AT1 receptor-associated protein and septic shock-induced vascular hyporeactivity: Another 'magic bullet' in the pipe?

Critical Care

Volumn 17, Issue 6, 2013, Pages

  Kimmoun, Antoine ^a,b   Levy, Bruno ^a,b  

^a CHU NANCY BRABOIS   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ASSOCIATED PROTEIN 1; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE; HYPERTENSIVE FACTOR; UNCLASSIFIED DRUG; AGTRAP PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

BLOOD VESSEL REACTIVITY; CALCIUM CELL LEVEL; CARDIOMYOPATHY; CLINICAL TRIAL (TOPIC); EDITORIAL; GENE EXPRESSION; HORMONAL REGULATION; HUMAN; KIDNEY VASCULAR RESISTANCE; MEAN ARTERIAL PRESSURE; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SEPTIC SHOCK; VASCULAR SMOOTH MUSCLE; ANIMAL; HYPOTENSION; MALE; METABOLISM; SEPSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; HYPOTENSION; MALE; SEPSIS;

EID: 84887861300     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13116     Document Type: Editorial

References (4)

1. Mederle K, Schweda F, Kattler V, Doblinger E, Miyata K, Höcherl K, Oike Y, Castrop H. The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension. Crit Care 2013, 17:R130. 10.1186/cc12809, 23844607.
2. Doblinger E, Hocherl K, Mederle K, Kattler V, Walter S, Hansen PB, Jensen B, Castrop H. Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II. Am J Physiol Renal Physiol 2012, 302:F1313-F1324. 10.1152/ajprenal.00620.2011, 22357923.
3. Kimmoun A, Ducrocq N, Levy B. Mechanisms of vascular hyporesponsiveness in septic shock. Curr Vasc Pharmacol 2013, 11:139-149.
4. Hagiwara S, Iwasaka H, Hidaka S, Hasegawa A, Koga H, Noguchi T. Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats. Intensive Care Med 2009, 35:1471-1478. 10.1007/s00134-009-1545-x, 19529910.