Prebiotic supplementation in preterm neonates: Updated systematic review and meta-analysis of randomised controlled trials

Clinical Nutrition

Volumn 32, Issue 6, 2013, Pages 958-965

  Srinivasjois, Ravisha ^a,c   Rao, Shripada ^b,c,d   Patole, Sanjay ^b,d  

^a Joondalup Health Campus and Joondalup Child Development Centre ^*  (Australia)

^b KING EDWARD MEMORIAL HOSPITAL   (Australia)

^c PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Bifidobacteria; Enteral feeds; Lactobacillus; Necrotising enterocolitis; Prebiotic oligosaccharides; Sepsis

Indexed keywords

OLIGOSACCHARIDE; PLACEBO; PREBIOTIC AGENT;

ABNORMAL FECES COMPOSITION; ARTICLE; ARTIFICIAL MILK; BACTERIAL COLONIZATION; BIFIDOBACTERIALES; BREAST FEEDING; CARBOHYDRATE INTOLERANCE; DIET SUPPLEMENTATION; ENTERIC FEEDING; FECES ANALYSIS; FOOD SAFETY; GROWTH CURVE; HUMAN; INCIDENCE; INTESTINE MUCOSA PERMEABILITY; META ANALYSIS; NECROTIZING ENTEROCOLITIS; OUTCOME ASSESSMENT; PH MEASUREMENT; PREMATURITY; PRODUCT SAFETY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEPSIS; SYSTEMATIC REVIEW; VISCOSITY;

BIFIDOBACTERIA; ENTERAL FEEDS; LACTOBACILLUS; NECROTISING ENTEROCOLITIS; PREBIOTIC OLIGOSACCHARIDES; SEPSIS;

BIFIDOBACTERIUM; DIETARY SUPPLEMENTS; ENTERAL NUTRITION; ENTEROCOLITIS, NECROTIZING; FECES; GASTROINTESTINAL TRACT; HUMANS; INCIDENCE; INFANT; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; OLIGOSACCHARIDES; PREBIOTICS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; SEPSIS;

EID: 84887619413     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.05.009     Document Type: Article

References (37)

1. Gibson G.R., Roberfroid M.B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. JNutr 1995, 125(6):1401-1412.
2. Gibson G.R. Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin. JNutr 1999, 129(7 Suppl.):1438S-1441S.
3. Guarner F., Malagelada J.R. Gut flora in health and disease. Lancet 2003, 361(9356):512-519.
4. Westerbeek E.A., van den B.A., Lafeber H.N., Knol J., Fetter W.P., van Elburg R.M. The intestinal bacterial colonisation in preterm infants: a review of the literature. Clin Nutr 2006, 25(3):361-368.
5. Srinivasjois R., Rao S., Patole S. Prebiotic supplementation of formula in preterm neonates: a systematic review and meta-analysis of randomised controlled trials. Clin Nutr 2009, 28(3):237-242.
6. Sherman P.M., Cabana M., Gibson G.R., Koletzko B.V., Neu J., Veereman-Wauters G., et al. Potential roles and clinical utility of prebiotics in newborns, infants, and children: proceedings from a global prebiotic summit meeting, New York city, June 27-28, 2008. JPediatr 2009, 155(5):S61-S70.
7. Riskin A., Hochwald O., Bader D., Srugo I., Naftali G., Kugelman A., et al. The effects of lactulose supplementation to enteral feedings in premature infants: a pilot study. JPediatr 2010, 156(2):209-214.
8. Modi N., Uthaya S., Fell J., Kulinskaya E. Arandomized, double-blind, controlled trial of the effect of prebiotic oligosaccharides on enteral tolerance in preterm infants (ISRCTN77444690). Pediatr Res 2010, 68(5):440-445.
9. Mugambi M.N., Musekiwa A., Lombard M., Young T., Blaauw R. Probiotics, prebiotics infant formula use in preterm or low birth weight infants: a systematic review. Nutr J 2012, 11(1):58.
10. Higgins J.P., Altman D.G., Gotzsche P.C., Juni P., Moher D., Oxman A.D., et al. The cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011, 343:d5928.
11. Liberati A., Altman D.G., Tetzlaff J., Mulrow C., Gotzsche P.C., Ioannidis J.P., et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009, 339:b2700.
12. Review manager version 5.1 2011, 2012. The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen.
13. Boehm G., LiDestri M., Casetta P., Jelinek J., Negretti F., Stahl B., et al. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonatal Ed 2002, 86(3):F178-F181.
14. Westerbeek E.A., van den Berg J.P., Lafeber H.N., Fetter W.P., Boehm G., Twisk J.W., et al. Neutral and acidic oligosaccharides in preterm infants: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2010, 91(3):679-686.
15. Mihatsch W.A., Hoegel J., Pohlandt F. Prebiotic oligosaccharides reduce stool viscosity and accelerate gastrointestinal transport in preterm infants. Acta Paediatr 2006, 95(7):843-848.
16. Kapiki A., Costalos C., Oikonomidou C., Triantafyllidou A., Loukatou E., Pertrohilou V. The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Hum Dev 2007, 83(5):335-339.
17. Indrio F., Riezzo G., Raimondi F., Bisceglia M., Cavallo L., Francavilla R. Effects of probiotic and prebiotic on gastrointestinal motility in newborns. JPhysiol Pharmacol 2009, 60(Suppl. 6):27-31.
18. Westerbeek E.A., van Elburg R.M., van den Berg A., van den Berg J., Twisk J.W., Fetter W.P., et al. Design of a randomised controlled trial on immune effects of acidic and neutral oligosaccharides in the nutrition of preterm infants: carrot study. BMC Pediatr 2008, 8:46.
19. Westerbeek E.A., Lafeber H.N., van Elburg R.M. Prebiotic effect of lactulose in preterm infants. JPediatr 2010, 157(2):347.
20. Westerbeek E.A., Morch E., Lafeber H.N., Fetter W.P., Twisk J.W., van Elburg R.M. Effect of neutral and acidic oligosaccharides on fecal IL-8 and fecal Calprotectin in preterm infants. Pediatr Res 2011, 69(3):255-258.
21. Westerbeek E.A., van den Berg A., Lafeber H.N., Fetter W.P., van Elburg R.M. The effect of enteral supplementation of a prebiotic mixture of non-human milk galacto-, fructo- and acidic oligosaccharides on intestinal permeability in preterm infants. Br J Nutr 2011, 105(2):268-274.
22. Westerbeek E.A., Hensgens R.L., Mihatsch W.A., Boehm G., Lafeber H.N., van Elburg R.M. The effect of neutral and acidic oligosaccharides on stool viscosity, stool frequency and stool pH in preterm infants. Acta Paediatr 2011, 100(11):1426-1431.
23. Boehm G., Moro G. Structural and functional aspects of prebiotics used in infant nutrition. JNutr 2008, 138(9):1818S-1828S.
24. Knol J., Boehm G., LiDestri M., Negretti F., Jelinek J., Agosti M., et al. Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants. Acta Paediatr Suppl 2005, 94(449):31-33.
25. LiDestri M., Agosti M., Marini A., Boehm G. Oligosaccharides might stimulate calcium absorption in formula-fed preterm infants. Acta Paediatr Suppl 2003, 91(441):91-92.
26. Marini A., Negretti F., Boehm G., Li D.M., Clerici-Bagozzi D., Mosca F., et al. Pro- and pre-biotics administration in preterm infants: colonization and influence on faecal flora. Acta Paediatr Suppl 2003, 91(441):80-81.
27. Underwood M.A., Salzman N.H., Bennett S.H., Barman M., Mills D.A., Marcobal A., et al. Arandomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids. JPediatr Gastroenterol Nutr 2009, 48(2):216-225.
28. Veereman-Wauters G., Staelens S., Van de Broek H., Plaskie K., Wesling F., Roger L.C., et al. Physiological and bifidogenic effects of prebiotic supplements in infant formulae. JPediatr Gastroenterol Nutr 2011, 52(6):763-771.
29. Salvini F., Riva E., Salvatici E., Boehm G., Jelinek J., Banderali G., et al. Aspecific prebiotic mixture added to starting infant formula has long-lasting bifidogenic effects. JNutr 2011, 141(7):1335-1339.
30. Deshpande G., Rao S., Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials. Lancet 2007, 369(9573):1614-1620.
31. Moro G., Minoli I., Mosca M., Fanaro S., Jelinek J., Stahl B., et al. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. JPediatr Gastroenterol Nutr 2002, 34(3):291-295.
32. Barrat E., Michel C., Poupeau G., David-Sochard A., Rival M., Pagniez A., et al. Supplementation with galactooligosaccharides and inulin increases bacterial translocation in artificially reared newborn rats. Pediatr Res 2008, 64(1):34-39.
33. Ten Bruggencate S.J., Bovee-Oudenhoven I.M., Lettink-Wissink M.L., Katan M.B., Van Der Meer R. Dietary fructo-oligosaccharides and inulin decrease resistance of rats to salmonella: protective role of calcium. Gut 2004, 53(4):530-535.
34. Bongaerts G., Severijnen R., Timmerman H. Effect of antibiotics, prebiotics and probiotics in treatment for hepatic encephalopathy. Med Hypotheses 2005, 64(1):64-68.
35. Kuppala V.S., Meinzen-Derr J., Morrow A.L., Schibler K.R. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. JPediatr 2011 Nov, 159(5):720-725.
36. Cotten C.M., Taylor S., Stoll B., Goldberg R.N., Hansen N.I., Sanchez P.J., et al. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. JPediatr 2009 Jan, 123(1):58-66.
37. Hussey S., Wall R., Gruffman E., O'Sullivan L., Ryan C.A., Murphy B., et al. Parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates. Int J Microbiol 2011, 2011:130574.