Scientific Opinion on the substantiation of a health claim related to glucosamine hydrochloride and reduced rate of cartilage degeneration and reduced risk of development of osteoarthritis pursuant to Article 14 of Regulation (EC) No 1924/2006

EFSA Journal

Volumn 7, Issue 10, 2009, Pages

[No Author Info available]

Author keywords

cartilage; Glucosamine; health claims; joints; osteoarthritis

Indexed keywords

EID: 84888281173     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2009.1358     Document Type: Article

References (20)

1. Basak M, Joseph S, Joshi S, Sawant S, 2004. Comparative bioavailability of a novel timed release and powder-filled glucosamine sulphate formulation – a multidose, randomized, crossover study. International Journal of Clinical Pharmacology and Therapeutics 42, 597–601.
2. Beren J, Hill SL, Diener-West M, Rose NR, 2001. Effect of Pre-Loading Oral Glucosamine HCl/Chondroitin Sulfate/Manganese Ascorbate Combination on Experimental Arthritis in Rats. E.B.M. 226, 144–151.
3. Braham R, Dawson B, Goodman C, 2003. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine 37, 45–49.
4. Canapp SO, McLaughlin RM, Hoskinson JJ, Roush JK, Butine MD, 1999. Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulphate. Am. J. Vet. Res. 60, 1552–1557.
5. Cibere J, Kopec JA, Thorne A, Singer J, Canvin J, Robinson DB, Pope J, Hong P, Grant E, Esdaile JM, 2004. Randomized, Double-Blind, Placebo-Controlled Glucosamine Discontinuation Trial in Knee Osteoarthritis. Arthritis and Rheumatism 51, 738–745.
6. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ, 2006. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine 354, 795–808.
7. FDA (U.S. Food and Drug Administration), 2004. Letter Regarding the Relationship Between the Consumption of Crystalline Glucosamine Sulfate and a Reduced Risk of Osteoarthritis (Docket No. 2004P-0060).
8. Houpt JB, McMillan R, Wein C, Paget-Dellio SD, 1999. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. The Journal of Rheumatology 26, 2423–2430.
9. Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD, 1999. Glucosamine, Chondroitin and Manganese Ascorbate for Degenerative Joint Disease of the Knee or Low Back: A Randomized, Double-blind, Placebo-Controlled Pilot Study. Military Medicine 164, 85–91.
10. McAlindon TE, LaValley MP, Gulin JP, Felson DT, 2000. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 283, 1469–1475.
11. Nguyen P, Mohamed SE, Gardiner D, Salinas T, 2001. A Randomized, Double-blind, Clinical Trial of the Effect of Chondroitin Sulphate and Glucosamine Hydrochloride on Temporomandibular Joint Disorders: A Pilot Study. The Journal of Cranio-Mandibula Practice 19, 130–139.
12. Thie NM, Prasad NG, Major PW, 2001. Evaluation of Glucosamine Sulfate compared to Ibuprofen for the Treatment of Temporomandibular Joint (TMJ) Osteoarthritis: A Randomized, Doubleblind, Controlled 3 Month Clinical Trial. The Journal of Rheumatology 28, 1347–1355.
13. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC, 2002. Glucosamine Sulphate Use and Delay of Progression of Knee Osteoarthritis: A 3-Year, Randomized, Placebo-Controlled, Double-blind Study. Archives of Internal Medicine 162, 2113–2123.
14. Poolsup N, Suthisisang C, Channark P, Kittikulsuth W, 2005. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. The Annals of Pharmacotherapy 39, 1080–1087.
15. Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I, 1998. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittel-Forschung 48, 469–474.
16. Qiu GX, Weng XS, Zhang K, Zhou YX, Lou SQ, Wang YP, Li W, Zhang H, Liu Y, 2005. A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulphate in the treatment of knee osteoarthritis. Natl. Med. J. China 85, 3067–3070.
17. Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin, Y, Dacre, JE, Gossett C, 2001. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 357, 251–256.
18. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY, 2003. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine 163, 1514–1522.
19. Tiku ML, Narla H, Jain M, Yalamanchili P, 2007. Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation. Arthritis Research & Therapy 9, 1–10.
20. Usha PR, Naidu MUR, 2004. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clinical Drug Investigation 24, 353–363.