Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient

International Journal of Medical Microbiology

Volumn 303, Issue 8, 2013, Pages 693-696

  Navarro, Yurena ^a,b,c,d   Pérez Lago, Laura ^a,b,d   Sislema, Fernanda ^a,b   Herranz, Marta ^a,b,d   de Juan, Lucía ^c   Bouza, Emilio ^a,b,c,d   García de Viedma, Darío ^a,b,c,d  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Clonal variants; Infectivity; Mycobacterium tuberculosis

Indexed keywords

ALLELE; ARTICLE; CLONAL VARIATION; HUMAN; IN VITRO STUDY; LUNG TUBERCULOSIS; MACROPHAGE; MIXED INFECTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE;

CLONAL VARIANTS; INFECTIVITY; MYCOBACTERIUM TUBERCULOSIS;

BLOOD; GENETIC VARIATION; GENOTYPE; HUMANS; MOLECULAR TYPING; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SPUTUM; TUBERCULOSIS; URINE;

EID: 84887606464     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2013.10.002     Document Type: Article

References (9)

1. Akhtar P., Singh S., Bifani P., Kaur S., Srivastava B.S., Srivastava R. Variable-number tandem repeat 3690 polymorphism in Indian clinical isolates of Mycobacterium tuberculosis and its influence on transcription. J. Med. Microbiol. 2009, 58:798-805.
2. Al-Hajoj S.A., Akkerman O., Parwati I., al-Gamdi S., Rahim Z., van Soolingen D., van Ingen J., Supply P., van der Zanden A.G. Microevolution of Mycobacterium tuberculosis in a tuberculosis patient. J. Clin. Microbiol. 2010, 48:3813-3816.
3. Brites D., Gagneux S. Old and new selective pressures on Mycobacterium tuberculosis. Infect. Genet. Evol. 2012, 12:678-685.
4. Cohen T., van Helden P.D., Wilson D., Colijn C., McLaughlin M.M., Abubakar I., Warren R.M. Mixed-strain Mycobacterium tuberculosis infections and the implications for tuberculosis treatment and control. Clin. Microbiol. Rev. 2012, 25:708-719.
5. Garcia de Viedma D., Lorenzo G., Cardona P.J., Rodriguez N.A., Gordillo S., Serrano M.J., Bouza E. Association between the infectivity of Mycobacterium tuberculosis strains and their efficiency for extrarespiratory infection. J. Infect. Dis. 2005, 192:2059-2065.
6. Navarro Y., Herranz M., Perez-Lago L., Martinez Lirola M., Ruiz-Serrano M.J., Bouza E., Garcia de Viedma D. Systematic survey of clonal complexity in tuberculosis at a populational level and detailed characterization of the isolates involved. J. Clin. Microbiol. 2011, 49:4131-4137.
7. Perez-Lago L., Herranz M., Lirola M.M., Bouza E., Garcia de Viedma D. Characterization of microevolution events in Mycobacterium tuberculosis strains involved in recent transmission clusters. J. Clin. Microbiol. 2011, 49:3771-3776.
8. Tantivitayakul P., Panapruksachat S., Billamas P., Palittapongarnpim P. Variable number of tandem repeat sequences act as regulatory elements in Mycobacterium tuberculosis. Tuberculosis (Edinb.) 2010, 90:311-318.
9. Yokobori N., Lopez B., Geffner L., Sabio Y.G.C., Schierloh P., Barrera L., de la Barrera S., Sakai S., Kawamura I., Mitsuyama M., Ritacco V., Del Carmen Sasiain M. Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models. Infect. Genet. Evol. 2013, 16C:151-156.