Relationship between onset-to-door time and door-to-thrombolysis time: A pooled analysis of 10 dedicated stroke centers

Stroke

Volumn 44, Issue 10, 2013, Pages 2808-2813

  Strbian, Daniel ^a   Michel, Patrik ^b   Ringleb, Peter ^c   Numminen, Heikki ^d   Breuer, Lorenz ^e   Bodenant, Marie ^f   Seiffge, David J ^g   Jung, Simon ^h   Obach, Victor ⁱ   Weder, Bruno ^h,j   Tiainen, Marjaana ^a   Eskandari, Ashraf ^b   Gumbinger, Christoph ^c   Gensicke, Henrik ^g   Chamorro, Angel ⁱ   Mattle, Heinrich P ^h   Engelter, Stefan T ^g   Leys, Didier ^f   Köhrmann, Martin ^e   Parkkila, Anna Kaisa ^d   Hacke, Werner ^c   Tatlisumak, Turgut ^a   more..

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^f UNIV LILLE   (France)

^g UNIVERSITY HOSPITAL BASEL   (Switzerland)

^h UNIVERSITY OF BERN   (Switzerland)

ⁱ HOSPITAL CLÍNIC   (Spain)

^j CANTONAL HOSPITAL ST GALLEN   (Switzerland)

more..

Author keywords

Door to needle time; Emergencies; Ischemic stroke; Outcome thrombolysis

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; DOOR TO NEEDLE TIME; FEMALE; GERIATRICS; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OCTOGENARIAN; ONSET TO DOOR TIME; PRIORITY JOURNAL; PROSPECTIVE STUDY; THERAPY DELAY; TIME MANAGEMENT; TREATMENT OUTCOME;

DOOR-TO-NEEDLE TIME; EMERGENCIES; ISCHEMIC STROKE; OUTCOME; THROMBOLYSIS;

AGE FACTORS; AGED; AGED, 80 AND OVER; DELIVERY OF HEALTH CARE; EUROPE; FEMALE; HOSPITALIZATION; HOSPITALS, SPECIAL; HUMANS; MALE; MIDDLE AGED; SEX FACTORS; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS;

EID: 84888357274     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.000995     Document Type: Article

References (20)

1. Saver JL. Time is brain-quantified. Stroke. 2006;37:263-266.
2. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-Pa stroke trials. Lancet. 2004;363:768-774.
3. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, et al. Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2010;375:1695-1703.
4. Khatri P, Abruzzo T, Yeatts SD, Nichols C, Broderick JP, Tomsick TA. Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology. 2009;73:1066-1072.
5. Romano JG, Muller N, Merino JG, Forteza AM, Koch S, Rabinstein AA. In-hospital delays to stroke thrombolysis: paradoxical effect of early arrival. Neurol Res. 2007;29:664-666.
6. Ferrari J, Knoflach M, Kiechl S, Willeit J, Matosevic B, Seyfang L, et al. Stroke thrombolysis: having more time translates into delayed therapy: data from the Austrian Stroke Unit Registry. Stroke. 2010;41:2001-2004.
7. Mikulik R, Kadlecova P, Czlonkowska A, Kobayashi A, Brozman M, Svigelj V, et al. Factors influencing in-hospital delay in treatment with intravenous thrombolysis. Stroke. 2012;43:1578-1583.
8. Fonarow GC, Smith EE, Saver JL, Reeves MJ, Bhatt DL, Grau-Sepulveda MV, et al. Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: patient characteristics, hospital factors, and outcomes associated with door-to-needle times within 60 minutes. Circulation. 2011;123:750-758.
9. Saver JL, Smith EE, Fonarow GC, Reeves MJ, Zhao X, Olson DM, et al; GWTG-Stroke Steering Committee and Investigators. The golden hour and acute brain ischemia: presenting features and lytic therapy in 30, 000 patients arriving within 60 minutes of stroke onset. Stroke. 2010;41:1431-1439.
10. Albers GW, Bates VE, Clark WM, Bell R, Verro P, Hamilton SA. Intravenous tissue-type plasminogen activator for treatment of acute stroke: The Standard Treatment with Alteplase to Reverse Stroke (STARS) study. J Am Med Assoc. 2000;283:1145-1150.
11. Asplund K, Glader EL, Norrving B, Eriksson M. Effects of extending the time window of thrombolysis to 4.5 hours: observations in the Swedish stroke register (RIKS-Stroke). Stroke. 2011;42:2492-2497.
12. Ahmed N, Wahlgren N, Grond M, Hennerici M, Lees KR, Mikulik R, et al. Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: An updated analysis from SITS-ISTR. Lancet Neurol. 2010;9:866-874.
13. Fluri F, Hatz F, Voss B, Lyrer PA, Engelter ST. Restenosis after carotid endarterectomy: significance of newly acquired risk factors. Eur J Neurol. 2010;17:493-498.
14. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke. 1993;24:35-41.
15. Reiner-Deitemyer V, Teuschl Y, Matz K, Reiter M, Eckhardt R, Seyfang L, et al. Helicopter transport of stroke patients and its influence on thrombolysis rates: data from the Austrian Stroke Unit Registry. Stroke. 2011;42:1295-1300.
16. Casolla B, Bodenant M, Girot M, Cordonnier C, Pruvo JP, Wiel E, et al. Intra-hospital delays in stroke patients treated with rt-PA: impact of preadmission notification. J Neurol. 2013;260:635-639.
17. Strbian D, Soinne L, Sairanen T, Häppölä O, Lindsberg PJ, Tatlisumak T, et al. Ultraearly thrombolysis in acute ischemic stroke is associated with better outcome and lower mortality. Stroke. 2010;41:712-716.
18. The IST-3 Collaborative Group. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third International Stroke Trial [IST-3]): A randomised controlled trial. The Lancet. 2012;379:2352-2363.
19. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329.
20. Meretoja A, Strbian D, Mustanoja S, Tatlisumak T, Lindsberg PJ, Kaste M. Reducing in-hospital delay to 20 minutes in stroke thrombolysis. Neurology. 2012;79:306-313.