Identification and determination of the chemical constituents in a herbal preparation, compound kushen injection, by HPLC and LC-DAD-MS/MS

Journal of Liquid Chromatography and Related Technologies

Volumn 37, Issue 2, 2014, Pages 207-220

  Ma, Yue ^a   Gao, Huimin ^a,b   Liu, Jing ^c   Chen, Liangmian ^a,b   Zhang, Qiwei ^a,b   Wang, Zhimin ^a,b  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines   (China)

^c China National Center for Biotechnology Development   (China)

Author keywords

Compound kushen injection; Heterosmilacis japonicae rhizomae; HPLC; LC DAD MS MS; Sophorae flavescentis radix

Indexed keywords

CHEMICAL CONSTITUENTS; CHROMATOGRAPHIC PEAKS; HETEROSMILACIS JAPONICAE RHIZOMAE; HPLC; LC-DAD-MS/MS; MANUFACTURING PROCESS; QUALITATIVE AND QUANTITATIVE ANALYSIS; SOPHORAE FLAVESCENTIS RADIX;

CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

QUALITY CONTROL;

5ALPHA, 9ALPHA HYDROXYMATRINE; 7,11 DEHYDROMATRINE; 9ALPHA HYDROXYMATRINE; 9ALPHA HYDROXYSOPHOCARPINE; BAPTIFOLINE; CAULOPHYLLINE; DEHYDROLUPANINE; HERBACEOUS AGENT; ISOMATRINE; ISOSOPHOCARPINE; LAMPROLOBINE; MATRINE; METHYLAZOXYMETHANOL PRIMEVEROSIDE; N METHYLCYTICINE; OXYMATRINE; OXYSOPHOCARPINE; OXYSOPHORANOL; OXYSOPHORIDINE; PISCIDIC ACID; SOPHOCARPINE; SOPHORANOL; SOPHORIDINE; TRIFOLIRHIZIN; UNCLASSIFIED DRUG;

ARTICLE; CHINESE MEDICINE; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

EID: 84887563876     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2012.738623     Document Type: Article

References (16)

1. Ji, K. M.; Chen, J. J.; Li, M.; Liu, Z. G.; Xia, L. X.; Wang, C. B.; Zhan, Z. K.; Wu, X. L. Comments on Serious Anaphylaxis Caused by Nine Chinese Herbal Injections Used to Treat Common Colds and Upper Respiratory Tract Infections. Regul. Toxicol. Pharm. 2009, 55, 134-138.
2. Drug Standards of Ministry of Health of People's Republic of China, China Medical Science and Technology Press: Beijing, 1997.
3. Liu, Q.; Zhang, H. G.; Liu, Y. G.; Zheng, Y. S. Analysis of Chemical Components in Compound Kushen Injection by HPLC-MSn. Chin. Tradit. Pat. Med. 2006, 28, 1488-1491.
4. Tian, J.; Wang, W. H.; Gao, H. M.; Wang, Z. M. Determination of Matrine, Sophoridine and Oxymatrine in Compound Kushen Injection by HPLC. China J. Chin. Mater. Med. 2007, 32, 222-224.
5. Wu, D.; Liang, J.; Lian, J. W.; Zhang, L.; Chen, X. H.; Bi, K. S. Simultaneous RP-HPLC Determination of Oxysophocarpine, Oxymatrine and Matrine in Compound Kushen Injection. J. Shenyang Pharm. Univ. 2006, 23, 220-223.
6. Rao, Y.; Wei, H. Z.; Wang, Y. M.; Luo, G. A. Simultaneous Determination of Three Alkaloids in Compound Kushen Injection by Capillary Electrophoresis. J. Anal. Sci. 2003, 19, 225-227.
7. Liu, X. Q.; Wang, J. Y.; Tong, Y.; Wang, R. Z.; Zhang, Y. X.; Wang, Z. M.; Zhang, Q. W. Studies on Key Processes of Fufang Kushen Injection. China J. Chin. Mater. Med. 2011, 36, 666-671.
8. Liu, G. Q.; Dong, J.; Wang, H.; Hashi, Y. K.; Chen, S. Z. Characterization of Alkaloids in Sophora flavescens Ait. by High-Performance Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry. J. Pharm. Biomed. Anal. 2011, 54, 1065-1072.
9. Toshima, H.; Saito, M.; Yoshihara, T. Total Synthesis of (+)-(2S, 3 R)-Piscidic Acid via Catalytic Asymmetric Dihydroxylation of a Trisubstituted Olefin. Biosci. Biotechnol. Biochem. 1999, 63, 964-967.
10. Lindblad, P.; Tadera, K.; Yagi, F. Occurrence of Azoxyglycosides in Macrozamia Riedlei and Their Effects on the Free-Living Isolated Nostoc Pcc 73102. Environ. Exp. Bot. 1990, 30, 429-434.
11. Qiao, L.; Yuan, J. Z.; Cheng, H. Y.; Chen, X. H.; Bi, K. S. Studies on Chemical Constituents from Rhizoma Heterosmilacis Japonicae. J. Chin. Med. Materials 2007, 30, 1243-1244.
12. Sagen, A. L.; Gertsch, J.; Becker, R.; Heilmann, J.; Sticher, O. Quinolizidine Alkaloids from the Curare Adjuvant Clathrotropis glaucophylla. Phytochemistry 2002, 61, 975-978.
13. Wang, Y. H.; Li, J. S.; Jiang, Z. R.; Kubo, H.; Higashiyama, K.; Ohmiya, S. Lupin Alkaloids from Chinese Maackia amurensis. Chem. Pharm. Bull. 2000, 48, 641-645.
14. Yagi, A.; Fukunaga, M.; Okuzako, N.; Mifuchi, I.; Kawamoto, F. Antifungal Substances from Sophora flavescens. Shoyakugaku Zasshi. 1989, 43, 343-347.
15. Yagi, F. Azoxyglycoside Content and β-Glycosidase Activities in Leaves of Various Cycads. Phytochemistry 2004, 65, 3243-3247.
16. Qiao, L.; Chen, X. H.; Bi, K. S. Determination of Macrozamin in Rhizome Heterosmilacis Japonicae by RP-HPLC. China J. Chin. Mater. Med. 2007, 32, 1900-1902.