The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer

Stem Cells

Volumn 31, Issue 12, 2013, Pages 2607-2619

  Chou, Yu Ting ^a   Lee, Chih Chan ^b   Hsiao, Shih Hsin ^c,d   Lin, Sey En ^e   Lin, Sheng Chieh ^a   Chung, Chih Hung ^b   Chung, Chi Hsiu ^f   Kao, Yu Rong ^b   Wang, Yuan Hung ^g,h   Chen, Chien Tsun ^f   Wei, Yau Huei ^f,i   Wu, Cheng Wen ^a,b,c,f,j  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c Program in Molecular Medicine   (Taiwan)

^d Department of Internal Medicine   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f Institute of Biochemistry and Molecular Biology   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^h TAIPEI MEDICAL UNIVERSITY   (Taiwan)

ⁱ MACKAY MEDICAL COLLEGE   (Taiwan)

^j NATIONAL YANG MING UNIVERSITY   (Taiwan)

more..

Author keywords

Apoptosis; Autophagy; Cancer stem cells; Lung cancer; Oncogenic pathway; Stem cell signaling

Indexed keywords

BCL2L1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN BCL 2; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; BCL2L1 PROTEIN, HUMAN; CISPLATIN; EGFR PROTEIN, HUMAN; PACLITAXEL; PROTEIN BCL X; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER STEM CELL; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; LUNG CANCER; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PHENOTYPE; POSITIVE FEEDBACK; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL GROWTH; DRUG RESISTANCE; GENETICS; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SURVIVAL; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; APOPTOSIS; AUTOPHAGY; BCL-X PROTEIN; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CISPLATIN; DRUG RESISTANCE, NEOPLASM; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HETEROGRAFTS; HUMANS; LUNG NEOPLASMS; MICE; PACLITAXEL; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; SURVIVAL ANALYSIS;

EID: 84887796196     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1518     Document Type: Article

References (33)

1. Doe CQ. Neural stem cells: Balancing self-renewal with differentiation. Development 2008;135:1575-1587.
2. Chen X, Vega VB, Ng HH. Transcriptional regulatory networks in embryonic stem cells. Cold Spring Harb Symp Quant Biol 2008;73: 203-209.
3. Que JW, Luo XY, Schwartz RJ et al. Multiple roles for Sox2 in the developing and adult mouse trachea. Development 2009;136:1899-1907.
4. Tompkins DH, Besnard V, Lange AW et al. Sox2 is required for maintenance and differentiation of bronchiolar clara, ciliated, and goblet cells. PLoS One 2009;4:e8248.
5. Chen Y, Shi L, Zhang L et al. The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem 2008; 283:17969-17978.
6. Sholl LM, Long KB, Hornick JL. Sox2 expression in pulmonary nonsmall cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol 2010;18:55-61.
7. Bass AJ, Watanabe H, Mermel CH et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009;41:1238-1242.
8. Lu Y, Futtner C, Rock JR et al. Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One 2010;5:e11022.
9. Van Winkle LS, Isaac JM, Plopper CG. Distribution of epidermal growth factor receptor and ligands during bronchiolar epithelial repair from naphthalene-induced Clara cell injury in the mouse. Am J Pathol 1997;151:443-459.
10. Gazdar AF, Minna JD. Deregulated EGFR signaling during lung cancer progression: Mutations, amplicons, and autocrine loops. Cancer Prev Res (Phila) 2008;1:156-160.
11. Rusch V, Baselga J, Cordon-Cardo C et al. Differential expression of the epidermal growth factor receptor and its ligands in primary nonsmall cell lung cancers and adjacent benign lung. Cancer Res 1993;53: 2379-2385.
12. Ho JN, Kang GY, Lee SS et al. Bcl-XL and STAT3 mediate malignant actions of gamma-irradiation in lung cancer cells. Cancer Sci 2010;101:1417-1423.
13. Vander Heiden MG, Chandel NS, Williamson EK et al. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 1997;91:627-637.
14. Cheng EH, Wei MC, Weiler S et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- And BAK-mediated mitochondrial apoptosis. Mol Cell 2001;8:705-711.
15. Pattingre S, Tassa A, Qu X et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005;122:927-939.
16. Lei XY, Huang ZX, Zhong M et al. Bcl-XL small interfering RNA sensitizes cisplatin-resistant human lung adenocarcinoma cells. Acta Biochim Biophys Sin 2007;39:344-350.
17. Ben-Porath I, Thomson MW, Carey VJ et al. An embryonic stem celllike gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499-507.
18. Chu YW, Yang PC, Yang SC et al. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 1997;17:353-360.
19. Chou YT, Hsieh CH, Chiou SH et al. CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence. Cell Death Differ 2012;19:2015-2028.
20. Xin L, Lukacs RU, Lawson DA et al. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells 2007;25:2760-2769.
21. Hung C-L, Wu Y-J, Liu C-C et al. Rationale and design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) study: A community-based cohort investigating mitochondria-related aging and cardiovascular diseases in suburban areas of Northern Taiwan. Int J Gerontol 2012;6:122-126.
22. Hill BG, Dranka BP, Zou L et al. Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4- hydroxynonenal. Biochem J 2009;424:99-107.
23. Hotta A, Cheung AY, Farra N et al. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods 2009;6: 370-376.
24. Mizushima N, Yamamoto A, Matsui M et al. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-1111.
25. Hu Q, Zhang L, Wen J et al. The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells. Stem Cells 2010;28:279-286.
26. Tomioka M, Nishimoto M, Miyagi S et al. Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex. Nucleic Acids Res 2002;30:3202-3213.
27. Sikorska M, Sandhu JK, Deb-Rinker P et al. Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation. J Neurosci Res 2008;86:1680-1693.
28. Varlakhanova NV, Cotterman RF, deVries WN et al. myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation 2010;80:9-19.
29. Couillard M, Trudel M. C-myc as a modulator of renal stem/progenitor cell population. Dev Dyn 2009;238:405-414.
30. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
31. Tomasson MH. Cancer stem cells: A guide for skeptics. J Cell Biochem 2009;106:745-749.
32. Zhou F, Yang Y, Xing D. Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J 2011;278:403-413.
33. Carey KD, Garton AJ, Romero MS et al. Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res 2006;66:8163-8171.