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Volumn 22, Issue 12, 2013, Pages 1569-1580

New dual-acting bronchodilator treatments for COPD, muscarinic antagonists and β2 agonists in combination or combined into a single molecule

Author keywords

2 agonist; Bronchodilator; COPD; Corticosteroid; Inhaled drug; MABA; Muscarinic antagonist

Indexed keywords

ACLIDINIUM BROMIDE; AZD 2115; AZD 3199; AZD 8683; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; FORMOTEROL; FORMOTEROL FUMARATE; GLYCOPYRRONIUM BROMIDE; GSK 961081; INDACATEROL; LAS 190792; LAS 40464; MUSCARINIC RECEPTOR BLOCKING AGENT; OLODATEROL; PF 3429281; PF 4348325; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; PT 001; PT 003; PT 005; QVA 149; SALMETEROL; SUN 102; TD 5959; TEI 3252; THRX 198321; THRX 200495; TIOTROPIUM BROMIDE; UMECLIDINIUM; UMECLIDINIUM PLUS VILANTEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILANTEROL;

EID: 84887665188     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2013.833182     Document Type: Review
Times cited : (12)

References (56)
  • 1
    • 84930479279 scopus 로고    scopus 로고
    • Pharmacology and therapeutics of bronchodilators
    • Invaluable review of the state of the art
    • Cazzola M, Page CP, Calzetta L, Matera MG. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev 2012;64(3):450-504.. Invaluable review of the state of the art.
    • (2012) Pharmacol Rev , vol.64 , Issue.3 , pp. 450-504
    • Cazzola, M.1    Page, C.P.2    Calzetta, L.3    Matera, M.G.4
  • 2
    • 77953314140 scopus 로고    scopus 로고
    • Mono-and combination therapy of long-acting bronchodilators and inhaled corticosteroids in advanced COPD
    • Review focusing on the key treatments for COPD
    • Ohar JA, Donohue JF. Mono-and combination therapy of long-acting bronchodilators and inhaled corticosteroids in advanced COPD. Semin Respir Crit Care Med 2010;31(3):321-33. Review focusing on the key treatments for COPD
    • (2010) Semin Respir Crit Care Med , vol.31 , Issue.3 , pp. 321-333
    • Ohar, J.A.1    Donohue, J.F.2
  • 3
    • 0016758997 scopus 로고
    • Combined administration of ipratropium bromide (sch 1000) and fenoterol in patients with chronic obstructive airway disease
    • First demonstration of the additive bronchodilator effects of the two classes of drug
    • Kaik G. Combined administration of ipratropium bromide (sch 1000) and fenoterol in patients with chronic obstructive airway disease Wien Klin Wochenschr. 1975;87:653-6. First demonstration of the additive bronchodilator effects of the two classes of drug
    • (1975) Wien Klin Wochenschr , vol.87 , pp. 653-656
    • Kaik, G.1
  • 4
    • 0036798629 scopus 로고    scopus 로고
    • Delivery of ipratropium and albuterol combination therapy for chronic obstructive pulmonary disease: Effectiveness of a two-in-one inhaler versus separate inhalers
    • Chrischilles E, Gilden D, Kubisiak J, et al. Delivery of ipratropium and albuterol combination therapy for chronic obstructive pulmonary disease: Effectiveness of a two-in-one inhaler versus separate inhalers. Am J Manag Care 2002;8:902-11
    • (2002) Am J Manag Care , vol.8 , pp. 902-911
    • Chrischilles, E.1    Gilden, D.2    Kubisiak, J.3
  • 5
    • 0033022767 scopus 로고    scopus 로고
    • Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD
    • Friedman M, Serby CW, Menjoge SS, et al. Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD. Chest 1999;115(3):635-41
    • (1999) Chest , vol.115 , Issue.3 , pp. 635-641
    • Friedman, M.1    Serby, C.W.2    Menjoge, S.S.3
  • 6
    • 84887796152 scopus 로고    scopus 로고
    • GOLD, Global Strategy for the Diagnosis, Management and Prevention of COPD 20 February 2013. Document defining the disease and its currently recommended treatments
    • GOLD, Global Strategy for the Diagnosis, Management and Prevention of COPD 20 February 2013.. Document defining the disease and its currently recommended treatments.
  • 7
    • 84875959946 scopus 로고    scopus 로고
    • Long-acting muscarinic receptor antagonists for the treatment of respiratory disease
    • Up to date review on LAMA developments
    • Cazzola M, Page C, Matera MG. Long-acting muscarinic receptor antagonists for the treatment of respiratory disease. Pulm Pharmacol Ther 2013;26(3):307-17.. Up to date review on LAMA developments.
    • (2013) Pulm Pharmacol Ther , vol.26 , Issue.3 , pp. 307-317
    • Cazzola, M.1    Page, C.2    Matera, M.G.3
  • 8
    • 78649635656 scopus 로고    scopus 로고
    • QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease
    • First demonstration that concurrent administration of LABAs and LAMAs produces additive effects
    • van Noord JA, Buhl R, Laforce C, et al. QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease. Thorax 2010;65(12):1086-91. First demonstration that concurrent administration of LABAs and LAMAs produces additive effects.
    • (2010) Thorax , vol.65 , Issue.12 , pp. 1086-1091
    • Van Noord, J.A.1    Buhl, R.2    Laforce, C.3
  • 9
    • 84880229392 scopus 로고    scopus 로고
    • Dual bronchodilation with QVA149 versus single bronchodilator therapy: The SHINE study
    • [Epub ahead of print].. Full details of a key comparison study
    • Bateman ED, Ferguson GT, Barnes N, et al. Dual bronchodilation with QVA149 versus single bronchodilator therapy: The SHINE study. Eur Respir J 2013; [Epub ahead of print].. Full details of a key comparison study.
    • (2013) Eur Respir J
    • Bateman, E.D.1    Ferguson, G.T.2    Barnes, N.3
  • 10
    • 84884819644 scopus 로고    scopus 로고
    • Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: The enlighten study
    • [Epub ahead of print]. Full details of a 52 week study
    • Dahl R, Chapman KR, Rudolf M, et al. Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: The enlighten study. Respir Med 2013; [Epub ahead of print]. Full details of a 52 week study.
    • (2013) Respir Med
    • Dahl, R.1    Chapman, K.R.2    Rudolf, M.3
  • 11
    • 84877131237 scopus 로고    scopus 로고
    • Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomized double-blind parallel-group study
    • The critical comparison of QVA-149 with tiotropium
    • Wedzicha JA, Decramer M, Ficker JH, et al. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomized, double-blind, parallel-group study. Lancet Respir Med 2013;1(3):199-209.. The critical comparison of QVA-149 with tiotropium.
    • (2013) Lancet Respir Med , vol.1 , Issue.3 , pp. 199-209
    • Wedzicha, J.A.1    Decramer, M.2    Ficker, J.H.3
  • 12
    • 84885836796 scopus 로고    scopus 로고
    • Superior lung function with once-daily QVA149 translates into improvements in patient-reported breathlessness compared with placebo and tiotropium in COPD patients: The blaze study
    • Mahler DA, Decramer M, DUrzo AD, et al. Superior lung function with once-daily QVA149 translates into improvements in patient-reported breathlessness compared with placebo and tiotropium in COPD patients: The blaze study. Am J Respir Crit Care Med 2013;187:A6070
    • (2013) Am J Respir Crit Care Med , vol.187
    • Mahler, D.A.1    Decramer, M.2    Durzo, A.D.3
  • 13
    • 84877676197 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): A randomised double-blind parallel group study
    • One of the first key comparisons of LAMA/LABA and ICS/LABA combinations
    • Vogelmeir CF, Bateman ED, Pallante J, et al. Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): A randomised, double-blind, parallel group study. Lancet Respir Med 2013;1(1):51-60. One of the first key comparisons of LAMA/LABA and ICS/LABA combinations.
    • (2013) Lancet Respir Med , vol.1 , Issue.1 , pp. 51-60
    • Vogelmeir, C.F.1    Bateman, E.D.2    Pallante, J.3
  • 14
    • 84897467374 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study
    • Donohoe JF, Maleki-Yazedi M, Kilbride S, et al. Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study. Am J Respir Crit Care Med 2013;187:A4275
    • (2013) Am J Respir Crit Care Med , vol.187
    • Donohoe, J.F.1    Maleki-Yazedi, M.2    Kilbride, S.3
  • 15
    • 84887788953 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily umeclidinium/vilanterol 125/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study
    • Celli BR, Crater G, Kilbride S, et al. Efficacy and safety of once-daily umeclidinium/vilanterol 125/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study. Am J Respir Crit Care Med 2013;187:A2435
    • (2013) Am J Respir Crit Care Med , vol.187
    • Celli, B.R.1    Crater, G.2    Kilbride, S.3
  • 16
    • 84886395702 scopus 로고    scopus 로고
    • The efficacy and safety of umeclidinium/vilanterol compared with tiotropium or vilanterol over 24 weeks in subjects with COPD
    • Anzueto A, Decramer M, Kaelin T, et al. The efficacy and safety of umeclidinium/vilanterol compared with tiotropium or vilanterol over 24 weeks in subjects with COPD. Am J Respir Crit Care Med 2013;187:A4268
    • (2013) Am J Respir Crit Care Med , vol.187
    • Anzueto, A.1    Decramer, M.2    Kaelin, T.3
  • 18
    • 84887688236 scopus 로고    scopus 로고
    • Almirall and Forest Laboratories announce positive results of a Phase III Study for aclidinium and formoterol combination in COPD
    • Almirall SA. Almirall and Forest Laboratories announce positive results of a Phase III Study for aclidinium and formoterol combination in COPD. Press Release; 2013
    • (2013) Press Release
    • Almirall, S.A.1
  • 19
    • 84887688236 scopus 로고    scopus 로고
    • Almirall and Forest Laboratories announce positive results for the second Phase III Study for aclidinium and formoterol combination in COPD
    • Almirall SA. Almirall and Forest Laboratories announce positive results for the second Phase III Study for aclidinium and formoterol combination in COPD. Press Release; 2013
    • (2013) Press Release
    • Almirall, S.A.1
  • 20
    • 84867755100 scopus 로고    scopus 로고
    • Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers
    • Vehring R, Lechuga-Ballesteros D, Joshi V, et al. Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers. Langmuir 2012;28(42):15015-23
    • (2012) Langmuir , vol.28 , Issue.42 , pp. 15015-15023
    • Vehring, R.1    Lechuga-Ballesteros, D.2    Joshi, V.3
  • 21
    • 84887721737 scopus 로고    scopus 로고
    • Pearl Therapeutics. Pearl therapeutics initiates PT003 phase 3 program for the treatment of individuals with moderate-to-severe COPD. Press Release 2013
    • Pearl Therapeutics. Pearl therapeutics initiates PT003 phase 3 program for the treatment of individuals with moderate-to-severe COPD. Press Release; 2013
  • 22
    • 84887813809 scopus 로고    scopus 로고
    • Low doses of pearl therapeutics LAMA/LABA combination MDI (GFF MDI, PT003) provide superior bronchodilation compared to components and to open-label spiriva handihaler in a randomized, double-blind, placebo-controlled phase IIb study in patients with COPD
    • Reisner C, Gotfried M, Denenberg MB, et al. Low doses of pearl therapeutics LAMA/LABA combination MDI (GFF MDI, PT003) provide superior bronchodilation compared to components and to open-label spiriva handihaler in a randomized, double-blind, placebo-controlled phase IIb study in patients with COPD. Am J Respir Crit Care Med 2013;187:A2434
    • (2013) Am J Respir Crit Care Med , vol.187
    • Reisner, C.1    Gotfried, M.2    Denenberg, M.B.3
  • 23
    • 84875945300 scopus 로고    scopus 로고
    • Pearl therapeutics combination LAMA/LABA MDI (GFF MDI, PT003) Provides a significant benefit on home peak expiratory flow rate (PEFR) and reduces the need for rescue albuterol use compared to its components administered alone, spiriva-handihaler-18 g and foradil-aerolizer-12 g in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD
    • Rennard S, Fogerty C, Fischer T, et al. Pearl therapeutics combination LAMA/LABA MDI (GFF MDI, PT003) Provides a Significant Benefit on Home Peak Expiratory Flow Rate (PEFR) and reduces the need for rescue albuterol use compared to its components administered alone, spiriva-handihaler-18 g and foradil-aerolizer-12 g in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD. Am J Respir Crit Care Med 2012;185:A2259
    • (2012) Am J Respir Crit Care Med , vol.185
    • Rennard, S.1    Fogerty, C.2    Fischer, T.3
  • 24
    • 80053196166 scopus 로고    scopus 로고
    • Dual-pharmacology muscarinic antagonist and b agonist molecules for the treatment of chronic obstructive pulmonary disease
    • One of two key reviews on the MABA strategy
    • Hughes AD, Jones LH. Dual-pharmacology muscarinic antagonist and b agonist molecules for the treatment of chronic obstructive pulmonary disease. Future Med Chem 2011;3(13):1585-605. One of two key reviews on the MABA strategy.
    • (2011) Future Med Chem , vol.3 , Issue.13 , pp. 1585-1605
    • Hughes, A.D.1    Jones, L.H.2
  • 25
    • 84859915668 scopus 로고    scopus 로고
    • Multivalent dual pharmacology muscarinic antagonist and b2 agonist (MABA) molecules for the treatment of COPD
    • One of two key reviews on the MABA strategy
    • Hughes AD, McNamara A, Steinfeld T. Multivalent dual pharmacology muscarinic antagonist and b2 agonist (MABA) molecules for the treatment of COPD. Prog Med Chem 2012;51:71-95. One of two key reviews on the MABA strategy.
    • (2012) Prog Med Chem , vol.51 , pp. 71-95
    • Hughes, A.D.1    McNamara, A.2    Steinfeld, T.3
  • 26
    • 67649395693 scopus 로고    scopus 로고
    • Muscarinic antagonist-beta-adrenergic agonist dual pharmacology molecules as bronchodilators: A patent review
    • Review highlighting companies activities in this area
    • Ray NC, Alcaraz L. Muscarinic antagonist-beta-adrenergic agonist dual pharmacology molecules as bronchodilators: A patent review. Expert Opin Ther Pat 2009;19(1):1-12. Review highlighting companies activities in this area.
    • (2009) Expert Opin Ther Pat , vol.19 , Issue.1 , pp. 1-12
    • Ray, N.C.1    Alcaraz, L.2
  • 27
    • 79951997039 scopus 로고    scopus 로고
    • THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner
    • First pharmacological characterisation of MABAs
    • Steinfeld T, Hughes AD, Klein U, et al. THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner. Mol Pharmacol 2011;79(3):389-99. First pharmacological characterisation of MABAs.
    • (2011) Mol Pharmacol , vol.79 , Issue.3 , pp. 389-399
    • Steinfeld, T.1    Hughes, A.D.2    Klein, U.3
  • 28
    • 84865955542 scopus 로고    scopus 로고
    • Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and b(2)-adrenoceptor agonist (MABA)
    • McNamara A, Steinfeld T, Pulido-Rios MT, et al. Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and b(2)-adrenoceptor agonist (MABA). Pulm Pharmacol Ther 2012;25(5):357-63
    • (2012) Pulm Pharmacol Ther , vol.25 , Issue.5 , pp. 357-363
    • McNamara, A.1    Steinfeld, T.2    Pulido-Rios, M.T.3
  • 29
    • 79951727504 scopus 로고    scopus 로고
    • Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules
    • Hughes AD, Chin KH, Dunham SL, et al. Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules. Bioorg Med Chem Lett 2011;21(5):1354-8
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.5 , pp. 1354-1358
    • Hughes, A.D.1    Chin, K.H.2    Dunham, S.L.3
  • 30
    • 84887706252 scopus 로고    scopus 로고
    • Glaxo Group Ltd. Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-12-dihydroquinolin-5-yl) ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester and its use for treating pulmonary disorders. WO-2007090859 2007
    • Glaxo Group Ltd. Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester and its use for treating pulmonary disorders. WO-2007090859; 2007
  • 31
    • 84887767440 scopus 로고    scopus 로고
    • A randomised, double-blind, dose escalating study in healthy volunteers to assess the safety, tolerability, extra pulmonary pharmacodynamics and pharmacokinetics of single doses of GSK961081 (succinate salt), NCT00550225 2007 Available from
    • A randomised, double-blind, dose escalating study in healthy volunteers to assess the safety, tolerability, extra pulmonary pharmacodynamics and pharmacokinetics of single doses of GSK961081 (succinate salt), NCT00550225. 2007. Available from: http://clinicaltrials.gov
  • 32
    • 84856668776 scopus 로고    scopus 로고
    • In vitro characterization of TD 5959: A novel bi functional molecule with muscarinic antagonist and beta2 adrenergic agonist activity
    • Aiyar J, Steinfeld T, Pulido Rios MT, et al. In vitro characterization of TD 5959: A novel bi functional molecule with muscarinic antagonist and beta2 adrenergic agonist activity. Am J Respir Crit Care Med 2009;179:A4552
    • (2009) Am J Respir Crit Care Med , vol.179
    • Aiyar, J.1    Steinfeld, T.2    Pulido Rios, M.T.3
  • 33
    • 79953719780 scopus 로고    scopus 로고
    • TD 5959: A novel bi functional muscarinic antagonist beta2 adrenergic agonist with potent and sustained in vivo bronchodilator activity in guinea pigs
    • Pulido Rios MT, McNamara A, et al. TD 5959: A novel bi functional muscarinic antagonist beta2 adrenergic agonist with potent and sustained in vivo bronchodilator activity in guinea pigs. Am J Respir Crit Care Med 2009;179:A6195
    • (2009) Am J Respir Crit Care Med , vol.179
    • Pulido Rios, M.T.1    McNamara, A.2
  • 34
    • 84886517217 scopus 로고    scopus 로고
    • A new class of bronchodilator improves lung function in COPD: A trial with GSK961081
    • Epub ahead of print.. The most significant clinical data published in GSK-961081
    • Wielders PL, Ludwig-Sengpiel A, Locantore N, et al. A new class of bronchodilator improves lung function in COPD: A trial with GSK961081. Eur Respir J 2013; Epub ahead of print.. The most significant clinical data published in GSK-961081.
    • (2013) Eur Respir J
    • Wielders, P.L.1    Ludwig-Sengpiel, A.2    Locantore, N.3
  • 35
    • 84882590787 scopus 로고    scopus 로고
    • Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD
    • doi:pii: S1094-5539(13 00089-8)
    • Bateman ED, Kornmann O, Ambery C, Norris V. Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD. Pulm Pharmacol Ther 2013;doi:pii: S1094-5539(13)00089-8
    • (2013) Pulm Pharmacol Ther
    • Bateman, E.D.1    Kornmann, O.2    Ambery, C.3    Norris, V.4
  • 36
    • 84882601233 scopus 로고    scopus 로고
    • Bronchodilation and safety of supratherapeutic doses of salbutamol or ipratropium bromide added to single dose GSK961081 in patients with moderate to severe COPD
    • doi:pii: S1094-5539
    • Norris V, Ambery C. Bronchodilation and safety of supratherapeutic doses of salbutamol or ipratropium bromide added to single dose GSK961081 in patients with moderate to severe COPD. Pulm Pharmacol Ther 2013;doi:pii: S1094-5539
    • (2013) Pulm Pharmacol Ther
    • Norris, V.1    Ambery, C.2
  • 37
    • 84887647897 scopus 로고    scopus 로고
    • A single-dose study to investigate the effects of 3 different doses of inhaled AZD2115 in COPD patients 2011 Available from
    • A single-dose study to investigate the effects of 3 different doses of inhaled AZD2115 in COPD patients. 2011. Available from: http://clinicaltrials. gov NCT01498081
  • 38
    • 84867792631 scopus 로고    scopus 로고
    • Ltd. New Combinations for the treatment of asthma. WO-2011012897
    • AstraZeneca AB, Pulmagen Therapeutics (Synergy) Ltd. New Combinations for the treatment of asthma. WO-2011012897; 2011
    • (2011) Pulmagen Therapeutics (Synergy)
    • Astrazeneca, A.B.1
  • 39
    • 84857527653 scopus 로고    scopus 로고
    • Novel dihydroquinoline-based MABAs; Clues to the identity of LAS-190792: Evaluation of WO2011141180
    • See Norman P. Novel dihydroquinoline-based MABAs; clues to the identity of LAS-190792: Evaluation of WO2011141180. Expert Opin Ther Pat 2012;22(2):185-92
    • (2012) Expert Opin Ther Pat , vol.22 , Issue.2 , pp. 185-192
    • See Norman, P.1
  • 40
    • 84887780130 scopus 로고    scopus 로고
    • Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168349 2012
    • Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168349; 2012
  • 41
    • 84887726917 scopus 로고    scopus 로고
    • Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168359 2012
    • Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168359; 2012
  • 42
    • 79955473596 scopus 로고    scopus 로고
    • Inhalation by design: Dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD
    • Pfizers MABA strategy
    • Jones LH, Baldock H, Bunnage ME, et al. Inhalation by design: dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD. Bioorg Med Chem Lett 2011;21(9):2759-63. Pfizers MABA strategy.
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.9 , pp. 2759-2763
    • Jones, L.H.1    Baldock, H.2    Bunnage, M.E.3
  • 43
    • 79960947814 scopus 로고    scopus 로고
    • The in-vitro pharmacology of PF-3429281-A novel inhaled dual antimuscarinic/beta2 adrenoceptor agonist
    • Patel S, Marshall S, Summerhill S. The in-vitro pharmacology of PF-3429281-A novel inhaled dual antimuscarinic/beta2 adrenoceptor agonist. Eur Respir J 2010;36(Suppl 54):219s
    • (2010) Eur Respir J , vol.36 , Issue.SUPPL. 54
    • Patel, S.1    Marshall, S.2    Summerhill, S.3
  • 44
    • 84858997802 scopus 로고    scopus 로고
    • Demonstration of dual pharmacology in vivo of PF-3429281: A novel inhaled dualantimuscarinic/beta2 adrenoceptor agonist
    • Philip J, Gray A, Clarke N, et al. Demonstration of dual pharmacology in vivo of PF-3429281: A novel inhaled dualantimuscarinic/beta2 adrenoceptor agonist. Eur Respir J 2010;36(Suppl 54):218s
    • (2010) Eur Respir J , vol.36 , Issue.SUPPL. 54
    • Philip, J.1    Gray, A.2    Clarke, N.3
  • 45
    • 80052349377 scopus 로고    scopus 로고
    • Optimized glucuronidation of dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD Med
    • Hilton L, Osborne R, Kenyon AS, et al. Optimized glucuronidation of dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD Med. Chem Commun 2011; 2: 870-6
    • (2011) Chem Commun , vol.2 , pp. 870-876
    • Hilton, L.1    Osborne, R.2    Kenyon, A.S.3
  • 46
    • 79953678771 scopus 로고    scopus 로고
    • Pharmacological profile of a novel bronchodilator, TEI3252, as bifunctional M3 antagonist and beta2 agonist
    • Sugiyama H, Nomura J, Hara T. Pharmacological profile of a novel bronchodilator, TEI3252, as bifunctional M3 antagonist and beta2 agonist. Am J Respir Crit Care Med 2010;181:A4436
    • (2010) Am J Respir Crit Care Med , vol.181
    • Sugiyama, H.1    Nomura, J.2    Hara, T.3
  • 47
    • 84887641664 scopus 로고    scopus 로고
    • Teijin Pharma Ltd. Quaternary ammonium salt compound. WO2010126025 2010
    • Teijin Pharma Ltd. Quaternary ammonium salt compound. WO2010126025; 2010
  • 48
    • 55749112997 scopus 로고    scopus 로고
    • Formoterol mono-and combination therapy with tiotropium in patients with COPD: A 6-month study
    • Vogelmeier C, Kardos P, Harari S, et al. Formoterol mono-and combination therapy with tiotropium in patients with COPD: A 6-month study. Respir Med 2008;14:1511-20
    • (2008) Respir Med , vol.14 , pp. 1511-1520
    • Vogelmeier, C.1    Kardos, P.2    Harari, S.3
  • 49
    • 77952914041 scopus 로고    scopus 로고
    • Combining tiotropium and salmeterol in COPD: Effects on airflow obstruction and symptoms
    • van Noord JA, Aumann J-L, Janssens E, et al. Combining tiotropium and salmeterol in COPD: Effects on airflow obstruction and symptoms. Respir Med 2010;14:995-1004
    • (2010) Respir Med , vol.14 , pp. 995-1004
    • Van Noord, J.A.1    Aumann, J.-L.2    Janssens, E.3
  • 50
    • 84877924800 scopus 로고    scopus 로고
    • Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: The PATHOS study
    • Larsson K, Janson C, Lisspers K, et al. Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: The PATHOS study. J Intern Med 2013;273(6):584-94
    • (2013) J Intern Med , vol.273 , Issue.6 , pp. 584-594
    • Larsson, K.1    Janson, C.2    Lisspers, K.3
  • 51
    • 79959732794 scopus 로고    scopus 로고
    • Triple inhalers for obstructive airways disease: Will they be useful
    • Barnes PJ. Triple inhalers for obstructive airways disease: will they be useful Expert Rev Respir Med 2011;5(3):297-300
    • (2011) Expert Rev Respir Med , vol.5 , Issue.3 , pp. 297-300
    • Barnes, P.J.1
  • 52
    • 79953283384 scopus 로고    scopus 로고
    • Combination inhaled steroid and long-acting beta2-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease
    • Karner C, Cates CJ. Combination inhaled steroid and long-acting beta2-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012;CD008532
    • (2012) Cochrane Database Syst Rev
    • Karner, C.1    Cates, C.J.2
  • 53
    • 84887805993 scopus 로고    scopus 로고
    • A study to assess the systemic exposure, systemic pharmacodynamics and safety and tolerability of fluticasonefuroate, umeclidinium and vilanterol in healthy subjects NCT01691547 Available from
    • A study to assess the systemic exposure, systemic pharmacodynamics and safety and tolerability of fluticasonefuroate, umeclidinium and vilanterol in healthy subjects; NCT01691547. Available from: http://clinicaltrials.gov
  • 54
    • 79960864218 scopus 로고    scopus 로고
    • Available from
    • Chiesi Farmaceutici SA, Annual Report. 2012. Available from: http://www. chiesigroup.com/web/guest/chi-siamo/key-figures/report-finanziariidt=5790)
    • (2012) Annual Report
    • Chiesi Farmaceutici, S.A.1
  • 55
    • 84877682284 scopus 로고    scopus 로고
    • Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease
    • Useful review of recent developments
    • Tashkin DP, Ferguson GT. Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respir Res 2013;14:49. Useful review of recent developments.
    • (2013) Respir Res , vol.14 , pp. 49
    • Tashkin, D.P.1    Ferguson, G.T.2
  • 56
    • 0345414503 scopus 로고    scopus 로고
    • The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD
    • Cazzola M, Di Marco F, Santus P, et al. The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD. Pulm Pharmacol Ther 2004;17(1):35-9
    • (2004) Pulm Pharmacol Ther , vol.17 , Issue.1 , pp. 35-39
    • Cazzola, M.1    Di Marco, F.2    Santus, P.3


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