Ketone bodies upregulate endothelial connexin 43 (Cx43) gap junctions

Veterinary Journal

Volumn 198, Issue 3, 2013, Pages 696-701

  Ho, Chia Fang ^a   Chan, Kun Wei ^b   Yeh, Hung I ^c   Kuo, James ^a   Liu, Hung Jen ^a   Wang, Chi Young ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^c MACKAY MEDICAL COLLEGE   (Taiwan)

Author keywords

Cell migration; Endothelial cells; Gap junction; Ketone body; Ketosis

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ACETONE; CONNEXIN 43; KETONE BODY; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14;

ANIMAL CELL; ARTICLE; BOVINE AORTIC ENDOTHELIAL CELL; CELL ACTIVITY; CELL MIGRATION; CELL PROLIFERATION; CELLULAR PARAMETERS; CONFOCAL MICROSCOPY; CONNEXIN 43 GENE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GAP JUNCTION; GAP JUNCTIONAL INTERCELLULAR COUPLING; GENE EXPRESSION; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS); BOVINAE;

CELL MIGRATION; ENDOTHELIAL CELLS; GAP JUNCTION; KETONE BODY; KETOSIS;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; ACETONE; ANIMALS; AORTA; BLOTTING, WESTERN; CATTLE; CONNEXIN 43; ENDOTHELIAL CELLS; GAP JUNCTIONS; KETOSIS; MICROSCOPY, CONFOCAL; POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 84888436733     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2013.09.069     Document Type: Article

References (24)

1. Bates D.C., Sin W.C., Aftab Q., Naus C.C. Connexin43 enhances glioma invasion by a mechanism involving the carboxy terminus. Glia 2007, 55:1554-1564.
2. Cheng S., Wu Q., Yang F., Xu M., Leski M., Chen G.Q. Influence of l-beta-hydroxybutyric acid on cell proliferation and calcium influx. Biomacromolecules 2005, 6:593-597.
3. Correa M.T., Erb H., Scarlett J. Path analysis for seven postpartum disorders of Holstein cows. Journal of Dairy Science 1993, 76:1305-1312.
4. Duffield T.F., Lissemore K.D., McBride B.W., Leslie K.E. Impact of hyperketonemia in early lactation dairy cows on health and production. Journal of Dairy Science 2009, 92:571-580.
5. Gross J., van Dorland H.A., Bruckmaier R.M., Schwarz F.J. Performance and metabolic profile of dairy cows during a lactational and deliberately induced negative energy balance with subsequent realimentation. Journal of Dairy Science 2011, 94:1820-1830.
6. Hsiao H.J., Liu P.A., Yeh H.I., Wang C.Y. Classical swine fever virus down-regulates endothelial connexin43 gap junctions. Archives of Virology 2010, 115:1107-1116.
7. Jain S.K., Kannan K., Lim G. Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells. Free Radical Biology and Medicine 1998, 25:1083-1088.
8. Kanemitsu M.Y., Lau A.F. Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-O-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: The possible involvement of mitogen-activated protein kinase. Molecular Biology of the Cell 1993, 4:837-848.
9. Kuroki T., Inoguchi T., Umeda F., Ueda F., Nawata F. High glucose induces alteration of gap junction permeability and phosphorylation of connexin43 in cultured aortic smooth muscle cells. Diabetes 1998, 47:931-936.
10. Kwak B.R., Silacci P., Stergiopulos N., Hayoz D., Meda P. Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells. Cell Communication and Adhesion 2005, 12:261-270.
11. Lampe P.D., Lau A.F. Regulation of gap junctions by phosphorylation of connexins. Archives of Biochemistry and Biophysics 2000, 384:205-215.
12. Larid D.W. The gap junction proteome and its relationship to disease. Trends in Cell Biology 2010, 20:92-101.
13. Liu C.L., Huang Y.S., Hosokawa M., Miyashita K., Hu M.L. Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication. Chemico-Biological Interactions 2009, 182:165-172.
14. Loncke C., Oritigues-Marty J., Vernet H., Lapierre H., Sauvant D., Noziere P. Empirical prediction of net portal appearance of volatile fatty acids, glucose, and their secondary metabolites (β-hydroxybutyrate, lactate) from dietary characteristics in ruminants: A meta-analysis approach. Journal of Animal Science 2009, 87:253-268.
15. Petrich B.G., Gong X., Lerner D.L., Wang X., Brown J.H., Saffitz J.E., Wang Y. C-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circulation Research 2002, 91:640-647.
16. Robinson A., Williamson D. Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiological Reviews 1980, 60:143-187.
17. Sato T., Haimovici R., Kao R., Li A.F., Roy S. Down-regulation of connexins expression by high glucose reduces gap junction activity in microvascular endothelial cells. Diabetes 2002, 51:1565-1571.
18. Schwartz S.M. Selection and characterization of bovine aortic endothelial cells. In Vitro 1978, 14:966-980.
19. Suriyasathaporn W., Heuer C., Noordhuizen-Stassen E.N., Schukken Y.H. Hyperketonemia and udder defense: A review. Veterinary Research 2000, 31:397-412.
20. Wagner S.A., Schimek D.E. Evaluation of the effect of bolus administration of 50% dextrose solution on measures of electrolyte and energy balance in postpartum dairy cows. American Journal of Veterinary Research 2010, 71:1074-1080.
21. Wang C.Y., Liu H.J., Chen H.J., Lin Y.C., Wang H.H., Hung T.C., Yeh H.I. AGE-BSA down-regulates endothelial connexin43 gap junctions. BMC Cell Biology 2011, 12:19.
22. Zdzisinska B., Filar J., Paduch R., Kaczor J., Lokaj I., Kandefer-Szerszen M. The influence of ketone bodies and glucose on interferon, tumor necrosis factor production and NO release in bovine aorta endothelial cells. Veterinary Immunology and Immunopathology 2000, 74:237-247.
23. Zhao Y., Rivieccio M.A., Lutz S., Scemes E., Brosnan C.F. The TLR3 ligand polyI:C downregulates connexin43 expression and function in astrocytes by a mechanism involving the NF-kappaB and PI3 kinase pathways. Glia 2006, 54:775-785.
24. Zou X.H., Li H.M., Wang S., Leski M., Yao Y.C., Yang X.D., Huang Q.J., Chen G.Q. The effect of 3-hydroxybutyrate methyl ester on learning and memory in mice. Biomaterials 2009, 30:1532-1541.