메뉴 건너뛰기




Volumn 7, Issue , 2013, Pages 1399-1408

Canagliflozin: A novel treatment option for type 2 diabetes

Author keywords

Canagliflozin; Oral hypoglycemic; SGLT2 inhibitor; Type 2 diabetes

Indexed keywords

CANAGLIFLOZIN; CYTOCHROME P450; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A9; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; METFORMIN; PLACEBO; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2; SULFONYLUREA; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE B4;

EID: 84888165589     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S48937     Document Type: Review
Times cited : (22)

References (20)
  • 1
    • 0003770851 scopus 로고    scopus 로고
    • American Diabetes Association. Available from Accessed September 14, 2013
    • American Diabetes Association. Diabetes Statistics. Available from http://www.diabetes.org/diabetes-basics/diabetes-statistics/. Accessed September 14, 2013.
    • Diabetes Statistics
  • 2
    • 84875637478 scopus 로고    scopus 로고
    • More patients get good diabetes control, but only a minority meet all goals
    • Mitka M. More patients get good diabetes control, but only a minority meet all goals. JAMA. 2013;309(13):1335-1336.
    • (2013) JAMA. , vol.309 , Issue.13 , pp. 1335-1336
    • Mitka, M.1
  • 3
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach
    • Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al;position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Diabetes Care. 2012;35(10): 1364-1379.
    • (2012) Diabetes Care , vol.35 , Issue.10 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 4
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 Inhibition-a novel strategy for diabetes treatment
    • Chao EC, Henry RR. SGLT2 Inhibition-a novel strategy for diabetes treatment. Nat Rev Drug Discov. 2010;9(7):551-559.
    • (2010) Nat Rev Drug Discov. , vol.9 , Issue.7 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 5
    • 0034997336 scopus 로고    scopus 로고
    • Renal Na+ glucose cotransporters
    • Wright EM. Renal Na+ glucose cotransporters. Am J Physiol Renal Physiol. 2001;280(1):F10-F18.
    • (2001) Am J Physiol Renal Physiol. , vol.280 , Issue.1
    • Wright, E.M.1
  • 6
    • 12644311551 scopus 로고    scopus 로고
    • Biophysical characteristics of the pig kidney Na+/glucose cotransporter SGLT2 reveal a common mechanism for SGLT1 and SGLT2
    • Mackenzie B, Loo DD, Panayotova-Heiermann M, Wright EM. Biophysical characteristics of the pig kidney Na+/glucose cotransporter SGLT2 reveal a common mechanism for SGLT1 and SGLT2. J Biol Chem. 1996;271(51):32678-32683.
    • (1996) J Biol Chem. , vol.271 , Issue.51 , pp. 32678-32683
    • Mackenzie, B.1    Loo, D.D.2    Panayotova-Heiermann, M.3    Wright, E.M.4
  • 7
    • 0028044629 scopus 로고
    • The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose
    • Kanai Y, Lee WS, You G, Brown D, Hediger MA. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Invest. 1994;93(1): 397-404.
    • (1994) J Clin Invest. , vol.93 , Issue.1 , pp. 397-404
    • Kanai, Y.1    Lee, W.S.2    You, G.3    Brown, D.4    Hediger, M.A.5
  • 8
    • 64749094872 scopus 로고
    • Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
    • Farber SJ, Berger EY, Earle DP. Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose. J Clin Invest. 1951;30(2):125-129.
    • (1951) J Clin Invest. , vol.30 , Issue.2 , pp. 125-129
    • Farber, S.J.1    Berger, E.Y.2    Earle, D.P.3
  • 9
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • Sha S, Devineni D, Ghosh A, et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab. 2011;13: 669-672.
    • (2011) Diabetes Obes Metab. , vol.13 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3
  • 10
    • 84877865378 scopus 로고    scopus 로고
    • Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: Results of a randomized, placebo-controlled study
    • Polidori D, Sha S, Mudaliar S, et al. Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care. 2013;36(8):2154-2161.
    • (2013) Diabetes Care. , vol.36 , Issue.8 , pp. 2154-2161
    • Polidori, D.1    Sha, S.2    Mudaliar, S.3
  • 11
    • 84888163835 scopus 로고    scopus 로고
    • INVOKANA® (canagliflozin) [package insert]. Titusville, NJ: Janssen Pharmaceuticals, Inc
    • INVOKANA® (canagliflozin) [package insert]. Titusville, NJ: Janssen Pharmaceuticals, Inc;2013.
    • (2013)
  • 12
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlöf K, Cefalu WT, Kim KA, et al. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab. 2013;15(4):372-382.
    • (2013) Diabetes Obes Metab. , vol.15 , Issue.4 , pp. 372-382
    • Stenlöf, K.1    Cefalu, W.T.2    Kim, K.A.3
  • 13
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • Canagliflozin DIA 2001 Study Group
    • Rosenstock J, Aggarwal N, Polidori D, et al;Canagliflozin DIA 2001 Study Group. Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care. 2012;35(6):1232-1238.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3
  • 14
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea
    • Schernthaner G, Gross JL, Rosenstock J, et al. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea. Diabetes Care. 2013;36(9):2508-2515.
    • (2013) Diabetes Care. , vol.36 , Issue.9 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 15
    • 84860252876 scopus 로고    scopus 로고
    • Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    • Devineni, D, Morrow L, Hompesch M, et al. Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab. 2012;14(6): 539-545.
    • (2012) Diabetes Obes Metab. , vol.14 , Issue.6 , pp. 539-545
    • Devineni, D.1    Morrow, L.2    Hompesch, M.3
  • 16
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • Yale JF, Bakris G, Cariou B, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15(5):463-473.
    • (2013) Diabetes Obes Metab. , vol.15 , Issue.5 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 17
    • 84880543926 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: A randomized trial
    • Bode B, Stenlöf K, Sullivan D, Fung A, Usiskin K. Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: a randomized trial. Hosp Pract. 2013;41(2):72-84.
    • (2013) Hosp Pract. , vol.41 , Issue.2 , pp. 72-84
    • Bode, B.1    Stenlöf, K.2    Sullivan, D.3    Fung, A.4    Usiskin, K.5
  • 18
    • 84888141518 scopus 로고    scopus 로고
    • GoodRx [webpage on the Internet]. Available from: Accessed September 15, 2013
    • GoodRx [webpage on the Internet]. Available from: http://www.goodRx.com. Accessed September 15, 2013.
  • 19
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the canagliflozin cardiovascular assessment study (CANVAS)-a randomized placebo controlled trial
    • Neal B, Perkovic V, de Zeeue D, et al. Rationale, design, and baseline characteristics of the canagliflozin cardiovascular assessment study (CANVAS)-a randomized placebo controlled trial. Am Heart J. 2013;166(2);217-223.
    • (2013) Am Heart J. , vol.166 , Issue.2 , pp. 217-223
    • Neal, B.1    Perkovic, V.2    de Zeeue, D.3
  • 20
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • Zambrowicz B, Freiman J, Brown PM, et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012;92(2):158-169.
    • (2012) Clin Pharmacol Ther. , vol.92 , Issue.2 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.