-
1
-
-
84930479279
-
Pharmacology and therapeutics of bronchodilators
-
Invaluable review of the state of the art
-
Cazzola M, Page CP, Calzetta L, Matera MG. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev 2012;64(3):450-504.. Invaluable review of the state of the art.
-
(2012)
Pharmacol Rev
, vol.64
, Issue.3
, pp. 450-504
-
-
Cazzola, M.1
Page, C.P.2
Calzetta, L.3
Matera, M.G.4
-
2
-
-
77953314140
-
Mono-and combination therapy of long-acting bronchodilators and inhaled corticosteroids in advanced COPD
-
Review focusing on the key treatments for COPD
-
Ohar JA, Donohue JF. Mono-and combination therapy of long-acting bronchodilators and inhaled corticosteroids in advanced COPD. Semin Respir Crit Care Med 2010;31(3):321-33. Review focusing on the key treatments for COPD
-
(2010)
Semin Respir Crit Care Med
, vol.31
, Issue.3
, pp. 321-333
-
-
Ohar, J.A.1
Donohue, J.F.2
-
3
-
-
0016758997
-
Combined administration of ipratropium bromide (sch 1000) and fenoterol in patients with chronic obstructive airway disease
-
First demonstration of the additive bronchodilator effects of the two classes of drug
-
Kaik G. Combined administration of ipratropium bromide (sch 1000) and fenoterol in patients with chronic obstructive airway disease Wien Klin Wochenschr. 1975;87:653-6. First demonstration of the additive bronchodilator effects of the two classes of drug
-
(1975)
Wien Klin Wochenschr
, vol.87
, pp. 653-656
-
-
Kaik, G.1
-
4
-
-
0036798629
-
Delivery of ipratropium and albuterol combination therapy for chronic obstructive pulmonary disease: Effectiveness of a two-in-one inhaler versus separate inhalers
-
Chrischilles E, Gilden D, Kubisiak J, et al. Delivery of ipratropium and albuterol combination therapy for chronic obstructive pulmonary disease: Effectiveness of a two-in-one inhaler versus separate inhalers. Am J Manag Care 2002;8:902-11
-
(2002)
Am J Manag Care
, vol.8
, pp. 902-911
-
-
Chrischilles, E.1
Gilden, D.2
Kubisiak, J.3
-
5
-
-
0033022767
-
Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD
-
Friedman M, Serby CW, Menjoge SS, et al. Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD. Chest 1999;115(3):635-41
-
(1999)
Chest
, vol.115
, Issue.3
, pp. 635-641
-
-
Friedman, M.1
Serby, C.W.2
Menjoge, S.S.3
-
6
-
-
84887796152
-
-
GOLD, Global Strategy for the Diagnosis, Management and Prevention of COPD 20 February 2013. Document defining the disease and its currently recommended treatments
-
GOLD, Global Strategy for the Diagnosis, Management and Prevention of COPD 20 February 2013.. Document defining the disease and its currently recommended treatments.
-
-
-
-
7
-
-
84875959946
-
Long-acting muscarinic receptor antagonists for the treatment of respiratory disease
-
Up to date review on LAMA developments
-
Cazzola M, Page C, Matera MG. Long-acting muscarinic receptor antagonists for the treatment of respiratory disease. Pulm Pharmacol Ther 2013;26(3):307-17.. Up to date review on LAMA developments.
-
(2013)
Pulm Pharmacol Ther
, vol.26
, Issue.3
, pp. 307-317
-
-
Cazzola, M.1
Page, C.2
Matera, M.G.3
-
8
-
-
78649635656
-
QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease
-
First demonstration that concurrent administration of LABAs and LAMAs produces additive effects
-
van Noord JA, Buhl R, Laforce C, et al. QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease. Thorax 2010;65(12):1086-91. First demonstration that concurrent administration of LABAs and LAMAs produces additive effects.
-
(2010)
Thorax
, vol.65
, Issue.12
, pp. 1086-1091
-
-
Van Noord, J.A.1
Buhl, R.2
Laforce, C.3
-
9
-
-
84880229392
-
Dual bronchodilation with QVA149 versus single bronchodilator therapy: The SHINE study
-
[Epub ahead of print].. Full details of a key comparison study
-
Bateman ED, Ferguson GT, Barnes N, et al. Dual bronchodilation with QVA149 versus single bronchodilator therapy: The SHINE study. Eur Respir J 2013; [Epub ahead of print].. Full details of a key comparison study.
-
(2013)
Eur Respir J
-
-
Bateman, E.D.1
Ferguson, G.T.2
Barnes, N.3
-
10
-
-
84884819644
-
Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: The enlighten study
-
[Epub ahead of print]. Full details of a 52 week study
-
Dahl R, Chapman KR, Rudolf M, et al. Safety and efficacy of dual bronchodilation with QVA149 in COPD patients: The enlighten study. Respir Med 2013; [Epub ahead of print]. Full details of a 52 week study.
-
(2013)
Respir Med
-
-
Dahl, R.1
Chapman, K.R.2
Rudolf, M.3
-
11
-
-
84877131237
-
Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomized double-blind parallel-group study
-
The critical comparison of QVA-149 with tiotropium
-
Wedzicha JA, Decramer M, Ficker JH, et al. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): A randomized, double-blind, parallel-group study. Lancet Respir Med 2013;1(3):199-209.. The critical comparison of QVA-149 with tiotropium.
-
(2013)
Lancet Respir Med
, vol.1
, Issue.3
, pp. 199-209
-
-
Wedzicha, J.A.1
Decramer, M.2
Ficker, J.H.3
-
12
-
-
84885836796
-
Superior lung function with once-daily QVA149 translates into improvements in patient-reported breathlessness compared with placebo and tiotropium in COPD patients: The blaze study
-
Mahler DA, Decramer M, DUrzo AD, et al. Superior lung function with once-daily QVA149 translates into improvements in patient-reported breathlessness compared with placebo and tiotropium in COPD patients: The blaze study. Am J Respir Crit Care Med 2013;187:A6070
-
(2013)
Am J Respir Crit Care Med
, vol.187
-
-
Mahler, D.A.1
Decramer, M.2
Durzo, A.D.3
-
13
-
-
84877676197
-
Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): A randomised double-blind parallel group study
-
One of the first key comparisons of LAMA/LABA and ICS/LABA combinations
-
Vogelmeir CF, Bateman ED, Pallante J, et al. Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): A randomised, double-blind, parallel group study. Lancet Respir Med 2013;1(1):51-60. One of the first key comparisons of LAMA/LABA and ICS/LABA combinations.
-
(2013)
Lancet Respir Med
, vol.1
, Issue.1
, pp. 51-60
-
-
Vogelmeir, C.F.1
Bateman, E.D.2
Pallante, J.3
-
14
-
-
84897467374
-
Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study
-
Donohoe JF, Maleki-Yazedi M, Kilbride S, et al. Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study. Am J Respir Crit Care Med 2013;187:A4275
-
(2013)
Am J Respir Crit Care Med
, vol.187
-
-
Donohoe, J.F.1
Maleki-Yazedi, M.2
Kilbride, S.3
-
15
-
-
84887788953
-
Efficacy and safety of once-daily umeclidinium/vilanterol 125/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study
-
Celli BR, Crater G, Kilbride S, et al. Efficacy and safety of once-daily umeclidinium/vilanterol 125/25 Mcg in COPD: A randomized, placebo-controlled, 24-week study. Am J Respir Crit Care Med 2013;187:A2435
-
(2013)
Am J Respir Crit Care Med
, vol.187
-
-
Celli, B.R.1
Crater, G.2
Kilbride, S.3
-
16
-
-
84886395702
-
The efficacy and safety of umeclidinium/vilanterol compared with tiotropium or vilanterol over 24 weeks in subjects with COPD
-
Anzueto A, Decramer M, Kaelin T, et al. The efficacy and safety of umeclidinium/vilanterol compared with tiotropium or vilanterol over 24 weeks in subjects with COPD. Am J Respir Crit Care Med 2013;187:A4268
-
(2013)
Am J Respir Crit Care Med
, vol.187
-
-
Anzueto, A.1
Decramer, M.2
Kaelin, T.3
-
18
-
-
84887688236
-
Almirall and Forest Laboratories announce positive results of a Phase III Study for aclidinium and formoterol combination in COPD
-
Almirall SA. Almirall and Forest Laboratories announce positive results of a Phase III Study for aclidinium and formoterol combination in COPD. Press Release; 2013
-
(2013)
Press Release
-
-
Almirall, S.A.1
-
19
-
-
84887688236
-
Almirall and Forest Laboratories announce positive results for the second Phase III Study for aclidinium and formoterol combination in COPD
-
Almirall SA. Almirall and Forest Laboratories announce positive results for the second Phase III Study for aclidinium and formoterol combination in COPD. Press Release; 2013
-
(2013)
Press Release
-
-
Almirall, S.A.1
-
20
-
-
84867755100
-
Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers
-
Vehring R, Lechuga-Ballesteros D, Joshi V, et al. Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers. Langmuir 2012;28(42):15015-23
-
(2012)
Langmuir
, vol.28
, Issue.42
, pp. 15015-15023
-
-
Vehring, R.1
Lechuga-Ballesteros, D.2
Joshi, V.3
-
21
-
-
84887721737
-
-
Pearl Therapeutics. Pearl therapeutics initiates PT003 phase 3 program for the treatment of individuals with moderate-to-severe COPD. Press Release 2013
-
Pearl Therapeutics. Pearl therapeutics initiates PT003 phase 3 program for the treatment of individuals with moderate-to-severe COPD. Press Release; 2013
-
-
-
-
22
-
-
84887813809
-
Low doses of pearl therapeutics LAMA/LABA combination MDI (GFF MDI, PT003) provide superior bronchodilation compared to components and to open-label spiriva handihaler in a randomized, double-blind, placebo-controlled phase IIb study in patients with COPD
-
Reisner C, Gotfried M, Denenberg MB, et al. Low doses of pearl therapeutics LAMA/LABA combination MDI (GFF MDI, PT003) provide superior bronchodilation compared to components and to open-label spiriva handihaler in a randomized, double-blind, placebo-controlled phase IIb study in patients with COPD. Am J Respir Crit Care Med 2013;187:A2434
-
(2013)
Am J Respir Crit Care Med
, vol.187
-
-
Reisner, C.1
Gotfried, M.2
Denenberg, M.B.3
-
23
-
-
84875945300
-
Pearl therapeutics combination LAMA/LABA MDI (GFF MDI, PT003) Provides a significant benefit on home peak expiratory flow rate (PEFR) and reduces the need for rescue albuterol use compared to its components administered alone, spiriva-handihaler-18 g and foradil-aerolizer-12 g in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD
-
Rennard S, Fogerty C, Fischer T, et al. Pearl therapeutics combination LAMA/LABA MDI (GFF MDI, PT003) Provides a Significant Benefit on Home Peak Expiratory Flow Rate (PEFR) and reduces the need for rescue albuterol use compared to its components administered alone, spiriva-handihaler-18 g and foradil-aerolizer-12 g in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD. Am J Respir Crit Care Med 2012;185:A2259
-
(2012)
Am J Respir Crit Care Med
, vol.185
-
-
Rennard, S.1
Fogerty, C.2
Fischer, T.3
-
24
-
-
80053196166
-
Dual-pharmacology muscarinic antagonist and b agonist molecules for the treatment of chronic obstructive pulmonary disease
-
One of two key reviews on the MABA strategy
-
Hughes AD, Jones LH. Dual-pharmacology muscarinic antagonist and b agonist molecules for the treatment of chronic obstructive pulmonary disease. Future Med Chem 2011;3(13):1585-605. One of two key reviews on the MABA strategy.
-
(2011)
Future Med Chem
, vol.3
, Issue.13
, pp. 1585-1605
-
-
Hughes, A.D.1
Jones, L.H.2
-
25
-
-
84859915668
-
Multivalent dual pharmacology muscarinic antagonist and b2 agonist (MABA) molecules for the treatment of COPD
-
One of two key reviews on the MABA strategy
-
Hughes AD, McNamara A, Steinfeld T. Multivalent dual pharmacology muscarinic antagonist and b2 agonist (MABA) molecules for the treatment of COPD. Prog Med Chem 2012;51:71-95. One of two key reviews on the MABA strategy.
-
(2012)
Prog Med Chem
, vol.51
, pp. 71-95
-
-
Hughes, A.D.1
McNamara, A.2
Steinfeld, T.3
-
26
-
-
67649395693
-
Muscarinic antagonist-beta-adrenergic agonist dual pharmacology molecules as bronchodilators: A patent review
-
Review highlighting companies activities in this area
-
Ray NC, Alcaraz L. Muscarinic antagonist-beta-adrenergic agonist dual pharmacology molecules as bronchodilators: A patent review. Expert Opin Ther Pat 2009;19(1):1-12. Review highlighting companies activities in this area.
-
(2009)
Expert Opin Ther Pat
, vol.19
, Issue.1
, pp. 1-12
-
-
Ray, N.C.1
Alcaraz, L.2
-
27
-
-
79951997039
-
THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner
-
First pharmacological characterisation of MABAs
-
Steinfeld T, Hughes AD, Klein U, et al. THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner. Mol Pharmacol 2011;79(3):389-99. First pharmacological characterisation of MABAs.
-
(2011)
Mol Pharmacol
, vol.79
, Issue.3
, pp. 389-399
-
-
Steinfeld, T.1
Hughes, A.D.2
Klein, U.3
-
28
-
-
84865955542
-
Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and b(2)-adrenoceptor agonist (MABA)
-
McNamara A, Steinfeld T, Pulido-Rios MT, et al. Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and b(2)-adrenoceptor agonist (MABA). Pulm Pharmacol Ther 2012;25(5):357-63
-
(2012)
Pulm Pharmacol Ther
, vol.25
, Issue.5
, pp. 357-363
-
-
McNamara, A.1
Steinfeld, T.2
Pulido-Rios, M.T.3
-
29
-
-
79951727504
-
Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules
-
Hughes AD, Chin KH, Dunham SL, et al. Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules. Bioorg Med Chem Lett 2011;21(5):1354-8
-
(2011)
Bioorg Med Chem Lett
, vol.21
, Issue.5
, pp. 1354-1358
-
-
Hughes, A.D.1
Chin, K.H.2
Dunham, S.L.3
-
30
-
-
84887706252
-
-
Glaxo Group Ltd. Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-12-dihydroquinolin-5-yl) ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester and its use for treating pulmonary disorders. WO-2007090859 2007
-
Glaxo Group Ltd. Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester and its use for treating pulmonary disorders. WO-2007090859; 2007
-
-
-
-
31
-
-
84887767440
-
-
A randomised, double-blind, dose escalating study in healthy volunteers to assess the safety, tolerability, extra pulmonary pharmacodynamics and pharmacokinetics of single doses of GSK961081 (succinate salt), NCT00550225 2007 Available from
-
A randomised, double-blind, dose escalating study in healthy volunteers to assess the safety, tolerability, extra pulmonary pharmacodynamics and pharmacokinetics of single doses of GSK961081 (succinate salt), NCT00550225. 2007. Available from: http://clinicaltrials.gov
-
-
-
-
32
-
-
84856668776
-
In vitro characterization of TD 5959: A novel bi functional molecule with muscarinic antagonist and beta2 adrenergic agonist activity
-
Aiyar J, Steinfeld T, Pulido Rios MT, et al. In vitro characterization of TD 5959: A novel bi functional molecule with muscarinic antagonist and beta2 adrenergic agonist activity. Am J Respir Crit Care Med 2009;179:A4552
-
(2009)
Am J Respir Crit Care Med
, vol.179
-
-
Aiyar, J.1
Steinfeld, T.2
Pulido Rios, M.T.3
-
33
-
-
79953719780
-
TD 5959: A novel bi functional muscarinic antagonist beta2 adrenergic agonist with potent and sustained in vivo bronchodilator activity in guinea pigs
-
Pulido Rios MT, McNamara A, et al. TD 5959: A novel bi functional muscarinic antagonist beta2 adrenergic agonist with potent and sustained in vivo bronchodilator activity in guinea pigs. Am J Respir Crit Care Med 2009;179:A6195
-
(2009)
Am J Respir Crit Care Med
, vol.179
-
-
Pulido Rios, M.T.1
McNamara, A.2
-
34
-
-
84886517217
-
A new class of bronchodilator improves lung function in COPD: A trial with GSK961081
-
Epub ahead of print.. The most significant clinical data published in GSK-961081
-
Wielders PL, Ludwig-Sengpiel A, Locantore N, et al. A new class of bronchodilator improves lung function in COPD: A trial with GSK961081. Eur Respir J 2013; Epub ahead of print.. The most significant clinical data published in GSK-961081.
-
(2013)
Eur Respir J
-
-
Wielders, P.L.1
Ludwig-Sengpiel, A.2
Locantore, N.3
-
35
-
-
84882590787
-
Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD
-
doi:pii: S1094-5539(13 00089-8)
-
Bateman ED, Kornmann O, Ambery C, Norris V. Pharmacodynamics of GSK961081, a bi-functional molecule, in patients with COPD. Pulm Pharmacol Ther 2013;doi:pii: S1094-5539(13)00089-8
-
(2013)
Pulm Pharmacol Ther
-
-
Bateman, E.D.1
Kornmann, O.2
Ambery, C.3
Norris, V.4
-
36
-
-
84882601233
-
Bronchodilation and safety of supratherapeutic doses of salbutamol or ipratropium bromide added to single dose GSK961081 in patients with moderate to severe COPD
-
doi:pii: S1094-5539
-
Norris V, Ambery C. Bronchodilation and safety of supratherapeutic doses of salbutamol or ipratropium bromide added to single dose GSK961081 in patients with moderate to severe COPD. Pulm Pharmacol Ther 2013;doi:pii: S1094-5539
-
(2013)
Pulm Pharmacol Ther
-
-
Norris, V.1
Ambery, C.2
-
37
-
-
84887647897
-
-
A single-dose study to investigate the effects of 3 different doses of inhaled AZD2115 in COPD patients 2011 Available from
-
A single-dose study to investigate the effects of 3 different doses of inhaled AZD2115 in COPD patients. 2011. Available from: http://clinicaltrials. gov NCT01498081
-
-
-
-
38
-
-
84867792631
-
-
Ltd. New Combinations for the treatment of asthma. WO-2011012897
-
AstraZeneca AB, Pulmagen Therapeutics (Synergy) Ltd. New Combinations for the treatment of asthma. WO-2011012897; 2011
-
(2011)
Pulmagen Therapeutics (Synergy)
-
-
Astrazeneca, A.B.1
-
39
-
-
84857527653
-
Novel dihydroquinoline-based MABAs; Clues to the identity of LAS-190792: Evaluation of WO2011141180
-
See Norman P. Novel dihydroquinoline-based MABAs; clues to the identity of LAS-190792: Evaluation of WO2011141180. Expert Opin Ther Pat 2012;22(2):185-92
-
(2012)
Expert Opin Ther Pat
, vol.22
, Issue.2
, pp. 185-192
-
-
See Norman, P.1
-
40
-
-
84887780130
-
-
Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168349 2012
-
Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168349; 2012
-
-
-
-
41
-
-
84887726917
-
-
Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168359 2012
-
Chiesi Farmaceutici SpA. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity. WO2012168359; 2012
-
-
-
-
42
-
-
79955473596
-
Inhalation by design: Dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD
-
Pfizers MABA strategy
-
Jones LH, Baldock H, Bunnage ME, et al. Inhalation by design: dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD. Bioorg Med Chem Lett 2011;21(9):2759-63. Pfizers MABA strategy.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, Issue.9
, pp. 2759-2763
-
-
Jones, L.H.1
Baldock, H.2
Bunnage, M.E.3
-
43
-
-
79960947814
-
The in-vitro pharmacology of PF-3429281-A novel inhaled dual antimuscarinic/beta2 adrenoceptor agonist
-
Patel S, Marshall S, Summerhill S. The in-vitro pharmacology of PF-3429281-A novel inhaled dual antimuscarinic/beta2 adrenoceptor agonist. Eur Respir J 2010;36(Suppl 54):219s
-
(2010)
Eur Respir J
, vol.36
, Issue.SUPPL. 54
-
-
Patel, S.1
Marshall, S.2
Summerhill, S.3
-
44
-
-
84858997802
-
Demonstration of dual pharmacology in vivo of PF-3429281: A novel inhaled dualantimuscarinic/beta2 adrenoceptor agonist
-
Philip J, Gray A, Clarke N, et al. Demonstration of dual pharmacology in vivo of PF-3429281: A novel inhaled dualantimuscarinic/beta2 adrenoceptor agonist. Eur Respir J 2010;36(Suppl 54):218s
-
(2010)
Eur Respir J
, vol.36
, Issue.SUPPL. 54
-
-
Philip, J.1
Gray, A.2
Clarke, N.3
-
45
-
-
80052349377
-
Optimized glucuronidation of dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD Med
-
Hilton L, Osborne R, Kenyon AS, et al. Optimized glucuronidation of dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPD Med. Chem Commun 2011; 2: 870-6
-
(2011)
Chem Commun
, vol.2
, pp. 870-876
-
-
Hilton, L.1
Osborne, R.2
Kenyon, A.S.3
-
46
-
-
79953678771
-
Pharmacological profile of a novel bronchodilator, TEI3252, as bifunctional M3 antagonist and beta2 agonist
-
Sugiyama H, Nomura J, Hara T. Pharmacological profile of a novel bronchodilator, TEI3252, as bifunctional M3 antagonist and beta2 agonist. Am J Respir Crit Care Med 2010;181:A4436
-
(2010)
Am J Respir Crit Care Med
, vol.181
-
-
Sugiyama, H.1
Nomura, J.2
Hara, T.3
-
47
-
-
84887641664
-
-
Teijin Pharma Ltd. Quaternary ammonium salt compound. WO2010126025 2010
-
Teijin Pharma Ltd. Quaternary ammonium salt compound. WO2010126025; 2010
-
-
-
-
48
-
-
55749112997
-
Formoterol mono-and combination therapy with tiotropium in patients with COPD: A 6-month study
-
Vogelmeier C, Kardos P, Harari S, et al. Formoterol mono-and combination therapy with tiotropium in patients with COPD: A 6-month study. Respir Med 2008;14:1511-20
-
(2008)
Respir Med
, vol.14
, pp. 1511-1520
-
-
Vogelmeier, C.1
Kardos, P.2
Harari, S.3
-
49
-
-
77952914041
-
Combining tiotropium and salmeterol in COPD: Effects on airflow obstruction and symptoms
-
van Noord JA, Aumann J-L, Janssens E, et al. Combining tiotropium and salmeterol in COPD: Effects on airflow obstruction and symptoms. Respir Med 2010;14:995-1004
-
(2010)
Respir Med
, vol.14
, pp. 995-1004
-
-
Van Noord, J.A.1
Aumann, J.-L.2
Janssens, E.3
-
50
-
-
84877924800
-
Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: The PATHOS study
-
Larsson K, Janson C, Lisspers K, et al. Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: The PATHOS study. J Intern Med 2013;273(6):584-94
-
(2013)
J Intern Med
, vol.273
, Issue.6
, pp. 584-594
-
-
Larsson, K.1
Janson, C.2
Lisspers, K.3
-
51
-
-
79959732794
-
Triple inhalers for obstructive airways disease: Will they be useful
-
Barnes PJ. Triple inhalers for obstructive airways disease: will they be useful Expert Rev Respir Med 2011;5(3):297-300
-
(2011)
Expert Rev Respir Med
, vol.5
, Issue.3
, pp. 297-300
-
-
Barnes, P.J.1
-
52
-
-
79953283384
-
Combination inhaled steroid and long-acting beta2-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease
-
Karner C, Cates CJ. Combination inhaled steroid and long-acting beta2-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012;CD008532
-
(2012)
Cochrane Database Syst Rev
-
-
Karner, C.1
Cates, C.J.2
-
53
-
-
84887805993
-
-
A study to assess the systemic exposure, systemic pharmacodynamics and safety and tolerability of fluticasonefuroate, umeclidinium and vilanterol in healthy subjects NCT01691547 Available from
-
A study to assess the systemic exposure, systemic pharmacodynamics and safety and tolerability of fluticasonefuroate, umeclidinium and vilanterol in healthy subjects; NCT01691547. Available from: http://clinicaltrials.gov
-
-
-
-
54
-
-
79960864218
-
-
Available from
-
Chiesi Farmaceutici SA, Annual Report. 2012. Available from: http://www. chiesigroup.com/web/guest/chi-siamo/key-figures/report-finanziariidt=5790)
-
(2012)
Annual Report
-
-
Chiesi Farmaceutici, S.A.1
-
55
-
-
84877682284
-
Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease
-
Useful review of recent developments
-
Tashkin DP, Ferguson GT. Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respir Res 2013;14:49. Useful review of recent developments.
-
(2013)
Respir Res
, vol.14
, pp. 49
-
-
Tashkin, D.P.1
Ferguson, G.T.2
-
56
-
-
0345414503
-
The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD
-
Cazzola M, Di Marco F, Santus P, et al. The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD. Pulm Pharmacol Ther 2004;17(1):35-9
-
(2004)
Pulm Pharmacol Ther
, vol.17
, Issue.1
, pp. 35-39
-
-
Cazzola, M.1
Di Marco, F.2
Santus, P.3
|