메뉴 건너뛰기




Volumn 45, Issue 22, 2013, Pages 1060-1071

Pancreastatin is an endogenous peptide that regulates glucose homeostasis

Author keywords

Chromogranin A; G protein; Insulin; Pancreastatin; Protein kinase C; Type 2 diabetes

Indexed keywords

CALCIUM; CHROMOGRANIN A; CYCLIC GMP; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCOGEN; HUMAN PANCREASTATIN; INSULIN; LACTIC ACID; LEPTIN; LIPID; NITRIC OXIDE; PANCREASTATIN; PARATHYROID HORMONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOLIPASE C BETA3; PROTEIN KINASE C; RECOMBINANT PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

EID: 84887601829     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00131.2013     Document Type: Review
Times cited : (25)

References (89)
  • 1
    • 0029890698 scopus 로고    scopus 로고
    • Immunohistochemical identification and effects of atrial natriuretic peptide, pancreastatin, leucine-enkephalin, and galanin in the porcine pancreas
    • Adeghate E, Ember Z, Donath T, Pallot DJ, Singh J. Immunohistochemical identification and effects of atrial natriuretic peptide, pancreastatin, leucine-enkephalin, and galanin in the porcine pancreas. Peptides 17: 503-509, 1996.
    • (1996) Peptides , vol.17 , pp. 503-509
    • Adeghate, E.1    Ember, Z.2    Donath, T.3    Pallot, D.J.4    Singh, J.5
  • 2
    • 0028293982 scopus 로고
    • The post-translational processing of chromogranin A in the pancreatic islet: Involvement of the eukaryote subtilisin PC2
    • Arden SD, Rutherford NG, Guest PC, Curry WJ, Bailyes EM, Johnston CF, Hutton JC. The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2. Biochem J 298: 521-528, 1994.
    • (1994) Biochem J , vol.298 , pp. 521-528
    • Arden, S.D.1    Rutherford, N.G.2    Guest, P.C.3    Curry, W.J.4    Bailyes, E.M.5    Johnston, C.F.6    Hutton, J.C.7
  • 3
    • 23644442552 scopus 로고    scopus 로고
    • ATP-sensitive potassium channelopathies: Focus on insulin secretion
    • Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest 115: 2047-2058, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2047-2058
    • Ashcroft, F.M.1
  • 4
    • 0021741559 scopus 로고
    • Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells
    • Ashcroft FM, Harrison DE, Ashcroft SJ. Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Nature 312: 446-448, 1984.
    • (1984) Nature , vol.312 , pp. 446-448
    • Ashcroft, F.M.1    Harrison, D.E.2    Ashcroft, S.J.3
  • 6
    • 0037024637 scopus 로고    scopus 로고
    • Studies of the dysglycemic peptide, pancreastatin, using a human forearm model
    • Cadman PE, Rao F, Mahata SK, O'Connor DT. Studies of the dysglycemic peptide, pancreastatin, using a human forearm model. Ann NY Acad Sci 971: 528-529, 2006.
    • (2006) Ann NY Acad Sci , vol.971 , pp. 528-529
    • Cadman, P.E.1    Rao, F.2    Mahata, S.K.3    O'Connor, D.T.4
  • 7
    • 29044440372 scopus 로고    scopus 로고
    • Signalling mechanisms regulating lipolysis
    • Carmen GY, Víctor SM. Signalling mechanisms regulating lipolysis. Cell Signal 18: 401-408, 2006.
    • (2006) Cell Signal , vol.18 , pp. 401-408
    • Carmen, G.Y.1    Víctor, S.M.2
  • 8
    • 9944227667 scopus 로고    scopus 로고
    • eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells
    • Díaz-Troya S, Najib S, Sánchez-Margalet V. eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells. Regul Pept 125: 41-46, 2005.
    • (2005) Regul Pept , vol.125 , pp. 41-46
    • Díaz-Troya, S.1    Najib, S.2    Sánchez-Margalet, V.3
  • 9
    • 0026588529 scopus 로고
    • Pancreastatin and bovine parathyroid cell secretion
    • Drees BM, Hamilton JW. Pancreastatin and bovine parathyroid cell secretion. Bone Miner 17: 335-346, 1992.
    • (1992) Bone Miner , vol.17 , pp. 335-346
    • Drees, B.M.1    Hamilton, J.W.2
  • 10
    • 84857111394 scopus 로고    scopus 로고
    • Characterization of major elements of insulin signaling cascade in chicken adipose tissue: Apparent insulin refractoriness
    • Dupont J, Metayer-Coustard S, Ji B, Rame C, Gespach C, Voy B, Simon J. Characterization of major elements of insulin signaling cascade in chicken adipose tissue: apparent insulin refractoriness. Gen Comp Endocrinol 176: 86-93, 2012.
    • (2012) Gen Comp Endocrinol , vol.176 , pp. 86-93
    • Dupont, J.1    Metayer-Coustard, S.2    Ji, B.3    Rame, C.4    Gespach, C.5    Voy, B.6    Simon, J.7
  • 12
    • 0023662168 scopus 로고
    • Is chromogranin a prohormone?
    • Eiden LE. Is chromogranin a prohormone? Nature 325: 301, 1987.
    • (1987) Nature , vol.325 , pp. 301
    • Eiden, L.E.1
  • 13
    • 0030016321 scopus 로고    scopus 로고
    • Chromogranin A processing and secretion: Specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway
    • Eskeland NL, Zhou A, Dinh TQ, Wu H, Parmer RJ, Mains RE, O'Connor DT. Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway. J Clin Invest 98: 148-156, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 148-156
    • Eskeland, N.L.1    Zhou, A.2    Dinh, T.Q.3    Wu, H.4    Parmer, R.J.5    Mains, R.E.6    O'Connor, D.T.7
  • 14
    • 0025078121 scopus 로고
    • Autocrine regulation of parathyroid secretion: Inhibition of secretion by chromogranin-A (secretory protein-I) and potentiation of secretion by chromogranin-A and pancreastatin antibodies
    • Fasciotto BH, Gorr SU, Bourdeau AM, Cohn DV. Autocrine regulation of parathyroid secretion: inhibition of secretion by chromogranin-A (secretory protein-I) and potentiation of secretion by chromogranin-A and pancreastatin antibodies. Endocrinology 127: 1329-1335, 1990.
    • (1990) Endocrinology , vol.127 , pp. 1329-1335
    • Fasciotto, B.H.1    Gorr, S.U.2    Bourdeau, A.M.3    Cohn, D.V.4
  • 15
    • 0024422723 scopus 로고
    • Pancreastatin, a presumed product of chromogranin-A (secretory protein-I) processing, inhibits secretion from porcine parathyroid cells in culture
    • Fasciotto BH, Gorr SU, Defranco DJ, Levine MA, Cohn DV. Pancreastatin, a presumed product of chromogranin-A (secretory protein-I) processing, inhibits secretion from porcine parathyroid cells in culture. Endocrinology 125: 1617-1622, 1989.
    • (1989) Endocrinology , vol.125 , pp. 1617-1622
    • Fasciotto, B.H.1    Gorr, S.U.2    Defranco, D.J.3    Levine, M.A.4    Cohn, D.V.5
  • 18
    • 0024600456 scopus 로고
    • Effect of pancreastatin on pancreatic endocrine function in the conscious rat
    • Funakoshi A, Miyasaka K, Kitani K, Tatemoto K. Effect of pancreastatin on pancreatic endocrine function in the conscious rat. Regul Pept 24: 225-231, 1989.
    • (1989) Regul Pept , vol.24 , pp. 225-231
    • Funakoshi, A.1    Miyasaka, K.2    Kitani, K.3    Tatemoto, K.4
  • 19
    • 0025079968 scopus 로고
    • Elevated plasma levels of pancreastatin (PST) in patients with non-insulindependent diabetes mellitus (NIDDM)
    • Funakoshi A, Tateishi K, Shinozaki H, Matsumoto M, Wakasugi H. Elevated plasma levels of pancreastatin (PST) in patients with non-insulindependent diabetes mellitus (NIDDM). Regul Pept 30: 159-164, 1990.
    • (1990) Regul Pept , vol.30 , pp. 159-164
    • Funakoshi, A.1    Tateishi, K.2    Shinozaki, H.3    Matsumoto, M.4    Wakasugi, H.5
  • 22
    • 0036930158 scopus 로고    scopus 로고
    • Pancreastatin, a chromogranin A-derived peptide, activates protein synthesis signaling cascade in rat adipocytes
    • González-Yanes C, Sánchez-Margalet V. Pancreastatin, a chromogranin A-derived peptide, activates protein synthesis signaling cascade in rat adipocytes. Biochem Biophys Res Commun 299: 525-531, 2002.
    • (2002) Biochem Biophys Res Commun , vol.299 , pp. 525-531
    • González-Yanes, C.1    Sánchez-Margalet, V.2
  • 23
    • 0347361462 scopus 로고    scopus 로고
    • Pancreastatin, a chromogranin A-derived peptide, inhibits leptin and enhances UCP-2 expression in isolated rat adipocytes
    • Gonzalez-Yanes C, Sanchez-Margalet V. Pancreastatin, a chromogranin A-derived peptide, inhibits leptin and enhances UCP-2 expression in isolated rat adipocytes. Cell Mol Life Sci 60: 2749-2756, 2003.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 2749-2756
    • Gonzalez-Yanes, C.1    Sanchez-Margalet, V.2
  • 24
    • 0033853606 scopus 로고    scopus 로고
    • Pancreastatin modulates insulin signaling in rat adipocytes: Mechanisms of cross-talk
    • González-Yanes C, Sánchez-Margalet V. Pancreastatin modulates insulin signaling in rat adipocytes: mechanisms of cross-talk. Diabetes 49: 1288-1294, 2000.
    • (2000) Diabetes , vol.49 , pp. 1288-1294
    • González-Yanes, C.1    Sánchez-Margalet, V.2
  • 25
    • 0035940972 scopus 로고    scopus 로고
    • Pancreastatin, a chromogranin-A-derived peptide, inhibits insulin-stimulated glycogen synthesis by activating GSK-3 in rat adipocytes
    • González-Yanes C, Sánchez-Margalet V. Pancreastatin, a chromogranin-A-derived peptide, inhibits insulin-stimulated glycogen synthesis by activating GSK-3 in rat adipocytes. Biochem Biophys Res Commun 289: 282-287, 2001.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 282-287
    • González-Yanes, C.1    Sánchez-Margalet, V.2
  • 28
    • 0028907440 scopus 로고
    • Circulating pancreastatin is a marker for the enterochromaffin-like cells of the rat stomach
    • Håkanson R, Ding XQ, Norlén P, Chen D. Circulating pancreastatin is a marker for the enterochromaffin-like cells of the rat stomach. Gastroenterology 108: 1445-1452, 1995.
    • (1995) Gastroenterology , vol.108 , pp. 1445-1452
    • Håkanson, R.1    Ding, X.Q.2    Norlén, P.3    Chen, D.4
  • 30
    • 9644276789 scopus 로고    scopus 로고
    • The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: Comparative and functional aspects
    • Helle KB. The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects. Biol Rev Camb Philos Soc 79: 769-794, 2004.
    • (2004) Biol Rev Camb Philos Soc , vol.79 , pp. 769-794
    • Helle, K.B.1
  • 31
    • 0029940888 scopus 로고    scopus 로고
    • Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calciumdirected exocytosis
    • Hertelendy Z, Patel D, Knittel J. Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calciumdirected exocytosis. Cell Calcium 19: 125-132, 1996.
    • (1996) Cell Calcium , vol.19 , pp. 125-132
    • Hertelendy, Z.1    Patel, D.2    Knittel, J.3
  • 32
    • 0026588713 scopus 로고
    • Pancreastatin inhibits pancreatic enzyme secretion by presynaptic modulation of acetylcholine release
    • Herzig KH, Louie DS, Tatemoto K, Chung O. Pancreastatin inhibits pancreatic enzyme secretion by presynaptic modulation of acetylcholine release. Am J Physiol Gastrointest Liver Physiol 262: G113-G117, 1992.
    • (1992) Am J Physiol Gastrointest Liver Physiol , vol.262
    • Herzig, K.H.1    Louie, D.S.2    Tatemoto, K.3    Chung, O.4
  • 33
    • 0023662174 scopus 로고
    • Chromogranin A and pancreastatin
    • Huttner WB, Benedum U. Chromogranin A and pancreastatin. Nature 325: 305, 1987.
    • (1987) Nature , vol.325 , pp. 305
    • Huttner, W.B.1    Benedum, U.2
  • 34
    • 0023787513 scopus 로고
    • The molecular cloning of the chromogranin A-like precursor of β-granin and pancreastatin from the endocrine pancreas
    • Hutton JC, Nielsen E, Kastern W. The molecular cloning of the chromogranin A-like precursor of β-granin and pancreastatin from the endocrine pancreas. FEBS Lett 236: 269-274, 1988.
    • (1988) FEBS Lett , vol.236 , pp. 269-274
    • Hutton, J.C.1    Nielsen, E.2    Kastern, W.3
  • 35
    • 81255153657 scopus 로고    scopus 로고
    • Engaging people with diabetes in the post-summit world
    • Keeling A. Engaging people with diabetes in the post-summit world. Diabetes Res Clin Pr 94: 305, 2011.
    • (2011) Diabetes Res Clin Pr , vol.94 , pp. 305
    • Keeling, A.1
  • 36
    • 0023555747 scopus 로고
    • The primary structure of human chromogranin A and pancreastatin
    • Konecki DS, Benedum UM, Gerdes HH, Huttner W. The primary structure of human chromogranin A and pancreastatin. J Biol Chem 262: 17026-17030, 1987.
    • (1987) J Biol Chem , vol.262 , pp. 17026-17030
    • Konecki, D.S.1    Benedum, U.M.2    Gerdes, H.H.3    Huttner, W.4
  • 37
    • 0024211337 scopus 로고
    • Pancreastatin: A novel peptide inhibitor of parietal cell secretion
    • Lewis J, Zdon M, Adrian T, Modlin I. Pancreastatin: a novel peptide inhibitor of parietal cell secretion. Surgery 104: 1031, 1988.
    • (1988) Surgery , vol.104 , pp. 1031
    • Lewis, J.1    Zdon, M.2    Adrian, T.3    Modlin, I.4
  • 41
    • 0027436425 scopus 로고
    • Intracellular and extracellular processing of chromogranin A Determination of cleavage sites
    • Metz-Boutigue MH, Garcia-Sablone P, Hogue-Angeletti R, Aunis D. Intracellular and extracellular processing of chromogranin A. Determination of cleavage sites. Eur J Biochem 217: 247-257, 1993.
    • (1993) Eur J Biochem , vol.217 , pp. 247-257
    • Metz-Boutigue, M.H.1    Garcia-Sablone, P.2    Hogue-Angeletti, R.3    Aunis, D.4
  • 42
    • 0024377053 scopus 로고
    • Effects of porcine pancreastatin on postprandial pancreatic exocrine secretion and endocrine functions in the conscious rat
    • Miyasaka K, Funakoshi A, Nakamura R, Kitani K, Shimizu F, Tatemoto K. Effects of porcine pancreastatin on postprandial pancreatic exocrine secretion and endocrine functions in the conscious rat. Digestion 43: 204-211, 1989.
    • (1989) Digestion , vol.43 , pp. 204-211
    • Miyasaka, K.1    Funakoshi, A.2    Nakamura, R.3    Kitani, K.4    Shimizu, F.5    Tatemoto, K.6
  • 46
    • 24344487170 scopus 로고    scopus 로고
    • Pancreastatin: Multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism
    • O'Connor DT, Cadman PE, Smiley C, Salem RM, Rao F, Smith J, Funk SD, Mahata SK, Mahata M, Wen G. Pancreastatin: multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism. J Clin Endocrinol Metab 90: 5414-5425, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5414-5425
    • O'Connor, D.T.1    Cadman, P.E.2    Smiley, C.3    Salem, R.M.4    Rao, F.5    Smith, J.6    Funk, S.D.7    Mahata, S.K.8    Mahata, M.9    Wen, G.10
  • 47
    • 0024952071 scopus 로고
    • Effect of porcine pancreastatin on endocrine function of canine pancreas
    • Ohneda A, Koizumi F, Ohneda M. Effect of porcine pancreastatin on endocrine function of canine pancreas. Tohoku J Exp Med 159: 291-298, 1989.
    • (1989) Tohoku J Exp Med , vol.159 , pp. 291-298
    • Ohneda, A.1    Koizumi, F.2    Ohneda, M.3
  • 48
    • 0024349911 scopus 로고
    • Pancreastatin inhibits insulin secretion as induced by glucagon, vasoactive intestinal peptide, gastric inhibitory peptide, and 8-cholecystokinin in the perfused rat pancreas
    • Peiro E, Miralles P, Silvestre RA, Villanueva ML, Marco J. Pancreastatin inhibits insulin secretion as induced by glucagon, vasoactive intestinal peptide, gastric inhibitory peptide, and 8-cholecystokinin in the perfused rat pancreas. Metabolism 38: 679-682, 1989.
    • (1989) Metabolism , vol.38 , pp. 679-682
    • Peiro, E.1    Miralles, P.2    Silvestre, R.A.3    Villanueva, M.L.4    Marco, J.5
  • 49
    • 84867336668 scopus 로고    scopus 로고
    • Study of the involvement of pancreastatin in the physiopathology of diabetes mellitus associated with nonsecreting pituitary adenomas
    • Prévost G, Eas F, Duparc C, Cauliez B, Laquérrière A, Fréger P, Lefebvre H, Kuhn J. Study of the involvement of pancreastatin in the physiopathology of diabetes mellitus associated with nonsecreting pituitary adenomas. Horm Metab Res 42: 861-865, 2012.
    • (2012) Horm Metab Res , vol.42 , pp. 861-865
    • Prévost, G.1    Eas, F.2    Duparc, C.3    Cauliez, B.4    Laquérrière, A.5    Fréger, P.6    Lefebvre, H.7    Kuhn, J.8
  • 50
    • 0028334622 scopus 로고
    • Pancreastatin activates pertussis-toxin-sensitive guanylate cyclase and pertussis-toxin-insensitive phospholipase C in rat liver membranes
    • Sánchez-Margalet V, Goberna R. Pancreastatin activates pertussis-toxin-sensitive guanylate cyclase and pertussis-toxin-insensitive phospholipase C in rat liver membranes. J Cell Biochem 55: 173-181, 1994.
    • (1994) J Cell Biochem , vol.55 , pp. 173-181
    • Sánchez-Margalet, V.1    Goberna, R.2
  • 51
    • 0028290630 scopus 로고
    • Pancreastatin inhibits insulin-stimulated glycogen synthesis but not glycolysis in rat hepatocytes
    • Sánchez-Margalet V, Goberna R. Pancreastatin inhibits insulin-stimulated glycogen synthesis but not glycolysis in rat hepatocytes. Regul Pept 51: 215-220, 1994.
    • (1994) Regul Pept , vol.51 , pp. 215-220
    • Sánchez-Margalet, V.1    Goberna, R.2
  • 53
    • 0034933529 scopus 로고    scopus 로고
    • Pancreastatin, a chromogranin A-derived peptide, inhibits DNA and protein synthesis by producing nitric oxide in HTC rat hepatoma cells
    • Sánchez-Margalet V, González-Yanes C, Najib S. Pancreastatin, a chromogranin A-derived peptide, inhibits DNA and protein synthesis by producing nitric oxide in HTC rat hepatoma cells. J Hepatol 35: 80-85, 2001.
    • (2001) J Hepatol , vol.35 , pp. 80-85
    • Sánchez-Margalet, V.1    González-Yanes, C.2    Najib, S.3
  • 56
    • 0343586506 scopus 로고    scopus 로고
    • Pancreastatin action in the liver: Dual coupling to different G proteins
    • Sánchez-Margalet V, Lucas M, Goberna R. Pancreastatin action in the liver: dual coupling to different G proteins. Cell Signal 8: 9-12, 1996.
    • (1996) Cell Signal , vol.8 , pp. 9-12
    • Sánchez-Margalet, V.1    Lucas, M.2    Goberna, R.3
  • 57
    • 0027989701 scopus 로고
    • Pancreastatin activates protein kinase C by stimulating the formation of 1, 2-diacylglycerol in rat hepatocytes
    • Sánchez-Margalet V, Lucas M, Goberna R. Pancreastatin activates protein kinase C by stimulating the formation of 1, 2-diacylglycerol in rat hepatocytes. Biochem J 303: 51, 1994.
    • (1994) Biochem J , vol.303 , pp. 51
    • Sánchez-Margalet, V.1    Lucas, M.2    Goberna, R.3
  • 59
    • 0027305365 scopus 로고
    • + in rat hepatocytes, involving both pertussis-toxin-sensitive and-insensitive mechanisms
    • + in rat hepatocytes, involving both pertussis-toxin-sensitive and-insensitive mechanisms. Biochem J 294: 439-442, 1993.
    • (1993) Biochem J , vol.294 , pp. 439-442
    • Sánchez-Margalet, V.1    Lucas, M.2    Goberna, R.3
  • 60
    • 0030909930 scopus 로고    scopus 로고
    • Solubilization and molecular characterization of active pancreastatin receptors from rat liver membranes
    • Sánchez-Margalet V, Santos-Álvarez J. Solubilization and molecular characterization of active pancreastatin receptors from rat liver membranes. Endocrinology 138: 1712-1718, 1997.
    • (1997) Endocrinology , vol.138 , pp. 1712-1718
    • Sánchez-Margalet, V.1    Santos-Álvarez, J.2
  • 62
    • 0028141395 scopus 로고
    • Receptors for pancreastatin in rat liver membranes: Molecular identification and characterization by covalent cross-linking
    • Sanchez-Margalet V, Valle M, Goberna R. Receptors for pancreastatin in rat liver membranes: molecular identification and characterization by covalent cross-linking. Mol Pharmacol 46: 24-29, 1994.
    • (1994) Mol Pharmacol , vol.46 , pp. 24-29
    • Sanchez-Margalet, V.1    Valle, M.2    Goberna, R.3
  • 63
    • 0029115684 scopus 로고
    • Plasma pancreastatin-like immunoreactivity correlates with plasma norepinephrine levels in essential hypertension
    • Sánchez-Margalet V, Valle M, Lobón J, Escobar-Jimenez F, Perez-Cano R, Goberna R. Plasma pancreastatin-like immunoreactivity correlates with plasma norepinephrine levels in essential hypertension. Neuropeptides 29: 97-101, 1995.
    • (1995) Neuropeptides , vol.29 , pp. 97-101
    • Sánchez-Margalet, V.1    Valle, M.2    Lobón, J.3    Escobar-Jimenez, F.4    Perez-Cano, R.5    Goberna, R.6
  • 65
    • 0025267140 scopus 로고
    • Glycogenolytic effect of pancreastatin in the rat
    • Sanchez V, Calvo JR, Goberna R. Glycogenolytic effect of pancreastatin in the rat. Biosci Rep 10: 87-91, 1990.
    • (1990) Biosci Rep , vol.10 , pp. 87-91
    • Sanchez, V.1    Calvo, J.R.2    Goberna, R.3
  • 67
    • 0031938027 scopus 로고    scopus 로고
    • Pancreastatin receptor is coupled to a guanosine triphosphate-binding protein of the Gg/11α family in rat liver membranes
    • Santos-Álvarez J, González-Yanes C, Sánchez-Margalet V. Pancreastatin receptor is coupled to a guanosine triphosphate-binding protein of the Gg/11α family in rat liver membranes. Hepatology 27: 608-614, 1998.
    • (1998) Hepatology , vol.27 , pp. 608-614
    • Santos-Álvarez, J.1    González-Yanes, C.2    Sánchez-Margalet, V.3
  • 68
    • 0032566262 scopus 로고    scopus 로고
    • Pancreastatin activates b3 isoform of phospholipase C via Ga11 protein stimulation in rat liver membranes
    • Santos-Alvarez J, Sanchez-Margalet V. Pancreastatin activates b3 isoform of phospholipase C via Ga11 protein stimulation in rat liver membranes. Mol Cell Endocrinol 143: 101-106, 1998.
    • (1998) Mol Cell Endocrinol , vol.143 , pp. 101-106
    • Santos-Alvarez, J.1    Sanchez-Margalet, V.2
  • 69
    • 0342657062 scopus 로고    scopus 로고
    • Affinity purification of pancreastatin receptor-Gq/11 protein complex from rat liver membranes
    • Santos-Alvarez J, Sánchez-Margalet V. Affinity purification of pancreastatin receptor-Gq/11 protein complex from rat liver membranes. Arch Biochem Biophys 378: 151-156, 2000.
    • (2000) Arch Biochem Biophys , vol.378 , pp. 151-156
    • Santos-Alvarez, J.1    Sánchez-Margalet, V.2
  • 70
    • 0344654769 scopus 로고    scopus 로고
    • G protein Gαq/11 and Gαi1, 2 are activated by pancreastatin receptors in rat liver: Studies with GTP-γ35S and azido-GTP-α-32P
    • Santos-Álvarez J, Sánchez-Margalet V. G protein Gαq/11 and Gαi1, 2 are activated by pancreastatin receptors in rat liver: studies with GTP-γ35S and azido-GTP-α-32P. J Cell Biochem 73: 469-477, 1999.
    • (1999) J Cell Biochem , vol.73 , pp. 469-477
    • Santos-Álvarez, J.1    Sánchez-Margalet, V.2
  • 71
    • 0025902193 scopus 로고
    • Pancreastatin-a novel regulatory peptide?
    • Schmidt WE, Creutzfeldt W. Pancreastatin-a novel regulatory peptide? Acta Oncol 30: 441-449, 1991.
    • (1991) Acta Oncol , vol.30 , pp. 441-449
    • Schmidt, W.E.1    Creutzfeldt, W.2
  • 72
    • 0023733506 scopus 로고
    • Isolation and primary structure of tumor-derived peptides related to human pancreastatin and chromogranin A
    • Schmidt WE, Siegel EG, Kratzin H, Creutzfeldt W. Isolation and primary structure of tumor-derived peptides related to human pancreastatin and chromogranin A. Proc Natl Acad Sci USA 85: 8231-8235, 1988.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8231-8235
    • Schmidt, W.E.1    Siegel, E.G.2    Kratzin, H.3    Creutzfeldt, W.4
  • 73
    • 0025949601 scopus 로고
    • The effect of pancreastatin on endocrine and exocrine pancreas
    • Schönfeld JV, Müller MK. The effect of pancreastatin on endocrine and exocrine pancreas. Scand J Gastroenterol 26: 993-999, 1991.
    • (1991) Scand J Gastroenterol , vol.26 , pp. 993-999
    • Schönfeld, J.V.1    Müller, M.K.2
  • 75
    • 0024424806 scopus 로고
    • Biochemistry of the chromogranin A protein family
    • Simon JP, Aunis D. Biochemistry of the chromogranin A protein family. Biochem J 262: 1, 1989.
    • (1989) Biochem J , vol.262 , pp. 1
    • Simon, J.P.1    Aunis, D.2
  • 76
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 87: 377-389, 1996.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 77
    • 0025353781 scopus 로고
    • Isolation and characterization of a tumor derived human protein related to chromogranin A and its in vitro conversion to human pancreastatin-48
    • Tamamura H, Ohta M, Yoshizawa K, Ono Y, Funakoshi A, Miyasaka K, Tateishi K, Jimi A, Yajima H, Fujii N. Isolation and characterization of a tumor derived human protein related to chromogranin A and its in vitro conversion to human pancreastatin-48. Eur J Biochem 191: 33-39, 1990.
    • (1990) Eur J Biochem , vol.191 , pp. 33-39
    • Tamamura, H.1    Ohta, M.2    Yoshizawa, K.3    Ono, Y.4    Funakoshi, A.5    Miyasaka, K.6    Tateishi, K.7    Jimi, A.8    Yajima, H.9    Fujii, N.10
  • 78
  • 79
  • 80
    • 0012664686 scopus 로고
    • Chemical determination of polypeptide hormones
    • Tatemoto K, Mutt V. Chemical determination of polypeptide hormones. Proc Natl Acad Sci USA 75: 4115-4119, 1978.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 4115-4119
    • Tatemoto, K.1    Mutt, V.2
  • 83
    • 0027366147 scopus 로고
    • Post-translational processing of chromogranin A: Differential distribution of phosphorylated variants of pancreastatin and fragments 248-313 and 297-313 in bovine pancreas and ileum
    • Watkinson A, Rogers M, Dockray G. Post-translational processing of chromogranin A: differential distribution of phosphorylated variants of pancreastatin and fragments 248-313 and 297-313 in bovine pancreas and ileum. Biochem J 295: 649-654, 1993.
    • (1993) Biochem J , vol.295 , pp. 649-654
    • Watkinson, A.1    Rogers, M.2    Dockray, G.3
  • 84
    • 0026680263 scopus 로고
    • The chromogranins A and B: The first 25 years and future perspectives
    • Winkler H, Fischer-Colbrie R. The chromogranins A and B: the first 25 years and future perspectives. Neuroscience 49: 497-528, 1992.
    • (1992) Neuroscience , vol.49 , pp. 497-528
    • Winkler, H.1    Fischer-Colbrie, R.2
  • 86
    • 0028267042 scopus 로고
    • Pancreastatin, a chromogranin A-derived peptide, inhibits transcription of the parathyroid hormone and chromogranin A genes and decreases the stability of the respective messenger ribonucleic acids in parathyroid cells in culture
    • Zhang J, Fasciotto B, Darling D, Cohn D. Pancreastatin, a chromogranin A-derived peptide, inhibits transcription of the parathyroid hormone and chromogranin A genes and decreases the stability of the respective messenger ribonucleic acids in parathyroid cells in culture. Endocrinology 134: 1310-1316, 1994.
    • (1994) Endocrinology , vol.134 , pp. 1310-1316
    • Zhang, J.1    Fasciotto, B.2    Darling, D.3    Cohn, D.4
  • 89
    • 70350025390 scopus 로고    scopus 로고
    • New insights into graninderived peptides: Evolution and endocrine roles
    • Zhao E, Zhang D, Basak A, Trudeau VL. New insights into graninderived peptides: evolution and endocrine roles. Gen Comp Endocrinol 164: 161-174, 2009.
    • (2009) Gen Comp Endocrinol , vol.164 , pp. 161-174
    • Zhao, E.1    Zhang, D.2    Basak, A.3    Trudeau, V.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.