The obesity paradox in heart failure: Is etiology a key factor?

International Journal of Cardiology

Volumn 166, Issue 3, 2013, Pages 601-605

  Zamora, Elisabet ^a   Lupón, Josep ^b   De Antonio, Marta ^b   Urrutia, Agustín ^b   Coll, Ramon ^b   Díez, Crisanto ^b   Altimir, Salvador ^b   Bayés Genís, Antoni ^b  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Body mass index; Etiology; Heart failure; Ischemic heart disease; Mortality

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOOP DIURETIC AGENT; NITRATE; SPIRONOLACTONE;

AGE DISTRIBUTION; AGED; ALCOHOLIC CARDIOMYOPATHY; ARTICLE; BODY MASS; BODY WEIGHT; CARDIOMYOPATHY; CARDIOVASCULAR MORTALITY; COMORBIDITY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEART DISEASE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIA; LONG TERM SURVIVAL; MAJOR CLINICAL STUDY; MALE; OBESITY; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX DIFFERENCE; COHORT ANALYSIS; MIDDLE AGED; MORTALITY; SURVIVAL RATE; TRENDS;

AGED; BODY MASS INDEX; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; OBESITY; PROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84888422320     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2011.11.022     Document Type: Article

References (22)

1. Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med 2002; 347: 305-13.
2. Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006; 113: 898-918.
3. Govindarajan G, Whaley-Connell A, Mugo M, Stump C, Sowers JR. The cardiometabolic syndrome as a cardiovascular risk factor. Am J Med Sci 2005; 330: 311-8.
4. Morisco C, Lembo G, Trimarco B. Insulin resistance and cardiovascular risk: new insights from molecular and cellular biology. Trends Cardiovasc Med 2006; 16: 183-8.
5. Contaldo F, Pasanisi F, Finelli C, de Simone G. Obesity, heart failure and sudden death. Nutr Metab Cardiovasc Dis 2002; 12: 190-7.
6. Peterson LR, Waggoner AD, Schechtman KB, et al. Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. J Am Coll Cardiol 2004; 43: 1399-404.
7. Powell BD, Redfield MM, Bybee KA, Freeman WK, Rihal CS. Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease. Am J Cardiol 2006; 98: 116-20.
8. Dagenais GR, Yi Q, Mann JF, Bosch J, Pogue J, Yusuf S. Prognostic impact of body weight and abdominal obesity in women and men with cardiovascular disease. Am Heart J 2005; 149: 54-60.
9. Oreopoulos A, Padwal R, Kalantar-Zadeh K, Fonarow GC, Norris CM, McAlister FA. Body mass index and mortality in heart failure: a meta-analysis. Am Heart J 2008; 156: 13-22.
10. Zamora E, Lupón J, Urrutia A, et al. Does body mass index influence mortality in patients with heart failure? Rev Esp Cardiol 2007; 60: 1127-34.
11. Zamora E, Lupón J, Urrutia A, et al. Obesity and long term prognosis in heart failure: the paradox continues. Rev Esp Cardiol 2010; 63: 1210-2.
12. Urrutia A, Zamora E, Lupón J, et al. Clinical, echocardiographic and prognostic evaluation of atrial fibrillation in patients with heart failure. Med Clin (Barc) 2007; 129: 321-5.
13. Zamora E, Lupón J, López-Ayerbe J, et al. Left atrium diameter: a simple echocardiographic parameter with high prognostic value in heart failure. Med Clin (Barc) 2007; 129: 441-5.
14. Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC. Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure. J Am Coll Cardiol 2004; 43: 1439-44.
15. Kalantar-Zadeh K, Kopple JD. Obesity paradox in patients on maintenance dialysis. Contrib Nephrol 2006; 151: 57-69.
16. Adamopoulos C, Meyer P, Desai RV, et al. Absence of obesity paradox in patients with chronic heart failure and diabetes mellitus: a propensity-matched study. Eur J Heart Fail 2011; 13: 200-6.
17. Lopez-Jimenez F, Jacobsen SJ, Reeder GS, Weston SA, Meverden RA, Roger VL. Prevalence and secular trends of excess body weight and impact on outcomes after myocardial infarction in the community. Chest 2004; 125: 1205-12.
18. Lavie CJ, Milani RV, Artham SM, Patel DA, Ventura HO. The obesity paradox, weight loss, and coronary disease. Am J Med 2009; 122: 1106-14.
19. Romero-Corral A, Montori VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 2006; 368: 666-78.
20. Benderly M, Boyko V, Goldbourt U. Relation of body mass index to mortality among men with coronary heart disease. Am J Cardiol 2010; 106: 297-304.
21. Arena R, Myers JM, Abella J, et al. Influence of etiology of heart failure on the obesity paradox. Am J Cardiol 2009; 104: 1116-21.
22. Coutinho T, Goel K, Corrêa de Sa D, et al. Central obesity and survival in subjects with coronary artery disease. A systematic review of the literature and collaborative analysis with individual subject data. J Am Coll Cardiol 2011; 57: 1877-86.