Hepatotoxicity in obese versus nonobese patients with acetaminophen poisoning who are treated with intravenous n-acetylcysteine

American Journal of Therapeutics

Volumn 23, Issue 3, 2016, Pages e714-e719

  Radosevich, John J ^a   Patanwala, Asad E ^b   Erstad, Brian L ^b  

^a MARICOPA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

acetaminophen; antidote; obesity; overdose

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; PARACETAMOL; ANTIDOTE; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANAPHYLAXIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DRUG INTOXICATION; DRUG OVERDOSE; FEMALE; HUMAN; IDEAL BODY WEIGHT; INTERNATIONAL NORMALIZED RATIO; LENGTH OF STAY; LIVER FUNCTION TEST; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; OBESITY; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROTHROMBIN TIME; PRURITUS; RASH; RETROSPECTIVE STUDY; SEIZURE; URTICARIA; BLOOD; CHEMICAL AND DRUG INDUCED LIVER INJURY; COMPARATIVE STUDY; INCIDENCE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; UNITED STATES;

ACETAMINOPHEN; ACETYLCYSTEINE; ADMINISTRATION, INTRAVENOUS; ADULT; ALANINE TRANSAMINASE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIDOTES; ASPARTATE AMINOTRANSFERASES; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG OVERDOSE; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; OBESITY; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 84887883159     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/01.mjt.0000434043.62372.00     Document Type: Article

References (16)

1. Ogden CL, Carroll MD, Kit BK, et al. Prevalence of Obesity in the United States, 2009-2010. NCHS Data Brief, No 82. Hyattsville, MD: National Center for Health Statistics; 2012
2. Erstad BL. Which weight for weight-based dosage regimens in obese patients?. Am J Health-Syst Pharm. 2002; 59: 2105-2110
3. Erstad BL. Dosing medications in morbidly obese patients in the intensive care unit setting. Intensive Care Med. 2004; 30: 18-32
4. Erstad BL. Obesity in critical illness: what weight or why weight?. Crit Care Med. 2012; 40: 1657-1659
5. Jacques KA, Erstad BL. Availability of information for dosing injectable medications in underweight or obese patients. Am J Health Syst Pharm. 2010; 67: 1948-1950
6. Blouin RA, Warren GW. Pharmacokinetic considerations in obesity. J Pharm Sci. 1999; 88: 1-7
7. Corcoran GB, Wong BK. Obesity as a risk factor in druginduced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat. J Pharmacol Exp Ther. 1987; 241: 921-927
8. Chan SC, Liu CL, Lo CM, et al. Estimating liver weights in adults by body weight and gender. World J Gastroenterol. 2006; 12: 2217-2222
9. Geraghty EM, Boone JM, McGahan JP, et al. Normal organ volume assessment from abdominal CT. Abdom Imaging. 2004; 29: 482-490
10. Bosy-Westphal A, Reinecke U, Schlorke T, et al. Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults. Int J Obes Relat Metab Disord. 2004; 28: 72-79
11. Acetadote IV injection [acetylcysteine IV injection]. Nashville, TN: Cumberland Pharmaceuticals Inc; 2011
12. Varney SM, Buchanan JA, Kokko J, et al. Acetylcysteine for acetaminophen overdose in patients who weigh .100 kg. Am J Ther. 2012. Epub ahead of print. Doi: 10.1097/MJT.0b013e3182459c40
13. Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988; 319: 1557-1562
14. Prescott LF. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med. 1981; 141: 386-389
15. Marchesini G, Moscatiello S, Domizio S, et al. Obesityassociated liver disease. J Clin Endocrinol Metab. 2008; 93: S74-S80
16. Buechler C, Weiss TS. Does hepatic steatosis affect drug metabolism enzymes in the liver?. Curr Drug Metab. 2011; 12: 24-34