MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS

Archives of Virology

Volumn 158, Issue 12, 2013, Pages 2443-2452

  Zhang, Shanchao ^a   Liu, Lei ^a   Wang, Ruijin ^a   Tuo, Houzhen ^a   Guo, Yanjun ^a   Yi, Li ^a   Wang, Jiawei ^a   Wang, Dexin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MICRORNA; MIRN199 MICRORNA, HUMAN; NOS3 PROTEIN, HUMAN; SIRT1 PROTEIN, HUMAN; SIRTUIN 1;

BIOSYNTHESIS; CELL MOTION; CYTOMEGALOVIRUS INFECTION; DOWN REGULATION; ENDOTHELIUM CELL; HOST PATHOGEN INTERACTION; HUMAN; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; VIROLOGY;

CELL MOVEMENT; CYTOMEGALOVIRUS INFECTIONS; DOWN-REGULATION; ENDOTHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; SIRTUIN 1;

EID: 84888004362     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-013-1744-1     Document Type: Article

References (46)

1. Murray CJ, Lopez AD (1997) Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet 349: 1436-1442.
2. Epstein SE, Zhou YF, Zhu J (1999) Infection and atherosclerosis: emerging mechanistic paradigms. Circulation 100: e20-e28.
3. Libby P, Ridker PM, Maseri A (2002) Inflammation and atherosclerosis. Circulation 105: 1135-1143.
4. Streblow DN, Orloff SL, Nelson JA (2001) Do pathogens accelerate atherosclerosis? J Nutr 131: 2798S-2804S.
5. Streblow DN, Dumortier J, Moses AV, Orloff SL, Nelson JA (2008) Mechanisms of cytomegalovirus-accelerated vascular disease: induction of paracrine factors that promote angiogenesis and wound healing. Curr Top Microbiol Immunol 325: 397-415.
6. Soderberg-Naucler C (2006) Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J Intern Med 259: 219-246.
7. Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C (2011) Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. PLoS Pathog 7: e1002016.
8. Billingham ME (1992) Histopathology of graft coronary disease. J Heart Lung Transplant 11: S38-S44.
9. Hosenpud JD, Shipley GD, Wagner CR (1992) Cardiac allograft vasculopathy: current concepts, recent developments, and future directions. J Heart Lung Transplant 11: 9-23.
10. Libby P, Salomon RN, Payne DD, Schoen FJ, Pober JS (1989) Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis. Transplant Proc. 21: 3677-3684.
11. Khurana R, Simons M (2003) Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease. Trends Cardiovasc Med 13: 116-122.
12. Shibata M, Suzuki H, Nakatani M, Koba S, Geshi E, Katagiri T, Takeyama Y (2001) The involvement of vascular endothelial growth factor and flt-1 in the process of neointimal proliferation in pig coronary arteries following stent implantation. Histochem Cell Biol 116: 471-481.
13. Dumortier J, Streblow DN, Moses AV, Jacobs JM, Kreklywich CN, Camp D, Smith RD, Orloff SL, Nelson JA (2008) Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol 82: 6524-6535.
14. Caposio P, Orloff SL, Streblow DN (2011) The role of cytomegalovirus in angiogenesis. Virus Res 157: 204-211.
15. Botto S, Streblow DN, DeFilippis V, White L, Kreklywich CN, Smith PP, Caposio P (2011) IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin. Blood 117: 352-361.
16. Bentz GL, Yurochko AD (2008) Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrins. Proc Natl Acad Sci USA 105: 5531-5536.
17. Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
18. Ambros V (2001) microRNAs: tiny regulators with great potential. Cell 107: 823-826.
19. He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5: 522-531.
20. Chan YC, Roy S, Huang Y, Khanna S, Sen CK (2012) The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway. J Biol Chem 287: 41032-41043.
21. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M (2009) Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 104: 879-886.
22. Potente M, Dimmeler S (2008) Emerging roles of SIRT1 in vascular endothelial homeostasis. Cell Cycle 7: 2117-2122.
23. Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, DeRicco J, Kasuno K, Irani K (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci USA 104: 14855-14860.
24. Isenberg JS, Ridnour LA, Perruccio EM, Espey MG, Wink DA, Roberts DD (2005) Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc Natl Acad Sci USA 102: 13141-13146.
25. Grahame-Clarke C, Chan NN, Andrew D, Ridgway GL, Betteridge DJ, Emery V, Colhoun HM, Vallance P (2003) Human cytomegalovirus seropositivity is associated with impaired vascular function. Circulation 108: 678-683.
26. Shen Q, Cicinnati VR, Zhang X, Iacob S, Weber F, Sotiropoulos GC, Radtke A, Lu M, Paul A, Gerken G, Beckebaum S (2010) Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer 9: 227.
27. Sakurai K, Furukawa C, Haraguchi T, Inada K, Shiogama K, Tagawa T, Fujita S, Ueno Y, Ogata A, Ito M, Tsutsumi Y, Iba H (2011) MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 71: 1680-1689.
28. Cheung HH, Davis AJ, Lee TL, Pang AL, Nagrani S, Rennert OM, Chan WY (2011) Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene 30: 3404-3415.
29. Xu N, Zhang J, Shen C, Luo Y, Xia L, Xue F, Xia Q (2012) Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. Biochem Biophys Res Commun 423: 826-831.
30. Pencheva N, Tran H, Buss C, Huh D, Drobnjak M, Busam K, Tavazoie SF (2012) Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell 151: 1068-1082.
31. Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, Moriya J, Komuro I (2009) Protective role of SIRT1 in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol 29: 889-894.
32. Stein S, Lohmann C, Schafer N, Hofmann J, Rohrer L, Besler C, Rothgiesser KM, Becher B, Hottiger MO, Boren J, McBurney MW, Landmesser U, Luscher TF, Matter CM (2010) SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. Eur Heart J 31: 2301-2309.
33. Takemura A, Iijima K, Ota H, Son BK, Ito Y, Ogawa S, Eto M, Akishita M, Ouchi Y (2011) Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 31: 2054-2062.
34. Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC (2008) Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res 80: 191-199.
35. Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S (2007) SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21: 2644-2658.
36. Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D (2007) SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J Biol Chem 282: 151-158.
37. Stein S, Matter CM (2011) Protective roles of SIRT1 in atherosclerosis. Cell Cycle 10: 640-647.
38. Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z (2008) Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol 294: H2721-H2735.
39. Cheeran MC, Hu S, Yager SL, Gekker G, Peterson PK, Lokensgard JR (2001) Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: antiviral implications. J Neurovirol 7: 135-147.
40. Shen YH, Zhang L, Utama B, Wang J, Gan Y, Wang X, Wang J, Chen L, Vercellotti GM, Coselli JS, Mehta JL, Wang XL (2006) Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10). Cardiovasc Res 69: 502-511.
41. Ota H, Eto M, Ogawa S, Iijima K, Akishita M, Ouchi Y (2010) SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. J Atheroscler Thromb 17: 431-435.
42. Jia Y, Gao P, Chen H, Wan Y, Zhang R, Zhang Z, Yang R, Wang X, Xu J, Liu D (2013) SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells. Sci China Life Sci 56: 19-25.
43. Caposio P, Musso T, Luganini A, Inoue H, Gariglio M, Landolfo S, Gribaudo G (2007) Targeting the NF-kappaB pathway through pharmacological inhibition of IKK2 prevents human cytomegalovirus replication and virus-induced inflammatory response in infected endothelial cells. Antiviral Res 73: 175-184.
44. Marinos RS, Zhang W, Wu G, Kelly KA, Meininger CJ (2001) Tetrahydrobiopterin levels regulate endothelial cell proliferation. Am J Physiol Heart Circ Physiol 281: H482-H489.
45. Valantine HA (2004) The role of viruses in cardiac allograft vasculopathy. Am J Transplant 4: 169-177.
46. Xia N, Strand S, Schlufter F, Siuda D, Reifenberg G, Kleinert H, Forstermann U, Li H (2013) Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Nitric Oxide 32: 29-35.