Association of cytokine gene polymorphisms (IL6, IL10, TNF-α, TGF-β and IFN-γ) and graves' disease in Turkish population

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 13, Issue 2, 2013, Pages 163-167

  Kutluturk, Faruk ^a   Yarman, Sema ^b   Oguz Sarvan, Fatma ^b   Kekik, Cigdem ^b  

^a GAZIOSMANPASA UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Cytokine; Graves' disease; Interferon; Interleukin; Polymorphism; Transforming growth factor; Tumour necrosis factor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

174CC GENE; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENETIC ASSOCIATION; GENOTYPING TECHNIQUE; GRAVES DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; TURKEY (REPUBLIC);

ADULT; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GRAVES DISEASE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; TURKEY;

EID: 84888099705     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/18715303113139990001     Document Type: Article

References (36)

1. Vaidya, B.; Kendall-Taylor, P. and Pearce S.H. (2002) The genetics of autoimmune thyroid disease. J. Clin. Endocrinol. Metab., 87, 5385-5397.
2. Weetman, A.P. (2004) Cellular immune responses in autoimmune thyroid disease. Clin. Endocrinol. (Oxf)., 61, 405-413.
3. Brix, T.H.; Kyvik, K.O.; Christensen, K. and Hegedus, L. (2001) Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J. Clin. Endocrinol. Metab., 86, 930-934.
4. Tomer, Y. and Davies, T.F. (2003) Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr. Rev., 24, 694-717.
5. Kawashima, A.; Tanigawa, K.; Akama, T.; Yoshihara, A.; Ishii, N. and Suzuki, K. (2011) Innate immune activation and thyroid autoimmunity. J. Clin. Endocrinol. Metab., 96, 3661-3671.
6. Senturk, T.; Kozaci, D.; Kok, F.; Kadikoylu, G. and Bolaman, Z. (2003) Proinflammatory cytokine levels in hyperthyroidism. Clin. Invest. Med., 26, 58-63.
7. Inoue, N.; Watanabe, M.; Nanba, T.; Wada, M.; Akamizu, T. and Iwatani, Y. (2009) Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody. Clin. Exp. Immunol., 156, 199-204.
8. Weetman, A.P. (2000) Graves' Disease. N. Engl. J. Med., 343, 1236-1248.
9. Ganesh, B.B.; Bhattacharya, P.; Gopisetty, A. and Prabhakar, B.S. (2011) Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity. J. Interferon. Cytokine Res., 31, 721-731.
10. Ikeda, Y.; Yoshida, W.; Noguchi, T.; Asaba, K.; Nishioka, T.; Takao, T. and Hashimoto K. (2004) Lack of association between IL-12B gene polymorphism and autoimmune thyroid disease in Japanese patients. Endocr. J., 51, 609-613.
11. Gianoukakis, A.G.; Martino, L.J.; Horst, N.; Cruikshank, W.W. and Smith, T.J. (2003) Cytokine-induced lymphocyte chemoattraction from cultured human thyrocytes: evidence for interleukin-16 and regulated upon activation, normal T cell expressed, and secreted expression. Endocrinology, 144, 2856-2864.
12. Chen, R.H.; Chen, W.C.; Wang, T.Y.; Tsai, C.H. and Tsai, F.J. (2005) Lack of association between pro-inflammatory cytokine (IL-6, IL-8 and TNF-alpha) gene polymorphisms and Graves' disease. Int. J. Immunogene, 32, 343-347.
13. Inoue, N.; Watanabe, M.; Morita, M.; Tatusmi, K.; Hidaka, Y.; Akamizu, T. and Iwatani Y. (2011) Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases. Clin. Exp. Immunol., 163, 318-323.
14. Liu, S.; Hou, P.; Morahan, G. and Shi B. (2012) No association between IL12B gene polymorphisms and Graves' disease in the Chinese population. Endocr. Res., 37, 182-87.
15. Yamada, H.; Watanabe, M.; Nanba, T.; Akamizu, T. and Iwatani, Y. (2008) The +869T/C polymorphism in the transforming growth factor-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease. Clin. Exp. Immunol., 151, 379-382.
16. Bougacha-Elleuch, N.; Rebai, A.; Mnif, M.; Makni, H.; Bellassouad, M.; Jouida, J.; Abid, M. and Hammadi A. (2004) Analysis of MHC genes in a Tunisian isolate with autoimmune thyroid diseases: implication of TNF -308 gene polymorphism. J. Autoimmun., 23, 75-80.
17. Bednarczuk, T.; Hiromatsu, Y.; Seki, N.; Ploski, R.; Fukutani, T.; Kurylowicz, A.; Jazdzewski, K.; Chojnowski, K.; Itoh, K. and Nauman, J. (2004) Association of tumour necrosis factor and human leukocyte antigen DRB1 alleles with Graves' ophthalmopathy. Hum. Immunol., 65, 632-639.
18. Kula, D.; Jurecka-Tuleja, B.; Gubala, E.; Krawczyk, A.; Szpak, S. and Jarzab, M. (2001) Association of polymorphism of LT-alpha and TNF genes with Graves' disease. Histochem. Cytobiol., 39, 77-78.
19. Simmonds, M.J.; Heward, J.M.; Howson, J.M.; Foxall, H.; Nithiyananthan, R.; Franklyn, J.A. and Gough S.C. (2004) A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves' disease. Genes Immun., 4, 267-273.
20. Khalilzadeh, O.; Anvari, M.; Esteghamati, A.; Momen-Heravi, F.; Mahmoudi, M.; Rashidi, A.; Amiri, HM.; Ranjbar, M.; Tabataba- Vakili, S. and Amirzargar, A. (2010) The interleukin-1 family gene polymorphisms and Graves' disease. Ann. Endocrinol., 71, 281-285.
21. Liu, N.; Lu, H.; Tao, F.; Guo, T; Liu, C; Cui, B. and Ning, G (2011) An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations. Endocrine, 40, 90-94.
22. Nakkuntod, J.; Wongsurawat, T.; Charoenwongse, P.; Snabboon, T.; Sridama, V. and Hirankarn, N. (2006) Association of TNFalpha, TNF-beta, IFN-gamma and IL-1Ra gene polymorphisms with Graves' disease in the Thai population. Asian Pac. J. Allergy Immunol., 24, 207-211.
23. Guo, T.; Huo, Y.; Zhu, W.; Xu, F.; Liu, C.; Liu, N.; Cao, M.; Cui, B. and Ning, G. (2013) Genetic association between IL-17F gene polymorphisms and the pathogenesis of Graves'Disease in the Han Chinese population. Gene, 512, 300-304.
24. Bossowski, A.; Harasymczuk, J.; Moniuszko, A.; Bossowska A.; Hilczer, M. and Ratomski, K. (2011) Cytometric evaluation of intracellular IFN and IL-4 levels in thyroid follicular cells from patients with autoimmune thyroid diseases. Thyroid Res., 4, 13.
25. Lichiardopol, C. and Moa M. (2009) The thyroid and autoimmunity. Rom. J. Intern. Med., 47, 207-215.
26. Pedro, A.B.; Romaldini, J.H. and Takei, K. (2011) Changes of serum cytokines in hyperthyroid Graves' disease patients at diagnosis and during methimazole treatment. Neuroimmunomodulation, 18, 45-51.
27. Khalilzadeh, O.; Noshad, S.; Rashidi, A. and Amirzargar, A. (2011) Graves' ophthalmopathy: a review of immunogenetics. Curr. Genomics, 12, 564-575.
28. Kamizono, S.; Hiromatsu, Y.; Seki, N.; Bednarczuk, T.; Matsumoto, H.; Kimura, A. and Itoh K. (2000) A polymorphism of the 5' flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese. Clin. Endocrinol. (Oxf)., 52, 759-764.
29. Anvari, M.; Khalilzadeh, O.; Esteghamati, A.; Momen-Heravi, F.; Mahmoudi, M.; Esfahani, S.A.; Rashidi, A. and Amirzargar, A. (2010) Graves' disease and gene polymorphism of TNF, IL-2, IL- 6, IL-12, and IFN. Endocrine, 37, 344-348.
30. Li, N.; Zhou, Z.; Liu, X.; Liu Y.; Zhang J.; Du, L.; Wei M. and Chen, X. (2008) Association of tumour necrosis factor alpha (TNFalpha) polymorphisms with Graves' disease: A meta-analysis. Clin. Biochem., 41, 881-886.
31. Shiau, M.Y.; Huang, C.N.; Yang, T.P.; Hwang Y.C.; Tsai K.J.; Chi, C.J. and Chang Y.H. (2007) Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease. Clin. Biochem., 40, 213-217.
32. Salvi, M.; Girasole, G. and Pedrazzoni, M. (1996) Increased serum concentrations of IL-6 and soluble IL-6 receptor in patients with Graves' disease. J. Clin. Endocrinol. Metab., 81, 2976-2979.
33. Mysliwiec, J.; Adamczyk, M.; Nikolajuk, A. and Gorska, M. (2011) Interleukin-6 and its considerable role in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in postmenopausal women. Endokrynol. Pol., 62, 299-302.
34. Bednarczuk, T.; Kurylowicz, A.; Hiromatsu, Y.; Kiljanskic, J.; Telichowska, A. and Nauman, J. (2004) Association of G-174C polymorphism of the interleukin-6 gene promoter with Graves' ophthalmopathy. Autoimmunity., 37, 223-226.
35. Hunt, P.J.; Marshall, S.E.; Weetman, A.P.; Bell, J.I.; Wass, J.A. and Welsh, K.I. (2008) Cytokine gene polymorphisms in autoimmune thyroid disease. J. Clin. Endocrinol. Metab., 85, 1984-1988.
36. Kumar, S.; Schiefer, R.; Coenen, M.J. and Bahn, R.S. (2010) A stimulatory thyrotropin receptor antibody (M22) and thyrotropin increase interleukin-6 expression and secretion in Graves' orbital preadipocyte fibroblasts. Thyroid, 20, 59-65.