Fine-needle aspiration of histoplasmosis in the era of endoscopic ultrasound and endobronchial ultrasound: Cytomorphologic features and correlation with clinical laboratory testing

Cancer Cytopathology

Volumn 121, Issue 9, 2013, Pages 508-517

  Gailey, Michael P ^a   Klutts, J Stacey ^a   Jensen, Chris S ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Aspiration cytopathology; Fine needle aspiration; Histoplasmosis; Lymph node cytology; Mediastinal cytology

Indexed keywords

FUNGUS ANTIBODY; FUNGUS ANTIGEN;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ANTIBODY DETECTION; ANTIGEN EXPRESSION; ARTICLE; CELL DEATH; CLINICAL ARTICLE; COMPLEMENT FIXATION TEST; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST ACCURACY STUDY; ENDOBRONCHIAL ULTRASONOGRAPHY; ENDOSCOPIC ECHOGRAPHY; ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE BIOPSY; FEMALE; FUNGUS CULTURE; FUNGUS IDENTIFICATION; GRANULOMA; GROCOTT METHENAMINE SILVER STAINING; HISTOPLASMOSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IMMUNODIFFUSION; INTERMETHOD COMPARISON; MALE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEX RATIO; SILVER STAINING; URINALYSIS; ASPIRATION CYTOPATHOLOGY; CLINICAL CHEMISTRY; CYTODIAGNOSIS; DIAGNOSTIC TEST; FINE-NEEDLE ASPIRATION; HISTOPLASMA; LYMPH NODE CYTOLOGY; MEDIASTINAL CYTOLOGY; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PROGNOSIS; VERY ELDERLY;

ASPIRATION CYTOPATHOLOGY; FINE-NEEDLE ASPIRATION; HISTOPLASMOSIS; LYMPH NODE CYTOLOGY; MEDIASTINAL CYTOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CLINICAL CHEMISTRY TESTS; CYTODIAGNOSIS; DIAGNOSTIC TESTS, ROUTINE; ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION; FEMALE; HISTOPLASMA; HISTOPLASMOSIS; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; YOUNG ADULT;

EID: 84887555162     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.21298     Document Type: Article

References (39)

1. Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev. 2007;20: 115-132.
2. Bradsher RW. Histoplasmosis and blastomycosis. Clin Infect Dis. 1996;22(suppl 2): S102-S111.
3. Knox KS, Hage CA. Histoplasmosis. Proc Am Thorac Soc. 2010;7: 169-172.
4. Edwards JA, Rappleye CA. Histoplasma mechanisms of pathogenesis-portfolio doesn't fit all. FEMS Microbiol Lett. 2011;324: 1-9.
5. Bryant AS, Cerfolio RJ. The maximum standardized uptake values on integrated FDG-PET/CT is useful in differentiating benign from malignant pulmonary nodules. Ann Thorac Surg. 2006;82: 1016-1020.
6. Salhab KF, Baram D, Bilfinger TV. Growing PET positive nodule in a patient with histoplasmosis: case report. J Cardiothorac Surg. 2006;1: 23.
7. Matos Figueroa JR, Vazquez Torres OL, Hernandez I, Vila A. PET-CT scan positive pulmonary nodule revealing histoplasmosis: a case report. Bol Asoc Med P R. 2010;4: 47-50.
8. Wheat LJ, Conces D, Allen SD, Blue-Hnidy D, Loyd J. Pulmonary histoplasmosis syndromes: recognition, diagnosis, and management. Semin Respir Crit Care Med. 2004;25: 129-144.
9. Wheat LJ, Slama TG, Zeckel ML. Histoplasmosis and the acquired immune deficiency syndrome. Am J Med. 1985;78: 203-210.
10. Hage CA, Knox KS, Wheat LJ. Endemic mycoses: overlooked causes of community acquired pneumonia. Respir Med. 2012;106: 769-776.
11. Hage CA, Wheat LJ, Loyd J, Allen SD, Blue D, Knox KS. Pulmonary histoplasmosis. Semin Respir Crit Care Med. 2008;29: 151-165.
12. Asrani NS. Disseminated histoplasmosis associated with the treatment of rheumatoid arthritis with anticytokine therapy. Ann Intern Med. 2008;149: 594-595.
13. Gupta N, Fox CM, Grisolano SW. Disseminated histoplasmosis with colonic ulcers in a patient receiving infliximab. Gastrointest Endosc. 2009;70: 597-598.
14. Curtis JR, Martin C, Saag KG, et al. Confirmation of administrative claims-identified opportunistic infections and other serious potential adverse events associated with tumor necrosis factor alpha antagonists and disease-modifying antirheumatic drugs. Arthritis Rheum. 2007;57: 343-346.
15. Singh S, Chhabra S, Goyal R, Garg S. Cytodiagnosis of histoplasmosis: case reports from two patients with variable clinical presentation. Diagn Cytopathol. 2012;40: 1090-1092.
16. Singh S, Kalra R, Chhabra S, Agarwal R, Garg S, Mathur SK. Variable clinical presentations of histoplasmosis: a report of six cases. Trop Doct. 2012;42: 32-34.
17. Ahuja A, Mathur SR, Iyer VK, Sharma SK, Kumar N, Agarwal S. Histoplasmosis presenting as bilateral adrenal masses: cytomorphological diagnosis of three cases. Diagn Cytopathol. 2012;40: 729-731.
18. Rana C, Krishnani N, Kumari N. Bilateral adrenal histoplasmosis in immunocompetent patients. Diagn Cytopathol. 2011;39: 294-296.
19. Gupta N, Arora SK, Rajwanshi A, Nijhawan R, Srinivasan R. Histoplasmosis: cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology. Cytopathology. 2010;21: 240-244.
20. Jaiswal S, Vij M, Chand G, Misra R, Pandey R. Diagnosis of adrenal histoplasmosis by fine needle aspiration cytology: an analysis based on five cases. Cytopathology. 2011;22: 323-328.
21. Deepe GS. Histoplasma capsulatum. Mandell, Douglas, and Bennett s Principles and Practice of Infectious Diseases. Eds. Mandell GL, Bennett JE, Dolin R. 7th ed. Philadelphia: Churchill Livingstone/Elsevier; 2010: 3310.
22. Peikert T, Colby TV, Midthun DE, et al. Fibrosing mediastinitis: clinical presentation, therapeutic outcomes, and adaptive immune response. Medicine (Baltimore). 2011;90: 412-423.
23. Kauffman CA, Israel KS, Smith JW, White AC, Schwarz J, Brooks GF. Histoplasmosis in immunosuppressed patients. Am J Med. 1978;64: 923-932.
24. Zafar N. Histoplasmosis in fine-needle aspiration cytology of axillary lymph node in an HIV-positive woman with clinical suspicion of lymphoma. Diagn Cytopathol. 2009;37: 584-585.
25. Longchampt E, Fabre M. Role of guided fine needle punction in the diagnosis of deep-seated AIDS-related infections: report of a case of hepato-nodal histoplasmosis [in French]. Ann Pathol. 1996; 16: 266-270.
26. Arghya B, Kaushik M, Mimi G, Subrata C. Cytodiagnosis of cutaneous histoplasmosis in HIV positive patient initially presenting with multiple umbilicated disseminated skin nodules [published online ahead of print October 11, 2011]. Diagn Cytopathol. doi: 10.1002/dc.21814.
27. Valente PT, Calafati SA. Diagnosis of disseminated histoplasmosis by fine needle aspiration of the adrenal gland. Acta Cytol. 1989;33: 341-343.
28. Narang V, Sinha T, Sandhu AS, et al. Clinically inapparent bilateral adrenal masses due to histoplasmosis. Eur Urol. 2009;55: 518-521.
29. Eloubeidi MA, Luz LP, Crowe DR, Snowden C, Morgan DE, Arnoletti PJ. Bilateral adrenal gland enlargement secondary to histoplasmosis mimicking adrenal metastases: diagnosis with EUSguided FNA. Diagn Cytopathol. 2010;38: 357-359.
30. Wheat LJ, Garringer T, Brizendine E, Connolly P. Diagnosis of histoplasmosis by antigen detection based upon experience at the histoplasmosis reference laboratory. Diagn Microbiol Infect Dis. 2002;43: 29-37.
31. Wheat LJ. Approach to the diagnosis of the endemic mycoses. Clin Chest Med. 2009;30: 379-389.
32. Wheat LJ, Kohler RB, Tewari RP. Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens. N Engl J Med. 1986;314: 83-88.
33. Srinivasan A, Kleiman MB, Debelenko L, Stokes DC, De Vencenzo J, Wheat LJ. False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen. Pediatr Infect Dis J. 2009;28: 447-449.
34. Hage CA, Ribes JA, Wengenack NL, et al. A multicenter evaluation of tests for diagnosis of histoplasmosis. Clin Infect Dis. 2011; 53: 448-454.
35. Wheat LJ. Current diagnosis of histoplasmosis. Trends Microbiol. 2003;11: 488-494.
36. Swartzentruber S, Rhodes L, Kurkjian K, et al. Diagnosis of acute pulmonary histoplasmosis by antigen detection. Clin Infect Dis. 2009;49: 1878-1882.
37. Hage CA, Davis TE, Fuller D, et al. Diagnosis of histoplasmosis by antigen detection in BAL fluid. Chest. 2010;137: 623-628.
38. Hage CA, Wheat LJ. Diagnosis of pulmonary histoplasmosis using antigen detection in the bronchoalveolar lavage. Expert Rev Respir Med. 2010;4: 427-429.
39. Guedes HL, Guimaraes AJ, Muniz Mde M, et al. PCR assay for identification of histoplasma capsulatum based on the nucleotide sequence of the M antigen. J Clin Microbiol. 2003;41: 535-539.