Recombinant human thrombopoietin is an effective treatment for thrombocytopenia in hemophagocytic lymphohistiocytosis

Annals of Hematology

Volumn 92, Issue 12, 2013, Pages 1695-1699

  Wang, Yini ^a   Wang, Zhao ^a   Wu, Lin ^a   Zhang, Jia ^a   Wang, Jingshi ^a   Yan, Lijuan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Hemophagocytic lymphohistiocytosis (HLH); Recombinant human thrombopoietin (rhTPO); Thrombocytopenia

Indexed keywords

RECOMBINANT THROMBOPOIETIN;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEMOPHAGOCYTIC SYNDROME; HUMAN; LUNG HEMORRHAGE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TREATMENT OUTCOME; URINARY TRACT HEMORRHAGE;

ADOLESCENT; ADULT; FEMALE; HUMANS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; THROMBOCYTOPENIA; THROMBOPOIETIN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84888127735     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-013-1819-9     Document Type: Article

References (13)

1. Janka GE (2007) Familial and acquired hemophagocytic lymphohistiocytosis. Eur J Pediatr 166:95-109
2. Wang YN, Wang Z, Wu L, Cen XN, Li BT, Ning F, Duan XZ, Li J (2009) A multicenter retrospective analysis of diagnosis and treatment of 72 hemophagocytic syndrome patients. Chin J Hematol 30(12):793-798
3. Wang XL, Wang Z, Wang YN, Wang JS, Wu L (2011) The analysis of prognostic factors of forty-four cases of hemophagocytic lymphohistiocytosis. Chin J Intern Med 50(4):333-334
4. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS (1994) Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369(6481):568-571
5. Kuter DJ, Begley CG (2002) Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100(10):3457-3469
6. Henter JI, Horne AC, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G (2007) HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48:124-131
7. Trottestam H, Horne AC, Aricò M, Egeler RM, Filipovich AH, Gadner H, Imashuku S, Ladisch S, Webb D, Janka G, Henter JI (2011) Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol. Blood 118:4577-4584
8. James WV, William JG (2006) Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives. Annals of Medicine 38:20-31
9. Jordan MB, Hildeman D, Kappler J, Marrack P (2004) An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood 104:735-743
10. Trottestam H, Berglöf E, Horne A, Onelöv E, Beutel K, Lehmberg K, Sieni E, Silfverberg T, Aricò M, Janka G, Henter JI (2011) Risk factors for early death in children with haemophagocytic lymphohistiocytosis. Acta Paediatr 101:313-318
11. Mareucci R, Roamno M (2008) Thrombopoietin and its splicing variants: structure and functions in thrombopoiesis and beyond. Biochim Biophys Acta 1782:427-432
12. Wang XL, Wang Z, Wang YN, Wang JS, Wu L (2011) Expression of serum thrombopoietin in patients with hemophagocytic syndrome. J Leuk Lymphoma 20(6):347-349
13. Kunie S, Makoto H, Kayo I, Hiroshi F, Yoshinari K, Atsushi K, Junsuke Y, Kenichi S (2006) Phagocytosis of codeveloping megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-α and its possible role in hemophagocytic syndrome. Blood 107:1366-1374