Network medicine: Finding the links to personalized therapy

Clinical Pharmacology and Therapeutics

Volumn 94, Issue 6, 2013, Pages 613-616

  Chen, J Y ^a   Piquette Miller, M ^b   Smith, B P ^c  

^a Indiana University   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; LIGAND;

BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CANCER CELL; CANCER CHEMOTHERAPY; CARDIOVASCULAR DISEASE; COMPUTER; COMPUTER MODEL; DISEASE CLASSIFICATION; EXPERIMENTAL THERAPY; GENE CONTROL; GENETIC ASSOCIATION; GENOMICS; HUMAN; INTERDISCIPLINARY RESEARCH; LIGAND BINDING; MATHEMATICS; MEDICAL RESEARCH; MEDICINE; MOLECULAR INTERACTION; NEOPLASM; NETWORK MEDICINE; PERSONALIZED MEDICINE; PHENOTYPE; PHYSICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; REVIEW; SOCIOLOGY; SYSTEMS BIOLOGY;

COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG DISCOVERY; INDIVIDUALIZED MEDICINE; MOLECULAR TARGETED THERAPY; PHARMACOLOGY; SYSTEMS BIOLOGY;

EID: 84887959327     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2013.195     Document Type: Review

References (13)

1. Hood, L. et al. Systems biology and new technologies enable predictive and preventative medicine. Science 306, 640-643 (2004). (Pubitemid 39440903)
2. Naylor, S. & Chen, J.Y. Unraveling human complexity and disease with systems biology and personalized medicine. Per. Med. 7, 275-289 (2010).
3. Chan, S.Y. & Loscalzo, J. The emerging paradigm of network medicine in the study of human disease. Circ. Res. 111, 359-374 (2012).
4. Sorger, P.K. et al. Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms. An NIH White Paper by the QSP Workshop Group.http://www.nigms.nih.gov/nr/rdonlyres/8ecb1f7c-be3b-431f-89e6- a43411811ab1/0/systemspharmawpsorger2011.pdf (October 2011).
5. Lee, M. Network medicine: using systems biology and signaling networks to create novel cancer therapeutics, Fall 2012. MIT OpenCourseWare (course 7.343): Massachusetts Institute of Technology. License: Creative Commons BY-NC-SA.http://ocw.mit.edu/courses/biology/7-343-network-medicine-using- systemsbiology-and-signaling-networks-to-create-novelcancer-therapeutics-fall- 2012 (Fall 2012).
6. Barabási, A.L., Gulbahce, N. & Loscalzo, J. Network medicine: a network-based approach to human disease. Nat. Rev. Genet. 12, 56-68 (2011).
7. Newman, M.E.J. Networks: An Introduction. Oxford University Press: Oxford, UK, 2010.
8. Hansen, J. & Iyengar, R. Computation as the mechanistic bridge between precision medicine and systems therapeutics. Clin. Pharmacol. Ther. 93, 117-128 (2013).
9. Silverman, E.K. & Loscalzo, J. Developing new drug treatments in the era of network medicine. Clin. Pharmacol. Ther. 93, 26-28 (2013).
10. Jacunski, A. & Tatonetti, N.P. Connecting the dots: applications of network medicine in pharmacology and disease. Clin. Pharmacol. Ther. 94, 659-669 (2013).
11. Chen, B. & Butte, A.J. Network medicine in disease analysis and therapeutics. Clin. Pharmacol. Ther. 94, 627-629 (2013).
12. Robin, X., Creixell, P., Radetskaya, O., Santini, C.C., Longden, J. & Linding, R. Personalized network-based treatments in oncology. Clin. Pharmacol. Ther. 94, 646-650 (2013).
13. Harrold, J.M., Ramanathan, M. & Mager, D.E. Networkbased approaches in drug discovery and early development. Clin. Pharmacol. Ther. 94, 651-658 (2013).