Forced expression of indoleamine-2,3-dioxygenase in human umbilical cord-derived mesenchymal stem cells abolishes their anti-apoptotic effect on leukemia cell lines in vitro

In Vitro Cellular and Developmental Biology - Animal

Volumn 49, Issue 10, 2013, Pages 752-758

  Yuan, Yin ^a,b   Lu, Xin ^c   Tao, Chang Li ^a   Chen, Xuan ^a   Shao, Hong Wei ^a   Huang, Shu Lin ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c SOUTH CHINA NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; Indoleamine 2,3 dioxygenase; Leukemia; Mesenchymal stem cells; Umbilical cord

Indexed keywords

ADENOVIRIDAE;

COMPLEMENTARY DNA; INDOLEAMINE 2,3 DIOXYGENASE;

ANALYSIS OF VARIANCE; APOPTOSIS; ARTICLE; CULTURE TECHNIQUE; CYTOLOGY; ENZYMOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; METHODOLOGY; MOLECULAR CLONING; PHYSIOLOGY; TUMOR CELL LINE; UMBILICAL CORD; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; APOPTOSIS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MESENCHYMAL STROMAL CELLS; UMBILICAL CORD;

EID: 84887844425     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-013-9667-4     Document Type: Article

References (27)

1. Baksh D.; Yao R.; Tuan R. S. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem. Cells 25: 1384-1392; 2007.
2. Ball L. M.; Bernardo M. E.; Roelofs H.; Lankester A.; Cometa A.; Egeler R. M.; Locatelli F.; Fibbe W. E. Cotransplantation of ex vivo-expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood 110: 2764-2767; 2007.
3. Chen K.; Wang D.; Du W. T.; Han Z. B.; Ren H.; Chi Y.; Yang S. G.; Zhu D.; Bayard F.; Han Z. C. Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism. Clin. Immunol. 135: 448-458; 2010.
4. da Silva Meirelles L.; Chagastelles P. C.; Nardi N. B. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J. Cell Sci. 119: 2204-2213; 2006.
5. Däubener W.; Wanagat N.; Pilz K.; Seghrouchni S.; Fischer H. G.; Hadding U. A new, simple, bioassay for human IFN-γ. J. Immunol. Methods 168: 39-47; 1994.
6. Di Ianni M.; Del Papa B.; De Ioanni M.; Moretti L.; Bonifacio E.; Cecchini D.; Sportoletti P.; Falzetti F.; Tabilio A. Mesenchymal cells recruit and regulate T regulatory cells. Exp. Hematol. 36: 309-318; 2008.
7. Fallarino F.; Grohmann U.; Vacca C.; Bianchi R.; Orabona C.; Spreca A.; Fioretti M.; Puccetti P. T cell apoptosis by tryptophan catabolism. Cell Death. Differ. 9: 1069; 2002.
8. Friedenstein A.; Ivanov-Smolenski A.; Chajlakjan R.; Gorskaya U.; Kuralesova A.; Latzinik N.; Gerasimow U. Origin of bone marrow stromal mechanocytes in radiochimeras and heterotopic transplants. Exp. Hematol. 6: 440; 1978.
9. Hodgkinson C. P.; Gomez J. A.; Mirotsou M.; Dzau V. J. Genetic engineering of mesenchymal stem cells and its application in human disease therapy. Hum. Gene Ther. 21: 1513-1526; 2010.
10. Konopleva M.; Konoplev S.; Hu W.; Zaritskey A.; Afanasiev B.; Andreeff M. Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leuk. Off. J. Leuk. Soc. Am. Leuk. Res. Fund UK 16: 1713; 2002.
11. Lazarus H. M.; Koc O. N.; Devine S. M.; Curtin P.; Maziarz R. T.; Holland H. K.; Shpall E. J.; McCarthy P.; Atkinson K.; Cooper B. W. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol. Blood Marrow Transplant. 11: 389-398; 2005.
12. Le Blanc K.; Rasmusson I.; Sundberg B.; Götherström C.; Hassan M.; Uzunel M.; Ringdén O. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363: 1439-1441; 2004.
13. Lee G. K.; Park H. J.; Macleod M.; Chandler P.; Munn D. H.; Mellor A. L. Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology 107: 452-460; 2002.
14. Lu L.-L.; Liu Y.-j.; Yang S.-G.; Zhao Q.-J.; Wang X.; Gong W.; Han Z.-B.; Xu Z.-S.; Lu Y.-X.; Liu D. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica 91: 1017-1026; 2006.
15. Meisel R.; Zibert A.; Laryea M.; Gobel U.; Daubener W.; Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 103: 4619-4621; 2004.
16. Mitchell K. E.; Weiss M. L.; Mitchell B. M.; Martin P.; Davis D.; Morales L.; Helwig B.; Beerenstrauch M.; Abou-Easa K.; Hildreth T. Matrix cells from Wharton's jelly form neurons and glia. Stem. Cells 21: 50-60; 2003.
17. Nefedova Y.; Landowski T.; Dalton W. Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms. Leukemia 17: 1175-1182; 2003.
18. Ning H.; Yang F.; Jiang M.; Hu L.; Feng K.; Zhang J.; Yu Z.; Li B.; Xu C.; Li Y. The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia 22: 593-599; 2008.
19. Nwabo Kamdje A. H.; Mosna F.; Bifari F.; Lisi V.; Bassi G.; Malpeli G.; Ricciardi M.; Perbellini O.; Scupoli M. T.; Pizzolo G.; Krampera M. Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells. Blood 118: 380-389; 2011.
20. Pittenger M. F.; Mackay A. M.; Beck S. C.; Jaiswal R. K.; Douglas R.; Mosca J. D.; Moorman M. A.; Simonetti D. W.; Craig S.; Marshak D. R. Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147; 1999.
21. Platten M.; Ho P. P.; Youssef S.; Fontoura P.; Garren H.; Hur E. M.; Gupta R.; Lee L. Y.; Kidd B. A.; Robinson W. H. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Sci. Signal. 310: 850; 2005.
22. Ramasamy R.; Lam E. W.; Soeiro I.; Tisato V.; Bonnet D.; Dazzi F. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 21: 304-310; 2006.
23. Sato K.; Ozaki K.; Oh I.; Meguro A.; Hatanaka K.; Nagai T.; Muroi K.; Ozawa K. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109: 228-234; 2007.
24. Scupoli M. T.; Perbellini O.; Krampera M.; Vinante F.; Cioffi F.; Pizzolo G. Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma. Haematologica 92: 264-266; 2007.
25. Spaggiari G. M.; Capobianco A.; Abdelrazik H.; Becchetti F.; Mingari M. C.; Moretta L. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood 111: 1327-1333; 2008.
26. Terness P.; Bauer T. M.; Röse L.; Dufter C.; Watzlik A.; Simon H.; Opelz G. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells mediation of suppression by tryptophan metabolites. J. Exp. Med. 196: 447-457; 2002.
27. Weiss M. L.; Anderson C.; Medicetty S.; Seshareddy K. B.; Weiss R. J.; VanderWerff I.; Troyer D.; McIntosh K. R. Immune properties of human umbilical cord Wharton's jelly-derived cells. Stem Cells 26: 2865-2874; 2008.