Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia1-3

Journal of Nutrition

Volumn 143, Issue 12, 2013, Pages 2007-2014

  Tomita, Luciana Y ^a,b   D'Almeida, Vania ^a   Villa, Luisa L ^b,i   Franco, Eduardo L ^c   Cardoso, Marly A ^b   Almeida, Lana C ^b   Filho, Adhemar Longatto ^d   de Castro Ferraz, Maria da Gloria Mattosinho ^d   Utagawa, Maria Lucia ^d   Aguiar, Luciana S ^d   Roteli Martins, Cecília ^e   Rangel Costa, Ronaldo Lucio ^f   Ricci, Marcos Desidério ^g   Ferreira Alves, Venañcio Avancini ^b   Sperança, Márcia A ^h   Francisco Bagnariolli, Anete M ^h   Costa, Maria Cecília ⁱ   Avilla Andreoli, Maria Antonieta ⁱ   Pereira Sobrinho, João Simão ⁱ   Mann Prado, José Carlos ⁱ  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c MCGILL UNIVERSITY   (Canada)

^d INSTITUTO ADOLFO LUTZ   (Brazil)

^e HOSPITAL MATERNIDADE LEONOR MENDES DE BARROS   (Brazil)

^f Instituto Brasileiro de Controle do Cancer   (Brazil)

^g Hospital Pérola Byngton   (Brazil)

^h Laboratory of Pharmacology   (Brazil)

ⁱ LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE SYNTHASE REDUCTASE; PYRIDOXINE; REDUCED FOLATE CARRIER;

ADULT; AGED; ARTICLE; BRAZIL; CANCER RISK; CONFOUNDING VARIABLE; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOLATE METABOLISM; FOLIC ACID BLOOD LEVEL; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PAPILLOMAVIRUS INFECTION; SINGLE NUCLEOTIDE POLYMORPHISM; UTERINE CERVIX CARCINOMA IN SITU; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; BLOOD; DIET; GENETIC POLYMORPHISM; MIDDLE AGED; UTERINE CERVIX TUMOR;

ADULT; DIET; FEMALE; FOLIC ACID; HUMANS; MIDDLE AGED; POLYMORPHISM, GENETIC; UTERINE CERVICAL NEOPLASMS; VITAMIN B 6;

EID: 84888427333     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.182212     Document Type: Article

References (64)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127:2893-917.
2. Parikh S, Brennan P, Boffetta P. Meta-analysis of social inequality and the risk of cervical cancer. Int J Cancer. 2003; 105:687-91.
3. Walboomers JM, Jacobs M, Manos M, Bosch F, Kummer J, Shah K, Snijders P, Peto J, Meijer C, Munoz N. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999; 189:12-9.
4. Munoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith J, Shah K, Meijer C, Bosch F. IARCMCCS. Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet. 2002; 359:1093-101.
5. Moreno V, Bosch F, Munoz N, Meijer C, Shah K, Walboomers J, Herrero R, Franceschi S. IARC multicentric case-control study. Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study. Lancet. 2002; 359:1085-92.
6. Plummer M, Herrero R, Franceschi S, Meijer C, Snijders P, Bosch F, de Sanjose S, Munoz N, IARCMCCS. Smoking and cervical cancer: pooled analysis of the IARC multi-centric case-control study. Cancer Causes Control. 2003; 13:805-14.
7. Shane B. Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms. Food Nutr Bull. 2008; 29:S5-16; discussion S7-9.
8. Goodman MT, McDuffie K, Hernandez B, Wilkens LR, Bertram CC, Killeen J, Le Marchand L, Selhub J, Murphy S, Donlon TA. Association of methylenetetrahydrofolate reductase polymorphism C677T and dietary folate with the risk of cervical dysplasia. Cancer Epidemiol Biomarkers Prev. 2001; 10:1275-80.
9. Hernandez BY, McDuffie K, Wilkens L, Kamemoto L, Goodman M. Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. Cancer Causes Control. 2003; 14:859-70.
10. WideroffL, Potischman N, Glass AG, Greer CE, Manos MM, Scott DR, Burk RD, Sherman ME, Wacholder S, Schiffman M. A nested case-control study of dietary factors and the risk of incident cytological abnormalities of the cervix. Nutr Cancer. 1998; 30:130-6.
11. Kjellberg L, Hallmans G, Ahren AM, Johansson R, Bergman F, Wadell G, Angstrom T, Dillner J. Smoking, diet, pregnancy and oral contra-ceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection. Br J Cancer. 2000; 82:1332-8.
12. Shannon J, Thomas DB, Ray RM, Kestin M, Koetsawang A, Koetsawang S, Chitnarong K, Kiviat N, Kuypers J. Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand. Cancer Causes Control. 2002; 13:691-9.
13. Kanetsky PA, Gammon MD, Mandelblatt J, Zhang ZF, Ramsey E, Dnistrian A, Norkus EP, Wright TC Jr. Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, black women. Nutr Cancer. 1998; 31:31-40.
14. VanEenwyk J, Davis FG, Colman N. Folate, vitamin C, and cervical intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev. 1992; 1:119-24.
15. Sedjo RL, Fowler B, Schneider A, Henning S, Hatch K, Giuliano A. Folate, vitamin B12, and homocysteine status. Findings of no relation between human papillomavirus persistence and cervical dysplasia. Nutrition. 2003; 19:497-502.
16. Fowler BM, Giuliano A, Piyathilake C, Nour M, Hatch K. Hypome-thylation in cervical tissue: is there a correlation with folate status? Cancer Epidemiol Biomarkers Prev. 1998; 7:901-6.
17. Sedjo RL, Papenfuss M, Craft N, Giuliano A. Effect of plasma micronutrients on clearance of oncogenic human papillomavirus (HPV) infection (United States). Cancer Causes Control. 2003; 14:319-26.
18. Weinstein SJ, Ziegler R, Selhub J, Fears T, Strickler H, Brinton L, Hamman R, Levine R, Mallin K, Stolley P. Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women. Cancer Causes Control. 2001; 12:317-24.
19. Ziegler RG, Weinstein S, Fears T. Nutritional and genetic inefficiencies in one-carbon metabolism and cervical cancer risk. J Nutr. 2002; 132: S2345-9.
20. Alberg AJ, Selhub J, Shah K, Viscidi R, Comstock G, Helzlsouer K. The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine. Cancer Epidemiol Biomarkers Prev. 2000; 9:761-4.
21. Thomson SW, Heimburger D, Cornwell P, Turner M, Sauberlich H, Fox L, Butterworth C. Effect of total plasma homocysteine on cervical dysplasia risk. Nutr Cancer. 2000; 37:128-33.
22. Goodman MT, McDuffie K, Hernandez B, Wilkens L, Selhub J. Case-control study of plasma folate, homocysteine, vitamin B(12), and cysteine as markers of cervical dysplasia. Cancer. 2000; 89:376-82.
23. Tong SY, Kim MK, Lee JK, Lee JM, Choi SW, Friso S, Song ES, Lee KB, Lee JP. Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. Cancer Causes Control. 2011; 22:63-72.
24. Yeo AS, SchiffM, Montoya G, Masuk M, van Asselt-King L, Becker T. Serum micronutrients and cervical dysplasia in Southwestern American Indian women. Nutr Cancer. 2000; 38:141-50.
25. Piyathilake CJ. Update on micronutrients and cervical dysplasia. Ethn Dis. 2007; 17(2 Suppl 2):S2-14-7.
26. Carmel R. Folic acid. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern nutrition in health and disease. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 470-81.
27. Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost. 1997; 78:523-6.
28. Wang L, Chen W, Wang J, Tan Y, Zhou Y, Ding W, Hua Z, Shen J, Xu Y, Shen H. Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population. Eur J Cancer. 2006; 42:3206-11.
29. Tomita LY, Longatto Filho A, Costa M, Andreoli M, Villa L, Franco E, Cardoso M, BRINCA Study Team. Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women. Int J Cancer. 2010; 126:703-14.
30. WHO. Diet, nutrition and the prevention of chronic diseases. Technical report series no 916: Geneva: WHO; 2002.
31. Cardoso MA, Tomita LY, Laguna EC. Assessing the validity of a food frequency questionnaire among low-income women in Sao Paulo, southeastern Brazil. Cad Saude Publica. 2010; 26:2059-67.
32. Block G, Coyle LM, Hartman AM, Scoppa SM. Revision of dietary analysis software for the Health Habits and History Questionnaire. Am J Epidemiol. 1994; 139:1190-6.
33. Guerra-Shinohara EM, Paiva AA, Rondo PH, Yamasaki K, Terzi CA, D'Almeida V. Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12. BJOG. 2002; 109:784-91.
34. Sharma SK, Dakshinamurti K. Determination of vitamin B6 vitamers and pyridoxic acid in biological samples. J Chromatogr. 1992; 578:45-51.
35. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, Snijders PJ, Meijer CJ, Group IARCMCCS. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003; 348:518-27.
36. Myakishev MV, Khripin Y, Hu S, Hamer DH. High-throughput SNP genotyping by allele-specific PCR with universal energy-transfer-labeled primers. Genome Res. 2001; 11:163-9.
37. Rusch TL, Dickinson W, Che J, Fieweger K, Chudyk J, Doktycz M, Yu A, Weber JL. Instrumentation for continuous array genotyping of short insertion/deletion polymorphisms. Proceedings of the SPIE Microarrays and Combinatorial Technologies for Biomedical Applications: design, fabrication, and analysis; 2003 Jan 25; San Jose, CA. 4966:138-45. DOI:10.1117/12.483474.
38. Rodriguez S, Gaunt TR, Day IN. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol. 2009; 169:505-14.
39. Willett W. Nutritional epidemiology. 2nd ed. Oxford: Oxford University Press; 1998.
40. Szklo M, Nieto FJ. Epidemiology beyond the basics. Boston: Jones & Bartlett Publishers; 2000.
41. Kleimbaum DG. Logistic regression: a self-learning text. New York: Springer-Verlag; 1998.
42. Knol MJ, van der Tweel I, Grobbee DE, Numans ME, Geerlings MI. Estimating interaction on an additive scale between continuous determinants in a logistic regression model. IntJ Epidemiol. 2007; 36:1111-8.
43. Berrington A, Cox DR. Generalized least squares for the synthesis of correlated information. Biostatistics. 2003; 4:423-31.
44. Trumbo P, Yates AA, Schlicker S, Poos M. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc. 2001; 101:294-301.
45. Isotalo PA, Wells G, Donnelly J. Neonatal and fetal methylenetetrahy-drofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Am J Hum Genet. 2000; 67:986-90.
46. Cardon LR, Palmer LJ. Population stratification and spurious allelic association. Lancet. 2003; 361:598-604.
47. Goring HH, Terwilliger JD, Blangero J. Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet. 2001; 69:1357-69.
48. Jorde LB. Linkage disequilibrium and the search for complex disease genes. Genome Res. 2000; 10:1435-44.
49. Henao OL, Piyathilake CJ, Waterbor JW, Funkhouser E, Johanning GL, Heimburger DC, Partridge EE. Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3. Int J Cancer. 2005; 113:991-7.
50. Lambropoulos AF, Agorastos T, Foka ZJ, ChrisafiS, Constantinidis TC, Bontis J, Kotsis A. Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia. Cancer Lett. 2003; 191:187-91.
51. Shekari M, Sobti RC, Kordi Tamandani DM, Suri V. Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population. Arch Gynecol Obstet. 2008; 278:517-24.
52. Mei Q, Zhou D, Gao J, Shen S, Wu J, Guo L, Liang Z. The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis. BMC Cancer. 2012; 12:467.
53. Luo YL, Ye P, Zhang QH, Hu TT, Luo MH, Li MQ, Chen Q. Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia: a meta-analysis. PLoS ONE. 2012; 7:e46272.
54. Long S, Yang X, Liu X, Yang P. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and susceptibility for cervical lesions: a meta-analysis. PLoS ONE. 2012; 7:e52381.
55. Barker J, Horn EJ, Lebwohl M, Warren RB, Nast A, Rosenberg W, Smith C, Council IP. Assessment and management of methotrexate hepatotoxicity in psoriasis patients: report from a consensus conference to evaluate current practice and identify key questions toward optimizing methotrexate use in the clinic. J Eur Acad Dermatol Venereol. 2011; 25:758-64.
56. Kim YI. Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis. Nutr Rev. 2000; 58:205-9.
57. Ueland PM, Hustad S, Schneede J, Refsum H, Vollset S. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci. 2001; 22:195-201.
58. Sohn KJ, Jang H, Campan M, Weisenberger D, Dickhout J, Wang Y, Cho R, Yates Z, Lucock M, Chiang EP, et al. The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer. 2009; 124:1999-2005.
59. Yang Q, Bostick RM, Friedman JM, Flanders WD. Serum folate and cancer mortality among U.S. adults: findings from the Third National Health and Nutritional Examination Survey linked mortality file. Cancer Epidemiol Biomarkers Prev. 2009; 18:1439-47.
60. Thomson SW, Heimburger D, Cornwell P, Turner M, Sauberlich H, Fox L, Butterworth C. Correlates of total plasma homocysteine: folic acid, copper, and cervical dysplasia. Nutrition. 2000; 16:411-6.
61. Kwasniewska A, Tukendorf A, Goździcka-Józefiak A, Semczuk-Sikora A, Korobowicz E. Content of folic acid and free homocysteine in blood serum of human papillomavirus-infected women with cervical dysplasia. Eur J Gynaecol Oncol. 2002; 23:311-6.
62. Flatley JE, McNeir K, Balasubramani L, Tidy J, Stuart E, Young T, Powers H. Folate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis. Cancer Epidemiol Biomarkers Prev. 2009; 18:2782-9.
63. Piyathilake CJ, Macaluso M, Alvarez R, Bell W, Heimburger D, Partridge E. Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification era. Cancer Prev Res (Phila). 2009; 2:658-64.
64. Herrmann W, Obeid R. The mandatory fortification of staple foods with folic acid: a current controversy in Germany. Dtsch Arztebl Int. 2011; 108:249-54.