A randomised controlled trial of plasma filtration in severe paediatric sepsis

Critical Care and Resuscitation

Volumn 15, Issue 3, 2013, Pages 198-204

  Long, Elliot J ^a   Shann, Frank ^a   Pearson, Gale ^b   Buckley, David ^c   Butt, Warwick ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

^c STARSHIP CHILDREN S HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; AUSTRALIA; CHILD; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; INFANT; MALE; METHODOLOGY; MORTALITY; MULTICENTER STUDY; NEW ZEALAND; NEWBORN; PLASMAPHERESIS; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; SEPSIS; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TREATMENT OUTCOME; UNITED KINGDOM;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HUMANS; INFANT; INFANT, NEWBORN; MALE; NEW ZEALAND; PLASMAPHERESIS; RETROSPECTIVE STUDIES; SEPSIS; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TREATMENT OUTCOME; VICTORIA;

EID: 84887551724     PISSN: 14412772     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time. Crit Care Med 1998; 26: 2078-2086.
2. Pinsky MR. Sepsis: a pro- and anti-inflammatory disequilibrium syndrome. In: Ronco C, Bellomo R, La Greca G, editors. Blood purification in intensive care: 2nd international course on critical care nephrology, Vicenza, May 2001: proceedings. Vicenza: Karger, 2001.
3. Bone RC. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med 1996; 125: 680-687.
4. Camussi G, Montrucchio G, Dominioni L, Dionigi R. Septic shock--the unravelling of molecular mechanisms. Nephrol Dial Transplant 1995; 10: 1808-1813.
5. Zeni F, Freeman B, Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med 1997; 25: 1095-1100.
6. The Veterans Administration Systemic Sepsis Cooperative Study Group. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987; 317: 659-665.
7. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358: 111-124.
8. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA 2009; 301: 2362-2375.
9. Bernard GR, Vincent JL, Laterre P F, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
10. Nadel S, Goldstein B, Williams MD, et al. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet 2007; 369: 836-843.
11. Savel RH, Munro CL. Evidence-based backlash: the tale of drotrec-ogin alfa. Am J Crit Care 2012; 21: 81-83.
12. McMaster P, Shann F. The use of extracorporeal techniques to remove humoral factors in sepsis. Pediatr Crit Care Med 2003; 4: 2-7.
13. Braun N, Rosenfeld S, Giolai M, et al. Effect of continuous hemodiafiltration on IL-6, TNF-alpha, C3a, and TCC in patients with SIRS/septic shock using two different membranes. Contrib Nephrol 1995; 116: 89-98.
14. Tetta C, Mariano F, Buades J, et al. Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. Am J Kidney Dis 1997; 30 (5 Suppl 4): S57-65.
15. Reeves JH, Butt WW, Shann F, et al. Continuous plasmafiltration in sepsis syndrome. Plasmafiltration in Sepsis Study Group. Crit Care Med 1999; 27: 2096-104.
16. Hazards of apheresis. Lancet 1982; 2: 1025-6.
17. Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993; 328: 1471-1477.
18. Rana OR, Schröder JW, Kühnen JS, et al. The Modified Glasgow Outcome Score for the prediction of outcome in patients after cardiac arrest: a prospective clinical proof of concept study. Clin Res Cardiol 2012; 101: 533-543.
19. Namachivayam P, Shann F, Shekerdemian L, et al. Three decades of pediatric intensive care: who was admitted, what happened in intensive care, and what happened afterward. Pediatr Crit Care Med 2010; 11: 549-555.
20. Davidson J, Tong S, Hancock H, et al. Prospective validation of the vasoactive-inotropic score and correlation to short-term outcomes in neonates and infants after cardiothoracic surgery. Intensive Care Med 2012; 38: 1184-1190.
21. Reeves JH, Butt WW. Blood filtration in children with severe sepsis: safe adjunctive therapy. Intensive Care Med 1995; 21: 500-504.
22. Wernovsky G, Wypij D, Jonas RA, et al. Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest. Circulation 1995; 92: 2226-2235.
23. Gaies MG, Gurney JG, Yen AH, et al. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 2010; 11: 234-238.
24. Cohen J, Aslam M, Pusey CD, Ryan CJ. Protection from endotoxemia: a rat model of plasmapheresis and specific adsorption with poly-myxin B. J Infect Dis 1987; 155: 690-695.
25. Cohen J. Adjunctive therapy in sepsis: a critical analysis of the clinical trial programme. Br Med Bull 1999; 55: 212-225.
26. Tetta C, Gianotti L, Cavaillon JM, et al. Coupled plasma filtration-adsorption in a rabbit model of endotoxic shock. Crit Care Med 2000; 28: 1526-1533.
27. Muraji T, Okamoto E, Hoque S, Toyosaka A. Plasma exchange therapy for endotoxin shock in puppies. J Pediatr Surg 1986; 21: 1092-1095.
28. Natanson C, Hoffman WD, Koev LA, et al. Plasma exchange does not improve survival in a canine model of human septic shock. Tr ans fu -sion 1993; 33: 243-248.
29. Busund R, Lindsetmo RO, Rasmussen LT, et al. Tumor necrosis factor and interleukin 1 appearance in experimental gram-negative septic shock. The effects of plasma exchange with albumin and plasma infusion. Arch Surg 1991; 126: 591-597.
30. Beller-Todd B, Archer LT, Hinshaw LB. Recovery from endotoxin shock after extracorporeal perfusion without anticoagulation. Circ Shock 1979; 6: 261-269.
31. Asanuma Y, Takahashi T, Koyama K, et al. Exchange blood transfusion and on-line plasma exchange for sepsis in infants. ASAIO Trans 1989; 35: 343-345.
32. Sato T, Orlowski J P, Zborowski M. Experimental study of extracorpor-eal perfusion for septic shock. ASAIO J 1993; 39: M790-793.
33. Lonergan JM, Orlowski J P, Sato T, et al. Extracorporeal endotoxin removal in a canine model of septic shock. ASAIO J 1994; 40: M654-657.
34. Ullrich R, Roeder G, Lorber C, et al. Continuous venovenous hemofiltration improves arterial oxygenation in endotoxin-induced lung injury in pigs. Anesthesiology 2001; 95: 428-436.
35. Kodama M, Hanasawa K, Tani T. New therapeutic method against septic shock--removal of endotoxin using extracorporeal circulation. Adv Exp Med Biol 1990; 256: 653-664.
36. Busund R, Lindsetmo RO, Balteskard L, et al. Repeated plasma therapy induces fatal shock in experimental septicemia. Circ Shock 1993; 40: 268-275.
37. Scharfman WB, Tillotson JR, Taft EG, Wright E. Plasmapheresis for meningococcemia with disseminated intravascular coagulation. N Engl J Med 1979; 300: 1277-1278.
38. Bjorvatn B, Bjertnaes L, Fadnes HO, et al. Meningococcal septicaemia treated with combined plasmapheresis and leucapheresis or with blood exchange. Br Med J (Clin Res Ed) 1984; 288: 439-441.
39. Brandtzaeg P, Sirnes K, Folsland B, et al. Plasmapheresis in the treatment of severe meningococcal or pneumococcal septicaemia with DIC and fibrinolysis. Preliminary data on eight patients. Scand J Clin Lab Invest Suppl 1985; 178: 53-55.
40. Drapkin MS, Wisch JS, Gelfand JA, et al. Plasmapheresis for fulminant meningococcemia. Pediatr Infect Dis J 1989; 8: 399-400.
41. Dobos GJ, Meske S, Keller E, et al. Successful therapy of meningo-coccal sepsis in acute disseminated lupus erythematosus with plasmapheresis, immunosuppression, and antibiotics. Klin Wochenschr 1990; 68: 976-980.
42. Churchwell KB, McManus ML, Kent P, et al. Intensive blood and plasma exchange for treatment of coagulopathy in meningococ-cemia. J Clin Apher 1995; 10: 171-177.
43. Berlot G, Gullo A, Fasiolo S, et al. Hemodynamic effects of plasma exchange in septic patients: preliminary report. Blood Purif 1997; 15: 45-53.
44. Munteanu C, Bloodworth LL, Korn TH. Antithrombin concentrate with plasma exchange in purpura fulminans. Pediatr Crit Care Med 2000; 1: 84-87.
45. van Deuren M, Santman FW, van Dalen R, et al. Plasma and whole blood exchange in meningococcal sepsis. Clin Infect Dis 1992; 15: 424-430.
46. Westendorp RG, Brand A, Haanen J, et al. Leukaplasmapheresis in meningococcal septic shock. Am J Med 1992; 92: 577-578.
47. Gårdlund B, Sjölin J, Nilsson A, et al. Plasmapheresis in the treatment of primary septic shock in humans. Scand J Infect Dis 1993; 25: 757-761.
48. Schmidt J, Mann S, Mohr VD, et al. Plasmapheresis combined with continuous venovenous hemofiltration in surgical patients with sepsis. Intensive Care Med 2000; 26: 532-537.
49. Busund R, Koukline V, Utrobin U, Nedashkovsky E. Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial. Intensive Care Med 2002; 28: 1434-1439.
50. Ohlsson A, Lacy J. Intravenous immunoglobulin for suspected or subsequently proven infection in neonates. Cochrane Database Syst Rev 2010; (3): CD001239.
51. INIS Collaborative Group; Brocklehurst P, Farrell B, King A, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med 2011; 365: 1201-11.
52. Laupland KB, Kirkpatrick AW, Delaney A. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis. Crit Care Med 2007; 35: 2686-2692.
53. Ceneviva G, Paschall JA, Maffei F, Carcillo JA. Hemodynamic support in fluid-refractory pediatric septic shock. Pediatrics 1998; 102: e19.
54. Hazelzet JA, Risseeuw-Appel IM, Kornelisse RF, et al. Age-related differences in outcome and severity of DIC in children with septic shock and purpura. Thromb Haemost 1996; 76: 932-938.
55. Doughty L, Carcillo JA, Kaplan S, Janosky J. The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure. Chest 1998; 113: 1625-1631.
56. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004; 4: 553-564.
57. Levy O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 2007; 7: 379-390.
58. Holmes CL, Russell JA. Plasmafiltration in sepsis: removing the evil humors. Crit Care Med 1999; 27: 2287-2289.