BMP-2 induced early bone formation in spine fusion using rat ovariectomy osteoporosis model

Spine Journal

Volumn 13, Issue 10, 2013, Pages 1273-1280

  Park, Sung Bae ^a   Park, Seong Hoon ^b   Kim, Na Hyung ^b   Chung, Chun Kee ^a  

^a Seoul National University   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

Bone morphogenetic protein; Osteoporosis; Rat; Spine

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN GEL; OSTEOCALCIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SMAD1 PROTEIN; SMAD5 PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MASS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; GENE EXPRESSION; HISTOLOGY; ILIAC BONE; LUMBAR SPINE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINE FUSION;

BONE MORPHOGENETIC PROTEIN; OSTEOPOROSIS; RAT; SPINE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; OSTEOGENESIS; OSTEOPOROSIS, POSTMENOPAUSAL; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL FUSION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84888007827     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2013.06.010     Document Type: Article

References (31)

1. D.K. Chin, J.Y. Park, and Y.S. Yoon Prevalence of osteoporosis in patients requiring spine surgery: incidence and significance of osteoporosis in spine disease Osteoporos Int 18 2007 1219 1224
2. K. Nagahama, M. Kanayama, and D. Togawa Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial J Neurosurg Spine 14 2011 500 507
3. T.D. Rachner, S. Khosla, and L.C. Hofbauer Osteoporosis: now and the future Lancet 377 2011 1276 1287
4. J. Lu, D. Bhargav, A.Q. Wei, and A. Diwan Posterolateral intertransverse spinal fusion possible in osteoporotic rats with BMP-7 in a higher dose delivered on a composite carrier Spine 33 2008 242 249
5. N.K. Kanakaris, G. Petsatodis, M. Tagil, and P.V. Giannoudis Is there a role for bone morphogenetic proteins in osteoporotic fractures? Injury 40 3 Suppl 2009 S21 S26
6. S.D. Boden Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute Spine 15 2002 S26 S31
7. K.H. Bridwell, T.A. Sedgewick, and M.F. O'Brien The role of fusion and instrumentation in the treatment of degenerative spondylolisthesis with spinal stenosis J Spinal Disord 6 1993 461 472
8. S. Okuda, A. Miyauchi, and T. Oda Surgical complications of posterior lumbar interbody fusion with total laminectomy in 251 patients J Neurosurg Spine 4 2006 304 309
9. S.D. Glassman, D.W. Polly, and C.M. Bono Outcome of lumbar arthrodesis in patients sixty-five years of age or older J Bone Joint Surg Am 91 2009 783 790
10. S.B. Park, Y.J. Lee, and C.K. Chung Bone mineral density changes after ovariectomy in rats as an osteopenic model: stepwise description of double dorso-lateral approach J Korean Neurosurg Soc 48 2010 309 312
11. J.D. Coe, K.E. Warden, M.A. Herzig, and P.C. McAfee Influence of bone mineral density on the fixation of thoracolumbar implants. A comparative study of transpedicular screws, laminar hooks, and spinous process wires Spine 15 1990 902 907
12. J.M. Granjeiro, R.C. Oliveira, and J.C. Bustos-Valenzuela Bone morphogenetic proteins: from structure to clinical use Braz J Med Biol Res 38 2005 1463 1473
13. C. Deal Future therapeutic targets in osteoporosis Curr Opin Rheumatol 21 2009 380 385
14. X. Wu, W. Shi, and X. Cao Multiplicity of BMP signaling in skeletal development Ann N Y Acad Sci 1116 2007 29 49
15. A. Rogozinski, C. Rogozinski, and G. Cloud Accelerating autograft maturation in instrumented posterolateral lumbar spinal fusions without donor site morbidity Orthopedics 32 2009 809
16. J.A. Rihn, J. Makda, and J. Hong The use of RhBMP-2 in single-level transforaminal lumbar interbody fusion: a clinical and radiographic analysis Eur Spine J 18 2009 1629 1636
17. J.K. Burkus, M.F. Gornet, and T.C. Schuler Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2 J Bone Joint Surg Am 91 2009 1181 1189
18. H.X. Shen, J.M. Buchowski, and J.S. Yeom Pseudarthrosis in multilevel anterior cervical fusion with rhBMP-2 and allograft: analysis of one hundred twenty-seven cases with minimum two-year follow-up Spine 35 2010 747 753
19. R.K. Shah, V.M. Moncayo, and R.D. Smitson Recombinant human bone morphogenetic protein 2-induced heterotopic ossification of the retroperitoneum, psoas muscle, pelvis and abdominal wall following lumbar spinal fusion Skeletal Radiol 39 2010 501 504
20. T. Smoljanovic, I. Bojanic, and Z. Vlahovic Safety of posterior interbody fusions of the lumbar spine using rhBMP-2 J Spinal Disord Tech 23 2010 78
21. P. Moazzaz, M.C. Gupta, and M.M. Gilotra Estrogen-dependent actions of bone morphogenetic protein-7 on spine fusion in rats Spine 30 2005 1706 1711
22. H. Itoh, S. Ebara, and M. Kamimura Experimental spinal fusion with use of recombinant human bone morphogenetic protein 2 Spine 24 1999 1402 1405
23. N. Omi, and I. Ezawa Animal models for bone and joint disease. Low calcium diet-induced rat model of osteoporosis [in Japanese] Clin Calcium 21 2011 173 180
24. S.D. Boden, J.H. Schimandle, and W.C. Hutton An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics Spine 20 1995 412 420
25. L.L. Wiltse, and C.W. Spencer New uses and refinements of the paraspinal approach to the lumbar spine Spine 13 1988 696 706
26. M.L. Salamon, P.L. Althausen, M.C. Gupta, and J. Laubach The effects of BMP-7 in a rat posterolateral intertransverse process fusion model J Spinal Disord Tech 16 2003 90 95
27. G. Turgeman, Y. Zilberman, and S. Zhou Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice J Cell Biochem 86 2002 461 474
28. I. Pountos, T. Georgouli, and K. Henshaw The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone J Orthop Trauma 24 2010 552 556
29. J.S. Erulkar, J.N. Grauer, T.C. Patel, and M.M. Panjabi Flexibility analysis of posterolateral fusions in a New Zealand white rabbit model Spine 26 2001 1125 1130
30. C. Hidaka, K. Goshi, and B. Rawlins Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone Spine 28 2003 2049 2057
31. S. Boutroy, M.L. Bouxsein, F. Munoz, and P.D. Delmas In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography J Clin Endocrinol Metab 90 2005 6508 6515