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Volumn 12, Issue 6, 2013, Pages 842-848

Interplay between cholesterol and homocysteine in the exacerbation of amyloid-β toxicity in human neuroblastoma cells

Author keywords

Complex; Homocysteine toxicity; Neuronal cholesterol accumulation; ROS production

Indexed keywords

AMYLOID BETA PROTEIN; CHOLESTEROL; COPPER; HOMOCYSTEINE; MICROTUBULE ASSOCIATED PROTEIN 2; REACTIVE OXYGEN METABOLITE;

EID: 84888039960     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/18715273113129990083     Document Type: Article
Times cited : (18)

References (44)
  • 1
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J.; Selkoe, D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science, 2002, 297(5580), 353-356.
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 2
    • 58149497521 scopus 로고    scopus 로고
    • Biochemistry and molecular biology of amyloid β-protein and the mechanism of Alzheimer's disease
    • Selkoe, D.J. Biochemistry and molecular biology of amyloid β-protein and the mechanism of Alzheimer's disease. Handb. Clin. Neurol., 2008, 89, 245-260.
    • (2008) Handb. Clin. Neurol , vol.89 , pp. 245-260
    • Selkoe, D.J.1
  • 3
    • 78650403081 scopus 로고    scopus 로고
    • Reimagining Alzheimer's disease--an age-based hypothesis
    • Herrup, K. Reimagining Alzheimer's disease--an age-based hypothesis. J. Neurosci., 2010, 30(50), 16755-16762.
    • (2010) J. Neurosci , vol.30 , Issue.50 , pp. 16755-16762
    • Herrup, K.1
  • 5
    • 34547102265 scopus 로고    scopus 로고
    • Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment
    • Butterfield, D.A.; Reed, T.; Newman, S.F.; Sultana, R. Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic. Biol. Med., 2007, 43(5), 658-677.
    • (2007) Free Radic. Biol. Med. , vol.43 , Issue.5 , pp. 658-677
    • Butterfield, D.A.1    Reed, T.2    Newman, S.F.3    Sultana, R.4
  • 8
    • 78650850292 scopus 로고    scopus 로고
    • Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?
    • Struble, R.G.; Ala, T.; Patrylo, P.R.; Brewer, G.J.; Yan, X.X. Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J. Alzheimers Dis., 2010, 22(2), 393-399.
    • (2010) J. Alzheimers Dis , vol.22 , Issue.2 , pp. 393-399
    • Struble, R.G.1    Ala, T.2    Patrylo, P.R.3    Brewer, G.J.4    Yan, X.X.5
  • 9
    • 0034643831 scopus 로고    scopus 로고
    • Metal binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes
    • Miura, T.; Suzuki, K.; Kohata, N.; Takeuchi, H. Metal binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes. Biochemistry, 2000, 39(23), 7024-7031.
    • (2000) Biochemistry , vol.39 , Issue.23 , pp. 7024-7031
    • Miura, T.1    Suzuki, K.2    Kohata, N.3    Takeuchi, H.4
  • 10
    • 28444488974 scopus 로고    scopus 로고
    • Model studies of cholesterol and ascorbate oxidation by copper complexes: Relevance to Alzheimer's disease β-amyloid metallochemistry
    • Haeffner, F.; Smith, D.G.; Barnham, K.J.; Bush, A.I. Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease β-amyloid metallochemistry. J. Inorg. Biochem., 2005, 99(12), 2403-2422.
    • (2005) J. Inorg. Biochem , vol.99 , Issue.12 , pp. 2403-2422
    • Haeffner, F.1    Smith, D.G.2    Barnham, K.J.3    Bush, A.I.4
  • 12
    • 46749100924 scopus 로고    scopus 로고
    • Therapeutics for Alzheimer's disease based on the metal hypothesis
    • Bush, A.I.; Tanzi, R.E. Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics, 2008, 5(3), 421-432.
    • (2008) Neurotherapeutics , vol.5 , Issue.3 , pp. 421-432
    • Bush, A.I.1    Tanzi, R.E.2
  • 14
    • 46249124246 scopus 로고    scopus 로고
    • Cholesterol potentiates AA-amyloid-induced toxicity in human neuroblastoma cells: Involvement of oxidative stress
    • Ferrera, P.; Mercado-Gómez, O.; Silva-Aguilar, M.; Valverde, M.; Arias, C. Cholesterol potentiates AA-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress. Neurochem. Res., 2008, 33(8), 1509-1517.
    • (2008) Neurochem. Res , vol.33 , Issue.8 , pp. 1509-1517
    • Ferrera, P.1    Mercado-Gómez, O.2    Silva-Aguilar, M.3    Valverde, M.4    Arias, C.5
  • 15
    • 0027971798 scopus 로고
    • Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: Longitudinal apolipoprotein E genotype effects
    • Jarvik, G.P.; Austin, M.A.; Fabsitz, R.R.; Auwerx, J.; Reed, T.; Christian, J.C.; Deeb, S. Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects. Genet. Epidemiol., 1994, 11(4), 375-384.
    • (1994) Genet. Epidemiol , vol.11 , Issue.4 , pp. 375-384
    • Jarvik, G.P.1    Austin, M.A.2    Fabsitz, R.R.3    Auwerx, J.4    Reed, T.5    Christian, J.C.6    Deeb, S.7
  • 17
    • 0035826795 scopus 로고    scopus 로고
    • A fluid connection: Cholesterol and Aβ
    • Wolozin, B. A fluid connection: cholesterol and Aβ. Proc. Natl. Acad. Sci. USA, 2001, 98(10), 5371-5373.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.10 , pp. 5371-5373
    • Wolozin, B.1
  • 18
    • 84858993066 scopus 로고    scopus 로고
    • Peripheral cholesterol, metabolic disorders and Alzheimer's disease
    • Ledesma, M.D.; Dotti, C.G. Peripheral cholesterol, metabolic disorders and Alzheimer's disease. Front. Biosci., 2012, 4,181-194.
    • (2012) Front. Biosci , vol.4 , pp. 181-194
    • Ledesma, M.D.1    Dotti, C.G.2
  • 19
    • 79960459422 scopus 로고    scopus 로고
    • Cholesterol metabolism in neurons and astrocytes
    • Pfrieger, F.W.; Ungerer, N. Cholesterol metabolism in neurons and astrocytes. Prog. Lipid Res., 2011, 50(4), 357-371.
    • (2011) Prog. Lipid Res , vol.50 , Issue.4 , pp. 357-371
    • Pfrieger, F.W.1    Ungerer, N.2
  • 20
    • 85027929698 scopus 로고    scopus 로고
    • Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and metaregression
    • Ho, R.C.; Cheung, M.W.; Fu, E.; Win, H.H.; Zaw, M.H.; Ng, A.; Mak, A. Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and metaregression. Am. J. Geriatr. Psychiatry, 2011, 19(7), 607-617.
    • (2011) Am. J. Geriatr. Psychiatry , vol.19 , Issue.7 , pp. 607-617
    • Ho, R.C.1    Cheung, M.W.2    Fu, E.3    Win, H.H.4    Zaw, M.H.5    Ng, A.6    Mak, A.7
  • 21
  • 22
    • 80051601594 scopus 로고    scopus 로고
    • Relationship between lipid profiles and plasma total homocysteine, cysteine and the risk of coronary artery disease in coronary angiographic subjects
    • Xiao, Y.; Zhang, Y.; Lv, X.; Su, D.; Li, D.; Xia, M.; Qiu, J.; Ling, W.; Ma, J. Relationship between lipid profiles and plasma total homocysteine, cysteine and the risk of coronary artery disease in coronary angiographic subjects. Lipids Health Dis., 2011, 10, 137-143.
    • (2011) Lipids Health Dis , vol.10 , pp. 137-143
    • Xiao, Y.1    Zhang, Y.2    Lv, X.3    Su, D.4    Li, D.5    Xia, M.6    Qiu, J.7    Ling, W.8    Ma, J.9
  • 24
    • 17544374598 scopus 로고    scopus 로고
    • Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors
    • Woo, C.W., Siow, Y.L.; Pierce, G.N.; Choy, P.C.; Minuk, G.Y.; Mymin, D. Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Am. J. Physiol. Endocrinol. Metab., 2005, 288(5), E1002-E1010.
    • (2005) Am. J. Physiol. Endocrinol. Metab , vol.288 , Issue.5
    • Woo, C.W.1    Siow, Y.L.2    Pierce, G.N.3    Choy, P.C.4    Minuk, G.Y.5    Mymin, D.6
  • 25
    • 79954457930 scopus 로고    scopus 로고
    • Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia
    • Wu, N.; Sarna, L.K.; Siow, Y.L. Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2011, 300(3), R635-R643.
    • (2011) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.300 , Issue.3
    • Wu, N.1    Sarna, L.K.2    Siow, Y.L.3
  • 27
    • 0021234538 scopus 로고
    • Histochemical detection and differentiation of free and esterified cholesterol in swine atherosclerosis using filipin
    • Kruth, H.S.; Fry, D.L. Histochemical detection and differentiation of free and esterified cholesterol in swine atherosclerosis using filipin. Exp. Mol. Pathol., 1984, 40(3), 288-294.
    • (1984) Exp. Mol. Pathol , vol.40 , Issue.3 , pp. 288-294
    • Kruth, H.S.1    Fry, D.L.2
  • 29
    • 0035093878 scopus 로고    scopus 로고
    • Homocysteine potentiates copper and amyloid β peptide-mediated toxicity in primary cultures: Possible risk factors in the Alzheimer's-type neurodegenerative pathways
    • White, A.R.; Huang, X.; Jobling, M.F.; Barrow, C.J.; Beyreuther, K.; Masters, C.L.; Bush, A.I.; Cappai, R. Homocysteine potentiates copper and amyloid β peptide-mediated toxicity in primary cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. J. Neurochem., 2001, 76(5), 1509-1520.
    • (2001) J. Neurochem , vol.76 , Issue.5 , pp. 1509-1520
    • White, A.R.1    Huang, X.2    Jobling, M.F.3    Barrow, C.J.4    Beyreuther, K.5    Masters, C.L.6    Bush, A.I.7    Cappai, R.8
  • 30
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
    • Geula, C.; Wu, C.K.; Saroff, D.; Lorenzo, A.; Yuan, M.; Yankner, B.A. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nat. Med., 1998, 4(7), 827-831.
    • (1998) Nat. Med , vol.4 , Issue.7 , pp. 827-831
    • Geula, C.1    Wu, C.K.2    Saroff, D.3    Lorenzo, A.4    Yuan, M.5    Yankner, B.A.6
  • 31
    • 84856732033 scopus 로고    scopus 로고
    • Neuroimaging results impose new views on Alzheimer's disease-the role of amyloid revised
    • Fjell, A.M.; Walhovd, K.B. Neuroimaging results impose new views on Alzheimer's disease-the role of amyloid revised. Mol. Neurobiol., 2012, 45(1), 153-172.
    • (2012) Mol. Neurobiol , vol.45 , Issue.1 , pp. 153-172
    • Fjell, A.M.1    Walhovd, K.B.2
  • 32
    • 79955658979 scopus 로고    scopus 로고
    • Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: Insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder
    • Sultana, R.; Mecocci, P.; Mangialasche, F.; Cecchetti, R.; Baglioni, M.; Butterfield, D.A. Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder. J. Alzheimers Dis., 2011, 24(1), 77-84.
    • (2011) J. Alzheimers Dis , vol.24 , Issue.1 , pp. 77-84
    • Sultana, R.1    Mecocci, P.2    Mangialasche, F.3    Cecchetti, R.4    Baglioni, M.5    Butterfield, D.A.6
  • 33
    • 0037096251 scopus 로고    scopus 로고
    • A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage
    • Zou, K.; Gong, J.S.; Yanagisawa, K.; Michikawa, M. A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage. J. Neurosci., 2002, 22(12), 4833-4841.
    • (2002) J. Neurosci , vol.22 , Issue.12 , pp. 4833-4841
    • Zou, K.1    Gong, J.S.2    Yanagisawa, K.3    Michikawa, M.4
  • 35
    • 0031692918 scopus 로고    scopus 로고
    • Homocysteine stimulates the production and secretion of cholesterol in hepatic cells
    • Lynn, E.G.; Chung Y.H.; Siow, Y.L.; Man, R.Y.; Choy, P.C. Homocysteine stimulates the production and secretion of cholesterol in hepatic cells. Biochim. Biophys. Acta, 1998, 1393(2-3), 317-324.
    • (1998) Biochim. Biophys. Acta , vol.1393 , Issue.2-3 , pp. 317-324
    • Lynn, E.G.1    Chung, Y.H.2    Siow, Y.L.3    Man, R.Y.4    Choy, P.C.5
  • 36
    • 33747391975 scopus 로고    scopus 로고
    • Elevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer's disease?
    • Seshadri, S. Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease? J. Alzheimers Dis., 2006, 9(4), 393-398.
    • (2006) J. Alzheimers Dis , vol.9 , Issue.4 , pp. 393-398
    • Seshadri, S.1
  • 37
    • 0021749728 scopus 로고
    • Regional distribution of homocysteine in the mammalian brain
    • Broch, O.J.; Ueland, P.M. Regional distribution of homocysteine in the mammalian brain. J. Neurochem., 1984, 43(6), 1755-1757.
    • (1984) J. Neurochem. , vol.43 , Issue.6 , pp. 1755-1757
    • Broch, O.J.1    Ueland, P.M.2
  • 39
    • 84655164280 scopus 로고    scopus 로고
    • The role of metallobiology and amyloid-TTTpeptides in Alzheimer's disease
    • Roberts, B.R.; Ryan, T.M.; Bush, A.I.; Masters, C.L.; Duce, J.A. The role of metallobiology and amyloid-TTTpeptides in Alzheimer's disease. J. Neurochem., 2012, 120, 149-166.
    • (2012) J. Neurochem , vol.120 , pp. 149-166
    • Roberts, B.R.1    Ryan, T.M.2    Bush, A.I.3    Masters, C.L.4    Duce, J.A.5
  • 40
    • 77954387051 scopus 로고    scopus 로고
    • Homocysteine and copper induce cellular apoptosis via caspase activation and nuclear translocation of apoptosis-inducing factor in neuronal cell line SHSY5Y
    • Hirashima, Y.; Seshimo, S.; Fujiki, Y.; Okabe, M.; Nishiyama, K.; Matsumoto, M.; Kanouchi, H.; Oka, T. Homocysteine and copper induce cellular apoptosis via caspase activation and nuclear translocation of apoptosis-inducing factor in neuronal cell line SHSY5Y. Neurosci. Res., 2010, 67(4), 300-306.
    • (2010) Neurosci. Res , vol.67 , Issue.4 , pp. 300-306
    • Hirashima, Y.1    Seshimo, S.2    Fujiki, Y.3    Okabe, M.4    Nishiyama, K.5    Matsumoto, M.6    Kanouchi, H.7    Oka, T.8
  • 41
    • 69249084030 scopus 로고    scopus 로고
    • Paradoxical condensation of copper with elevated PP-amyloid in lipid rafts under cellular copper deficiency conditions: Implications for Alzheimer disease
    • Hung, Y.H.; Robb, E.L.; Volitakis, I.; Ho, M.; Evin, G.; Li, Q.X.; Culvenor, J.G.; Masters, C.L.; Cherny, R.A.; Bush, A.I. Paradoxical condensation of copper with elevated PP-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. J. Biol. Chem., 2010, 284(33), 21899-21907.
    • (2010) J. Biol. Chem , vol.284 , Issue.33 , pp. 21899-21907
    • Hung, Y.H.1    Robb, E.L.2    Volitakis, I.3    Ho, M.4    Evin, G.5    Li, Q.X.6    Culvenor, J.G.7    Masters, C.L.8    Cherny, R.A.9    Bush, A.I.10
  • 42
    • 14844304305 scopus 로고    scopus 로고
    • Oxidation of cholesterol by amyloid precursor protein and β-amyloid peptide
    • Nelson, T.J.; Alkon, D.L. Oxidation of cholesterol by amyloid precursor protein and β-amyloid peptide. J. Biol. Chem., 2005, 280(8), 7377-7387.
    • (2005) J. Biol. Chem , vol.280 , Issue.8 , pp. 7377-7387
    • Nelson, T.J.1    Alkon, D.L.2


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