Modified spleen stiffness measurement by transient elastography is associated with presence of large oesophageal varices in patients with compensated hepatitis C virus cirrhosis

Journal of Viral Hepatitis

Volumn 20, Issue 12, 2013, Pages 867-874

  Calvaruso, V ^a   Bronte, F ^a   Conte, E ^a   Simone, F ^a   Craxi A ^a   Di Marco, V ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

cirrhosis; liver stiffness; oesophageal varices; spleen stiffness; transient elastography

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ELASTOGRAPHY; ESOPHAGUS VARICES; FEMALE; GASTROINTESTINAL ENDOSCOPY; HEPATITIS C VIRUS; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PORTAL HYPERTENSION; PRIORITY JOURNAL; RADIOGRAPHY DEVICE; SENSITIVITY AND SPECIFICITY; SPLEEN; THROMBOCYTE; TRANSIENT ELASTOGRAPHY;

CIRRHOSIS; LIVER STIFFNESS; OESOPHAGEAL VARICES; SPLEEN STIFFNESS; TRANSIENT ELASTOGRAPHY;

ADULT; AGED; BIOLOGICAL MARKERS; ELASTICITY IMAGING TECHNIQUES; ESOPHAGEAL AND GASTRIC VARICES; FEMALE; FIBROSIS; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; SPLEEN; VARICOSE VEINS;

EID: 84887609829     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12114     Document Type: Article

References (30)

1. Ghany MG, Strader DB, Thomas DL, et al,. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009; 49: 1335-1374.
2. Bedossa P, Carrat F,. Liver biopsy: the best, not the gold standard. J Hepatol 2009; 50: 1-3.
3. de Franchis R,. Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2005; 43: 167-176.
4. Garcia-Tsao G, Bosch J, Groszmann RJ,. Portal hypertension and variceal bleeding-unresolved issues. Summary of an American Association for the study of liver diseases and European Association for the study of the liver single-topic conference. Hepatology 2008; 47: 1764-1772.
5. Rockey DC, Bissell DM,. Noninvasive measures of liver fibrosis. Hepatology 2006; 43: S113-S120.
6. Castera L,. Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis. J Viral Hepat 2009; 16: 300-314.
7. Bosch J,. Towards the non-invasive diagnosis of cirrhosis: the nuts-cirrhosis connection. J Hepatol 2009; 50: 4-6.
8. de Franchis R,. Non-invasive (and minimally invasive) diagnosis of oesophageal varices. J Hepatol 2008; 49: 520-527.
9. Foucher J, Chanteloup E, Vergniol J, et al,. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 2006; 55: 403-408.
10. Ganne-Carrie′ N, Ziol M, de Ledinghen V, et al,. Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases. Hepatology 2006; 44: 1511-1517.
11. Castéra L, Le Bail B, Roudot-Thoraval F, et al,. Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores. J Hepatol 2009; 50: 59-68.
12. Friedrich-Rust M, Ong MF, Martens S, et al,. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 2008; 134: 960-974.
13. Talwalkar JA, Kurtz DM, Schoenleber SJ, et al,. Ultrasound-based transient elastography for the detection of hepatic fibrosis: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2007; 5: 1214-1220.
14. Vizzutti F, Arena U, Romanelli RG, et al,. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology 2007; 45: 1290-1297.
15. Bureau C, Metivier S, Peron JM, et al,. Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease. Aliment Pharmacol Ther 2008; 27: 1261-1268.
16. Kazemi F, Kettaneh A, N'Kontchou G, et al,. Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices. J Hepatol 2006; 45: 230-235.
17. Lackner C, Struber G, Liegl B, et al,. Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C. Hepatology 2005; 41: 1376-1382.
18. Schepis F, Camma' C, Niceforo D, et al,. Which patients should undergo endoscopic screening for oesophageal varices detection? Hepatology 2001; 33: 333-338.
19. Giannini E, Botta F, Borro P, et al,. Platelet count/spleen diameter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis. Gut 2003; 52: 1200-1205.
20. Giannini E, Zaman A, Kreil A, et al,. Platelet count/spleen diameter ratio for the non invasive diagnosis of oesophageal varices. Results of a multicenter, prospective, validation study. Am J Gastroenterol 2006; 101: 2511-2519.
21. Manenti F, Williams R,. Injection studies of the splenic vasculature in portal hypertension. Gut 1966; 7: 175-180.
22. Bolognesi M, Merkel C, Sacerdoti D, et al,. Role of spleen enlargement in cirrhosis with portal hypertension. Dig Liver Dis 2002; 34: 144-150.
23. Piscaglia F, Zironi G, Gaiani S, et al,. Systemic and splanchnic hemodynamic changes after liver transplantation for cirrhosis: a long-term prospective study. Hepatology 1999; 30: 58-64.
24. Bolognesi M, Sacerdoti D, Bombonato G, et al,. A. Change in portal flow after liver transplantation: effect on hepatic arterial resistance indices and role of spleen size. Hepatology 2002; 35: 601-608.
25. Sandrin L, Fourquet B, Hasquenoph JM, et al,. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29: 1705-1713.
26. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med 1988; 319: 983-989.
27. Thabut D, Moreau R, Lebrec D,. Noninvasive assessment of portal hypertension in patients with cirrhosis. Hepatology 2011; 53 (2): 683-694.
28. Cammà C, Petta S, Di Marco V, et al,. Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis. Hepatology 2009; 49: 195-203.
29. Stefanescu H, Grigorescu M, Lupsor M, Procopet B, Maniu A, Badea R,. Spleen stiffness measurement using Fibroscan for the noninvasive assessment of esophageal varices in liver cirrhosis patients. J Gastroenterol Hepatol 2011; 26 (1): 164-170.
30. Colecchia A, Montrone L, Scaioli E, et al,. Measurement of spleen stiffness to evaluate portal hypertension and the presence of esophageal varices in patients with HCV-related cirrhosis. Gastroenterology. 2012; 143 (3): 646-654.