Porphyrins as urinary biomarkers for bladder cancer after 5-aminolevulinic acid (ALA) administration: The potential of photodynamic screening for tumors

Photodiagnosis and Photodynamic Therapy

Volumn 10, Issue 4, 2013, Pages 484-489

  Inoue, Keiji ^a   Ota, Urara ^b   Ishizuka, Masahiro ^b   Kawada, Chiaki ^a   Fukuhara, Hideo ^a   Shuin, Taro ^a   Okura, Ichiro ^c   Tanaka, Tohru ^b   Ogura, Shun ichiro ^c  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b SBI Pharmaceuticals Co   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

5 Aminolevulinic acid; Coproporphyrin; Tumor biomarker; Urine; Uroporphyrin

Indexed keywords

AMINOLEVULINIC ACID; COPROPORPHYRIN I; COPROPORPHYRIN III; CREATININE; PORPHYRIN; TUMOR MARKER; UNCLASSIFIED DRUG; UROPORPHYRIN;

ADULT; AGED; ARTICLE; BLADDER CANCER; CONTROLLED STUDY; CREATININE URINE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; URINALYSIS;

MUS;

5-AMINOLEVULINIC ACID; COPROPORPHYRIN; TUMOR BIOMARKER; URINE; UROPORPHYRIN;

ADULT; AGED; AMINOLEVULINIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EARLY DETECTION OF CANCER; FEASIBILITY STUDIES; HUMANS; MIDDLE AGED; PHOTOSENSITIZING AGENTS; PORPHYRINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 84888042435     PISSN: 15721000     EISSN: 18731597     Source Type: Journal    
DOI: 10.1016/j.pdpdt.2013.05.002     Document Type: Article

References (14)

1. Matsuda T., Marugame T., Kamo K., Katanoda K., Ajiki W., Sobue T. Japan cancer surveillance research, G. Cancer incidence and incidence rates in Japan in 2005: based on data from 12 population-based cancer registries in the monitoring of cancer incidence in Japan (MCIJ) project. Japanese Journal of Clinical Oncology 2011, 41:139-147.
2. Fife C.C., Farrow G.M., Utz D.C. Urine cytology of transitional cell neoplasms. Urologic Clinics of North America 1979, 6:599-612.
3. Krammer B., Plaetzer K. ALA and its clinical impact, from bench to bedside. Photochemical & Photobiological Sciences 2008, 7:283-289.
4. Kennedy J.C., Pottier R.H. Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. Journal of Photochemistry and Photobiology B 1992, 14:275-292.
5. Tabata K., Ogura S., Okura I. Photodynamic efficiency of protoporphyrin IX: comparison of endogenous protoporphyrin IX induced by 5-Aminolevulinic acid and exogenous porphyrin IX. Photochemistry and Photobiology 1997, 66:842-846.
6. Stummer W., Pichlmeier U., Meinel T., Wiestler O.D., Zanella F., Reulen H.J. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncology 2006, 7:392-401.
7. Inoue K., Fukuhara H., Shimamoto T., Kamada M., Iiyama T., Miyamura M., et al. Comparison between intravesical and oral administration of 5-aminolevulinic acid in the clinical benefit of photodynamic diagnosis for non-muscle invasive bladder cancer. Cancer 2011, 118:1062-1074.
8. Fukuhara H., Inoue K., Kuno T., Kamei M., Shimamoto T., Fukata S., et al. Preliminary experience of photodynamic diagnosis of positive margin during radical prostatectomy by oral 5-aminolevulnic acid. International Journal of Urology 2011, 18:585-591.
9. Ishizuka M., Hagiya Y., Mizokami Y., Honda K., Tabata K., Kamachi T., et al. Porphyrins in urine after administration of 5-aminolevulinic acid as a potential tumor marker. Photodiagnosis and Photodynamic Therapy 2011, 8:328-331.
10. Common Terminology Criteria for Adverse Events version 4.0.
11. Hagiya Y., Adachi T., Ogura S., An R., Tamura A., Nakagawa H. Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy. Journal of Experimental Therapeutics and Oncology 2008, 7:153-167.
12. Okayama A., Fujii S., Miura R. Optimized fluorometric determination of urinary δ-aminolevulinic acid by using pre-column derivatization, and identification of the derivative. Clinical Chemistry 1990, 36:1494-1497.
13. Dhima M., Salinas T.J., Wermers R.A., Weaver A.L., Koka S. Preference changes of adult outpatients for giving saliva, urine and blood for clinical testing after actual sample collection. Journal of Periodontal Research 2013, 57:51-56.
14. Masilamani V., Vijmasi T., Sslhi M.A., Govindaraj K., Vijaya-Raghavan A.P., Antonisamy B. Cancer detection by native fluorescence of urine. Journal of Biomedical Optics 2010, 15:057003.