메뉴 건너뛰기




Volumn 13, Issue 6, 2013, Pages 661-669

Optimizing outcomes following allogeneic hematopoietic progenitor cell transplantation in AML: The role of hypomethylating agents

Author keywords

AML; Azacitidine; Decitabine; GVHD; GvL; Hematopoietic progenitor cell transplant; Hypomethylating agents; MDS

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BORTEZOMIB; DNA METHYLTRANSFERASE; GAMMA INTERFERON; HISTONE DEACETYLASE INHIBITOR; IMATINIB; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MELANOMA ANTIGEN 4; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID;

EID: 84888095824     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/15680096113139990005     Document Type: Article
Times cited : (15)

References (67)
  • 1
    • 55049097649 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: Diagnosisand staging
    • Malcovati, L.; Nimer, S. D. Myelodysplastic syndromes: diagnosisand staging. Cancer Control. 2008, 15 (Suppl), 4-13.
    • (2008) Cancer Control , vol.15 , Issue.SUPPL. , pp. 4-13
    • Malcovati, L.1    Nimer, S.D.2
  • 3
    • 84855410095 scopus 로고    scopus 로고
    • Monitoring and preventionof relapse after allogeneic hematopoietic cell transplantation for myeloid malignancies
    • Bacher, U.; Talano, J. A.; Bishop, M. R. Monitoring and preventionof relapse after allogeneic hematopoietic cell transplantation for myeloid malignancies. Biol. Blood Marrow. Transplant. 2012, 18, S62-S73.
    • (2012) Biol. Blood Marrow. Transplant , vol.18
    • Bacher, U.1    Talano, J.A.2    Bishop, M.R.3
  • 5
    • 55049114781 scopus 로고    scopus 로고
    • Current and emerging strategies for themanagement of acute myeloid leukemia in the elderly
    • Laubach, J.; Rao, A. V. Current and emerging strategies for themanagement of acute myeloid leukemia in the elderly. Oncologist 2008, 13, 1097-1108.
    • (2008) Oncologist , vol.13 , pp. 1097-1108
    • Laubach, J.1    Rao, A.V.2
  • 6
    • 64049092296 scopus 로고    scopus 로고
    • Acute myelogenous leukemia in olderadults
    • Klepin, H. D.;Balducci, L. Acute myelogenous leukemia in olderadults. Oncologist 2009, 14, 222-232.
    • (2009) Oncologist , vol.14 , pp. 222-232
    • Klepin, H.1
  • 7
    • 0036676069 scopus 로고    scopus 로고
    • Bone marrow transplantation formyelodysplastic syndrome--who? when? and which? Bone
    • Luger, S.; Sacks, N. Bone marrow transplantation formyelodysplastic syndrome--who? when? and which? Bone. Marrow. Transplant. 2002, 30, 199-206.
    • (2002) Marrow. Transplant , vol.30 , pp. 199-206
    • Luger, S.1    Sacks, N.2
  • 10
    • 11244278531 scopus 로고    scopus 로고
    • Pretransplantation induction chemotherapy and posttransplantation relapse in patients with advanced myelodysplastic syndrome
    • Scott, B. L.; Storer, B.; Loken, M. R.; Storb, R.; Appelbaum, F. Reeg, Pretransplantation induction chemotherapy and posttransplantation relapse in patients with advanced myelodysplastic syndrome. Biol. Blood Marrow. Transplant. 2005, 11, 65-73.
    • (2005) Biol. Blood Marrow. Transplant , vol.11 , pp. 65-73
    • Scott, B.L.1    Storer, B.2    Loken, M.R.3    Storb, R.4    Appelbaum, F.R.5
  • 14
    • 68049107379 scopus 로고    scopus 로고
    • Reduced-intensity conditioning transplantation in myeloidmalignancies
    • Storb, R. Reduced-intensity conditioning transplantation in myeloidmalignancies. Curr. Opin. Oncol. 2009, 21 (Suppl 1), S3-S5.
    • (2009) Curr. Opin. Oncol , vol.21 , Issue.SUPPL. 1
    • Storb, R.1
  • 15
    • 58149196171 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for adults with myelodysplastic syndromes: Importance of pretransplant disease burden
    • Warlick, E. D.; Cioc, A.; DeFor, T.; Dolan, M.; Weisdorf, D. Allogeneic stem cell transplantation for adults with myelodysplastic syndromes: importance of pretransplant disease burden. Biol. Blood Marrow. Transplant. 2009, 15, 30-38.
    • (2009) Biol. Blood Marrow. Transplant , vol.15 , pp. 30-38
    • Warlick, E.D.1    Cioc, A.2    Defor, T.3    Dolan, M.4    Weisdorf, D.5
  • 19
    • 40849139208 scopus 로고    scopus 로고
    • Esteller, M. Epigenetics in cancer. N. Engl
    • Esteller, M. Epigenetics in cancer. N. Engl. J. Med. 2008, 358,1148-1159.
    • (2008) J. Med , vol.358 , pp. 1148-1159
  • 22
  • 25
    • 84855416811 scopus 로고    scopus 로고
    • Azacitidine in patients with acute myeloid leukemia medically unfit for or resistant to chemotherapy: A multicenter phase I/II study
    • Al-Ali, H. K.; Jaekel, N.; Junghanss, C.; Maschmeyer, G.; Krahl, R.; Cross, M.; Hoppe, G.; Niederwieser, D. Azacitidine in patients with acute myeloid leukemia medically unfit for or resistant to chemotherapy: a multicenter phase I/II study. Leuk. Lymphoma. 2012, 53, 110-117.
    • (2012) Leuk. Lymphoma , vol.53 , pp. 110-117
    • Al-Ali, H.K.1    Jaekel, N.2    Junghanss, C.3    Maschmeyer, G.4    Krahl, R.5    Cross, M.6    Hoppe, G.7    Niederwieser, D.8
  • 28
    • 84888322475 scopus 로고    scopus 로고
    • Azacitidine is well tolerated after allogeneic stem cell transplantation and its administration is associated with a reduced risk of acute graft-versus-host disease
    • Craddock, C.; Jilani, N.; Siddique, S.; Vyas, P.; Dennis, M.; Yin, J.; Russell, N.; Snowden, J.; Crawley, C. Azacitidine is well tolerated after allogeneic stem cell transplantation and its administration is associated with a reduced risk of acute graft-versus-host disease. Haematologica 2012,97 (suppl 1), 21.
    • (2012) Haematologica , vol.97 , Issue.SUPPL. 1 , pp. 21
    • Craddock, C.1    Jilani, N.2    Siddique, S.3    Vyas, P.4    Dennis, M.5    Yin, J.6    Russell, N.7    Snowden, J.8    Crawley, C.9
  • 29
    • 0034193057 scopus 로고    scopus 로고
    • The primacy of the gastrointestinal tract asa target organ of acute graft-versus-host disease: Rationale for the use of cytokine shields in allogeneic bone marrow transplantation
    • Hill, G. Ferrara, J. L. The primacy of the gastrointestinal tract asa target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 2000, 95, 2754-2759.
    • (2000) Blood , vol.95 , pp. 2754-2759
    • Hill, G.1    Ferrara, J.L.2
  • 31
    • 0028889993 scopus 로고
    • Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups
    • Zittoun, R. A.; Mandelli, F.; Willemze, R.; de, W. T.; Resegotti, L.; Leoni, F.; Damasio, E.; Visani, G.; Papa, G.;. Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups. N. Engl. J. Med. 1995, 332, 217-223.
    • (1995) N. Engl. J. Med , vol.332 , pp. 217-223
    • Zittoun, R.A.1    Mandelli, F.2    Willemze, R.3    De, W.T.4    Resegotti, L.5    Leoni, F.6    Damasio, E.7    Visani, G.8    Papa, G.9
  • 32
    • 84859572115 scopus 로고    scopus 로고
    • Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation
    • Yan, C. H.; Liu, D. H.; Liu, K. Y.; Xu, L. P.; Liu, Y. R.; Han, W.; Wang, Y.; Qin, Y. Z.; Huang, X. J. Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation. Blood 2012, 119, 3256-3262.
    • (2012) Blood , vol.119 , pp. 3256-3262
    • Yan, C.H.1    Liu, D.H.2    Liu, K.Y.3    Xu, L.P.4    Liu, Y.R.5    Han, W.6    Wang, Y.7    Qin, Y.Z.8    Huang, X.J.9
  • 33
    • 0018764352 scopus 로고
    • Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts
    • Weiden, P. L.; Flournoy, N.; Thomas, E. D.; Prentice, R.; Buckner, C. D.; Storb, R. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N. Engl.J. Med. 1979, 300, 1068-1073.
    • (1979) N. Engl.J. Med , vol.300 , pp. 1068-1073
    • Weiden, P.L.1    Flournoy, N.2    Thomas, E.D.3    Prentice, R.4    Buckner, C.D.5    Storb, R.6
  • 34
    • 77955984091 scopus 로고    scopus 로고
    • Cells prevent graft-versus-host disease while sparing the graft-versus-leukemia effect after bone marrow transplantation
    • Cao, J.; Chen, C.; Zeng, L.; Li, L.; Li, Z.; Xu, K. Engineeredregulatory T cells prevent graft-versus-host disease while sparing the graft-versus-leukemia effect after bone marrow transplantation. Leuk Res 2010, 34, 1374-1382.
    • (2010) Leuk Res , vol.34 , pp. 1374-1382
    • Cao, J.1    Chen, C.2    Zeng, L.3    Li, L.4    Li, Z.5    Xu, K.6    Engineeredregulatory, T.7
  • 35
    • 0141461418 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger, M.; Hoffmann, P.; Ermann, J.; Drago, K.; Fathman, C. G.; Strober, S.; Negrin, R. S. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 2003, 9, 1144-1150.
    • (2003) Nat. Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3    Drago, K.4    Fathman, C.G.5    Strober, S.6    Negrin, R.S.7
  • 39
    • 77955900102 scopus 로고    scopus 로고
    • In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia
    • Choi, J.; Ritchey, J.; Prior, J. L.; Holt, M.; Shannon, W. D.; Deych, E.; Piwnica-Worms, D. R.; DiPersio, J. F. In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood 2010, 116, 129-139.
    • (2010) Blood , vol.116 , pp. 129-139
    • Choi, J.1    Ritchey, J.2    Prior, J.L.3    Holt, M.4    Shannon, W.D.5    Deych, E.6    Piwnica-Worms, D.R.7    Dipersio, J.F.8
  • 43
    • 77956924038 scopus 로고    scopus 로고
    • Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia
    • Goodyear, O.; Agathanggelou, A.; Novitzky-Basso, I.; Siddique, S.; McSkeane, T.; Ryan, G.; Vyas, P.; Cavenagh, J.; Stankovic, T.; Moss, P.; Craddock, C. Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood 2010, 116, 1908-1918.
    • (2010) Blood , vol.116 , pp. 1908-1918
    • Goodyear, O.1    Agathanggelou, A.2    Novitzky-Basso, I.3    Siddique, S.4    McSkeane, T.5    Ryan, G.6    Vyas, P.7    Cavenagh, J.8    Stankovic, T.9    Moss, P.10    Craddock, C.11
  • 45
    • 0242539831 scopus 로고    scopus 로고
    • Epigenetic targets for immune intervention in human malignancies
    • Maio, M.; Coral, S.; Fratta, E.; Altomonte, M.; Sigalotti, L.Epigenetic targets for immune intervention in human malignancies. Oncogene 2003, 22, 6484-6488.
    • (2003) Oncogene , vol.22 , pp. 6484-6488
    • Maio, M.1    Coral, S.2    Fratta, E.3    Altomonte, M.4
  • 49
    • 77954597881 scopus 로고    scopus 로고
    • Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosomepositive leukemia
    • Nakasone, H.; Kanda, Y.; Takasaki, H.; Nakaseko, C.; Sakura, T.; Fujisawa, S.; Yokota, A.; Yano, S.; Usuki, K.; Maruta, A.; Abe, D.; Hoshino, T.; Takahashi, S.; Kanamori, H.; Okamoto, S. Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosomepositive leukemia. Leukemia 2010, 24, 1236-1239.
    • (2010) Leukemia , vol.24 , pp. 1236-1239
    • Nakasone, H.1    Kanda, Y.2    Takasaki, H.3    Nakaseko, C.4    Sakura, T.5    Fujisawa, S.6    Yokota, A.7    Yano, S.8    Usuki, K.9    Maruta, A.10    Abe, D.11    Hoshino, T.12    Takahashi, S.13    Kanamori, H.14    Okamoto, S.15
  • 50
    • 78649601394 scopus 로고    scopus 로고
    • Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: A dose and schedule finding study
    • de, L. M.; Giralt, S.; Thall, P. F.; de Padua, S. L.; Jones, R. Komanduri, K.; Braun, T. M.; Nguyen, H. Q.; Champlin, R.; Garcia-Manero, G. Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study. Cancer 2010, 116, 5420-5431.
    • (2010) Cancer , vol.116 , pp. 5420-5431
    • De, L.M.1    Giralt, S.2    Thall, P.F.3    de Padua, S.L.4    Jones, R.5    Komanduri, K.6    Braun, T.M.7    Nguyen, H.Q.8    Champlin, R.9    Garcia-Manero, G.10
  • 51
    • 84857039313 scopus 로고    scopus 로고
    • Optimizing hypomethylating agents inmyelodysplastic syndromes
    • Itzykson, R.; Fenaux, P. Optimizing hypomethylating agents inmyelodysplastic syndromes. Curr. Opin. Hematol. 2012, 19, 65-70.
    • (2012) Curr. Opin. Hematol , vol.19 , pp. 65-70
    • Itzykson, R.1    Fenaux, P.2
  • 57
    • 36849048316 scopus 로고    scopus 로고
    • Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: A retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party
    • Schmid, C.; Labopin, M.; Nagler, A.; Bornhauser, M.; Fassas, A.; Volin, L.; Gurman, G.; Maertens, J.; Bordigoni, P.; Holler, E.; Ehninger, G.; Polge, E.; Gorin, N. C.; Kolb, H. J.; Rocha, V. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J. Clin. Oncol. 2007, 25, 4938-4945.
    • (2007) J. Clin. Oncol , vol.25 , pp. 4938-4945
    • Schmid, C.1    Labopin, M.2    Nagler, A.3    Bornhauser, M.4    Fassas, A.5    Volin, L.6    Gurman, G.7    Maertens, J.8    Bordigoni, P.9    Holler, E.10    Ehninger, G.11    Polge, E.12    Gorin, N.C.13    Kolb, H.J.14    Rocha, V.15
  • 58
    • 79954573454 scopus 로고    scopus 로고
    • 5-azacytidine as salvage treatment in relapsed myeloid tumors after allogeneic bone marrow transplantation
    • Bolanos-Meade, J.; Smith, B. D.; Gore, S. D.; McDevitt, M., 5-azacytidine as salvage treatment in relapsed myeloid tumors after allogeneic bone marrow transplantation. Biol. Blood Marrow. Transplant. 2011, 17, 754-758.
    • (2011) Biol. Blood Marrow. Transplant , vol.17 , pp. 754-758
    • Bolanos-Meade, J.1    Smith, B.D.2    Gore, S.D.3    McDevitt, M.4
  • 59
    • 0036720416 scopus 로고    scopus 로고
    • Donor lymphocyte infusions mediate superior graftversus-leukemia effects in mixed compared to fully allogeneic chimeras: A critical role for host antigen-presenting cells
    • Mapara, M. Y.; Kim, Y. M.; Wang, S. P.; Bronson, R.; Sachs, D.H.; Sykes, M. Donor lymphocyte infusions mediate superior graftversus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells. Blood 2002, 100, 1903-1909.
    • (2002) Blood , vol.100 , pp. 1903-1909
    • Mapara, M.Y.1    Kim, Y.M.2    Wang, S.P.3    Bronson, R.4    Sachs, D.H.5    Sykes, M.6
  • 61
    • 24944495973 scopus 로고    scopus 로고
    • Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome
    • Schmid, C.; Schleuning, M.; Ledderose, G.; Tischer, J.; Kolb, H. Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome. J. Clin. Oncol. 2005, 23, 5675-5687.
    • (2005) J. Clin. Oncol , vol.23 , pp. 5675-5687
    • Schmid, C.1    Schleuning, M.2    Ledderose, G.3    Tischer, J.4    Kolb, H.5
  • 62
  • 63
    • 33845216261 scopus 로고    scopus 로고
    • Successful treatment of relapsed AML after allogeneic stem cell transplantation with azacitidine
    • Graef, T.; Kuendgen, A.; Fenk, R.; Zohren, F.; Haas, R.; Kobbe, G.Successful treatment of relapsed AML after allogeneic stem cell transplantation with azacitidine. Leuk. Res. 2007, 31, 257-259.
    • (2007) Leuk. Res , vol.31 , pp. 257-259
    • Graef, T.1    Kuendgen, A.2    Fenk, R.3    Zohren, F.4    Haas, R.5    Kobbe, G.6
  • 64
    • 77950614210 scopus 로고    scopus 로고
    • Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting
    • Lubbert, M.; Bertz, H.; Wasch, R.; Marks, R.; Ruter, B.; Claus, R.; Finke, J. Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting. Bone. Marrow. Transplant. 2010, 45, 627-632.
    • (2010) Bone. Marrow. Transplant , vol.45 , pp. 627-632
    • Lubbert, M.1    Bertz, H.2    Wasch, R.3    Marks, R.4    Ruter, B.5    Claus, R.6    Finke, J.7
  • 65
    • 84867616893 scopus 로고    scopus 로고
    • Phase II study of azacitidine and donor lymphocytr infusions as first salavage therapy in patients with acute myeloid leukemia or myelodysplastic syndromes relapsing after allogeneic HSCT: Final results of the AZARELA study
    • Schroeder, T.; Czibere, A.; Kroger, N.; Platzbecker, U.; Uharek, L.; Luft, T.; Wolschke, C.; Bruns, I.; Zohren, F.; Fenk, R.; Haas, R.; Kobbe, G. Phase II study of azacitidine and donor lymphocytr infusions as first salavage therapy in patients with acute myeloid leukemia or myelodysplastic syndromes relapsing after allogeneic HSCT: final results of the AZARELA study. Blood 2011, 118 (suppl).
    • (2011) Blood , vol.118 , Issue.SUPPL.
    • Schroeder, T.1    Czibere, A.2    Kroger, N.3    Platzbecker, U.4    Uharek, L.5    Luft, T.6    Wolschke, C.7    Bruns, I.8    Zohren, F.9    Fenk, R.10    Haas, R.11    Kobbe, G.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.