Physiopathological, clinical and therapeutic aspects of hepatopulmonary syndrome

Clinica Terapeutica

Volumn 161, Issue SUPPL.3, 2011, Pages

  Valenti, A ^a   Caimi, G ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Hypoxiemia; Orthodeoxia; Platypnea; Pulmonary arteriovenous shunts

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN 1 ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTERIOVENOUS SHUNT; CHRONIC LIVER DISEASE; CONTRAST ECHOCARDIOGRAPHY; HEPATOPULMONARY SYNDROME; HUMAN; HYPOXEMIA; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; LIVER CIRRHOSIS; LIVER FAILURE; LIVER TRANSPLANTATION; LUNG BLOOD VESSEL; LUNG CAPILLARY; PATHOPHYSIOLOGY; PORTAL HYPERTENSION; PORTOPULMONARY HYPERTENSION; REVIEW; SCREENING TEST; VASODILATATION;

EID: 84888022869     PISSN: 00099074     EISSN: 19726007     Source Type: Journal    
DOI: None     Document Type: Review

References (74)

1. Milani A, Basso M, Fiorini A, et al. Hepato-pulmonary sindrome and porto-pulmonary hypertension. Nosologic features and etiopathogenic considerations. Rec Prog Med 2001, 92, 158-63
2. Herve P, Le Pavec J, Sztrymf B, et al. Pulmonary vascular abnormalities in cirrhosis. Best Pract Res Clin Gastroenterol 2007, 21, 141-59
3. Hoeper MM, Krowa MJ, Strassburg CP. Portopulmonary hypertension and Hepatopulmonary syndrome. Lancet 2004, 364, 26-7
4. Colle I, Van Steenkiste C, Geerts A, et al. Hepatopulmonary syndrome and portopulmonary hypertension: wath's new? Acta Gasteroenterol Belg 2007, 70, 203-9
5. Ramsay MA, Simpson BR, Nguyen AT, et al. Severe pulmonary hypertension in liver transplantation candidates. Liver Translp Surg 1997, 3: 494-500
6. Castro M, Krowka MJ, Schroeder DR, et al. Frequency and clinical implications of increased pulmonary artery pressures in liver transplant patients. Mayo Clin Proc 1996, 71, 543-51
7. Kennedy TC, Knudson RJ. Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis. Chest1977, 72, 305-9
8. Sarkar P, Basu AK, Mandal SK, et al. Hepatopulmonary syndrome- an uncommon and severe complication of certain liver diseases. J Indian Med Assoc 2005, 103, 469-70
9. Aziz K, Kenan I, Kendal Y, et al. Hepatopulmonary syndrome and right ventricular diastolic functions: An Echocardiographic Examination. Ecocardiogr 2006, 23, 271-8
10. Gaines DI, Fallon MB. Hepatopulmonary syndrome. Liver Int 2004, 24, 397-401
11. Lange PA, Stoller JK. The Hepatopulmonary syndrome. Ann Intern Med 1995, 122, 521-529
12. Naeije R. Hepatopulmonary syndrome and portopulmonary hypertension. Swiss Med Wkly 2003, 133, 163-9
13. Naeije R, Mèlot C, Hallemans R, et al. Pulmonary hemodynamics in liver cirrhosis. Semin Respir Med 1985, 7, 164-71
14. Schenk P, Fuhrman V, Madl C, et al. Hepatopulmonary syndrome: prevalence and predictive value of various cut offs for arterial oxygenation and their clinical consequences. Gut 2002, 51, 853-9
15. Charalabopoulos K, Peschoc D, Zoganas L, et al. Alterations in arterial blood parameters in patients with liver cirrhosis and ascites. Int J Med Sci 2007, 4, 94-7
16. Martinez GP, Barbera JA, Visa J, et al. Hepatopulmonary syndrome in candidates for liver transplantation. J Hepatol 2001, 34, 651-7
17. Delclaux C, Mahut B, Zehar-Lancner F, et al. Increased nitric oxide output from alveolar origin during liver cirrhosis versus bronchial source during asthma. Am J Respir Crit Care Med 2002, 165, 332-7
18. Rolla G. Hepatopulmonary syndrome: role of nitric oxide and clinical aspects. Dig Liv Dis 2003, 36, 303-8
19. Degano B, Mittaine M, Hervè P, et al. Nitric oxide production by the alveolar compartment of the lungs in cirrhotic patiens. Eur Respir J 2009, 34, 138-44
20. Frossard JL, Schiffer E, Cikirikcioglu B, et al. Opposite regulation of endothelial NO synthase by HSP90 and caveolina in liver and lungs of rats with Hepatopulmonary syndrome. Am J Physiol Gastrointest Liver Physiol 2007, 293:G864-70
21. Battista S, Bar F, Mengozzi G, et al. Hyperdynamic circulation in patients with cirrhosis: direct measurements of nitric oxide levels in hepatic and portal veins. J Hepatol 1997, 26: 75-80
22. LaffiG, Foschi M, Masini E, et al. Increased production of nitric oxide by neutrophils and monocytes from cirrhotic patients with ascites and hyperdinamic circulation in cirrhotic rats. Gastroenterol 1995, 109, 1624-30
23. Matsmoto A, Ogura K, Hirata Y, et al. Increased nitric oxide in the exhaled air of patients with decompensated liver cirrhosis. Ann Intern Med 1995, 123, 110-3
24. Tumgor G, Berdeli A, Arikan C, et al. Mcp-1, e NOS, t PA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in HPS. Dig Dis Sci 2008, 53, 1345-51
25. Denie C, Vachiery F, Gadano A, et al. Influence of transjugular intrahepatic portosystemic shunts (TIPS) on tissue oxygenation in patients with Cirrhosis. Liver 1998;18, 239-44
26. Stanley N, Ackrill B, Wood J. Lung perfusion scanning in hepatic cirrhosis. Br Med J 1972, 4, 639-43
27. Muller C, Shen KP. Hepatopulmonary syndrome. Wien Klin Wochenschr 1999, 111, 339-47
28. Martinez G, Barbera JA, Navasa M. Hepatopulmonary syndrome associated with cardiorespiratory disease. J Hepatol 1999, 30, 882-9
29. Anel RML, Sheagren JN. Novel presentation and approach to management of Hepatopulmonary syndrome with the use of antimicrobial agents. Clin Infect Dis 2001, 32, 131-6
30. Shijo H, Sasaki H, Nishimaru K, et al. Recurrent intracranial hemorrhagic episodes in Hepatopulmonary syndrome. Intern Med 1992, 31, 86-90
31. Naschitz JE, Slobodin G, Lewis RJ, et al. Heart diseases affecting the liver and liver diseases affecting the heart. Am Heart J 2000, 140, 111-20
32. Wong F, Liu P, Lilly L, et al. Role of cardiac structural and functional abnormalities in the pathogenesis of hyperdynamic circulation and renal sodium retention in cirrhosis. Clin Sci 1999, 97, 259-67
33. Moller S, Henriksen JH. Cardiovascular dysfunction in cirrhosis. Pathophysiological evidence of a cirrhotic cardiomyopathy. Scand J Gastroenterol 2001, 36, 785-94
34. Piscione F, Manganiello V, Viola O, et al. Alterazioni morfofunzionali del sistema cardiovascolare in pazienti con cirrosi epatica. Ital Heart J Suppl 2003, 4, 85-95
35. Kowalski HJ, Abelman WH. The cardiac output at rest in Laennec cirrhosis. J Clin Invest 1953, 32, 1025-33
36. Lunseth JH, Olmstead EG, Forks G. A study of heart disease in 180 hospitalized patients dying with portal cirrhosis. Arch Intern Med 1958, 102, 405-13
37. Ma Z, Miyamoto A, Lee S. Role of altereted beta-adrenoceptor signal transduction in the pathogenesis of cirrhotic cardiomyopathy in rats. Gastroenterol 1996, 110, 1191-8
38. Pozzi M, Carugo S, Boari G, et al. Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatol 1997, 26, 1131-7
39. Karabulut A, Iltumur K, Yalcin K, et al. Hepatopulmonary syndrome and right ventricular diastolic functions: an echographic examination. Echocardiography 2006, 23, 271-8
40. Henrikesen JH, Fuglsang S, Bendtsen F, et al. Dyssynchronous electrical and mechanical systole in patients with cirrhosis. J Hepatol 2002, 36, 513-20
41. Murray FJ, Dawson AM, Sherlock S. Circulatory changes in chronic liver disease. Am J Med 1958, 24, 358-67
42. Schrier RW, Arroyo V, Bernardi M, et al. Peripheral arterial vasodilatation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatol 1998, 8, 1151-7
43. Arroyo V, Colmenero J. Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management. J Hepatol 2003, 38:S69-89
44. McNaughton L, Puttagunta L, Martinez-Cuesta MA, et al. Distribution of nitric oxide synthase in normal and cirrhotic human liver. Proc Nate Acad Sci USA 2002, 99, 17161-6
45. Moller S, Henriksen J. Cardiopulmonary complications in chronic liver disease. ISSN 1007-9327 CN 14-1219/R World J Gastroenterol 2006, 12, 526-38
46. Rodriguez-Roisin R, Agusti AG, Roca J. The hepatopulmonary syndrome: new name, old complexities. Thorax 1992, 47, 897-902
47. Møller S, Henriksen JH. Cirrhotic cardiomyopathy: a pathophysiological review of circulatory dysfunction in liver disease. Heart 2002, 87, 9-15
48. Liu H, Song D, Lee SS. Cirrhotic cardiomyopathy. Gastroenterol Clin Biol 2002, 26, 842-7
49. Ward CA, Ma Z, Lee SS, et al. Potassium currents in atrial and ventricular myocytes from a rat model of cirrhosis. Am J Physiol 1997, 273:G537-44
50. Ma Z, Lee SS. Cirrhotic cardiomyopathy: getting to the heart of the matter. Hepatol 1996, 24, 451-9
51. Day CP, James OF, Butler TJ, et al. QT prolongation and sudden cardiac death in patients with alcoholic liver disease. Lancet 1993, 341, 1423-8
52. Grose RD, Nolan J, Dillon JF, et al. Exercise- induced left ventricular dysfunction in alcoholic and non-alcoholic cirrhosis. J Hepatol 1995, 22, 326-32
53. De BK, Majumdar D, Das D, et al. Cardiac dysfunction in portal hypertension among patients with cirrhosis and non-cirrhotic portal fibrosis. J Hepatol 2003, 39, 315-9
54. Pozzi M, Carugo S, Boari G, et al. Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatol 1997, 26, 1131-7
55. Kelbaek H, Eriksen J, Brynjolf I, et al. Cardiac performance in patients with asymptomatic alcoholic cirrhosis of the liver. Am J Cardiol 1984, 54, 852-5
56. Torregrosa M, Aguade S, Dos L, et al. Cardiac alterations in cirrhosis: reversibility after liver transplantation. J Hepatol 2005, 42, 68-74
57. Bernardi M, Fornale L, Di Marco C, et al. Hyperdynamic circulation of advance cirrhosis: a reapprais al based on posture-induced changes in hemodynamics. J Hepatol 1995, 22, 309-18
58. Friedman HS, Cirillo N, Schiano F, et al. Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances. Alcohol Clin Exp Res 1995, 19, 123-1
59. Ruiz-del-Arbol L, Monescillo A, Arocena C, et al. Circulatory function and hepatorenal syndrome in cirrhosis. Hepatol 2005, 42, 439-47
60. Gentilini P, Romanelli RG, La Villa G, et al. Effects of low-dose captopril on renal hemodynamics and function in patients with cirrhosis of the liver. Gastroenterology 1993, 104, 588-94
61. Gonzalez-Abraldes J, Albillos A, Banares R, et al. Randomized comparison of long-term losartan versus propranolol in lowering portal pressure in cirrhosis. Gastroenterol 2001, 121, 382-8
62. Møller S, Henriksen JH. Review article: pathogenesis and pathophysiology of hepatorenal syndrome--is there scope for prevention? Aliment Pharmacol Ther 2004, 20(Suppl 3), 31-41
63. Zamirian M, Aslani A, Shahrzad S. Left atrial volume: a novel predictor of Hepatopulmonary syndrome. Am J Gastroenterol 2007, 13, 1464-5
64. Prediletto R, Catapano G, Bottai C, et al. Ruolo della radiografia del torace nella valutazione preoperatoria della funzione polmonare dei pazienti con cirrosi candidati al trapianto di fegato. Radiol Toracica 2003, 108, 320
65. Garcia-Pagan JC, Feu F, Navasa M, et al. Long-Term haemodynamic effects of isosorbide-5-mononitrate i patients with cirrosi and portal hypertension. J Hepatol 1990, 11, 189-95
66. Bosch J, Garcia-Pagan JC, Feu F, et al. New approaches in the pharmacologic treatment of portal hypertension. J Hepatol 1993;17:S41-5
67. Sztrymf B, Rabiller A, Nunes H, et al. Prevention of hepatopulmonary syndrome and hyperdynamic state by pentoxifylline in cirrhotic rats. Eur Respir J 2004, 23, 752-8
68. Huffmyer Julie L, Nemergut E. Respiratoty dysfunction and pulmonary disease in cirrhosis and other hepatic disordes. Respir Care 2007, 52, 1030-6
69. Naoki U, Patrick S.K. Hepatopulmonary syndrome and portopulmonary hypertension. Hepatol Res 2009, 39, 1020-2
70. Krowka MJ, Frantz RP, McGoon MD, et al. Improvement in pulmonary hemodynamics during intravenous epoprostenol (prostacyclin): a study of 15 patients with moderate to severe portopulmonary hypertension. Hepatology 1999, 30, 641-8
71. Aucejo F, Miller C, Vogt D, et al. Pulmonary Hypertension after liver transplantation in patients with antecedent hepatopulmonary syndrome: a report of two cases and review of the literature. Liver Transpl 2006, 12, 1278-82
72. Krowka MJ. Pulmonary hypertension, (high) risk of orthotopic liver transplantation, and some lessons from "primary" pulmonary hypertension (editorial). Liver Transpl 2002, 8, 389-90
73. Ramsay MA. Perioperative mortality in patients with portopulmonary hypertension undergoing liver transplantation. Liver Transpl 2000, 6, 451-2
74. Taillè C, Cadranel J, Bellocq A, et al. Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France. Transplantation 2003, 79, 1482-9