Statin restores cardiac autonomic response to acute hypoxia in hypercholesterolaemia

European Journal of Clinical Investigation

Volumn 43, Issue 12, 2013, Pages 1291-1298

  Brasileiro Santos, Maria S ^a,b,c   Barreto Filho, José A S ^a,d   Santos, Raul D ^a   Chacra, Ana P M ^a   Sangaleti, Carine Teles ^a,e   Alvez, Gisele ^a,b   Bezerra, Otavio Coelho ^f   Bortoloto, Luiz Aparecido ^a   Irigoyen, Maria C ^a,b   Consolim Colombo, Fernanda M ^a,d  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^d FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

^e UNIVERSIDADE ESTADUAL DO CENTRO OESTE   (Brazil)

^f UNIVERSIDADE NOVE DE JULHO   (Brazil)

Author keywords

Autonomic nervous system; Blood pressure; Hypercholesterolaemia; Hypoxia; Simvastatin

Indexed keywords

SIMVASTATIN;

ADULT; ANALYTICAL PARAMETERS; ARTERIAL PRESSURE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BLOOD VESSEL FUNCTION; CARDIOVASCULAR REFLEX; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; HUMAN; HYPOXIA; MALE; NEUROMODULATION; OUTCOME ASSESSMENT; PARASYMPATHETIC TONE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RR INTERVAL; SPECTROSCOPY; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TREATMENT OUTCOME;

AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; HYPERCHOLESTEROLAEMIA; HYPOXIA; SIMVASTATIN;

ACUTE DISEASE; ADULT; ANOXIA; AUTONOMIC NERVOUS SYSTEM; BAROREFLEX; BLOOD PRESSURE; FEMALE; HEART RATE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPOPROTEINEMIA TYPE II; MALE; MIDDLE AGED; REFLEX; SIMVASTATIN; YOUNG ADULT;

EID: 84888044421     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12177     Document Type: Article

References (31)

1. Davidson MH, Kastelein JJ, O'Connor AM. Diagnosis and treatment of familial hypercholesterolaemia. Eur Heart J 2013;34:962-71.
2. Vogel RA. Coronary risk factors, endothelial function, and atherosclerosis: a review. Clin Cardiol 1997;20:426-32.
3. Stapleton PA, Goodwill AG, James ME, Brock RW, Frisbee JC. Hypercholesterolemia and microvascular dysfunction: interventional strategies. J Inflamm 2010;7:54.
4. Lahiri MK, Kannankeril PJ, Goldberger JJ. Assessment of autonomic function in cardiovascular disease. J Am Coll Cardiol 2008;51:1725-33.
5. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 1996;17:354-81.
6. Haarala A, Kähönen M, Eklund C, Jylhävä J, Koskinen T, Taittonen L et al. Heart rate variability is independently associated with C-reactive protein but not with serum amyloid A. The cardiovascular risk in young finns study. Eur J Clin Invest 2011;41:951-7.
7. Rovere MT, Specchia G, Mortara A, Schwartz PJ. Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction. A prospective study. Circulation 1988;78:816-24.
8. Floras JS. Sympathetic activation in human heart failure: diverse mechanisms, therapeutic opportunities. Acta Physiol Scand 2003;177:391-8.
9. Rovere MT, Pinna GD, Maestri R, Mortara A, Capomolla S, Febo O et al. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 2003;107:565-70.
10. Barreto-Filho JAS, Consolim-Colombo FM, Barreto-Filho GM, Guerra- Riccio JAS, Santos RD, Lopes HF et al. Hypercholesterolemia blunts forearm vasorelaxation and enhances the pressor response during acute systemic hypoxia. Arterioscler Thromb Vasc Biol 2003;23:1660-6.
11. Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial Investigators. N Engl J Med 1996;335:1001-9.
12. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20, 536 high-risk individuals: a randomized placebo-controlled trial. Lancet 2002;360:7-22.
13. Gould AL, Davies GM, Alemao E, Yin DD, Cook JR. Cholesterol reduction yields clinical benefits: meta-analysis including recent trials. Clin Ther 2007;29:778-94.
14. Chopra V, Choksi PU, Cavusoglu E. Beyond lipid lowering: the anti-hypertensive role of statins. Cardiovasc Drugs Ther 2007;21:161-9.
15. Stroes ES, Koomans HA, de Bruin TW, Rabelink TJ. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet 1995;346:467-71.
16. Mason RP, Walter MF, Jacob RF. Effects of HMG-CoA reductase inhibitors on endothelial function. Role of microdomains and oxidative stress. Circulation 2004;109(29 suppl 1):1134-41.
17. Wassmann S, Laufs U, Baumer A, Muller K, Ahlbory Linz W, Linz W et al. HMG-CoA reductase inhibitors improve endothelial function in normocholesterolemic hypertension via reduced production of reactive species. Hypertension 2001;37:1450-7.
18. Pehlivanidis AN, Athyros VG, Demitriadis DS, Papageorgiou AA, Bouloukos VJ, Kontopoulos AG. Heart rate variability after long-term treatment with atorvastatin hypercholesterolaemic patients with or without coronary artery disease. Atherosclerosis 2000;157:463-9.
19. Melenovsky V, Melenovsky D, Simek J, Malik JMD, Haas T, Ceska R et al. Effect of atorvastatin and fenofibrate on autonomic tone in subjects with combined hyperlipidemia. Am J Cardiol 2003;92:337-41.
20. Szramka M, Harris L, Ninnio D, Windebank E, Brack J, Skiba M et al. The effect of rapid lipid lowering with atorvastatin on autonomic parameters in patients with coronary artery disease. Int J Cardiol 2007;117:287-91.
21. Civeira F. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis 2004;173:55-68.
22. Montano N, Ruscone TG, Porta A, Lombardi F, Pagani M, Malliani A. Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation 1994;90:1826-31.
23. Baselli G, Cerutti S, Civardi S, Liberati D, Lombardi F, Malliani A et al. Spectral and cross-spectral analysis of heart rate and arterial blood pressure variability signals. Comput Biomed Res 1986;19:520-34.
24. Somers VK, Mark AL, Zavala DC, Abboud FM. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 1989;67:2101-6.
25. Heistad DD, Abboud FM. Circulatory adjustments to hypoxia. Circulation 1980;61:463-70.
26. Duplain H, Vollenweider L, Delabays A, Nicod P, Bärtsch P, Scherrer U. Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 1999;99:1713-18.
27. Brown SJ, Barnes MJ. Autonomic cardiovascular response to acute hypoxia and passive head-up tilting in humans. Eur J Apll Physiol 2013;113:1731-6.
28. Allemann Y, Stuber T, de Marchi SF, Rexhaj E, Sartori C, Scherrer U et al. Pulmonary artery pressure and cardiac function in children and adolescents after rapid ascent to 3, 450 m. Am J Physiol Heart Circ Physiol 2012;302:H2646-53.
29. Klemenc M, Golja P. Baroreflex sensitivity in acute hypoxia and carbohydrate loading. Eur J Appl Physiol 2011;111:2509-15.
30. Briasoulis A, Agarwal V, Valachis A, Messerli FH. Antihypertensive effects of statins: a meta-analysis of prospective controlled studies. J Clin Hypertension (Greenwich) 2013;15:310-20.
31. Kastelein JJ, van Leuven SI, Burgess L, Evans GW, Kuivenhoven JA, Barter PJ et al. RADIANCE 1 Investigators. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007;356:1620-30.