Functional verification of computationally predicted qnr genes

Annals of Clinical Microbiology and Antimicrobials

Volumn 12, Issue 1, 2013, Pages

  Flach, Carl Fredrik ^a   Boulund, Fredrik ^b   Kristiansson, Erik ^b   Larsson, DG J ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

assembled qnr 1; E. coli; Functional verification; qnr; Recombinant expression; Vfuqnr

Indexed keywords

QUINOLONE;

ANTIBIOTIC RESISTANCE; ARTICLE; ASSEMBLED QNR 1 GENE; BACTERIAL GENOME; DNA SEQUENCE; ESCHERICHIA COLI; GENE; GENE EXPRESSION SYSTEM; GENETIC RESISTANCE; GENETIC VARIABILITY; METAGENOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENETIC TREE; PREDICTION; PROBABILITY; QUINOLONE RESISTANCE GENE; VFU QNR GENE;

ANTI-BACTERIAL AGENTS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLUOROQUINOLONES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA;

EID: 84887900879     PISSN: None     EISSN: 14760711     Source Type: Journal    
DOI: 10.1186/1476-0711-12-34     Document Type: Article

References (25)

1. Martinez-Martinez L, Pascual A, Jacoby GA. Quinolone resistance from a transferable plasmid. Lancet 1998, 351(9105):797-799. 10.1016/S0140-6736(97)07322-4, 9519952.
2. Tran JH, Jacoby GA. Mechanism of plasmid-mediated quinolone resistance. Proc Natl Acad Sci USA 2002, 99(8):5638-5642. 10.1073/pnas.082092899, 122823, 11943863.
3. Cavaco LM, Hasman H, Xia S, Aarestrup FM. qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob Agents Chemother 2009, 53(2):603-608. 10.1128/AAC.00997-08, 2630628, 19029321.
4. Hata M, Suzuki M, Matsumoto M, Takahashi M, Sato K, Ibe S, Sakae K. Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. Antimicrob Agents Chemother 2005, 49(2):801-803. 10.1128/AAC.49.2.801-803.2005, 547361, 15673773.
5. Jacoby GA, Walsh KE, Mills DM, Walker VJ, Oh H, Robicsek A, Hooper DC. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob Agents Chemother 2006, 50(4):1178-1182. 10.1128/AAC.50.4.1178-1182.2006, 1426915, 16569827.
6. Pons MJ, Gomes C, Ruiz J. QnrVC, a new transferable Qnr-like family. Enferm Infecc Microbiol Clin 2013, 31(3):191-192. 10.1016/j.eimc.2012.09.008, 23098826.
7. Wang M, Guo Q, Xu X, Wang X, Ye X, Wu S, Hooper DC. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob Agents Chemother 2009, 53(5):1892-1897. 10.1128/AAC.01400-08, 2681562, 19258263.
8. Cattoir V, Poirel L, Mazel D, Soussy CJ, Nordmann P. Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. Antimicrob Agents Chemother 2007, 51(7):2650-2651. 10.1128/AAC.00070-07, 1913262, 17452482.
9. Jacoby GA, Griffin CM, Hooper DC. Citrobacter spp. as a source of qnrB Alleles. Antimicrob Agents Chemother 2011, 55(11):4979-4984. 10.1128/AAC.05187-11, 3195048, 21844311.
10. Poirel L, Rodriguez-Martinez JM, Mammeri H, Liard A, Nordmann P. Origin of plasmid-mediated quinolone resistance determinant QnrA. Antimicrob Agents Chemother 2005, 49(8):3523-3525. 10.1128/AAC.49.8.3523-3525.2005, 1196254, 16048974.
11. Fonseca EL, Dos Santos FF, Vieira VV, Vicente AC. New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1. Emerg Infect Dis 2008, 14(7):1129-1131. 10.3201/eid1407.080132, 2600354, 18598639.
12. Guillard T, de Champs C, Moret H, Bertrand X, Scheftel JM, Cambau E. High-resolution melting analysis for rapid characterization of qnr alleles in clinical isolates and detection of two novel alleles, qnrB25 and qnrB42. J Antimicrob Chemother 2012, 67(11):2635-2639. 10.1093/jac/dks292, 22850691.
13. Sanchez MB, Hernandez A, Rodriguez-Martinez JM, Martinez-Martinez L, Martinez JL. Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol 2008, 8:148. 10.1186/1471-2180-8-148, 2556341, 18793450.
14. Boulund F, Johnning A, Pereira MB, Larsson DGJ, Kristiansson E. A novel method to discover fluoroquinolone antibiotic resistance (qnr) genes in fragmented nucleotide sequences. BMC Genomics 2012, 13:695. 10.1186/1471-2164-13-695, 3543242, 23231464.
15. Rodriguez-Martinez JM, Velasco C, Briales A, Garcia I, Conejo MC, Pascual A. Qnr-like pentapeptide repeat proteins in gram-positive bacteria. J Antimicrob Chemother 2008, 61(6):1240-1243. 10.1093/jac/dkn115, 18343805.
16. Lutz R, Bujard H. Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res 1997, 25(6):1203-1210. 10.1093/nar/25.6.1203, 146584, 9092630.
17. Hegde SS, Vetting MW, Mitchenall LA, Maxwell A, Blanchard JS. Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor. Antimicrob Agents Chemother 2011, 55(1):110-117. 10.1128/AAC.01158-10, 3019687, 20937785.
18. Lux TM, Lee R, Love J. Complete genome sequence of a free-living Vibrio furnissii sp. nov. strain (NCTC 11218). J Bacteriol 2011, 193(6):1487-1488. 10.1128/JB.01512-10, 3067634, 21217006.
19. Kuo PA, Kuo CH, Lai YK, Graumann PL, Tu J. Phosphate limitation induces the intergeneric inhibition of Pseudomonas aeruginosa by Serratia marcescens isolated from paper machines. FEMS Microbiol Ecol 2013, 84(3):577-587. 10.1111/1574-6941.12086, 3717176, 23398522.
20. Vetting MW, Hegde SS, Wang M, Jacoby GA, Hooper DC, Blanchard JS. Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor. J Biol Chem 2011, 286(28):25265-25273. 10.1074/jbc.M111.226936, 3137097, 21597116.
21. Rodriguez-Martinez JM, Briales A, Velasco C, Conejo MC, Martinez-Martinez L, Pascual A. Mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins QnrA. QnrB and QnrS J Antimicrob Chemother 2009, 63(6):1128-1134.
22. Jacoby GA, Corcoran MA, Mills DM, Griffin CM, Hooper DC. Mutational analysis of the Quinolone resistance protein QnrB1. Antimicrob Agents Chemother 2013, 57(11):5733-5736. 10.1128/AAC.01533-13, 23979738.
23. Ronquist F, Huelsenbeck JP. MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics 2003, 19(12):1572-1574. 10.1093/bioinformatics/btg180, 12912839.
24. Le TM, Baker S, Le TP, Cao TT, Tran TT, Nguyen VM, Campbell JI, Lam MY, Nguyen TH, Nguyen VV, Farrar J, Schultsz C. High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City. Vietnam J Med Microbiol 2009, 58(Pt 12):1585-1592.
25. Zhou TL, Chen XJ, Zhou MM, Zhao YJ, Luo XH, Bao QY. Prevalence of plasmid-mediated quinolone resistance in Escherichia coli isolates in Wenzhou, Southern China, 2002-2008. Jpn J Infect Dis 2011, 64(1):55-57.