Ventilatory efficiency slope correlates with functional capacity, outcomes, and disease severity in pediatric patients with pulmonary hypertension

International Journal of Cardiology

Volumn 169, Issue 6, 2013, Pages 445-448

  Rausch, Christopher M ^a,b   Taylor, Amy Lynne ^b   Ross, Hayley ^a   Sillau, Stefan ^c   Ivy, D Dunbar ^a,b  

^a University of Colorado Denver and Children s Hospital Colorado   (United States)

^b CHILDREN S HOSPITAL COLORADO   (United States)

^c Food Science and Human Nutrition   (United States)

Author keywords

Cardiopulmonary exercise testing; Pediatric; Pulmonary hypertension; VE VCO2 slope; Ventilatory efficiency slope

Indexed keywords

ADOLESCENT; ADULT; AORTA PRESSURE; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CHILD; CHILDHOOD MORTALITY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE MARKER; DISEASE SEVERITY; FEMALE; FUNCTIONAL STATUS; HEART CATHETERIZATION; HUMAN; LUNG ARTERY PRESSURE; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY TRACT PARAMETERS; RETROSPECTIVE STUDY; SCHOOL CHILD; VENTILATORY EFFICIENCY SLOPE;

CARDIOPULMONARY EXERCISE TEST; CARDIOPULMONARY EXERCISE TESTING; CPET; PEDIATRIC; PH; PULMONARY HYPERTENSION; VE/VCO2 SLOPE; VENTILATORY EFFICIENCY SLOPE;

ADOLESCENT; CHILD; EXERCISE TEST; FEMALE; HUMANS; HYPERTENSION, PULMONARY; MALE; OXYGEN CONSUMPTION; PROSPECTIVE STUDIES; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84888008900     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.10.012     Document Type: Article

References (29)

1. A.T. Yetman, A.L. Taylor, and A. Doran Utility of cardiopulmonary stress testing in assessing disease severity in children with pulmonary arterial hypertension Am J Cardiol 95 2005 697 699
2. G. Smith, J.T. Reyes, J.L. Russell, and T. Humpl Safety of maximal cardiopulmonary exercise testing in pediatric patients with pulmonary hypertension Chest 135 5 2009 1209 1214
3. R. Wensel, C.F. Opitz, and S.D. Anker Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing Circulation 106 2002 319 324
4. F.M. Sarullo, G. Fazio, and I. Brusca Cardiopulmonary exercise testing in patients with chronic heart failure: prognostic comparison from peak VO2 and VE/VCO2 slope Open Cardiovasc Med J 4 2010 127 134
5. R. Arena, J. Myers, S. Aslam, E. Varughese, and M. Peberdy Peak VO2 and VE/VCO2 slope in patients with heart failure: a prognostic comparison Am Heart J 147 2004 354 360
6. R. Poggio, H.C. Arazi, M. Giorgi, and S.G. Miriuka Prediction of severe cardiovascular events by VE/VCO2 slope versus peak VO2 in systolic heart failure: a meta-analysis of the published literature Am Heart J 160 6 2010 1004 1014
7. S. Miyamoto, N. Nagaya, and T. Satoh Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: comparison with cardiopulmonary exercise testing Am J Respir Crit Care Med 161 2000 487 492
8. R. Oudiz, R. Middle, and A. Hovenesyan Usefulness of right-to-left shunting and poor exercise gas exchange for predicting prognosis in patients with pulmonary arterial hypertension Am J Cardiol 105 2010 1186 1191
9. M. Schwaiblmair, C. Faul, W. von Scheidt, and T.M. Berghaus Ventilatory efficiency testing as prognostic value in patients with pulmonary hypertension BMC Pulm Med 12 2012 23
10. M. McGoon, D. Gutterman, and V. Steen Screening, early detection, and diagnosis of pulmonary arterial hypertension Chest 126 2004 14S 34S
11. L.J. Rubin Diagnosis and management of pulmonary arterial hypertension: ACCP Evidence-Based Clinical Practice Guidelines. Introduction Chest 126 2004 7S 10S
12. S. Paridon, B.S. Alpert, and S.R. Boas Clinical stress testing in the pediatric age group: a statement from the American heart association council on cardiovascular disease in the young, committee on atherosclerosis, hypertension, and obesity in youth Circulation 113 2006 1905 1920
13. R.P. Garofano, and R.J. Barst Exercise testing in children with primary pulmonary hypertension Pediatr Cardiol 20 1999 61 64
14. G. Simonneau, I. Robbins, and M. Beghetti Updated clinical classification of pulmonary hypertension J Am Coll Cardiol 54 2009 S43 S54
15. R.L.E. van Loon, M.T.R. Roofthooft, and H.L. Hillege Pediatric pulmonary hypertension in the Netherlands: epidemiology and characterization during the period 1991 to 2005 Circulation 124 2011 1755 1764
16. D. Yung, A. Widlitz, E. Rosenweig, D. Kerstein, G. Maislin, and R.J. Barst Outcomes in children with idiopathic pulmonary arterial hypertension Circulation 110 2004 660 665
17. D.D. Ivy, E. Rosenweig, J.-C. Lemarie, M. Brand, D. Rosenberg, and R.J. Barst Long-term outcomes in children with pulmonary arterial hypertension treated with bosentan in real-world clinical settings Am J Cardiol 106 2010 1332 1338
18. D.P. Francis, W. Shamim, and L.C. Davies Cardiopulmonary exercise testing for prognosis in chronic heart failure: continuous and independent prognostic value from VE/VCO2 slope and peak VO2 Eur Heart J 21 2000 154 161
19. J. Myers, L. Gullestad, and R. Vagelos Cardiopulmonary exercise testing and prognosis in severe heart failure: 14 mL/kg/min revisited Am Heart J 139 2000 78 84
20. M. Guazzi, P. Palermo, and G. Pontone Synergistic efficacy of enalapril and losartan on exercise performance and oxygen consumption at peak exercise in congestive heart failure Am J Cardiol 84 1999 1038 1043
21. P. Agostoni, M. Guazzi, and M. Bussotti Carvedilol reduces the inappropriate increase of ventilation during exercise in heart failure patients Chest 122 2002 2062 2067
22. G.D. Lewis, R. Shah, and K. Shahzad Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension Circulation 116 2007 1555 1562
23. M. Guazzi, M. Samaja, and R. Arena Long-term use of sildenafil in the therapeutic management of heart failure J Am Coll Cardiol 50 2007 2136 2144
24. R. Arena, C.J. Lavie, R.V. Milani, J. Myers, and M. Guazzi Cardiopulmonary exercise testing in patients with pulmonary arterial hypertension: an evidence based review J Heart Lung Transplant 29 2 2010 159 173
25. American Thoracic Society, American College of Chest Physicians.ATS/ACCP statement on cardiopulmonary exercise testing Am J Respir Crit Care Med 167 2003 211 277
26. G.E. D'Alonzo, L.A. Gianotti, and R.L. Pohil Comparison of progressive exercise performance of normal subjects and patients with pulmonary hypertension Chest 92 1987 57 62
27. M. Arzt, M. Harth, and A. Luchner Enhanced ventilatory response to exercise in patients with chronic heart failure and central sleep apnea Circulation 107 2003 1998 2003
28. J. Theodore, E.D. Robin, and A.J.R. Morris Augmented ventilatory response to exercise in pulmonary hypertension Chest 89 1986 39 44
29. R.J. Barst, D.D. Ivy, and G. Gaitan A randomized, double-blind, placebo-controlled, dose-ranging study of oral sildenafil citrate in treatment-naïve children with pulmonary arterial hypertension Circulation 125 2012 324 334