-
1
-
-
33845227643
-
Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors
-
Buck E., Eyzaguirre A., Brown E., Petti F., McCormack S., Haley J.D., Iwata K.K., Gibson N.W., Griffin G. Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Molecular Cancer Therapeutics 2006, 5:2676-2684.
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, pp. 2676-2684
-
-
Buck, E.1
Eyzaguirre, A.2
Brown, E.3
Petti, F.4
McCormack, S.5
Haley, J.D.6
Iwata, K.K.7
Gibson, N.W.8
Griffin, G.9
-
2
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas N. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012, 487:330-337.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
Cancer Genome Atlas, N.1
-
3
-
-
84862779787
-
Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR
-
Chen S.M., Liu J.L., Wang X., Liang C., Ding J., Meng L.H. Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR. Biochemical Pharmacology 2012, 83:1183-1194.
-
(2012)
Biochemical Pharmacology
, vol.83
, pp. 1183-1194
-
-
Chen, S.M.1
Liu, J.L.2
Wang, X.3
Liang, C.4
Ding, J.5
Meng, L.H.6
-
4
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
-
Choo A.Y., Yoon S.O., Kim S.G., Roux P.P., Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:17414-17419.
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
5
-
-
76549129820
-
Drug combination studies and their synergy quantification using the Chou-Talalay method
-
Chou T.-C. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Research 2010, 70:440-446.
-
(2010)
Cancer Research
, vol.70
, pp. 440-446
-
-
Chou, T.-C.1
-
6
-
-
33746622984
-
Strategies for optimizing combinations of molecularly targeted anticancer agents
-
Dancey J.E., Chen H.X. Strategies for optimizing combinations of molecularly targeted anticancer agents. Nature Reviews. Drug Discovery 2006, 5:649-659.
-
(2006)
Nature Reviews. Drug Discovery
, vol.5
, pp. 649-659
-
-
Dancey, J.E.1
Chen, H.X.2
-
7
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
L. Ding, G. Getz, D.A. Wheeler, E.R. Mardis, M.D. McLellan, K. Cibulskis, C. Sougnez, H. Greulich, D.M. Muzny, M.B. Morgan, L. Fulton, R.S. Fulton, Q. Zhang, M.C. Wendl, M.S. Lawrence, D.E. Larson, K. Chen, D.J. Dooling, A. Sabo, A.C. Hawes, H. Shen, S.N. Jhangiani, L.R. Lewis, O. Hall, Y. Zhu, T. Mathew, Y. Ren, J. Yao, S.E. Scherer, K. Clerc, G.A. Metcalf, B. Ng, A. Milosavljevic, M.L. Gonzalez-Garay, J.R. Osborne, R. Meyer, X. Shi, Y. Tang, D.C. Koboldt, L. Lin, R. Abbott, T.L. Miner, C. Pohl, G. Fewell, C. Haipek, H. Schmidt, B.H. Dunford-Shore, A. Kraja, S.D. Crosby, C.S. Sawyer, T. Vickery, S. Sander, J. Robinson, W. Winckler, J. Baldwin, L.R. Chirieac, A. Dutt, T. Fennell, M. Hanna, B.E. Johnson, R.C. Onofrio, R.K. Thomas, G. Tonon, B.A. Weir, X. Zhao, L. Ziaugra, M.C. Zody, T. Giordano, M.B. Orringer, J.A. Roth, M.R. Spitz, Wistuba, II, B. Ozenberger, P.J. Good, A.C. Chang, D.G. Beer, M.A. Watson, M. Ladanyi, S. Broderick, A. Yoshizawa, W.D. Travis, W. Pao, M.A. Province, G.M. Weinstock, H.E. Varmus, S.B. Gabriel, E.S. Lander, R.A. Gibbs, M. Meyerson, R.K. Wilson, Somatic mutations affect key pathways in lung adenocarcinoma, Nature 455 (2008) 1069-1075.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
Cibulskis, K.6
Sougnez, C.7
Greulich, H.8
Muzny, D.M.9
Morgan, M.B.10
Fulton, L.11
Fulton, R.S.12
Zhang, Q.13
Wendl, M.C.14
Lawrence, M.S.15
Larson, D.E.16
Chen, K.17
Dooling, D.J.18
Sabo, A.19
Hawes, A.C.20
Shen, H.21
Jhangiani, S.N.22
Lewis, L.R.23
Hall, O.24
Zhu, Y.25
Mathew, T.26
Ren, Y.27
Yao, J.28
Scherer, S.E.29
Clerc, K.30
Metcalf, G.A.31
Ng, B.32
Milosavljevic, A.33
Gonzalez-Garay, M.L.34
Osborne, J.R.35
Meyer, R.36
Shi, X.37
Tang, Y.38
Koboldt, D.C.39
Lin, L.40
Abbott, R.41
Miner, T.L.42
Pohl, C.43
Fewell, G.44
Haipek, C.45
Schmidt, H.46
Dunford-Shore, B.H.47
Kraja, A.48
Crosby, S.D.49
Sawyer, C.S.50
Vickery, T.51
Sander, S.52
Robinson, J.53
Winckler, W.54
Baldwin, J.55
Chirieac, L.R.56
Dutt, A.57
Fennell, T.58
Hanna, M.59
Johnson, B.E.60
Onofrio, R.C.61
Thomas, R.K.62
Tonon, G.63
Weir, B.A.64
Zhao, X.65
Ziaugra, L.66
Zody, M.C.67
Giordano, T.68
Orringer, M.B.69
Roth, J.A.70
Spitz, M.R.71
Wistuba II72
Ozenberger, B.73
Good, P.J.74
Chang, A.C.75
Beer, D.G.76
Watson, M.A.77
Ladanyi, M.78
Broderick, S.79
Yoshizawa, A.80
Travis, W.D.81
Pao, W.82
Province, M.A.83
Weinstock, G.M.84
Varmus, H.E.85
Gabriel, S.B.86
Lander, E.S.87
Gibbs, R.A.88
Meyerson, M.89
Wilson, R.K.90
more..
-
8
-
-
67749122122
-
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
-
Engelman J.A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nature Reviews. Cancer 2009, 9:550-562.
-
(2009)
Nature Reviews. Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
9
-
-
34548316976
-
Molecular basis for sunitinib efficacy and future clinical development
-
Faivre S., Demetri G., Sargent W., Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nature Reviews Drug Discovery 2007, 6:734-745.
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, pp. 734-745
-
-
Faivre, S.1
Demetri, G.2
Sargent, W.3
Raymond, E.4
-
10
-
-
77649268890
-
Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients
-
Ghayad S.E., Cohen P.A. Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent Patents on Anti-Cancer Drug Discovery 2010, 5:29-57.
-
(2010)
Recent Patents on Anti-Cancer Drug Discovery
, vol.5
, pp. 29-57
-
-
Ghayad, S.E.1
Cohen, P.A.2
-
11
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin D.A., Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
12
-
-
34548443831
-
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition
-
Holmes K., Roberts O.L., Thomas A.M., Cross M.J. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cellular Signalling 2007, 19:2003-2012.
-
(2007)
Cellular Signalling
, vol.19
, pp. 2003-2012
-
-
Holmes, K.1
Roberts, O.L.2
Thomas, A.M.3
Cross, M.J.4
-
13
-
-
23044439544
-
RAD001 (everolimus) improves the efficacy of replicating adenoviruses that target colon cancer
-
Homicsko K., Lukashev A., Iggo R.D. RAD001 (everolimus) improves the efficacy of replicating adenoviruses that target colon cancer. Cancer Research 2005, 65:6882-6890.
-
(2005)
Cancer Research
, vol.65
, pp. 6882-6890
-
-
Homicsko, K.1
Lukashev, A.2
Iggo, R.D.3
-
14
-
-
73949122305
-
Stage 2 combination testing of rapamycin with cytotoxic agents by the pediatric preclinical testing program
-
Houghton P.J., Morton C.L., Gorlick R., Lock R.B., Carol H., Reynolds C.P., Kang M.H., Maris J.M., Keir S.T., Kolb E.A., Wu J., Wozniak A.W., Billups C.A., Rubinstein L., Smith M.A. Stage 2 combination testing of rapamycin with cytotoxic agents by the pediatric preclinical testing program. Molecular Cancer Therapeutics 2010, 9:101-112.
-
(2010)
Molecular Cancer Therapeutics
, vol.9
, pp. 101-112
-
-
Houghton, P.J.1
Morton, C.L.2
Gorlick, R.3
Lock, R.B.4
Carol, H.5
Reynolds, C.P.6
Kang, M.H.7
Maris, J.M.8
Keir, S.T.9
Kolb, E.A.10
Wu, J.11
Wozniak, A.W.12
Billups, C.A.13
Rubinstein, L.14
Smith, M.A.15
-
15
-
-
40449091406
-
Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
-
Houghton P.J., Morton C.L., Kolb E.A., Gorlick R., Lock R., Carol H., Reynolds C.P., Maris J.M., Keir S.T., Billups C.A. Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatric Blood & Cancer 2008, 50:799-805.
-
(2008)
Pediatric Blood & Cancer
, vol.50
, pp. 799-805
-
-
Houghton, P.J.1
Morton, C.L.2
Kolb, E.A.3
Gorlick, R.4
Lock, R.5
Carol, H.6
Reynolds, C.P.7
Maris, J.M.8
Keir, S.T.9
Billups, C.A.10
-
16
-
-
59749091850
-
A complex interplay between Akt, TSC2, and the two mTOR complexes
-
Huang J., Manning B.D. A complex interplay between Akt, TSC2, and the two mTOR complexes. Biochemical Society Transactions 2009, 37:217.
-
(2009)
Biochemical Society Transactions
, vol.37
, pp. 217
-
-
Huang, J.1
Manning, B.D.2
-
17
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G., Carducci M., Tomczak P., Dutcher J., Figlin R., Kapoor A., Staroslawska E., Sosman J., McDermott D., Bodrogi I., Kovacevic Z., Lesovoy V., Schmidt-Wolf I.G., Barbarash O., Gokmen E., O'Toole T., Lustgarten S., Moore L., Motzer R.J., Global A.T. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. The New England Journal of Medicine 2007, 356:2271-2281.
-
(2007)
The New England Journal of Medicine
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
Global, A.T.20
more..
-
18
-
-
44649202112
-
Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
-
Huynh H., Chow P.K., Palanisamy N., Salto-Tellez M., Goh B.C., Lee C.K., Somani A., Lee H.S., Kalpana R., Yu K., Tan P.H., Wu J., Soong R., Lee M.H., Hor H., Soo K.C., Toh H.C., Tan P. Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. Journal of Hepatology 2008, 49:52-60.
-
(2008)
Journal of Hepatology
, vol.49
, pp. 52-60
-
-
Huynh, H.1
Chow, P.K.2
Palanisamy, N.3
Salto-Tellez, M.4
Goh, B.C.5
Lee, C.K.6
Somani, A.7
Lee, H.S.8
Kalpana, R.9
Yu, K.10
Tan, P.H.11
Wu, J.12
Soong, R.13
Lee, M.H.14
Hor, H.15
Soo, K.C.16
Toh, H.C.17
Tan, P.18
-
19
-
-
36749068988
-
Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
-
Huynh H., Teo C.C., Soo K.C. Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer. Molecular Cancer Therapeutics 2007, 6:2959-2966.
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, pp. 2959-2966
-
-
Huynh, H.1
Teo, C.C.2
Soo, K.C.3
-
20
-
-
79959278619
-
Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3
-
Kodera Y., Katanasaka Y., Kitamura Y., Tsuda H., Nishio K., Tamura T., Koizumi F. Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3. Breast Cancer Research 2011, 13:R66.
-
(2011)
Breast Cancer Research
, vol.13
-
-
Kodera, Y.1
Katanasaka, Y.2
Kitamura, Y.3
Tsuda, H.4
Nishio, K.5
Tamura, T.6
Koizumi, F.7
-
21
-
-
78049457409
-
Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements
-
Kummar S., Chen H.X., Wright J., Holbeck S., Millin M.D., Tomaszewski J., Zweibel J., Collins J., Doroshow J.H. Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements. Nature Reviews. Drug Discovery 2010, 9:843-856.
-
(2010)
Nature Reviews. Drug Discovery
, vol.9
, pp. 843-856
-
-
Kummar, S.1
Chen, H.X.2
Wright, J.3
Holbeck, S.4
Millin, M.D.5
Tomaszewski, J.6
Zweibel, J.7
Collins, J.8
Doroshow, J.H.9
-
22
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M., Sabatini D.M. MTOR signaling in growth control and disease. Cell 2012, 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
23
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
-
Motzer R.J., Escudier B., Oudard S., Hutson T.E., Porta C., Bracarda S., Grunwald V., Thompson J.A., Figlin R.A., Hollaender N., Urbanowitz G., Berg W.J., Kay A., Lebwohl D., Ravaud A., Group R.-S. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372:449-456.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
Grunwald, V.7
Thompson, J.A.8
Figlin, R.A.9
Hollaender, N.10
Urbanowitz, G.11
Berg, W.J.12
Kay, A.13
Lebwohl, D.14
Ravaud, A.15
Group, R.-S.16
-
24
-
-
70350655546
-
Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
-
Novello S., Scagliotti G.V., Rosell R., Socinski M.A., Brahmer J., Atkins J., Pallares C., Burgess R., Tye L., Selaru P., Wang E., Chao R., Govindan R. Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer. British Journal of Cancer 2009, 101:1543-1548.
-
(2009)
British Journal of Cancer
, vol.101
, pp. 1543-1548
-
-
Novello, S.1
Scagliotti, G.V.2
Rosell, R.3
Socinski, M.A.4
Brahmer, J.5
Atkins, J.6
Pallares, C.7
Burgess, R.8
Tye, L.9
Selaru, P.10
Wang, E.11
Chao, R.12
Govindan, R.13
-
25
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly K.E., Rojo F., She Q.-B., Solit D., Mills G.B., Smith D., Lane H., Hofmann F., Hicklin D.J., Ludwig D.L. MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Research 2006, 66:1500-1508.
-
(2006)
Cancer Research
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.-B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
-
26
-
-
70349637311
-
Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors
-
Soria J.C., Shepherd F.A., Douillard J.Y., Wolf J., Giaccone G., Crino L., Cappuzzo F., Sharma S., Gross S.H., Dimitrijevic S., Di Scala L., Gardner H., Nogova L., Papadimitrakopoulou V. Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Annals of Oncology: Official Journal of the European Society for Medical Oncology/ESMO 2009, 20:1674-1681.
-
(2009)
Annals of Oncology: Official Journal of the European Society for Medical Oncology/ESMO
, vol.20
, pp. 1674-1681
-
-
Soria, J.C.1
Shepherd, F.A.2
Douillard, J.Y.3
Wolf, J.4
Giaccone, G.5
Crino, L.6
Cappuzzo, F.7
Sharma, S.8
Gross, S.H.9
Dimitrijevic, S.10
Di Scala, L.11
Gardner, H.12
Nogova, L.13
Papadimitrakopoulou, V.14
-
27
-
-
6044243632
-
Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer
-
Stephan S., Datta K., Wang E., Li J., Brekken R.A., Parangi S., Thorpe P.E., Mukhopadhyay D. Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 2004, 10:6993-7000.
-
(2004)
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
, vol.10
, pp. 6993-7000
-
-
Stephan, S.1
Datta, K.2
Wang, E.3
Li, J.4
Brekken, R.A.5
Parangi, S.6
Thorpe, P.E.7
Mukhopadhyay, D.8
-
28
-
-
84876788448
-
A phase I trial of sunitinib and rapamycin in patients with advanced non-small cell lung cancer
-
Waqar S.N., Gopalan P.K., Williams K., Devarakonda S., Govindan R. A phase I trial of sunitinib and rapamycin in patients with advanced non-small cell lung cancer. Chemotherapy 2013, 59:8-13.
-
(2013)
Chemotherapy
, vol.59
, pp. 8-13
-
-
Waqar, S.N.1
Gopalan, P.K.2
Williams, K.3
Devarakonda, S.4
Govindan, R.5
-
29
-
-
79958816470
-
The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo
-
Xu C.X., Li Y., Yue P., Owonikoko T.K., Ramalingam S.S., Khuri F.R., Sun S.Y. The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo. PloS One 2011, 6:e20899.
-
(2011)
PloS One
, vol.6
-
-
Xu, C.X.1
Li, Y.2
Yue, P.3
Owonikoko, T.K.4
Ramalingam, S.S.5
Khuri, F.R.6
Sun, S.Y.7
-
30
-
-
51449095342
-
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises
-
Yap T.A., Garrett M.D., Walton M.I., Raynaud F., de Bono J.S., Workman P. Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Current Opinion in Pharmacology 2008, 8:393-412.
-
(2008)
Current Opinion in Pharmacology
, vol.8
, pp. 393-412
-
-
Yap, T.A.1
Garrett, M.D.2
Walton, M.I.3
Raynaud, F.4
de Bono, J.S.5
Workman, P.6
|