High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide predict mortality in stable coronary artery disease: Results from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Clinical Chemistry and Laboratory Medicine

Volumn 51, Issue 10, 2013, Pages 2019-2028

  Giannitsis, Evangelos ^a   Spanuth, Eberhard ^b   Horsch, Andrea ^c   Kleber, Marcus E ^b,d   Koch, Winfried ^e   Grammer, Tanja B ^b   Koenig, Wolfgang ^d   März, Winfried ^b,f,g  

^a DIAneering   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Roche Diagnostics AG   (Switzerland)

^d UNIVERSITY HOSPITAL ULM   (Germany)

^e BDS Koch   (Germany)

^f MEDICAL UNIVERSITY OF GRAZ   (Austria)

^g SYNLAB ACADEMY   (Germany)

Author keywords

High sensitivity troponin T; N terminal pro B type natriuretic peptide (NT proBNP); Net reclassification index (NRI); Risk stratification; Stable coronary artery disease

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CREATININE; DIGITALIS; DIURETIC AGENT; FIBRINOGEN; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HIGH SENSITIVITY CARDIAC TROPONIN T; TROPONIN T; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; AGED; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HEART FAILURE; HEART INFARCTION; HUMAN; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; NEW YORK HEART ASSOCIATION CLASS; PREDICTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROGNOSIS; SURVIVOR; VALVULAR HEART DISEASE;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOASSAY; LOGISTIC MODELS; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; PROGNOSIS; RISK; ROC CURVE; SURVIVAL ANALYSIS; TROPONIN T;

EID: 84888095902     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2012-0786     Document Type: Article

References (39)

1. Thygesen K, Alpert JS, White DH: Joint ESC/ACCF/AHA/WHF Task Force for the Rededfinition of Myocardial Infarction. Universal definition of myocardial infarction. Circulation 2007;116: 2634-53. (Pubitemid 350182388)
2. Jolly SS, Shenkman H, Brieger D, Fox KA, Yan AT, Eagle KA, et al. (GRACE Investigators) Quantitative troponin and death, cardiogenic shock, cardiac arrest and new heart failure in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS): insights from the Global Registry of Acute Coronary Events. Heart 2011;97: 197-202.
3. James S, Armstrong P, Califf R, Simons ML, Venge P, Wallentin L, et al. Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial. Am J Med 2003;115: 178-84. (Pubitemid 37338141)
4. Morrow DA, Cannon CP, Jesse RL, Newby LK, Ravkilde J, Storrow AB, et al. National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Circulation 2007;115:e356-75. (Pubitemid 46648624)
5. Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, Cannon CP, et al. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 1996;335: 1342-9. (Pubitemid 26360452)
6. Hsieh BP, Rogers AM, Na B, Wu AH, Schiller NB, Whooley MA. Prevalence and prognostic significance of incidental cardiac troponin T elevation in ambulatory patients with stable coronary artery disease: data from The Heart and Soul Study. Am Heart J 2009;158: 673-9.
7. Wallace TW, Abdullah SM, Drazner MH, Das SR, Khera A, McGuire DK, et al. Prevalence and determinants of troponin T elevation in the general population. Circulation 2006;113: 1958-65.
8. Zethelius B, Johnston N, Venge P. Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study. Circulation 2006;113: 1071-8.
9. Giannitsis E, Kurz K, Hallermeier K, Jarausch J, Jaffe AS, Katus HA. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 2010;56: 254-61.
10. Latini R, Masson S, Anand IS, Carlson M, Vago T, Angelici L, et al. Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation 2007;116: 1242-9. (Pubitemid 47517535)
11. Omland T, de Lemos JA, Sabatine MS, Christophi, CA, Rice MM, Jablonski KA, et al. (PEACE trial investigators). A sensitive cardiac troponin T assay in stable coronary artery disease. N Engl J Med 2009;361: 2538-47.
12. Omland T, Persson A, Ng L, O'Brien R, Karlsson T, Herlitz J, et al. N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes. Circulation 2002;106: 2913-8. (Pubitemid 35424741)
13. James SK, Lindahl B, Siegbahn A, Stridsberg M, Venge P, Armstrong P, et al. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open Occluded Arteries (GUSTO)-IV substudy. Circulation 2003;108: 275-81. (Pubitemid 36899016)
14. Jernberg T, James S, Lindahl B, Stridsberg M, Venge P, Wallentin L. NT-proBNP in unstable coronary artery disease: experiences from the FAST, GUSTO IV and FRISC II trials. Eur J Heart Fail 2004;6: 319-25. (Pubitemid 38253052)
15. Cameron SJ, Sokoll LJ, Laterza OF, Shah S, Green GB. A multimarker approach for the prediction of adverse events in patients with acute coronary syndromes. Clin Chim Acta 2007;376: 168-73. (Pubitemid 44880999)
16. Christ M, Laule K, Klima T, Hochholzer W, Breidhardt, T, Perruchoud AP, et al. Multimarker strategy for risk prediction in patients presenting with acute dyspnea to the emergency department. Int J Cardiol 2008;126: 73-8. (Pubitemid 351509629)
17. Kragelund C, Gronning B, Kober L, Hlidebrandt P, Steffensen R. N-terminal pro-B-type natriuretic peptide and long-term mortality in stable coronary artery disease. N Engl J Med 2005;352: 666-75. (Pubitemid 40239214)
18. Omland T, Richards AM, Wergeland R, Vik-Mo H. B-type natriuretic peptide and long-term survival in patients with stable coronary artery disease. Am J Cardiol 2005;95: 24-8. (Pubitemid 40051107)
19. Ivandic BT, Spanuth E, Kleber M, Grammer T, Maerz W. High-sensitivity troponin T improves the prognostic value of N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: results from the LURIC Study. Clin Chem Lab Med 2011;46: 1053-8.
20. Winkelmann BR, März W, Boehm BO, Zotz R, Hager J, Hellstern P, et al. Rationale and design of the LURIC study: a resource for functional genomics, pharmacogenomics, and long-term prognosis of cardiovascular disease. Pharmacogenomics 2001;2:S1-73.
21. Hickman PE, Koerbin G, Southcott E, Tate J, Dimeski G, Carter A, et al. Newer cardiac troponin I assays have similar performance to troponin T in patients with end-stage renal disease. Ann Clin Biochem 2007;44: 285-9. (Pubitemid 351724693)
22. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation: Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999;130: 461-70. (Pubitemid 29135798)
23. Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996;15: 361-87. (Pubitemid 26072233)
24. Cook NR. Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve. Clin Chem 2008;54: 17-23. (Pubitemid 351182592)
25. Pencina MJ, D'Agostino RB, Vasan RS. Evaluating the added predictive ability of a new biomarker: from area under the ROC curve to reclassification and beyond. Stat Med 2008;27: 157-72. (Pubitemid 351193639)
26. Sabatine MS, Morrow DA, de Lemos JA, Gibson CM, Murphy SA, Rifai N, et al. Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide. Circulation 2002;105: 1760-3. (Pubitemid 34408881)
27. James SK, Lindahl B, Timmer JR, Ottervanger JP, Siegbahn A, Stridsberg M, et al. Usefulness of biomarkers predicting long-term mortality in patients with diabetes mellitus and non-ST-elevation acute coronary syndromes (A GUSTO IV Substudy). Am J Cardiol 2006;97: 167-72. (Pubitemid 43139229)
28. Manzano-Fernandez S, Boronat-Garcia M, Albaladejo-Oton MD, Pastor P, Garrido IP, Pastor-Perez FJ, et al. Complementary prognostic value of cystatin C, N-terminal pro-B-type natriuretic peptide and cardiac troponin T in patients with acute heart failure. Am J Cardiol 2009;103: 1753-9.
29. Tello-Montoliu A, Marin F, Roldan V, Mainar L, Lopez MT, Sogorb F, et al. A multimarker risk stratification approach to non-ST elevation acute coronary syndrome: implications of troponin I, CRP, NT-proBNP and fibrin D-dimer levels. J Intern Med 2007;262: 651-8. (Pubitemid 350135197)
30. Morrow DA, Rifai N, Antman EM, McCabe CH, Cannon CP, Braunwald E. C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A Substudy. J Am Coll Cardiol 1998;31: 1460-5. (Pubitemid 28273285)
31. Toss H, Lindahl B, Siegbahn A, Wallentin L. Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease (FRISC Study Group). Circulation 1997;96: 4204-10. (Pubitemid 28007445)
32. Omland T. B-types natriuretic peptides: prognostic markers in stable coronary artery disease. Expert Rev Mol Diagn 2008;8: 217-25. (Pubitemid 351469441)
33. Khan NA, Hemmelgarn BR, Tonelli M, Thompson CR, Levin A. Prognostic value of troponin T and I among asymptotic patients with end-stage renal disease: a meta-analysis. Circulation 2005;112: 3088-96. (Pubitemid 43113440)
34. Korosoglou G, Lehrke S, Mueller D, Hosch W, Kauczor HU, Humpert PM, et al. Determinants of troponin release in patients with stable coronary artery disease: insights from CT angiography characteristics of atherosclerotic plaque. Heart 2011;97: 823-31.
35. de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. J Am Med Assoc 2010;304: 2503-12.
36. Koenig W, Breitling LP, Hahmann H, Wüsten B, Brenner H, Rothenbacher D. Cardiac troponin T measured by a high-sensitivity assay predicts recurrent cardiovascular events in stable coronary heart disease patients with 8-year follow-up. Clin Chem 2012;58: 1215-24.
37. Leistner DM, Klotsche J, Pieper L, Stalla GK, Lehnert H, Silber S, et al. Circulating troponin as measured by a sensitive assay for cardiovascular risk assessment in primary prevention. Clin Chem 2012;58: 200-8.
38. Apple FS, Collinson PO. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 2012;58: 54-61.
39. Ordonez-Llanos J, Collinson PO, Christenson RH. Amino-terminal pro B-type natriuretic peptide: analytical considerations. Am J Cardiol 2008;101:9-15.