Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division

Biological Chemistry

Volumn 394, Issue 11, 2013, Pages 1411-1423

  Thakur, Harish C ^a,b   Singh, Madhurendra ^b   Nagel Steger, Luitgard ^c,d   Prumbaum, Daniel ^e   Fansa, Eyad Kalawy ^b   Gremer, Lothar ^c,d   Ezzahoini, Hakima ^b   Abts, André ^c   Schmitt, Lutz ^c   Raunser, Stefan ^e   Ahmadian, Mohammad R ^b   Piekorz, Roland P ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Department of Orthopedic Surgery   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d FORSCHUNGSZENTRUM JÜLICH   (Germany)

^e MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Cancer; Centrosome; ChTOG CKAP5; Microtubules; Mitosis; TACC3

Indexed keywords

ADAPTOR PROTEIN; AURORA A KINASE; BETA TUBULIN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; HISTONE ACETYLTRANSFERASE PCAF; HYPOXIA INDUCIBLE FACTOR 1BETA; INITIATION FACTOR; MICROTUBULE ASSOCIATED PROTEIN; TRANSCRIPTION FACTOR GATA 1; TRANSFORMING ACIDIC COILED COIL 3; UNCLASSIFIED DRUG;

ANEUPLOIDY; CARCINOGENESIS; CELLULAR DISTRIBUTION; CENTROMERE; CENTROSOME; CHROMATIN ASSEMBLY AND DISASSEMBLY; DEPOLYMERIZATION; DICTYOSTELIUM DISCOIDEUM; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; GENOMIC INSTABILITY; HUMAN; MICROTUBULE; MICROTUBULE ASSEMBLY; MICROTUBULE ORGANIZING CENTER; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REVIEW; SACCHAROMYCES CEREVISIAE; TUMOR REGRESSION; XENOPUS LAEVIS; XENOPUS TROPICALIS;

ADAPTOR PROTEIN COMPLEX 3; ANIMALS; CELL DIVISION; CENTROSOME; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MULTIGENE FAMILY; PROTEIN STRUCTURE, TERTIARY; SPINDLE APPARATUS;

EID: 84888119772     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2013-0184     Document Type: Review

References (96)

1. Al-Bassam, J. and Chang, F. (2011). Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Trends Cell Biol. 21, 604-614.
2. Andersen, J.S., Wilkinson, C.J., Mayor, T., Mortensen, P., Nigg, E.A., and Mann, M. (2003). Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570-574. (Pubitemid 37522644)
3. Azimzadeh, J. and Bornens, M. (2005). The centrosome in evolution. In Centrosomes in Development and Disease (Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA), pp. 93-122.
4. Barr, A.R. and Gergely, F. (2008). MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics. Mol. Cell Biol. 28, 7199-7211.
5. Barros, T.P., Kinoshita, K., Hyman, A.A., and Raff, J.W. (2005). Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J. Cell Biol. 170, 1039-1046. (Pubitemid 41362636)
6. Bellanger, J.M. and Gonczy, P. (2003). TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos. Curr. Biol. 13, 1488-1498. (Pubitemid 37078404)
7. Booth, D.G., Hood, F.E., Prior, I.A., and Royle, S.J. (2011). A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J. 30, 906-919.
8. Bornens, M. (2002). Centrosome composition and microtubule anchoring mechanisms. Curr. Opin. Cell Biol. 14, 25-34. (Pubitemid 34131653)
9. Bornens, M. (2012). The centrosome in cells and organisms. Science 335, 422-426.
10. Brouhard, G.J., Stear, J.H., Noetzel, T.L., Al-Bassam, J., Kinoshita, K., Harrison, S.C., Howard, J., and Hyman, A.A. (2008). XMAP215 is a processive microtubule polymerase. Cell 132, 79-88.
11. Cappell, K.M., Sinnott, R., Taus, P., Maxfield, K., Scarbrough, M., and Whitehurst, A.W. (2012). Multiple cancer testis antigens function to support tumor cell mitotic fidelity. Mol. Cell Biol. 32, 4131-4140.
12. Charrasse, S., Mazel, M., Taviaux, S., Berta, P., Chow, T., and Larroque, C. (1995). Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors. Eur. J. Biochem. 234, 406-413.
13. Cheeseman, L.P., Harry, E.F., McAinsh, A.D., Prior, I.A., and Royle, S.J. (2013). Specific removal of TACC3/ch-TOG/clathrin at metaphase deregulates kinetochore fiber tension. J. Cell Sci. 126, 2102-2113.
14. Chen, X.P., Yin, H., and Huffaker, T.C. (1998). The yeast spindle pole body component Spc72p interacts with Stu2p and is required for proper microtubule assembly. J. Cell Biol. 141, 1169-1179. (Pubitemid 28265611)
15. Compton, D.A. (2000). Spindle assembly in animal cells. Annu. Rev. Biochem. 69, 95-114.
16. Conte, N., Charafe-Jauffret, E., Delaval, B., Adelaide, J., Ginestier, C., Geneix, J., Isnardon, D., Jacquemier, J., and Birnbaum, D. (2002). Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. Oncogene 21, 5619-5630. (Pubitemid 34983552)
17. Conte, N., Delaval, B., Ginestier, C., Ferrand, A., Isnardon, D., Larroque, C., Prigent, C., Seraphin, B., Jacquemier, J., and Birnbaum, D. (2003). TACC1-chTOG-Aurora A protein complex in breast cancer. Oncogene 22, 8102-8116. (Pubitemid 37487301)
18. Cully, M., Shiu, J., Piekorz, R.P., Muller, W.J., Done, S.J., and Mak, T.W. (2005). Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis. Cancer Res. 65, 10363-10370. (Pubitemid 41743729)
19. DeLuca, J.G. and Musacchio, A. (2012). Structural organization of the kinetochore-microtubule interface. Curr. Opin. Cell Biol. 24, 48-56.
20. Desai, A. and Mitchison, T.J. (1997). Microtubule polymerization dynamics. Annu. Rev. Cell Dev. Biol. 13, 83-117. (Pubitemid 28034521)
21. Duncan, C.G., Killela, P.J., Payne, C.A., Lampson, B., Chen, W.C., Liu, J., Solomon, D., Waldman, T., Towers, A.J., Gregory, S.G., et al. (2010). Integrated genomic analyses identify ERRFl1 and TACC3 as glioblastoma-targeted genes. Oncotarget 1, 265-277.
22. Eslinger, M.R., Lauffart, B., and Still, I.H. (2010). TACC3 (transforming, acidic coiled-coil containing protein 3). Atlas Genet. Cytogenet. Oncol. Haematol. 14, 527-553.
23. Foraker, A.B., Camus, S.M., Evans, T.M., Majeed, S.R., Chen, C.Y., Taner, S.B., Correa, I.R., Jr., Doxsey, S.J., and Brodsky, F.M. (2012). Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. J. Cell Biol. 198, 591-605.
24. Fu, W., Jiang, Q., and Zhang, C. (2011). Novel functions of endocytic player clathrin in mitosis. Cell Res. 21, 1655-1661.
25. Fu, W., Tao, W., Zheng, P., Fu, J., Bian, M., Jiang, Q., Clarke, P.R., and Zhang, C. (2010). Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. J. Cell Sci. 123, 3645-3651.
26. Gardner, M.K., Zanic, M., and Howard, J. (2013). Microtubule catastrophe and rescue. Curr. Opin. Cell Biol. 25, 14-22.
27. Garriga-Canut, M. and Orkin, S.H. (2004). Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J. Biol. Chem. 279, 23597-23605. (Pubitemid 38685674)
28. Gergely, F. (2002). Centrosomal TACCtics. Bioessays 24, 915-925. (Pubitemid 35180846)
29. Gergely, F., Draviam, V.M., and Raff, J.W. (2003). The ch-TOG/ XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev. 17, 336-341. (Pubitemid 36182191)
30. Gergely, F., Karlsson, C., Still, I., Cowell, J., Kilmartin, J., and Raff, J.W. (2000a). The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Proc. Natl. Acad. Sci. USA 97, 14352-14357. (Pubitemid 32016579)
31. Gergely, F., Kidd, D., Jeffers, K., Wakefield, J.G., and Raff, J.W. (2000b). D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. EMBO J. 19, 241-252. (Pubitemid 30042706)
32. Giet, R., McLean, D., Descamps, S., Lee, M.J., Raff, J.W., Prigent, C., and Glover, D.M. (2002). Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell Biol. 156, 437-451. (Pubitemid 34839893)
33. Gomez-Baldo, L., Schmidt, S., Maxwell, C.A., Bonifaci, N., Gabaldon, T., Vidalain, P.O., Senapedis, W., Kletke, A., Rosing, M., Barnekow, A., et al. (2010). TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle 9, 1143-1155.
34. Ha, G.H., Kim, J.L., and Breuer, E.K. (2013a). Transforming acidic coiled-coil proteins (TACCs) in human cancer. Cancer Lett. DOI: 10.1016/j.canlet.2013.04.022. Epub April 23, 2013.
35. Ha, G.H., Park, J.S., and Breuer, E.K. (2013b). TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways. Cancer Lett. 332, 63-73.
36. Hao, Z., Stoler, M.H., Sen, B., Shore, A., Westbrook, A., Flickinger, C.J., Herr, J.C., and Coonrod, S.A. (2002). TACC3 expression and localization in the murine egg and ovary. Mol. Reprod. Dev. 63, 291-299.
37. Hodis, E., Watson, I.R., Kryukov, G.V., Arold, S.T., Imielinski, M., Theurillat, J.P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012). A landscape of driver mutations in melanoma. Cell 150, 251-263.
38. Hood, F.E. and Royle, S.J. (2011). Pulling it together: the mitotic function of TACC3. BioArchitecture 1, 105-109.
39. Hubner, N.C., Bird, A.W., Cox, J., Splettstoesser, B., Bandilla, P., Poser, I., Hyman, A., and Mann, M. (2010). Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions. J. Cell Biol. 189, 739-754.
40. Hutchins, J.R., Toyoda, Y., Hegemann, B., Poser, I., Heriche, J.K., Sykora, M.M., Augsburg, M., Hudecz, O., Buschhorn, B.A., Bulkescher, J., et al. (2010). Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328, 593-599.
41. Jeng, J.-C., Lin, Y.-M., Lin, C.-H., and Shih, H.-M. (2009a). Cdh1 controls the stability of TACC3. Cell Cycle 8, 3537-3544.
42. Jeng, J.C., Lin, Y.M., Lin, C.H., and Shih, H.M. (2009b). Cdh1 controls the stability of TACC3. Cell Cycle 8, 3529-3536.
43. Jung, C.K., Jung, J.H., Park, G.S., Lee, A., Kang, C.S., and Lee, K.Y. (2006). Expression of transforming acidic coiled-coil containing protein 3 is a novel independent prognostic marker in non-small cell lung cancer. Pathol. Int. 56, 503-509. (Pubitemid 44258851)
44. Kay, B.K., Williamson, M.P., and Sudol, M. (2000). The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J. 14, 231-241. (Pubitemid 30086060)
45. Khodjakov, A. and Rieder, C.L. (2009). The nature of cell-cycle checkpoints: facts and fallacies. J. Biol. 8, 88.
46. Kiemeney, L.A., Sulem, P., Besenbacher, S., Vermeulen, S.H., Sigurdsson, A., Thorleifsson, G., Gudbjartsson, D.F., Stacey, S.N., Gudmundsson, J., Zanon, C., et al. (2010). A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat. Genet. 42, 415-419.
47. Kinoshita, K., Habermann, B., and Hyman, A.A. (2002). XMAP215: a key component of the dynamic microtubule cytoskeleton. Trends Cell Biol. 12, 267-273. (Pubitemid 34634175)
48. Kinoshita, K., Noetzel, T.L., Pelletier, L., Mechtler, K., Drechsel, D.N., Schwager, A., Lee, M., Raff, J.W., and Hyman, A.A. (2005). Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis. J. Cell Biol. 170, 1047-1055. (Pubitemid 41362637)
49. Klein, S.L., Strausberg, R.L., Wagner, L., Pontius, J., Clifton, S.W., and Richardson, P. (2002). Genetic and genomic tools for Xenopus research: the NIH Xenopus initiative. Dev. Dyn. 225, 384-391. (Pubitemid 35429723)
50. Kobayashi, T., Minowa, O., Kuno, J., Mitani, H., Hino, O., and Noda, T. (1999). Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res. 59, 1206-1211. (Pubitemid 29136248)
51. Lauffart, B., Dimatteo, A., Vaughan, M.M., Cincotta, M.A., Black, J.D., and Still, I.H. (2006). Temporal and spatial expression of TACC1 in the mouse and human. Dev. Dyn. 235, 1638-1647. (Pubitemid 43787966)
52. Lauffart, B., Vaughan, M., Eddy, R., Chervinsky, D., DiCioccio, R., Black, J., and Still, I. (2005). Aberrations of TACC1 and TACC3 are associated with ovarian cancer. BMC Women's Health 5, 8.
53. LeRoy, P.J., Hunter, J.J., Hoar, K.M., Burke, K.E., Shinde, V., Ruan, J., Bowman, D., Galvin, K., and Ecsedy, J.A. (2007). Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity. Cancer Res. 67, 5362-5370. (Pubitemid 46997276)
54. Lin, C.H., Hu, C.K., and Shih, H.M. (2010). Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. J. Cell Biol. 189, 1097-1105.
55. Mikolajka, A., Yan, X., Popowicz, G.M., Smialowski, P., Nigg, E.A., and Holak, T.A. (2006). Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. J. Mol. Biol. 359, 863-875. (Pubitemid 43831933)
56. Mitchison, T. and Kirschner, M. (1984). Dynamic instability of microtubule growth. Nature 312, 237-242. (Pubitemid 15201998)
57. Musacchio, A. (2011). Spindle assembly checkpoint: the third decade. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 3595-3604.
58. Neumann, B., Walter, T., Heriche, J.K., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., et al. (2010). Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464, 721-727.
59. Nigg, E.A. and Raff, J.W. (2009). Centrioles, centrosomes, and cilia in health and disease. Cell 139, 663-678.
60. O'Brien, L.L., Albee, A.J., Liu, L., Tao, W., Dobrzyn, P., Lizarraga, S.B., and Wiese, C. (2005). The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly. Mol. Biol. Cell 16, 2836-2847. (Pubitemid 40741228)
61. Parker, B.C., Annala, M.J., Cogdell, D.E., Granberg, K.J., Sun, Y., Ji, P., Li, X., Gumin, J., Zheng, H., Hu, L., et al. (2011). Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B. Proc. Natl. Acad. Sci. USA 108, 7739-7744.
62. Peset, I., Seiler, J., Sardon, T., Bejarano, L.A., Rybina, S., and Vernos, I. (2005). Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis. J. Cell Biol. 170, 1057-1066. (Pubitemid 41362638)
63. Peset, I. and Vernos, I. (2008). The TACC proteins: TACC-ling microtubule dynamics and centrosome function. Trends Cell Biol. 18, 379-388.
64. Piekorz, R.P., Hoffmeyer, A., Duntsch, C.D., McKay, C., Nakajima, H., Sexl, V., Snyder, L., Rehg, J., and Ihle, J.N. (2002). The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J. 21, 653-664. (Pubitemid 34174046)
65. Popov, A.V., Pozniakovsky, A., Arnal, I., Antony, C., Ashford, A.J., Kinoshita, K., Tournebize, R., Hyman, A.A., and Karsenti, E. (2001). XMAP215 regulates microtubule dynamics through two distinct domains. EMBO J. 20, 397-410. (Pubitemid 32126976)
66. Raff, J.W. (2002). Centrosomes and cancer: lessons from a TACC. Trends Cell Biol. 12, 222-225. (Pubitemid 34327614)
67. Rieder, C.L. (2011). Mitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints. Chromosome Res. 19, 291-306.
68. Rieder, C.L. and Maiato, H. (2004). Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev. Cell 7, 637-51. (Pubitemid 39462685)
69. Royle, S.J. (2012). The role of clathrin in mitotic spindle organisation. J. Cell Sci. 125, 19-28.
70. Sadek, C.M., Jalaguier, S., Feeney, E.P., Aitola, M., Damdimopoulos, A.E., Pelto-Huikko, M., and Gustafsson, J.A. (2000). Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Mech. Dev. 97, 13-26.
71. Samereier, M., Baumann, O., Meyer, I., and Graf, R. (2011). Analysis of Dictyostelium TACC reveals differential interactions with CP224 and unusual dynamics of Dictyostelium microtubules. Cell. Mol. Life Sci. 68, 275-287.
72. Sato, M., Koonrugsa, N., Toda, T., Vardy, L., Tournier, S., and Millar, J.B. (2003). Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast. Nat. Cell Biol. 5, 764-766; author reply 766. (Pubitemid 37087158)
73. Sato, M., Vardy, L., Angel Garcia, M., Koonrugsa, N., and Toda, T. (2004). Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. Mol. Biol. Cell 15, 1609-1622. (Pubitemid 38401812)
74. Schmidt, S., Essmann, F., Cirstea, I.C., Kuck, F., Thakur, H.C., Singh, M., Kletke, A., Jänicke, R.U., Wiek, C., Hanenberg, H., et al. (2010a). The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle 9, 4469-4473.
75. Schmidt, S., Schneider, L., Essmann, F., Cirstea, I.C., Kuck, F., Kletke, A., Jänicke, R.U., Wiek, C., Hanenberg, H., Ahmadian, et al. (2010b). The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29, 6184-6192.
76. Schneider, L., Essmann, F., Kletke, A., Rio, P., Hanenberg, H., Schulze-Osthoff, K., Nürnberg, B., and Piekorz, R.P. (2008). TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27, 116-125.
77. Schneider, L., Essmann, F., Kletke, A., Rio, P., Hanenberg, H., Wetzel, W., Schulze-Osthoff, K., Nürnberg, B., and Piekorz, R.P. (2007). The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J. Biol. Chem. 282, 29273-29283. (Pubitemid 350043368)
78. Schuendeln, M.M., Piekorz, R.P., Wichmann, C., Lee, Y., McKinnon, P.J., Boyd, K., Takahashi, Y., and Ihle, J.N. (2004). The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol. Cell. Biol. 24, 6403-6409. (Pubitemid 38891139)
79. Sillje, H.H., Nagel, S., Korner, R., and Nigg, E.A. (2006). HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr. Biol. 16, 731-742.
80. Singh, D., Chan, J.M., Zoppoli, P., Niola, F., Sullivan, R., Castano, A., Liu, E.M., Reichel, J., Porrati, P., Pellegatta, S., et al. (2012). Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235.
81. Srayko, M., Quintin, S., Schwager, A., and Hyman, A.A. (2003). Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules. Curr. Biol. 13, 1506-1511. (Pubitemid 37078406)
82. Still, I., Vettaikkorumakankauv, A., DiMatteo, A., and Liang, P. (2004). Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. BMC Evol. Biol. 4, 16.
83. Still, I.H., Hamilton, M., Vince, P., Wolfman, A., and Cowell, J.K. (1999a). Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. Oncogene 18, 4032-4038. (Pubitemid 29361342)
84. Still, I.H., Vince, P., and Cowell, J.K. (1999b). The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics 58, 165-170. (Pubitemid 29275761)
85. Takayama, K., Horie-Inoue, K., Suzuki, T., Urano, T., Ikeda, K., Fujimura, T., Takahashi, S., Homma, Y., Ouchi, Y., and Inoue, S. (2012). TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer. Mol. Endocrinol. 26, 748-761.
86. Tan, S., Lyulcheva, E., Dean, J., and Bennett, D. (2008). Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stability. J. Cell Biol. 182, 27-33. (Pubitemid 352008618)
87. Thakur, H.C. (2012). Biochemical and biophysical characterization of the centrosomal protein TACC3. Dissertation (Faculty of Mathematics and Natural Sciences of the Heinrich Heine University, Düsseldorf, Germany), November 2012.
88. Tsou, A.P., Yang, C.W., Huang, C.Y., Yu, R.C., Lee, Y.C., Chang, C.W., Chen, B.R., Chung, Y.F., Fann, M.J., Chi, C.W., et al. (2003). Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene 22, 298-307. (Pubitemid 36174187)
89. Widlund, P.O., Stear, J.H., Pozniakovsky, A., Zanic, M., Reber, S., Brouhard, G.J., Hyman, A.A., and Howard, J. (2011). XMAP215 polymerase activity is built by combining multiple tubulinbinding TOG domains and a basic lattice-binding region. Proc. Natl. Acad. Sci. USA 108, 2741-2746.
90. Williams, S.V., Hurst, C.D., and Knowles, M.A. (2012). Oncogenic FGFR3 gene fusions in bladder cancer. Hum. Mol. Genet. 22, 795-803.
91. Wong, J., Lerrigo, R., Jang, C.Y., and Fang, G. (2008). Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain. Mol. Biol. Cell 19, 2083-2091.
92. Wurdak, H., Zhu, S., Min, K.H., Aimone, L., Lairson, L.L., Watson, J., Chopiuk, G., Demas, J., Charette, B., Halder, R., et al. (2010). A small molecule accelerates neuronal differentiation in the adult rat. Proc. Natl. Acad. Sci. USA 107, 16542-16547.
93. Yao, R., Natsume, Y., and Noda, T. (2007). TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer Sci. 98, 555-562. (Pubitemid 46562747)
94. Yao, R., Natsume, Y., Saiki, Y., Shioya, H., Takeuchi, K., Yamori, T., Toki, H., Aoki, I., Saga, T., and Noda, T. (2011). Disruption of Tacc3 function leads to in vivo tumor regression. Oncogene 31, 135-148.
95. Yu, C.T., Hsu, J.M., Lee, Y.C., Tsou, A.P., Chou, C.K., and Huang, C.Y. (2005). Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell Biol. 25, 5789-5800.
96. Zyss, D. and Gergely, F. (2009). Centrosome function in cancer: guilty or innocent? Trends Cell Biol. 19, 334-346.