Desmoplastic melanoma: Recent advances and persisting challenges

Pathology

Volumn 45, Issue 5, 2013, Pages 453-463

  Wood, Benjamin A ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Desmoplastic melanoma; Melanoma

Indexed keywords

TUMOR MARKER;

BIOPSY; CLASSIFICATION; DIFFERENTIAL DIAGNOSIS; HUMAN; MELANOMA; METABOLISM; PATHOLOGY; PREVALENCE; REVIEW; SKIN; SKIN TUMOR;

BIOPSY; DIAGNOSIS, DIFFERENTIAL; HUMANS; MELANOMA; PREVALENCE; SKIN; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84887911513     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0b013e3283631c96     Document Type: Article

References (118)

1. Conley J, Lattes R, Orr W. Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma). Cancer 1971; 28: 914-36.
2. Troxel DB. Pitfalls in the diagnosis of mallignant melanoma. Findings of a risk management panel study. Am J Surg Pathol 2003; 27: 1278-83.
3. Smithers BM, McLeod GR, Little JH. Desmoplastic, neural transforming and neurotropic melanoma: a review of 45 cases. Aust N Z J Surg 1990; 60: 967-72.
4. Quinn MJ, Crotty KA, Thompson JF, et al. Desmoplastic and desmoplastic neurotropic melanoma: experience with 280 patients. Cancer 1998; 83: 1128-35.
5. Jain S, Allen PW. Desmoplastic malignant melanoma and its variants. A study of 45 cases. Am J Surg Pathol 1989; 13: 358-73.
6. Baer SC, Schultz D, Synnestvedt M, Elder DE. Desmoplasia and neurotropism. Prognostic variables in patients with stage I melanoma. Cancer 1995; 76: 2242-7.
7. Busam K, Mujumdar U, Hummer A, et al. Cutaneous desmoplastic melanoma: reappraisal of morphologic heterogeneity and prognostic factors. Am J Surg Pathol 2004; 28: 1518-25.
8. Hawkins WG, Busam KJ, Ben-Porat L, et al. Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanoma. Ann Surg Oncol 2005; 12: 207-13.
9. Gyorki DE, Busam K, Panageas K, et al. Sentinel lymph node biopsy for patients with cutaneous desmoplastic melanoma. Ann Surg Oncol 2003; 10: 403-7.
10. Pawlik TM, Ross MI, Prieto VG, et al. Assessment of the role of sentinel lymph node biopsy for primary cutaneous desmoplastic melanoma. Cancer 2006; 106: 900-6.
11. Smithers BM, McLeod GR, Little JH. Desmoplastic, neural transforming and neurotropic melanoma: a review of 45 cases. Australian NZ J Surg 1990; 60: 967-72.
12. Carlson JA, Dickersin GR, Sober AJ, Barnhill R. Desmoplastic neurotropic melanoma. A clinicopathologic analysis of 28 cases. Cancer 1995; 75: 478-94.
13. Arora A, Lowe L, Su L, et al. Wide excision without radiation for desmoplastic melanoma. Cancer 2005; 104: 1462-7.
14. Shaw HM, Quinn MJ, Scolyer RA, Thompson JF. Survival in patients with desmoplastic melanoma. J Clin Oncol 2006; 24: E12-3.
15. Busam KJ. Cutaneous desmoplastic melanoma. Adv Anat Pathol 2005; 12: 92-102.
16. McCarthy SW, Crotty KA, Scolyer RA. Desmoplastic melanoma and desmoplastic neurotropic melanoma. In: LeBoit PE, Burg G, Weedon D, Sarasian A, editors. World Health Organization Classification of Tumors Pathology and Genetics of Skin Tumours. Lyon, France: IARC Press, 2006; 76-8.
17. McCarthy S, Scolyer R, Palmer A. Desmoplastic melanoma: a diagnostic trap for the unwary. Pathology 2004; 36: 445-51.
18. Reed RJ, Leonard DD. Neurotropic melanoma. A variant of desmoplastic melanoma. Am J Surg Pathol 1979; 3: 301-11.
19. Carlson JA, Egbert BM. Desmoplastic neurotropic malignant melanoma. Pathology (Philadelphia) 1994; 2: 339-57.
20. Carlson JA, Dickersin GR, Sober AJ, Barnhill RL. Desmoplastic neurotropic melanoma. A clinicopathologic analysis of 28 cases. Cancer 1995; 75: 478-94.
21. Kossard S, Doherty E, Murray E. Neurotropic Melanoma. A variant of desmoplastic melanoma. Arch Dermatol 1987; 123: 907-12.
22. Feng Z, Wu X, Chen V, et al. Incidence and survival of desmoplastic melanoma in the United States, 1992-2007. J Cutan Pathol 2011; 38: 616-24.
23. de Almeida LS, Requena L, Rutten A, et al. Desmoplastic malignant melanoma: a clinicopathologic analysis of 113 cases. Am J Dermatopathol 2008; 30: 207-15.
24. Busam KJ, Mujumdar U, Hummer AJ, et al. Cutaneous desmoplastic melanoma: reappraisal of morphologic heterogeneity and prognostic factors. Am J Surg Pathol 2004; 28: 1518-25.
25. Hawkins WG, Busam KJ, Ben-Porat L, et al. Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanoma. Ann Surg Oncol 2005; 12: 207-13.
26. Livestro DP, Muzikansky A, Kaine EM, et al. Biology of desmoplastic melanoma: a case-control comparison with other melanomas. J Clin Oncol 2005; 23: 6739-46.
27. Lens MB, Newton-Bishop JA, Boon AP. Desmoplastic malignant melanoma: a systematic review. Br J Dermatol 2005; 152: 673-8.
28. Murali R, Shaw HM, Lai K, et al. Prognostic factors in cutaneous desmoplastic melanoma: a study of 252 patients. Cancer 2010; 116: 4130-8.
29. Pearce RL. Subungual desmoplastic melanoma in an aboriginal woman. Med J Aust 1995; 162: 611-2.
30. Busam KJ, Ariyan C, Coit DC. Desmoplastic melanoma in African American patients. Arch Dermatol 2010; 146: 796-7.
31. Emanuel PO, Idrees MT, Leytin A, et al. Aggressive osteogenic desmoplastic melanoma: a case report. J Cutan Pathol 2007; 34: 423-6.
32. Chan GS, Choy C, Ng WK, ChanKW. Desmoplastic malignant melanoma on the buttock of an 18-year-old girl: differentiation from desmoplastic nevus. Am J Dermatopathol 1999; 21: 170-3.
33. Collina G. Combined' desmoplastic melanoma of the vulva with poor clinical outcome. Pathologica 2011; 103: 337-9.
34. Mulvany NJ, Sykes P. Desmoplastic melanoma of the vulva. Pathology 1997; 29: 241-5.
35. Benda JA. Neurotropic desmoplastic melanoma of the vulva. Gynecol Oncol 1997; 64: 180.
36. Warner TF, Hafez GR, Buchler DA. Neurotropic melanoma of the vulva. Cancer 1982; 49: 999-1004.
37. Ishikura H, Kojo T, Ichimura H, Yoshiki T. Desmoplastic malignant melanoma of the uterine cervix: a rare primary malignancy in the uterus mimicking a sarcoma. Histopathology 1998; 33: 93-4.
38. Jou A, Miranda FV, Oliveira MG, et al. Oral desmoplastic melanoma mimicking inflammatory hyperplasia. Gerodontology 2012; 29: e1163-7.
39. Prasad ML, Patel SG, Busam KJ. Primary mucosal desmoplastic melanoma of the head and neck. Head Neck 2004; 26: 373-7.
40. Kavanagh BD, Campbell RL, Patterson JW, et al. Desmoplastic malignant melanoma of the palatal alveolar mucosa: sustained disease-free survival after surgery and postoperative radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000; 89: 465-70.
41. Kilpatrick SE, White WL, Browne JD. Desmoplastic malignant melanoma of the oral mucosa. An underrecognized diagnostic pitfall. Cancer 1996; 78: 383-9.
42. Cervantes SS, Baugh R. Primary mucosal desmoplastic melanoma of the nasal vestibule: the second case. Ear Nose Throat J 2011; 90: 483-5.
43. Tan KB, Moncrieff M, Thompson JF, et al. Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting. Am J Surg Pathol 2007; 31: 1902-12.
44. Rongioletti F, Gambini C, Semino MT, Rebora A. Desmoplastic and neurotropic subungueal melanoma. (French.) Ann Dermatol Venereol 1995; 122: 707-10.
45. Chun JK, Singer E, Kong A, et al. Desmoplastic amelanotic melanoma in an irradiated burn scar. Dermatol Surg 2006; 32: 161-4.
46. Fish LM, Duncan L, Gray KD, et al. Primary cutaneous melanoma arising in a long-standing irradiated keloid. Case Rep Surg 2012:165319.
47. Crotty K, McCarthy W, Quinn M, McCarthy S. Alopecia neoplastica caused by desmoplastic melanoma. Aust J Dermatol 2003; 44: 295-8.
48. George E, McClain SE, Slingluff CL, et al. Subclassification of desmoplastic melanoma: pure and mixed variants have significantly different capacities for lymph node metastasis. J Cutan Pathol 2009; 36: 425-32.
49. Grunwald MH, Rothem A. Desmoplastic cartilaginous formation in malignant melanoma. J Cutan Pathol 1987; 14: 255.
50. Moreno A, Lamarca J, Martinez R, Guix M. Osteoid and bone formation in desmoplastic malignant melanoma. J Cutan Pathol 1986; 13: 128-34.
51. Chen JY, Hruby G, Scolyer RA, et al. Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 cases. Cancer 2008; 113: 2770-8.
52. Ackerman AB, Jacobson M, Vitale P. Clues to Diagnosis in Dermatopathology I. Chicago: ASCP Press; 1991.
53. Jain S, Allen PW. Desmoplastic malignant melanoma and its variants. A study of 45 cases. Am J Surg Pathol 1989; 13: 358-73.
54. Whiteman DC, Pavan WJ, Bastian BC. The melanomas: a synthesis of epidemiological, clinical, histological, genetic and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res 2011; 24: 879-97.
55. McCarthy SW, Scolyer RA, Palmer AA. Desmoplastic melanoma: a diagnostic trap for the unwary. Pathology 2004; 36: 445-51.
56. Bryant E, Ronan SG, Felix EL, Manaligod JR. Desmoplastic malignant melanoma: a study by conventional and electron microscopy. Am J Dermatopathol 1982; 4: 467-74.
57. Valensi QJ. Desmoplastic malignant melanoma: A light and electron microscopic study of two cases. Cancer 1979; 43: 1148-55.
58. Valensi QJ. Desmoplastic malignant melanoma: study of a case by light and electron microscopy. J Dermatol Surg Oncol 1979; 5: 31-5.
59. From L, Hanna W, Kahn HJ, et al. Origin of the desmoplasia in desmoplastic malignant melanoma. Hum Pathol 1983; 14: 1072-80.
60. Fearns C, Dowdle EB. The desmoplastic response: induction of collagen synthesis by melanoma cells in vitro. Int J Cancer 1992; 50: 621-7.
61. Winnepenninckx V, De Vos R, Stas M, van den Oord JJ. New phenotypical and ultrastructural findings in spindle cell (desmoplastic/neurotropic) melanoma. Appl Immunohistochem Mol Morphol 2003; 11: 319-25.
62. Shendrik I, Silvers DN. Desmoplastic and desmoplastic neurotropic melanoma: experience with 280 patients. Cancer 1999; 85: 2491-2.
63. Payne WG, Kearney R, Wells K, et al. Desmoplastic melanoma. Am Surg 2001; 67: 1004-6.
64. Skelton HG, Smith KJ, Laskin WB, et al. Desmoplastic malignant melanoma. J Am Acad Dermatol 1995; 32: 717-25.
65. Scolyer RA, Thompson JF. Desmoplastic melanoma: a heterogeneous entity in which subclassification as 'pure' or 'mixed' may have important prognostic significance. Ann Surg Oncol 2005; 12: 197-9.
66. Skelton HG, Maceira J, Smith KJ, et al. HMB45 negative spindle cell malignant melanoma. Am J Dermatopathol 1997; 19: 580-4.
67. Chang KL, Folpe AL. Diagnostic utility of microphthalmia transcription factor in malignant melanoma and other tumors. Adv Anat Pathol 2001; 8: 273-5.
68. Koch MB, Shih IM, Weiss SW, Folpe AL. Microphthalmia transcription factor and melanoma cell adhesion molecule expression distinguish desmoplastic/spindle cell melanoma from morphologic mimics. Am J Surg Pathol 2001; 25: 58-64.
69. Iwamoto S, Odland PB, Piepkorn M, Bothwell M. Evidence that the p75 neurotrophin receptor mediates perineural spread of desmoplastic melanoma. J Am Acad Dermatol 1996; 35: 725-31.
70. Iwamoto S, Burrows RC, Agoff SN, et al. The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly expressed in spindled melanomas. Am J Dermatopathol 2001; 23: 288-94.
71. Lazova R, Tantcheva-Poor I, Sigal AC. P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. J Am Acad Dermatol 2010; 63: 852-8.
72. Otaibi S, Jukic DM, Drogowski L, et al. NGFR (p75) expression in cutaneous scars; Further evidence for a potential pitfall in evaluation of reexcision scars of cutaneous neoplasms, in particular desmoplastic melanoma. Am J Dermatopathol 2011; 33: 65-71.
73. Karamchandani JR, Nielsen TO, van de Rijn M, West RB. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol 2012; 20: 445-50.
74. Yeh I, McCalmont TH. Distinguishing neurofibroma from desmoplastic melanoma: the value of the CD34 fingerprint. J Cutan Pathol 2011; 38: 625-30.
75. Nonaka D, Chiriboga L, Rubin BP. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol 2008; 32: 1291-8.
76. Ramos-Herberth FI, Karamchandani J, Kim J, Dadras SS. SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar. J Cutan Pathol 2010; 37: 944-52.
77. Busam KJ, Zhao H, Coit DG, et al. Distinction of desmoplastic melanoma from non-desmoplastic melanoma by gene expression profiling. J Invest Dermatol 2005; 124: 412-8.
78. Narita N, Tanemura A, Murali R, et al. Functional RET G691S polymorphism in cutaneous malignant melanoma. Oncogene 2009; 28: 3058-68.
79. Barr J, Amato CM, Robinson SE, et al. The RET G691S polymorphism is a germline variant in desmoplastic malignant melanoma. Melanoma Res 2012; 22: 92-5.
80. Davison JM, Rosenbaum E, Barrett TL, et al. Absence of V599E BRAF mutations in desmoplastic melanomas. Cancer 2005; 103: 788-92.
81. Kim J, Lazar AJ, Davies MA, et al. BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma. J Cutan Pathol 2012; 39: 821-5.
82. Miller DD, Emley A, Yang S, et al. Mixed versus pure variants of desmoplastic melanoma: a genetic and immunohistochemical appraisal. Mod Pathol 2012; 25: 505-15.
83. Walsh NM, Roberts JT, Orr W, Simon GT. Desmoplastic malignant melanoma. A clinicopathologic study of 14 cases. Arch Pathol Lab Med 1988; 112: 922-7.
84. Jaroszewski DE, Pockaj BA, DiCaudo DJ, Bite U. The clinical behavior of desmoplastic melanoma. Am J Surg 2001; 182: 590-5.
85. Murali R, Loughman NT, McKenzie PR, et al. Cytologic features of metastatic and recurrent melanoma in patients with primary cutaneous desmoplastic melanoma. Am J Clin Pathol 2008; 130: 715-23.
86. Posther KE, Selim MA, Mosca PJ, et al. Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma. Ann Surg Oncol 2006; 13: 728-39.
87. Murali R, Zannino D, Synnott M, et al. Clinical and pathological features of metastases of primary cutaneous desmoplastic melanoma. Histopathology 2011; 58: 886-95.
88. Kaneishi NK, Cockerell CJ. Histologic differentiation of desmoplastic melanoma from cicatrices. Am J Dermatopathol 1998; 20: 128-34.
89. Eng W, Tschen JA. Comparison of S-100 versus hematoxylin and eosin staining for evaluating dermal invasion and peripheral margins by desmoplastic malignant melanoma. Am J Dermatopathol 2000; 22: 26-9.
90. Chorny JA, Barr RJ. S100-positive spindle cells in scars: a diagnostic pitfall in the re-excision of desmoplastic melanoma. Am J Dermatopathol 2002; 24: 309-12.
91. Yeh IVSMS, McCalmont TH. Neurofibroma-like spindle cell melanoma: CD34 fingerprint and CGH for diagnosis. Am J Dermatopathol 2012; 34: 688-770.
92. Maize JC, Foster G. Age-related changes in melanocytic naevi. Clin Exp Dermatol 1979; 4: 49-58.
93. Reed RJ, Ichinose H, Clark WH Jr, Mihm MC Jr. Common and uncommon melanocytic nevi and borderline melanomas. Semin Oncol 1975; 2: 119-47.
94. van Engen-van Grunsven AC, van Dijk MC, Ruiter DJ, et al. HRASmutated Spitz tumours: A subset of Spitz tumours with distinct features. Am J Surg Pathol 2010; 34: 1436-41.
95. Mackie RM, Doherty VR. The desmoplastic melanocytic naevus: a distinct histological entity. Histopathology 1992; 20: 207-11.
96. Harris GR, Shea CR, Horenstein MG, et al. Desmoplastic (sclerotic) nevus: an underrecognized entity that resembles dermatofibroma and desmoplastic melanoma. Am J Surg Pathol 1999; 23: 786-94.
97. Kiriu M, Patel RM, Busam KJ. Desmoplastic melanocytic nevi with lymphocytic aggregates. J Cutan Pathol 2012; 39: 940-4.
98. Barr RJ, Morales RV, Graham JH. Desmoplastic nevus: a distinct histologic variant of mixed spindle cell and epithelioid cell nevus. Cancer 1980; 46: 557-64.
99. Kucher C, Zhang PJ, Pasha T, et al. Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi. Am J Dermatopathol 2004; 26: 452-7.
100. Hilliard NJ, Krahl D, Sellheyer K. p16 expression differentiates between desmoplastic Spitz nevus and desmoplastic melanoma. J Cutan Pathol 2009; 36: 753-9.
101. Gerami P, Beilfuss B, Haghighat Z, et al. Fluorescence in situ hybridization as an ancillary method for the distinction of desmoplastic melanomas from sclerosing melanocytic nevi. J Cutan Pathol 2011; 38: 329-34.
102. McCalmont TE, Emanuel B, Fung M, Ruben BS. Perineuriomatous melanocytic nevi. J Cutan Pathol 2011; 38: 940-2.
103. Elston DF. Requisites in Dermatology: Dermatopathology. Philadelphia PA: Elsevier, 2009.
104. Pryor JG, Brown-Kipphut BA, Iqbal A, Scott GA. Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor. Am J Dermatopathol 2011; 33: 780-5.
105. Smithers BM, McLeod GR, Little JH. Desmoplastic melanoma: patterns of recurrence. World J Surg 1992; 16: 186-90.
106. Sassen S, Shaw HM, Colman MH, et al. The complex relationships between sentinel node positivity, patient age, and primary tumor desmoplasia: analysis of 2303 melanoma patients treated at a single center. Ann Surg Oncol 2008; 15: 630-7.
107. Cummins DL, Esche C, Barrett TL, et al. Lymph node biopsy results for desmoplastic malignant melanoma. Cutis 2007; 79: 390-4.
108. Gyorki DE, Busam K, Panageas K, et al. Sentinel lymph node biopsy for patients with cutaneous desmoplastic melanoma. Ann Surg Oncol 2003; 10: 403-7.
109. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17600 melanoma patients: validation of the American Joint Committee on Cancer melanoma Staging System. J Clin Oncol 2001; 19: 3622-34.
110. Morton DL, Thompson JF, Cochran AJ, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med 2006; 355: 1307-17.
111. Broer PN, Walker ME, Goldberg C, et al. Desmoplastic melanoma: A 12-year experience with sentinel lymph node biopsy. Eur J Surg Oncol 2013; 39: 681-5.
112. Han D, Zager JS, Yu D, et al. Desmoplastic melanoma: is there a role for sentinel lymph node biopsy? Ann Surg Oncol 2013; 20: 2345-51.
113. Smith VA, Lentsch EJ. Sentinel node biopsy in head and neck desmoplastic melanoma: an analysis of 244 cases. Laryngoscope 2012; 122: 116-20.
114. Eppsteiner RW, Swick BL, Milhem MM, et al. Sentinel node biopsy for head and neck desmoplastic melanoma: not a given. Otolaryngol Head Neck Surg 2012; 147: 271-4.
115. Mohebati A, Ganly I, Busam KJ, et al. The role of sentinel lymph node biopsy in the management of head and neck desmoplastic melanoma. Ann Surg Oncol 2012; 19: 4307-13.
116. Check W. SLN Dissection for melanoma- -two views. Dec 2011 (cited 10 Sept 2012). http://www.cap.org/apps/cap.portal?-nfpb=true&cntvwrPtlt- actionOverride=%2Fportlets%2FcontentViewer%2Fshow&-windowLabel= cntvwrPtlt&cntvwrPtlt%7BactionForm.contentReference%7D=cap- today%2F1211%2F1211c-sln.html&-state=maximized&-pageLabel=cntvwr.
117. Foote MC, Burmeister B, Burmeister E, et al. Desmoplastic melanoma: the role of radiotherapy in improving local control. Aust NZ J Surg 2008; 78: 273-6.
118. Vongtama R, Safa A, Gallardo D, et al. Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma. Head Neck 2003; 25: 423-8.