis with high pixel density. Nat. Photonics 6, 391-397 (2012).
14. S. J. Garg, J. Federman, Optogenetics, visual prosthesis and electrostimulation for retinal dystrophies. Curr. Opin. Ophthalmol. 24, 407-414 (2013).
15. M. S. Humayun, J. D. Dorn, L. Da Cruz, G. Dagnelie, J. A. Sahel, P. E. Stanga, A. V. Cideciyan, J. L. Duncan, D. Eliott, E. Filley, A. C. Ho, A. Santos, A. B. Safran, A. Arditi, L. V. Del Priore, R. J. Greenberg, I. I. Argus, Argus II Study Group, Interim results from the international trial of Second Sight's visual prosthesis. Ophthalmology 119, 779-788 (2012).
16. E. Zrenner, K. U. Bartz-Schmidt, H. Benav, D. Besch, A. Bruckmann, V. P. Gabel, F. Gekeler, U. Greppmaier, A. Harscher, S. Kibbel, J. Koch, A. Kusnyerik, T. Peters, K. Stingl, H. Sachs, A. Stett, P. Szurman, B. Wilhelm, R. Wilke, Subretinal electronic chips allow blind patients to read letters and combine them to words. Proc. Biol. Sci. 278, 1489-1497 (2011).
17. K. Stingl, K. U. Bartz-Schmidt, D. Besch, A. Braun, A. Bruckmann, F. Gekeler, U. Greppmaier, S. Hipp, G. Hörtdörfer, C. Kernstock, A. Koitschev, A. Kusnyerik, H. Sachs, A. Schatz, K. T. Stingl, T. Peters, B. Wilhelm, E. Zrenner, Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS. Proc. Biol. Sci. 280, 20130077 (2013).
18. A. Stett, W. Barth, S. Weiss, H. Haemmerle, E. Zrenner, Electrical multisite stimulation of the isolated chicken retina. Vision Res. 40, 1785-1795 (2000).
19. L. Da Cruz, B. F. Coley, J. Dorn, F. Merlini, E. Filley, P. Christopher, F. K. Chen, V. Wuyyuru, J. Sahel, P. Stanga, M. Humayun, R. J. Greenberg, G. Dagnelie, and the Argus II Study Group. The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss. Br. J. Ophthalmol. 97, 632-636 (2013).
20. A. Pérez Fornos, J. Sommerhalder, L. Da Cruz, J. A. Sahel, S. Mohand-Said, F. Hafezi, M. Pelizzone, Temporal properties of visual perception on electrical stimulation of the retina. Invest. Ophthalmol. Vis. Sci. 53, 2720-2731 (2012).
21. C. D. Eiber, N. H. Lovell, G. J. Suaning, Attaining higher resolution visual prosthetics: A review of the factors and limitations. J. Neural Eng. 10, 011002 (2013).
22. C. Hassler, T. Boretius, T. Stieglitz. Polymers for neural implants. J. Polymer Sci. Part B 49, 18-33 (2011).
23. E. D. Cohen, Effects of high-level pulse train stimulation on retinal function. J. Neural Eng. 6, 035005 (2009).
24. Y. Danilov, M. Tyler, Brainport: An alternative input to the brain. J. Integr. Neurosci. 4, 537-550 (2005).
25. P. A. Sieving, R. C. Caruso, W. Tao, H. R. Coleman, D. J. S. Thompson, K. R. Fullmer, R. A. Bush, Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc. Natl. Acad. Sci. U. S. A. 103, 3896-3901 (2006).
26. T. Morimoto, H. Kanda, M. Kondo, H. Terasaki, K. Nishida, T. Fujikado, Transcorneal electrical stimulation promotes survival of photoreceptors and improves retinal function in rhodopsin P347L transgenic rabbits. Invest. Ophthalmol. Vis. Sci. 53, 4254-4261 (2012).
27. A. Schatz, T. Röck, L. Naycheva, G. Willmann, B. Wilhelm, T. Peters, K. Bartz-Schmidt, E. Zrenner, A. Messias, F. Gekeler, Transcorneal electrical stimulation for patients with retinitis pigmentosa: A prospective, randomized, sham-controlled exploratory study. Invest. Ophthalmol. Vis. Sci. 52, 4485-4496 (2011).
28. K. Palczewski, Blind dogs that can see: Pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch. Ophthalmol. 128, 1483-1485 (2010).
29. A. T. Cideciyan, E. Moore, G. A. Zrenner, H. P. Fishman, L. I. Scholl, A. K. Van Den Born, S. Bittner, G. Sadigh, R. K. Dagnelie, Koenekoop, Increased vision within days of oral cis-retinoid (QLT091001) treatment in blindness due to mutations in retinal pigment epithelium-specific protein 65kDa (RPE65) or lecithin retinol acyltransferase (LRAT). ARVO Abstract # 6965, 2012.
30. J. Bennett, A. M. Maguire, Gene Therapy for Retinal Disease. In Retina (5th ed.), S. J. Ryan, Chief Ed. (Saunders/Elsevier, 2013), sect. 4, chap. 34, pp. 652-668.
31. G. M. Acland, G. D. Aguirre, J. Bennett, T. S. Aleman, A. V. Cideciyan, J. Bennicelli, N. S. Dejneka, S. E. Pearce-Kelling, A. M. Maguire, K. Palczewski, W. W. Hauswirth, S. G. Jacobson, Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol. Ther. 12, 1072-1082 (2005).
32. A. M. Maguire, F. Simonelli, E. A. Pierce, E. N. Pugh Jr., F. Mingozzi, J. Bennicelli, S. Banfi, K. A. Marshall, F. Testa, E. M. Surace, S. Rossi, A. Lyubarsky, V. R. Arruda, B. Konkle, E. Stone, J. Sun, J. Jacobs, L. Dell'Osso, R. Hertle, J. X. Ma, T. M. Redmond, X. Zhu, B. Hauck, O. Zelenaia, K. S. Shindler, M. G. Maguire, J. F. Wright, N. J. Volpe, J. W. McDonnell, A. Auricchio, K. A. High, J. Bennett, Safety and efficacy of gene transfer for Leber's congenital amaurosis. N. Engl. J. Med. 358, 2240-2248 (2008).
33. A. V. Cideciyan, S. G. Jacobson, W. A. Beltran, A. Sumaroka, M. Swider, S. Iwabe, A. J. Roman, M. B. Olivares, S. B. Schwartz, A. M. Komáromy, W. W. Hauswirth, G. D. Aguirre, Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proc. Natl. Acad. Sci. U. S. A. 110, E517-E525 (2013).
34. A. Gonzalez-Cordero, E. L. West, R. A. Pearson, Y. Duran, L. S. Carvalho, C. J. Chu, A. Naeem, S. J. Blackford, A. Georgiadis, J. Lakowski, M. Hubank, A. J. Smith, J. W. Bainbridge, J. C. Sowden, R. R. Ali, Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nat. Biotechnol. 31, 741-747 (2013).
35. S. D. Schwartz, J. P. Hubschman, G. Heilwell, V. Franco-Cardenas, C. K. Pan, R. M. Ostrick, E. Mickunas, R. Gay, I. Klimanskaya, R. Lanza, Embryonic stem cell trials for macular degeneration: A preliminary report. Lancet 379, 713-720 (2012).
36. A. O. Cramer, R. E. MacLaren. Clinical trials using induced pluripotent stem cells from bench to bedside: Application to retinal diseases. Current Gene Therapy 13, 139-151 (2013).
37. P. S. Lagali, D. Balya, G. B. Awatramani, T. A. Münch, D. S. Kim, V. Busskamp, C. L. Cepko, B. Roska, Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat. Neurosci. 11, 667-675 (2008).
38. J. A. Sahel, B. Roska, Gene therapy for blindness. Annu. Rev. Neurosci. 36, 467-488 (2013).