Diagnostic role of glypican 3 and CD34 for differentiating hepatocellular carcinoma from nonmalignant hepatocellular lesions

Annals of Diagnostic Pathology

Volumn 17, Issue 6, 2013, Pages 490-493

  Enan, Eman Tawfik ^a   El Hawary, Amira Kamal ^a   El Tantawy, Dina Abd El Aziz ^a   Abu Hashim, Maha Mohamed ^a   Helal, Nagwa Mokhtar ^a  

^a MANSOURA UNIVERSITY   (Egypt)

Author keywords

CD34; Combined; Glypican 3; Hepatocellular carcinoma

Indexed keywords

BIOLOGICAL MARKER; CD34 ANTIGEN; FORMALDEHYDE; GLYPICAN 3; GLYPICAN; GPC3 PROTEIN, HUMAN; PARAFFIN; TUMOR MARKER;

ARTICLE; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER CELL DAMAGE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; CARCINOMA, HEPATOCELLULAR; DIFFERENTIAL DIAGNOSIS; FEMALE; LIVER; LIVER DISEASES; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; PRECANCER;

ANTIGENS, CD34; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; FEMALE; GLYPICANS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER DISEASES; LIVER NEOPLASMS; PARAFFIN EMBEDDING; PRECANCEROUS CONDITIONS; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84888003460     PISSN: 10929134     EISSN: 15328198     Source Type: Journal    
DOI: 10.1016/j.anndiagpath.2013.08.001     Document Type: Article

References (24)

1. A. Alacacioglu, I. Somali, and I. Simsek Epidemiology and survival of hepatocellular carcinoma in turkey: outcome of multicenter study Jpn J Clin Oncol 38 10 2008 683 688
2. E.M. Lehman, and M.L. Wilson Epidemiology of hepatitis viruses among hepatocellular carcinoma cases and healthy people in Egypt: a systematic review and metaanalysis Int J Cancer 124 3 2009 690 697
3. N. Yamauchi, A. Watanabe, and M. Hishinuma The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma Mod Pathol 18 2005 1591 1598
4. N. Shafizadeh, L.D. Ferrell, and S. Kakar Utility and limitations of glypican-3 expression for the diagnosis of hepatocellular carcinoma at both ends of the differentiation spectrum Mod Pathol 21 2008 1011 1018
5. C. Morrison, W. Marsh Jr., and W.L. Frankel A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver Mod Pathol 15 2002 1279 1287
6. M. Capurro, I.R. Wanless, and M. Sherman Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma Gastroenterology 125 2003 89 97
7. W.M. Coston, S. Loera, and S.K. Lau Distinction of hepatocellular carcinoma from benign hepatic mimickers using glypican-3 and CD34 immunohistochemistry Am J Surg Pathol 32 2008 433 444
8. W.B. de Boer, A. Segal, and F.A. Frost Can CD34 discriminate between benign and malignant hepatocytic lesions in fine-needle aspirates and thin core biopsies? Cancer 90 2000 273 278
9. I.R. Wanless Terminology of nodular hepatocellular lesions. International Working Party Hepatology 22 1995 983 993
10. L. Di Tommaso, A. Destro, and J.Y. Seok The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma J Hepatol 50 2009 746 754
11. D. Kandil, G. Leiman, and M. Allegretta Glypican-3 immunocytochemistry in liver fine-needle aspirates: a novel stain to assist in the differentiation of benign and malignant liver lesions Cancer 111 2007 316 322
12. H. Shirakawa, T. Kuronuma, and Y. Nishimura Glypican-3 is a useful diagnostic marker form a component of hepatocellular carcinoma in human liver cancer Int J Oncol 34 2009 649 656
13. L. Zhang, H. Liu, and L. Sun Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: a tissue microarray-based study Acta Histochem 114 2012 547 552
14. S.M. Lagana, M. Salomao, and F. Bao Utility of an immunohistochemical panel consisting of Glypican-3, Heat-shock Protein-70, and Glutamine Synthetase in the distinction of low-grade hepatocellular carcinoma from hepatocellular adenoma Appl Immunohistochem Mol Morphol 21 2013 170 176
15. L. Libbrecht, T. Severi, and D. Cassiman Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules Am J Surg Pathol 30 2006 1405 1411
16. X.Y. Wang, F. Degos, and S. Dubois Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas Hum Pathol 37 2006 1435 1441
17. V. Paradis, I. Bieche, and D. Dargere Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RTPCR approach: determination of a molecular diagnostic index Am J Pathol 163 2003 733 741
18. H.L. Wang, F. Anatelli, and Q.J. Zhai Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions Arch Pathol Lab Med 132 2008 1723 1728
19. T. Maeda, E. Adachi, and K. Kajiyama CD34 expression in endothelial cells of small hepatocellular carcinoma: its correlation with tumour progression and angiographic findings J Gastroenterol Hepatol 10 1995 650 654
20. J. Stahl, and F. Voyvodic Biopsy diagnosis of malignant versus benign liver "nodules": new helpful markers. An update Adv Anat Pathol 7 2000 230 239
21. S. Ohmori, K. Shiraki, and K. Sugimoto Expression of CD34-positive sinusoidal endothelial cells in patients with HBV-associated chronic liver diseases Int J Mol Med 14 2004 179 184
22. R.S. Saad, T.M. Luckasevic, and C.M. Noga Diagnostic value of HepPar1, pCEA, CD10, and CD34 expression in separating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration cytology Diagn Cytopathol 30 2004 1 6
23. P. Tátrai, A. Somoracz, and E. Batmunkh Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions Am J Surg Pathol 33 2009 874 885
24. F. Wang, X. Jing, and T. Wang Differential diagnostic value of GPC3-CD34 combined staining in small liver nodules with diameter less than 3 cm Am J Clin Pathol 137 2012 937 945