C-Kit SCF receptor (CD117) expression and KIT gene mutation in conjunctival pigmented lesions

Acta Ophthalmologica

Volumn 91, Issue 8, 2013, Pages

  Alessandrini, Lara ^a   Parrozzani, Raffaele ^b   Bertorelle, Roberta ^c   Valentini, Elisa ^a   Candiotto, Cinzia ^c   Giacomelli, Luciano ^a   Midena, Edoardo ^a,c   Blandamura, Stella ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b IRCCS FONDAZIONE BIETTI   (Italy)

^c VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

conjunctiva; KIT expression; KIT mutations; melanoma; nevus; primary acquired melanosis

Indexed keywords

STEM CELL FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CLINICAL EVALUATION; CONJUNCTIVA TUMOR; CONJUNCTIVAL MELANOCYTIC TUMOR; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MELANOMA; MELANOSIS; METASTASIS; METASTASIS FREE SURVIVAL; MUTATIONAL ANALYSIS; ONCOGENE C KIT; PREDICTION; PRIORITY JOURNAL; THICKNESS; TUMOR LOCALIZATION;

CONJUNCTIVA; KIT EXPRESSION; KIT MUTATIONS; MELANOMA; NEVUS; PRIMARY ACQUIRED MELANOSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CONJUNCTIVAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MELANOSIS; MIDDLE AGED; MUTATION; NEVUS, PIGMENTED; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-KIT; YOUNG ADULT;

EID: 84888203143     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/aos.12166     Document Type: Article

References (18)

1. Alexeev V, &, Yoon K, (2006): Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes. J Invest Dermatol 126: 1102-1110.
2. Antonescu CR, Busam KJ, Francone TD, et al., (2007): L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. Int J Cancer 121: 257-264.
3. Beadling C, Jacobson-Dunlop E, Hodi FS, et al., (2008): KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 14: 6821-6828.
4. Corless CE, Guiver M, Borrow R, et al., (2002): Development and evaluation of a 'real-time' RT-PCR for the detection of enterovirus and parechovirus RNA in CSF and throat swab samples. J Med Virol 67: 555-562.
5. Curtin JA, Busam K, Pinkel D, &, Bastian BC, (2006): Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 24: 4340-4346.
6. Folberg R, McLean IW, &, Zimmerman LE, (1985): Primary acquired melanosis of the conjunctiva. Hum Pathol 16: 129-135.
7. Grichnik JM, (2006): Kit and melanocyte migration. J Invest Dermatol 126: 945-947.
8. Lefevre G, Glotin AL, Calipel A, et al., (2004): Roles of stem cell factor/c-kit and effects of glivec/sti571 in human uveal melanoma cell tumorigenesis. J Biol Chem 279: 31769-31779.
9. Rivera RS, Nagatsuka H, Gunduz M, et al., (2008): C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch 452: 27-32.
10. Shields CL, Demirci H, Karatza E, &, Shields JA, (2004): Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumors. Ophthalmology 11: 1747-1754.
11. Shields CL, Markowitz JS, Belinsky I, Schwartzstein H, George NS, Lally SE, Mashayekhi A, &, Shields JA, (2011): Conjunctival melanoma: outcomes based on tumor origin in 382 consecutive cases. Ophthalmology 118: 389-395.
12. Terada T, (2012): Malignant melanoma of the conjunctiva: a case report with examination of KIT and PDGFRA. Rare Tumors 4: 21-23.
13. Wallander ML, Layfield LJ, Emerson LL, et al., (2011): KIT mutations in ocular melanoma: frequency and anatomic distribution. Mod Pathol 24: 1031-1035.
14. Wehrle-Haller B, (2003): The role of Kit ligand in melanocyte development and epidermal homeostasis. Pigment Cell Res 16: 287-296.
15. Went PT, Dirnhofer S, Bundi M, et al., (2004): Prevalence of KIT expression in human tumors. J Clin Oncol 22: 4514-4522.
16. Willmore-Payne C, Holden JA, Tripp S, &, Layfield LJ, (2005a): Human malignant melanoma: detection of BRAF- and ckit-activating mutations by high resolution amplicon melting curve analysis. Hum Pathol 36: 486-493.
17. Willmore-Payne C, Layfield LJ, &, Holden JA, (2005b): C-KIT mutation analysis for diagnosis of gastrointestinal stromal tumors in fine needle aspiration specimens. Cancer 105: 165-170.
18. Zembowicz A, Mandal RV, &, Choopong P, (2010): Melanocytic lesions of the conjunctiva. Arch Pathol Lab Med 134: 1785-1792.