Improved Cav2.2 channel inhibitors through a gem -dimethylsulfone bioisostere replacement of a labile sulfonamide

ACS Medicinal Chemistry Letters

Volumn 4, Issue 11, 2013, Pages 1064-1068

  Shao, Pengcheng P ^a   Ye, Feng ^a   Chakravarty, Prasun K ^a   Herrington, James B ^a   Dai, Ge ^a   Bugianesi, Randal M ^a   Haedo, Rodolfo J ^a   Swensen, Andrew M ^a   Warren, Vivien A ^a   Smith, McHardy M ^a   Garcia, Maria L ^a   McManus, Owen B ^a   Lyons, Kathryn A ^a   Li, Xiaohua ^a   Green, Mitchell ^a   Jochnowitz, Nina ^a   McGowan, Erin ^a   Mistry, Shruti ^a   Sun, Shu Yu ^a   Abbadie, Catherine ^a   Kaczorowski, Gregory J ^a   Duffy, Joseph L ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

bioisostere; N type calcium channel; pain; sulfonamide; sulfone

Indexed keywords

BENZAMIDE; CALCIUM CHANNEL BLOCKING AGENT; DIMETHYL SULFONE; SULFONAMIDE; SULFONE;

ALLODYNIA; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROXYLATION; HYPERALGESIA; PRIORITY JOURNAL; REACTION OPTIMIZATION; SUBSTITUTION REACTION;

EID: 84887954371     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml4002612     Document Type: Article

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