Capillary electrophoresis-mass spectrometry in metabolomics: The potential for driving drug discovery and development

Current Drug Metabolism

Volumn 14, Issue 7, 2013, Pages 807-813

  Wang, Xu ^a,b   Li, Kefeng ^b,c   Adams, Erwin ^a   Van Schepdael, Ann ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MICHIGAN TECHNOLOGICAL UNIVERSITY   (United States)

Author keywords

Biomarkers; CE MS; Drug discovery and development; Drug efficacy; Drug toxicity metabolomics

Indexed keywords

AMINO ACID; ATORVASTATIN; BIOLOGICAL MARKER; GLUTATHIONE; NONSTEROID ANTIINFLAMMATORY AGENT; PENTOSE PHOSPHATE; ROSMARINUS OFFICINALIS EXTRACT; SELENOMETHIONINE; TRICARBOXYLIC ACID;

ARTICLE; CAPILLARY ELECTROPHORESIS; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG TOXICITY; GLUTATHIONE METABOLISM; GLYCOLYSIS; MASS SPECTROMETRY; METABOLOMICS; ROSEMARY; UREA CYCLE;

ANIMALS; DRUG DISCOVERY; DRUG THERAPY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; ELECTROPHORESIS, CAPILLARY; HUMANS; MASS SPECTROMETRY; METABOLOMICS; TREATMENT OUTCOME;

EID: 84887876275     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/13892002113149990101     Document Type: Article

References (39)

1. DiMasi, J.A.; Feldman, L.; Seckler, A.; Wilson, A. Trends in risks associated with new drug development: Success rates for investigational drugs. Clin. Pharmacol. Ther., 2010, 87, 272-277.
2. Ramautar, R.; Somsen, G.W.; de Jong G.J. CE-MS for metabolomics: Developments and applications in the period 2010-2012. Electrophoresis, 2013, 34, 86-98.
3. Ramautar, R.; Somsen, G.W.; de Jong G.J. In: Metabolomics in Practice: Successful Strategies to Generate and Analyze Metabolic Data; Michael Lämmerhofer and Wolfram Weckwerth, Ed.; Wiley-VCH, Berlin, 2013; pp.177-208.
4. Soga, T. In: Metabolomics: Methods and Protocol; Wolfram Weckwerth, Ed.; Springer, Berlin, 2006; pp.129-137.
5. Soga, T.; Sugimoto, M.; Honma, M.; Mori, M.; Igarashi, K.; Kashikura, K.; Ikeda, S.; Hirayama, A.; Yamamoto, T.; Yoshida, H. Otsuka, M. et al. Serum metabolomics reveals gamma-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease. J. Hepatol., 2011, 55, 896-905.
6. Kami, K.; Fujimori, T.; Sato, H.; Sato, M.; Yamamoto, H.; Ohashi, Y.; Sugiyama, N.; Ishihama, Y.; Onozuka, H.; Ochiai, A.; Esumi, H. et al: Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry. Metabolomics, 2013, 9, 444-453.
7. Sugimoto, M.; Ikeda, S.; Niigata, K.; Tomita, M.; Sato, H.; Soga, T. MMMDB: Mouse multiple tissue metabolome database. Nucleic Acids Res., 2012, 40(D1), D809-D814.
8. Robertson, D.G.; Reily, M.D. The current status of metabolomics in drug discovery and development. Drug. Develop. Res., 2012, 73, 535-546.
9. Maritim, A.C.; Sanders, R.A.; Watkins, J.B. 3rd. Diabetes, oxidative stress, and antioxidants: A review. J. Biochem. Mol. Toxicol. 2003, 17, 24-38.
10. Golbidi, S.; Ebadi, S.A.; Laher, I. Antioxidants in the treatment of diabetes. Curr. Diabetes Rev., 2011, 7, 106-125.
11. Moraes, E.P.; Ruperez, F.J. Plaza, M.; Herrero, M.; Barbas, C. Metabolomic assessment with CE-MS of the nutraceutical effect of cystoseira spp extracts in an animal model. Electrophoresis, 2011, 32, 2055-2062.
12. Peng, Y.; Yuan, J.; Liu, F. Ye, J. Determination of active components in rosemary by capillary electrophoresis with electrochemical detection. J. Pharm. Biomed. Anal., 2005, 39, 431-437.
13. Godzien, J.; García-Martínez, D.; Martinez-Alcazar, P.; Ruperez, F.J.; Barbas, C. Effect of a nutraceutical treatment on diabetic rats with targeted and CE-MS non-targeted approaches. Metabolomics, 2013, 9, 188-202.
14. Patti, M.E.; Virkamaki, A.; Landaker, E.J.; Kahn, C.R.; Yki-Jarvinen, H. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes, 1999, 48, 1562-1571.
15. Ibanez, C.; Simo, C.; Garcia-Canas, V.; Gomez-Martinez, A.; Ferragut, J.A. Cifuentes, A. CE/LC-MS multiplatform for broad metabolomic analysis of dietary polyphenols effect on colon cancer cells proliferation. Electrophoresis, 2012, 33, 2328-2336.
16. Canuto, G.A.; Castilho-Martins, E.A.; Tavares, M.; Lopez-Gonzalvez, A.; Rivas, L.; Barbas, C. CE-ESI-MS metabolic fingerprinting of leishmania resistance to antimony treatment. Electrophoresis, 2012, 33, 1901-1910.
17. Minami, S.; Hata, M.; Tamai, Y.; Hashida, M.; Takayama, T.; Yamamoto, S.; Okada, M.; Funatsu, T.; Tsuka, T. Imagawa, T. Clinical application of d-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis deformans. Carbohydrate Polymers, 2011, 84, 831-834.
18. Osaki, T.; Azuma, K.; Kurozumi, S.; Takamori, Y.; Tsuka, T.; Imagawa, T.; Okamoto, Y.; Minami, S.; Metabolomic analyses of blood plasma after oral administration of d-glucosamine hydrochloride to dogs. Mar. Drugs, 2012, 10, 1873-1882.
19. Akiyama, Y.; Takeuchi, Y.; Kikuchi, K.; Mishima, E.; Yamamoto, Y.; Suzuki, C.; Toyohara, T.; Suzuki, T.; Hozawa, A.; Ito, S.; Soga, T. et al: A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS). Toxins, 2012, 4, 1309-1322.
20. Robertson, D.G.; Watkins, P.B.; Reily, M.D. Metabolomics in toxicology: Preclinical and clinical applications. Toxicol. Sci., 2011, 120 Suppl 1, S146-S170.
21. Kumar, B.S.; Lee, Y.J.; Yi, H.J. Chung, B.C. Jung, B.H. Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach. Anal. Chim. Acta, 2010, 661, 47-59.
22. Zhao, R.; Domann, F.E.; Zhong, W. Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Mol. Cancer. Ther., 2006, 5, 3275-3284.
23. Kitajima, T.; Jigami, Y.; Chiba, Y. Cytotoxic mechanism of selenomethionine in yeast. J. Biol. Chem., 2012, 287, 10032-10038.
24. Steinmeyer, J. Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs. Arthritis. Res., 2000, 2, 379-385.
25. Takeuchi, K.; Ohishi, M.; Ota, S.; Suzumura, K.; Naraoka, H.; Ohata, T.; Seki, J.; Miyamae, Y.; Honma, M.; Soga, T. Metabolic profiling to identify potential serum biomarkers for gastric ulceration induced by nonsteroid anti-inflammatory drugs. J. Proteome. Res., 2013, 12, 1399-1407.
26. Zhong, X.; Maxwell, E.J.; Chen, D.D. Mass transport in a micro flow-through vial of a junction-at-the-tip capillary electrophoresismass spectrometry interface. Anal. Chem., 2011, 83, 4916-4923.
27. Ptolemy, A.S.; Britz-McKibbin, P. New advances in on-line sample preconcentration by capillary electrophoresis using dynamic pH junction. Analyst, 2008, 133, 1643-1648.
28. Maxwell, E.J.; Zhong, X.; Zhang, H.; van Zeijl, N.; Chen, DD. Decoupling CE and ESI for a more robust interface with MS. Electrophoresis, 2010, 31, 1130-1137.
29. Nemes, P.; Rubakhin, S.S.; Aerts, J.T.; Sweedler, J.V. Qualitative and quantitative metabolomic investigation of single neurons by capillary electrophoresis electrospray ionization mass spectrometry. Nat. Protoc., 2013, 8, 783-799.
30. Ibanez, C.; Simo, C.; Martin-Alvarez, P.J.; Kivipelto, M.; Winblad, B. Cedazo-Minguez, A.; Cifuentes, A. Toward a predictive model of Alzheimer's disease progression using capillary electrophoresismass spectrometry metabolomics. Anal. Chem., 2012, 84, 8532-8540.
31. Sugimoto, M.; Wong, D.T.; Hirayama, A.; Soga, T. Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics, 2010, 6, 78-95.
32. Lee, R.; Britz-McKibbin, P. Differential rates of glutathione oxidation for assessment of cellular redox status and antioxidant capacity by capillary electrophoresis-mass spectrometry: An elusive biomarker of oxidative stress. Anal. Chem., 2009, 81, 7047-7056.
33. Nevedomskaya, E.; Ramautar, R.; Derks, R.; Westbroek, I.; Zondag, G.; van der Pluijm, I.; Deelder, A.M.; Mayboroda, O.A. CE-MS for metabolic profiling of volume-limited urine samples: Application to accelerated aging ttd mice. J Proteome. Res., 2010, 9, 4869-4874.
34. Minami, Y.; Kasukawa, T.; Kakazu, Y.; Iigo, M.; Sugimoto, M.; Ikeda, S.; Yasui, A.; van der Horst, G.T.; Soga, T.; Ueda, H.R. Measurement of internal body time by blood metabolomics. Proc. Natl. Acad. Sci.USA., 2009, 106, 9890-9895.
35. Lee, R.; West, D.; Phillips, S.M.; Britz-McKibbin, P. Differential metabolomics for quantitative assessment of oxidative stress with strenuous exercise and nutritional intervention: Thiol-specific regulation of cellular metabolism with N-acetyl-l-cysteine pretreatment. Anal. Chem., 2010, 82, 2959-2968.
36. Ramautar, R.; Mayboroda, O.A.; Deelder, A.M.; Somsen, G.W.; de Jong, G.J. Metabolic analysis of body fluids by capillary electrophoresis using noncovalently coated capillaries. J. Chromatogr. B., 2008, 871, 370-374.
37. Hirayama, A.; Kami. K.; Sugimoto, M.; Sugawara, M.; Toki, N.; Onozuka, H.; Kinoshita, T.; Saito, N.; Ochiai, A.; Tomita, M.; Esumi, H. et al: Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res., 2009, 69, 4918-4925.
38. Chen, J.L.; Fan, J.; Yan, L.S.; Guo, H.Q.; Xiong, J.J.; Ren, Y.; Hu, J.D. Urine metabolite profiling of human colorectal cancer by capillary electrophoresis mass spectrometry based on mrb. Gastroenterology. Research. Practice, 2012, 2012, 1-8.
39. Naz, S.; Garcia, A.; Rusak, M.; Barbas, C. Method development and validation for rat serum fingerprinting with CE-MS: Application to ventilator-induced-lung-injury study. Anal. Bioanal. Chem., 2013, Epub ahead of print