Acute kidney injury in patients with cirrhosis: Perils and promise

Clinical Gastroenterology and Hepatology

Volumn 11, Issue 12, 2013, Pages 1550-1558

  Belcher, Justin M ^a,b   Parikh, Chirag R ^a,b   Garcia Tsao, Guadalupe ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Acute Tubular Necrosis; Ascites; Cirrhosis; Hepatorenal; Kidney Injury; Urinary Biomarkers

Indexed keywords

ALBUMIN; BILIRUBIN; BIOLOGICAL MARKER; CREATININE; FATTY ACID BINDING PROTEIN; FRESH FROZEN PLASMA; INTERLEUKIN 18; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PLACEBO; SODIUM; TERLIPRESSIN;

ACUTE KIDNEY FAILURE; ADULT; ALCOHOL ABUSE; ARTICLE; ASCITES; AUTOREGULATION; BILIRUBIN BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; CASE REPORT; CHRONIC KIDNEY DISEASE; CHRONIC LIVER DISEASE; CREATININE BLOOD LEVEL; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; END STAGE LIVER DISEASE; ERYTHROCYTE TRANSFUSION; FUNCTIONAL DISEASE; GLOMERULUS FILTRATION RATE; HEMATEMESIS; HEPATITIS C; HEPATORENAL SYNDROME; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; INTERNATIONAL NORMALIZED RATIO; KIDNEY BLOOD FLOW; LIVER CIRRHOSIS; LIVER PERFUSION; LIVER TRANSPLANTATION; MALE; MORTALITY; PROGNOSIS; SODIUM BLOOD LEVEL; SODIUM URINE LEVEL; STATISTICAL SIGNIFICANCE; URINE SEDIMENT;

ACUTE KIDNEY INJURY; ACUTE KIDNEY INJURY NETWORK; ACUTE TUBULAR NECROSIS; AKI; AKIN; ASCITES; ATN; CHRONIC KIDNEY DISEASE; CIRRHOSIS; CKD; FENA; FRACTIONAL EXCRETION OF SODIUM; GFR; GLOMERULAR FILTRATION RATE; HEPATORENAL; HEPATORENAL SYNDROME; HRS; IAC; ICU; INTENSIVE CARE UNIT; INTERNATIONAL ASCITES CLUB; KIDNEY INJURY; KIDNEY INJURY MOLECULE-1; KIM-1; MDRD; MODIFICATION OF DIET IN RENAL DISEASE; NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN; NGAL; ODDS RATIO; OR; PRA; PRERENAL AZOTEMIA; RAAS; RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM; URINARY BIOMARKERS;

ACUTE KIDNEY INJURY; ALCOHOLISM; BILIRUBIN; BIOLOGICAL MARKERS; CREATININE; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; SODIUM;

EID: 84888016486     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.03.018     Document Type: Article

References (58)

1. Garcia-Tsao G., Parikh C.R., Viola A. Acute kidney injury in cirrhosis. Hepatology 2008, 48:2064-2077.
2. Schrier R.W., Arroyo V., Bernardi M., et al. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988, 8:1151-1157.
3. Martin P.Y., Ohara M., Gines P., et al. Nitric oxide synthase (NOS) inhibition for one week improves renal sodium and water excretion in cirrhotic rats with ascites. J Clin Invest 1998, 101:235-242.
4. Lee F.Y., Colombato L.A., Albillos A., et al. N omega-nitro-L-arginine administration corrects peripheral vasodilation and systemic capillary hypotension, and ameliorates plasma volume expansion and sodium retention in portal hypertensive rats. Hepatology 1993, 17:84-90.
5. Mejias M., Garcia-Pras E., Tiani C., et al. Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology 2009, 49:1245-1256.
6. Arroyo V., Ginès P., Gerbes A.L., et al. Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club. Hepatology 1996, 23:164-176.
7. Guevara M., Bru C., Ginès P., et al. Increased cerebrovascular resistance in cirrhotic patients with ascites. Hepatology 1998, 28:39-44.
8. Laffi G., La Villa G., Pinzani M., et al. Arachidonic acid derivatives and renal function in liver cirrhosis. Semin Nephrol 1997, 17:530-548.
9. Krag A., Bendtsen F., Henriksen J.H., et al. Low cardiac output predicts development of hepatorenal syndrome and survival in patients with cirrhosis and ascites. Gut 2010, 59:105-110.
10. Ruiz-Del-Arbol L., Monescillo A., Arocena C., et al. Circulatory function and hepatorenal syndrome in cirrhosis. Hepatology 2005, 42:439-447.
11. Nazar A., Guevara M., Sitges M., et al. Left ventricular function assessed by echocardiography in cirrhosis: relationship to systemic hemodynamics and renal dysfunction. J Hepatol 2013, 58:51-57.
12. Cupples W.A., Braam B. Assessment of renal autoregulation. Am J Physiol Ren Physiol 2007, 292:F1105-F1123.
13. Sansoé E., Silvano S., Mengozzi G., et al. Loss of tubuloglomerular feedback in decompensated liver cirrhosis: physiopathological implications. Dig Dis Sci 2005, 50:955-963.
14. Stadlbauer V.P., Wright G.A.K., Banaji M., et al. Relationship between activation of the sympathetic nervous system and renal blood flow autoregulation in cirrhosis. Gastroenterology 2008, 134:111-119.
15. Albillos A., de la Hera A., Gonzalez M., et al. Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement. Hepatology 2003, 37:208-217.
16. Frances R., Benlloch S., Zapater P., et al. A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites. Hepatology 2004, 39:484-491.
17. Fallatah H.I., Al Nahdi H., Al Khatabi M., et al. Variceal hemorrhage: Saudi tertiary center experience of clinical presentations, complications and mortality. World J Hepatol 2012, 4:268-273.
18. Ginès A., Fernández-Esparrach G., Monescillo A., et al. Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis. Gastroenterology 1996, 111:1002-1010.
19. Ruiz del Arbol L., Monescillo A., Jimenez W., et al. Paracentesis-induced circulatory dysfunction: mechanism and effect on hepatic hemodynamics in cirrhosis. Gastroenterology 1997, 113:579-586.
20. Belcher J.M., Garcia-Tsao G., Sanyal A.J., et al. Association of AKI with mortality and complications in hospitalized patients with cirrhosis. Hepatology 2013, 57:753-762.
21. Carvalho J.R., Villela-Nogueira C.A., Luiz R.R., et al. Acute kidney injury network criteria as a predictor of hospital mortality in cirrhotic patients with ascites. J Clin Gastroenterol 2011, 46:e21-e26.
22. Davenport A. Difficulties in assessing renal function in patients with cirrhosis: potential impact on patient treatment. Intensive Care Med 2011, 37:930-932.
23. Pöge U., Gerhardt T., Stoffel-Wagner B., et al. Calculation of glomerular filtration rate based on cystatin C in cirrhotic patients. Nephrol Dial Transplant 2006, 21:660-664.
24. Levey A.S., Stevens L.A., Schmid C.H., et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009, 150:604-612.
25. Chen Y.W., Chen H.H., Wang T.E., et al. Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis. World J Gastroenterol 2011, 17:4532-4538.
26. Chen Y.C., Tsai M.H., Ho Y.P., et al. Comparison of the severity of illness scoring systems for critically ill cirrhotic patients with renal failure. Clin Nephrol 2004, 61:111-118.
27. Wong F., Nadim M.K., Kellum J.A., et al. Working party proposal for a revised classification system of renal dysfunction in patients with cirrhosis. Gut 2011, 60:702-709.
28. Ferreira C.N., Rodrigues T., Cortez-Pinto H., et al. The new definition of acute kidney injury in patients with cirrhosis: a critical look. Gut 2012, 61:1513.
29. Newsome B.B., Warnock D.G., McClellan W.M., et al. Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. Arch Intern Med 2008, 168:609-616.
30. Salerno F., Gerbes A., Ginés P., et al. Diagnosis, prevention and treatment of the hepatorenal syndrome in cirrhosis: a consensus workshop of the international ascites club. Gut 2007, 56:1310-1318.
31. Fang J.T., Tsai M.H., Tian Y.C., et al. Outcome predictors and new score of critically ill cirrhotic patients with acute renal failure. Nephrol Dial Transplant 2008, 23:1961-1969.
32. Cárdenas A., Ginés P., Uriz J., et al. Renal failure after upper gastrointestinal bleeding in cirrhosis: incidence, clinical course, predictive factors, and short-term prognosis. Hepatology 2001, 34:671-676.
33. Cholongitas E., Calvaruso V., Senzolo M., et al. RIFLE classification as predictive factor of mortality in patients with cirrhosis admitted to intensive care unit. J Gastroenterol Hepatol 2009, 24:1639-1647.
34. de Carvalho J.R., Villela-Nogueira C.A., Luiz R.R., et al. Acute kidney injury network criteria as a predictor of hospital mortality in cirrhotic patients with ascites. J Clin Gastroenterol 2012, 12:e21-e26.
35. Martin-Llahi M., Guevara M., Torre A., et al. Prognostic importance of the cause of renal failure in patients with cirrhosis. Gastroenterology 2010, 140:488-496.e4.
36. Carvalho G.C., Regis Cde A., Kalil J.R., et al. Causes of renal failure in patients with decompensated cirrhosis and its impact in hospital mortality. Ann Hepatol 2012, 11:90-95.
37. Dobre M., Demirjian S., Sehgal A.R., et al. Terlipressin in hepatorenal syndrome: a systematic review and meta-analysis. Int Urol Nephrol 2011, 43:175-184.
38. Schier R.W. Fluid administration in critically in patients with acute kidney injury. Clin J Am Soc Nephrol 2010, 5:733-739.
39. Bagshaw S.M., Langenberg C., Bellomo R. Urinary biochemistry and microscopy in septic acute renal failure: a systematic review. Am J Kidney Dis 2006, 48:695-705.
40. Esson M.L., Schrier R.W. Diagnosis and treatment of acute tubular necrosis. Ann Intern Med 2002, 137:744-752.
41. Krag A., Møller S., Henriksen J.H., et al. Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. Hepatology 2007, 46:1863-1871.
42. Diamond J.R., Yoburn D.C. Nonoligouric acute renal failure associated with a low fractional excretion of sodium. Ann Intern Med 1982, 96:597-600.
43. Verna E.C., Brown R.S., Farrand E., et al. Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis. Dig Dis Sci 2012, 57:2362-2370.
44. Perazella M.A., Coca S.G., Kanbay M., et al. Diagnostic utility of urine microscopy in the differential diagnosis of acute kidney injury. Clin Am J Soc Nephrol 2008, 3:1615-1619.
45. Boyer T.D., Sanyal A.J., Garcia-Tsao G., et al. Predictors of response to terlipressin plus albumin in hepatorenal syndrome (HRS) type 1: relationship of serum creatinine to hemodynamics. J Hepatol 2011, 55:315-321.
46. Abuelo J.G. Normotensive ischemic acute renal failure. N Engl J Med 2007, 357:797-805.
47. Northup P.G., Argo C.K., Bakhru M.R., et al. Pretransplant predictors of recovery of renal function after liver transplantation. Liver Transplant 2010, 16:440-446.
48. Simpson N., Cho Y.W., Cicciarelli J.C., et al. Comparison of renal allograft outcomes in combined liver-kidney transplantation versus subsequent kidney transplantation in liver transplant recipients: analysis of UNOS database. Transplantation 2006, 82:1298-1303.
49. Sanyal A.J., Boyer T., Garcia-Tsao G., et al. A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome. Gastroenterology 2008, 134:1360-1368.
50. Belcher J.M., Edelstein C.L., Parikh C.R. Clinical applications of biomarkers for acute kidney injury. Am J Kidney Dis 2011, 57:930-940.
51. Parikh C.R., Jani A., Melnikov V.Y., et al. Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis 2004, 43:405-414.
52. Han W.K., Bailly V., Abichandani R., et al. Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 2002, 62:237-244.
53. Nickolas T.L., O'Rourke M.J., Yang J., et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 2008, 148:810-819.
54. Koyner J.L., Garg A.X., Coca S.G., et al. Biomarkers predict progression of acute kidney injury after cardiac surgery. J Am Soc Nephrol 2012, 23:905-914.
55. Aghel A., Shrestha K., Mullens W., et al. Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. J Card Fail 2010, 16:49-54.
56. Siew E.D., Ikizler T.A., Gebretsadik T., et al. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol 2010, 5:1497-1505.
57. Hall I.E., Yarlagadda S.G., Coca S.G., et al. IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J Am Soc Nephrol 2010, 21:189-197.
58. Fagundes C., Pepin M.N., Guevara M., et al. Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis. J Hepatol 2012, 57:267-273.