Risks of mortality associated with common laboratory tests: A novel, simple and meaningful way to set decision limits from data available in the Electronic Medical Record

Clinical Chemistry and Laboratory Medicine

Volumn 51, Issue 9, 2013, Pages 1803-1813

  Solinger, Alan B ^b   Rothman, Steven I ^a,c  

^a ABS Professionals ^*  (United States)

^b ABS Professionals   (United States)

^c FAR Institute   (United States)

Author keywords

Blood chemical analysis standards; Blood urea nitrogen (BUN); Chloride; Clinical chemistry tests; Creatinine; Decision limits; Potassium; Reference standards; Reference values; Sodium

Indexed keywords

CHLORIDE; CREATININE; POTASSIUM; SODIUM;

ADULT; AGED; ARTICLE; CHLORIDE BLOOD LEVEL; CREATININE BLOOD LEVEL; ELECTRONIC MEDICAL RECORD; FEMALE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MORTALITY; POPULATION; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SODIUM BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

ADULT; AGED; BLOOD CHEMICAL ANALYSIS; CLINICAL LABORATORY TECHNIQUES; COHORT STUDIES; ELECTRONIC HEALTH RECORDS; HOSPITAL MORTALITY; HUMANS; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84888115202     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2013-0167     Document Type: Article

References (34)

1. Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline. Third Edition. CLSI document C28-A3. Wayne, PA: Clinical and Laboratory Standards Institute; 2008.
2. Horn PS, Pesce AJ. Reference intervals: an update. Clin Chim Acta 2003;334: 5-23. (Pubitemid 36836056)
3. Chester JG, Rudolph JL. Vital signs in older patients: age-related changes. J Am Med Dir Assoc 2011;12: 337-43.
4. CLIA Regulations and Federal Register Documents - Centers for Medicare & Medicaid Services. Available from: http://www. cms.gov/Regulations-and- Guidance/Legislation/CLIA/CLIA- Regulations-and-Federal-Register-Documents.html. Accessed 25 May, 2012.
5. Valenstein P, editor. Quality management in clinical laboratories: promoting patient safety through risk reduction and continuous improvement. Chicago: College of American Pathologists, 2005: 99-104.
6. Solberg HE. A guide to IFCC recommendations on reference values. J Int Fed Clin Chem 1993;5: 162-5. (Pubitemid 23308170)
7. Petersen PH, Jensen EA, Brandslund I. Analytical performance, reference values and decision limits. A need to differentiate between reference intervals and decision limits and to define analytical quality specifications. Clin Chem Lab Med 2011;50: 819-31.
8. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation 2012;125: 188-97.
9. Schwartz LM, Woloshin S. Changing disease definitions: implications for disease prevalence. Analysis of the Third National Health and Nutrition Examination Survey, 1988-1994. Eff Clin Pract 1999:2;76-85.
10. Bradford RH, Rifkind BM. Lowering blood cholesterol to reduce coronary heart disease risk. Clin Lab Med 1989;9: 1-6. (Pubitemid 19070294)
11. Ioannidis JP, Karvouni E, Katritsis DG. Mortality risk conferred by small elevations of creatine kinase-MB isoenzyme after percutaneous coronary intervention. J Am Coll Cardiol 2003;42: 1406-11. (Pubitemid 37267281)
12. Ellis SG, Chew D, Chan A, Whitlow PL, Schneider JP, Topol EJ. Death following creatine kinase-MB elevation after coronary intervention: identification of an early risk period: importance of creatine kinase-MB level, completeness of revascularization, ventricular function, and probable benefit of statin therapy. Circulation 2002;106: 1205-10. (Pubitemid 34988637)
13. Elsayem A, Mori M, Parsons HA, Munsell MF, Hui D, Delgado-Guay MO, et al. Predictors of inpatient mortality in an acute palliative care unit at a comprehensive cancer center. Support Care Cancer 2010;18: 67-76.
14. Aronson D, Mittleman MA, Burger AJ. Elevated blood urea nitrogen level as a predictor of mortality in patients admitted for decompensated heart failure. Am J Med 2004;116: 466-73. (Pubitemid 38388616)
15. Kinugasa Y, Kato M, Sugihara S, Hirai M, Kotani K, Ishida K, et al. A simple risk score to predict in-hospital death of elderly patients with acute decompensated heart failure- hypoalbuminemia as an additional prognostic factor. Circ J 2009;73: 2276-81.
16. Novack V, Pencina M, Zahger D, Fuchs L, Nevzorov R, Jotkowitz A, et al. Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure. PLoS One 2010;5:e12184.
17. Concordet D, Geffré A, Braun JP, Trumel C. A new approach for the determination of reference intervals from hospital-based data. Clin Chim Acta 2009;405: 43-8.
18. Sarasota County QuickFacts from the US Census Bureau. Available from: http://quickfacts.census.gov/qfd/ states/12/12115.html. Accessed 27 January, 2013.
19. Rosner B. Fundamentals of biostatistics, 5th ed. Boston: Brooks/Cole, 2000: 584-602.
20. Rosner B. Fundamentals of biostatistics, 5th ed. Boston: Brooks/Cole, 2000:627.
21. Low potassium (hypokalemia) - MayoClinic.com. Available from: http://www.mayoclinic.com/health/low-potassium/ MY00760. Accessed 25 May, 2012.
22. Walker HK, Hall WD, Hurst JW, editors. Clinical methods: the history, physical, and laboratory examinations, 3rd ed. Boston: Butterworths, 1990.
23. Potassium test: MedlinePlus Medical Encyclopedia. Available from: http://www.nlm.nih.gov/medlineplus/ency/ article/003484.htm. Accessed 25 May, 2012.
24. University of Minnesota: Medical School Student Website. Available from: http://www.student.med.umn.edu/ wardmanual/normallabs.php. Accessed 25 May, 2012.
25. Goyal A, Spertus JA, Gosch K, Venkitachalam L, Jones PG, Van den Berghe G, et al. Serum potassium levels and mortality in acute myocardial infarction. J Am Med Assoc 2012;307: 157-64.
26. Clinical Lab Products - News Story. Available from: http://www. clpmag.com/issues/articles/2006-05-03.asp. Accessed 25 May, 2012.
27. Katayev A, Balciza C, Seccombe DW. Establishing reference intervals for clinical laboratory test results: is there a better way? Am J Clin Pathol 2010;133: 180-6.
28. Friedberg RC, Souers R, Wagar EA, Stankovic AK, Valenstein PN. College of American Pathologists: the origin of reference intervals. Arch Pathol Lab Med 2007;131: 348-57.
29. Ceriotti F. Prerequisites for use of common reference intervals. Clin Biochem Rev 2007;28: 115-21.
30. Henny J, Petitclerc C, Fuentes-Arderiu X, Hyltoft Petersen P, Queralto JM, Schiele F, et al. Need for revisiting the concept of reference values. Clin Chem Lab Med 2000;38: 589-95.
31. Siest G, Henny J, Gräsbeck R, Wilding P, Petitclerc C, Queraltó JM, et al. The theory of reference values: an unfinished symphony. Clin Chem Lab Med 2012;24: 1-18.
32. Grossi E, Colombo R, Cavuto S, Franzini C. The REALAB project: a new method for the formulation of reference intervals based on current data. Clin Chem 2005;51: 1232-40. (Pubitemid 43079402)
33. Rothman MJ, Solinger AB, Rothman SI, Finlay GD. Clinical implications and validity of nursing assessments: a longitudinal measure of patient condition from analysis of the electronic medical record. Br Med J Open 2012;2:000849.
34. Rothman SI, Rothman MJ, Solinger AB. Placing clinical variables on a common linear scale of empirically-based risk as a step toward construction of a general patient acuity score from the Electronic Health Record: A modelling study. Br Med J Open 2013;3:e2367.