High levels of extended-spectrum beta-lactamases in a major teaching hospital in Ghana: The need for regular monitoring and evaluation of antibiotic resistance

American Journal of Tropical Medicine and Hygiene

Volumn 89, Issue 5, 2013, Pages 960-964

  Obeng Nkrumah, Noah ^a   Twum Danso, Kingsley ^a   Krogfelt, Karen A ^b   Newman, Mercy J ^a  

^a UNIVERSITY OF GHANA   (Ghana)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE; AMPICILLIN; CARBAPENEM; CEFOTAXIME; CEFTAZIDIME; CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; COTRIMOXAZOLE; GENTAMICIN; MEROPENEM; QUINOLONE; SULFONAMIDE; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BROTH DILUTION; CITROBACTER FREUNDII; CITROBACTER KOSERI; CONTROLLED STUDY; DISK DIFFUSION; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; GHANA; GROUPS BY AGE; INFECTION RISK; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PREVALENCE; PROTEUS MIRABILIS; PROTEUS VULGARIS; TEACHING HOSPITAL; URINARY TRACT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; CHILD; CHILD, PRESCHOOL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; EPIDEMIOLOGICAL MONITORING; FEMALE; FLUOROQUINOLONES; GENE EXPRESSION; GHANA; HOSPITALS, TEACHING; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; SULFONAMIDES;

EID: 84887620711     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.12-0642     Document Type: Article

References (22)

1. Wilke MS, Lovering AL, Strynadka NCJ, 2005. β-lactam antibiotic resistance: a current structural perspective. Curr Opin Microbiol 8: 525-533.
2. Jacoby GA, Munoz-Price LS, 2005. The new β-lactamases. N Engl J Med 352: 380-391.
3. Thomson K, 2013. Detection of gram-negative β-lactamase producing pathogens in the clinical lab. Curr Pharm Des 19: 250-256.
4. Liebana E, Carattoli A, Coque TM, Hasman H, Magiorakos AP, Mevius D, Peixe L, Poirel L, Schuepbach-Regula G, Torneke K, Torren-Edo J, Torres C, Threlfall J, 2013. The public health risks of enterobacterial isolates producing extended-spectrum β-lactamases (ESBL) or AmpC β-lactamases in food and foodproducing animals: an EU perspective of epidemiology, analytical methods, risk factors and control options. Clin Infect Dis 56: 1030-1037.
5. Cantón R, Bryan J, 2012. Global antimicrobial resistance: from surveillance to stewardship. Part 1: surveillance and risk factors for resistance. Expert Rev Anti Infect Ther 10: 1269-1271.
6. Yi-Hui W, Po-Lin C, Yuan-Pin H, Wen-Chien K, 2012. Risk factors and clinical impact of levofloxacin or cefazolin nonsusceptibility or ESBL production among uropathogens in adults with community-onset urinary tract infections. J Microbiol Immunol Infect 2012 Oct 11. pii:S1684-1182(12)00206-X, doi:1.1016/j.jmii2012.09.001 [Epub ahead of print].
7. Essack SY, Hall LM, Pillay DG, McFadyen ML, Livermore DM, 2001. Complexity and diversity of Klebsiella pneumoniae strains with extended-spectrum β-lactamases isolated in 1994 and 1996 at a teaching hospital in Durban, South Africa. Antimicrob Agents Chemother 45: 88-95.
8. Bell JM, Turnidge JD, Gales AC, Pfaller MA, Jones RN, 2002. Prevalence of extended-spectrum β-lactamase (ESBL)-producing clinical isolates in the Asia-Pacific region and South Africa: regional results from SENTRY Antimicrobial Surveillance Program (1998 to 99). Diagn Microbiol Infect Dis 42: 193-198.
9. Tau NP, Smith AM, Sooka A, Keddy KH, 2012. Molecular characterization of extended-spectrum β-lactamase-producing Shigella isolates from humans in South Africa, 2003-2009. J Med Microbiol 61: 162-164.
10. Bouchillon SK, Johnso BM, Hoban DJ, 2004. Determining incidence of extended-spectrum β-lactamase-producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001 to 2002. Int J Antimicrob Agents 24: 119-124.
11. Khalaf NG, Eletreby MM, Hanson ND, 2009. Characterization of CTX-M ESBLs in Enterobacter cloacae, Escherichia coli and Klebsiella pneumoniae clinical isolates from Cairo, Egypt. BMC Infect Dis 9: 84-89.
12. Ben-Hamouda T, Foulon T, Ben-Mahrez K, 2004. Involvement of SHV-12 and SHV-2a encoding plasmids in outbreaks of extendedspectrum β-lactamase- producing Klebsiella pneumoniae in a Tunisian neonatal ward. Microb Drug Resist 10: 132-138.
13. Aitmhand R, Soukri A, Moustaoui N, Amarouch H, Eimdaghri N, Sirot D, Benbachir M, 2002. Plasmid-mediated TEM-3 extendedspectrum β-lactamase- production in Salmonella typhimurium in Casablanca. J Antimicrob Chemother 49: 169-172.
14. Blomberg B, Jureen R, Manji KP, Tamim BS, Mwakagile DS, Urassa WK, Fataki M, Msangi V, Tellevik MG, Maselle SY, Langeland N, 2005. High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum β-lactamases in Dar es Salaam, Tanzania. J Clin Microbiol 43: 745-749.
15. Aibinu I, Odugbemi T, Koenig W, Ghebremedhin B, 2012. Sequence type ST131 and ST10 complex (ST617) predominant among CTX-M-15-producing Escherichia coli isolates from Nigeria. Clin Microbiol Infect 18: E49-E51.
16. Cowan ST, Steel KJ, 2004. Characteristics of gram negative bacteria. Barrow GI, Feltham RK, eds. Cowans and Steels Manual for Identification of Medical Bacteria. Third edition. London: Cambridge University Press, 94-150.
17. Clinical and Laboratory Standards Institute (CLSI), 2007. Performance standards for antimicrobial susceptibility testing, 17th informational supplement.M100-S17.Wayne, PA: The Institute.
18. Clinical and Laboratory Standards Institute (CLSI), 2006.Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically, 7th edition. Approved standard.M7-A7.Wayne, PA: The Institute.
19. Hoban D, Lascols C, Nicolle LE, Badal R, Bouchillon S, Hackel M, Hawser S, 2012. Antimicrobial susceptibility of Enterobacteriaceae, including molecular characterization of extended-spectrum beta-lactamase-producing species, in urinary tract isolates from hospitalized patients in North America and Europe: results from the SMART study. Diagn Microbiol Infect Dis 74: 62-64.
20. European Centre for Disease Prevention and Control (ECDC), 2011. Antimicrobial resistance surveillance in Europe 2010. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net).
21. Newman MJ, Frimpong E, Asamoah-Adu A, Sampane-Donkor E, Opintan JA, 2011. Resistance to antimicrobial drugs in Ghana. Infect Drug Resist 4: 215-220.
22. Codjoe FS, Newman MJ, Enweronu-Laryea C, 2009. Neonatal infections: is extended-spectrum β-lactamase-producing gramnegative bacilli part of the problem? Ghana J. of Allied Health Sciences 3: 15-29.