Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: Ready for the prime time?

Expert Review of Cardiovascular Therapy

Volumn 11, Issue 12, 2013, Pages 1587-1589

  Tzikas, Apostolos ^a   Freixa, Xavier ^b   Ibrahim, Réda ^c  

^a Interbalkan Medical Centre   (Greece)

^b UNIVERSITY OF BARCELONA   (Spain)

^c MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Atrial fibrillation; Future perspectives; Imaging; Left atrial appendage; Stroke prevention

Indexed keywords

ACETYLSALICYLIC ACID PLUS CLOPIDOGREL; ANTICOAGULANT AGENT; WARFARIN;

ANTICOAGULATION; BLOOD CLOTTING; CEREBROVASCULAR ACCIDENT; CLINICAL DECISION MAKING; COLOR ULTRASOUND FLOWMETRY; DRUG EFFICACY; DRUG SAFETY; FALSE POSITIVE RESULT; FOLLOW UP; HEART ATRIUM APPENDAGE; HEART ATRIUM FIBRILLATION; HUMAN; INTRACARDIAC ECHOCARDIOGRAPHY; LEFT ATRIAL APPENDAGE CLOSURE DEVICE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PATIENT PREFERENCE; PATIENT SELECTION; PRIMARY PREVENTION; REVIEW; SECONDARY PREVENTION; THROMBOEMBOLISM; TRANSCATHETER AORTIC VALVE IMPLANTATION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY;

ADMINISTRATION, ORAL; ANTICOAGULANTS; ATRIAL APPENDAGE; ATRIAL FIBRILLATION; HUMANS; STROKE; THROMBOEMBOLISM; TIME FACTORS;

EID: 84888052924     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.2013.846216     Document Type: Review

References (16)

1. Lloyd-Jones DM, Wang TJ, Leip EP et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 110, 1042-1046 (2004).
2. Connolly SJ, Ezekowitz MD, Yusuf S et al. Dabigatran versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. 361, 1139-1151 (2009).
3. Connolly SJ, Eikelboom J, Joyner C et al. Apixaban in patients with atrial fibrillation. N. Engl. J. Med. 364, 806-817 (2011).
4. Patel MR, Mahaffey KW, Garg J et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N. Engl. J. Med. 365, 883-891 (2011).
5. Holmes DR, Reddy VY, Turi ZG et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet 374, 534-542 (2009).
6. Park JW, Bethencourt A, Sievert H et al. Left atrial appendage closure with amplatzer cardiac plug in atrial fibrillation: initial european experience. Catheter Cardiovasc. Interv. 77, 700-706 (2011).
7. Bartus K, Han FT, Bednarek J et al. Percutaneous left atrial appendage suture ligation using the LARIAT device in patients with atrial fibrillation: initial clinical experience. J. Am. Coll. Cardiol. 62, 108-118 (2013).
8. Camm AJ, Lip GY, De Caterina R et al. 2012 focused update of the ESC guidelines for the management of atrial fibrillation: an update of the 2010 ESC guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur. Heart J. 33, 2719-2747 (2012).
9. Blackshear JL, Odell JA. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann. Thorac. Surg. 61, 755-759 (1996).
10. Reddy VY, Möbius-Winkler S, Miller MA et al. Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation: ASA Plavix feasibility study with Watchman left atrial appendage closure technology (ASAP study). J. Am. Coll. Cardiol. 61(25), 2551-2556 (2013).
11. Viles-Gonzalez JF, Kar S, Douglas P et al. The clinical impact of incomplete left atrial appendage closure with the watchman device in patients with atrial fibrillation: a PROTECT AF (percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation) substudy. J. Am. Coll. Cardiol. 59, 923-929 (2012). • Important study on incomplete closure.
12. Kanderian AS, Gillinov AM, Pettersson GB, Blackstone E, Klein AL. Success of surgical left atrial appendage closure: assessment by transesophageal echocardiography. J. Am. Coll. Cardiol. 52, 924-929 (2008).
13. Freixa X, Tzikas A, Sobrino A, Chan J, Basmadjian AJ, Ibrahim R. Left atrial appendage closure with the Amplatzer Cardiac Plug: impact of shape and device sizing on follow-up leaks. Int. J. Cardiol. doi:10.1016/j.ijcard.2012.10. 031 (2012) (Epub ahead of print).
14. Tzikas A, Schultz CJ, Piazza N et al. Assessment of the aortic annulus by multislice computed tomography, contrast aortography, and trans-thoracic echocardiography in patients referred for transcatheter aortic valve implantation. Catheter Cardiovasc. Interv. 77, 868-875 (2011).
15. The Heart. www.theheart.org/article/1515107.do
16. Role of MSCT in LAAO. www.laaocclusion.org/lectures/is-there-a-role-in- of-msct-prior-to-the-laa-occlusion-procedure-and-in-post-procedure-care