Early improvement as a predictor of acute treatment outcome in manic or mixed episodes in bipolar-1 disorder: A pooled, post hoc analysis from the asenapine development program

Journal of Affective Disorders

Volumn 150, Issue 3, 2013, Pages 745-752

  Szegedi, Armin ^a   Zhao, Jun ^a   McIntyre, Roger S ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Antipsychotics; Bipolar mania; CGI BP; Early improvement; YMRS

Indexed keywords

ASENAPINE; OLANZAPINE; PLACEBO;

ARTICLE; BIPOLAR I DISORDER; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; HUMAN; MAJOR CLINICAL STUDY; MIXED MANIA AND DEPRESSION; POST HOC ANALYSIS; PRIORITY JOURNAL; REMISSION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTIPSYCHOTICS; BIPOLAR MANIA; CGI-BP; EARLY IMPROVEMENT; YMRS;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BIPOLAR DISORDER; FEMALE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84888363476     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2013.01.024     Document Type: Article

References (14)

1. Agid, O., Kapur, S., Arenovich, T., Zipursky, R.B., 2003. Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected. Archives of General Psychiatry 60 (12), 1228-1235.
2. Busner, J., Targum, S.D., 2007. The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont.) 4 (7), 28-37.
3. Kapur, S., Arenovich, T., Agid, O., Zipursky, R., Lindborg, S., Jones, B., 2005. Evidence for onset of antipsychotic effects within the first 24 hours of treatment. American Journal of Psychiatry 162 (5), 939-946.
4. Kemp, D.E., Ganocy, S.J., Brecher, M., Carlson, B.X., Edwards, S., Eudicone, J.M., Evoniuk, G., Jansen, W., Leon, A.C., Minkwitz, M., Pikalov, A., Stassen, H.H., Szegedi, A., Tohen, M., Van Willigenburg, A.P., Calabrese, J.R., 2011a. Clinical value of early partial symptomatic improvement in the prediction of response and remission during short-term treatment trials in 3369 subjects with bipolar I or II depression. Journal of Affective Disorders 130 (1-2), 171-179.
5. Kemp, D.E., Johnson, E., Wang, W.V., Tohen, M., Calabrese, J.R., 2011b. Clinical utility of early improvement to predict response or remission in acute mania: focus on olanzapine and risperidone. Journal of Clinical Psychiatry 72 (9), 1236-1241.
6. Ketter, T.A., Agid, O., Kapur, S., Loebel, A., Siu, C.O., Romano, S.J., 2010. Rapid antipsychotic response with ziprasidone predicts subsequent acute manic/mixed episode remission. Journal of Psychiatric Research 44 (1), 8-14.
7. Kinon, B.J., Chen, L., Ascher-Svanum, H., Stauffer, V.L., Kollack-Walker, S., Sniadecki, J.L., Kane, J.M., 2008. Predicting response to atypical antipsychotics based on early response in the treatment of schizophrenia. Schizophrenia Research 102 (1-3), 230-240.
8. Kinon, B.J., Chen, L., Ascher-Svanum, H., Stauffer, V.L., Kollack-Walker, S., Zhou, W., Kapur, S., Kane, J.M., 2010. Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophrenia. Neuropsychopharmacology 35 (2), 581-590.
9. Leucht, S., Busch, R., Hamann, J., Kissling, W., Kane, J.M., 2005. Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended. Biological Psychiatry 57 (12), 1543-1549.
10. Leucht, S., Busch, R., Kissling, W., Kane, J.M., 2007. Early prediction ofantipsychotic nonresponse among patients with schizophrenia. Journal ofClinical Psychiatry 68 (3), 352-360.
11. McIntyre, R.S., Cohen, M., Zhao, J., Alphs, L., Macek, T.A., Panagides, J., 2009. A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states. Bipolar Disorder 11 (7), 673-686.
12. McIntyre, R.S., Cohen, M., Zhao, J., Alphs, L., Macek, TA, Panagides, J., 2010. Asenapine in the treatment of acute mania in bipolar I disorder: a randomized, double-blind, placebo-controlled trial. Journal of Affective Disorders 122 (1-2), 27-38.
13. Stassen, H.H., Angst, J., Hell, D., Scharfetter, C., Szegedi, A., 2007. Is there a common resilience mechanism underlying antidepressant drug response? Evidence from 2848 patients. Journal of Clinical Psychiatry 68 (8), 1195-1205.
14. Szegedi, A., Jansen, W.T., Van Willigenburg, A.P., van der Meulen, E., Stassen, H.H., Thase, M.E., 2009. Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients. Journal of Clinical Psychiatry 70 (3), 344-353.