Microbiological and molecular characterization of extreme drug-resistant carbapenemase-producing Klebsiella pneumoniae isolates

International Journal of Immunopathology and Pharmacology

Volumn 26, Issue 3, 2013, Pages 785-790

  Santino, Iolanda ^a   Bono, S ^b   Nuccitelli, A ^b   Martinelli, D ^a   Petrucci, C ^a   Alari, A ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Genoma Molecular Genetics Laboratory   (Italy)

Author keywords

Carbapenemase; Colistin resistance; Klebsiella pneumoniae; KPC 3; Multilocus sequence typing

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; BETA LACTAMASE AMPC; CARBAPENEM DERIVATIVE; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; TIGECYCLINE; TOBRAMYCIN; EXTENDED SPECTRUM BETA LACTAMASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BLAKPC 3 GENE; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA PNEUMONIAE; HOSPITAL; HUMAN; ITALY; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ADULT; AGED; ANTIBIOTIC SENSITIVITY; CARBAPENEMASE PRODUCING KLEBSIELLA PNEUMONIAE; CLINICAL ARTICLE; COLISTIN RESISTANT KLEBSIELLA PNEUMONIAE; CONTROLLED STUDY; FEMALE; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; COLISTIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; GENOTYPE; HUMANS; ITALY; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PHENOTYPE; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 84887496092     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201302600325     Document Type: Article

References (25)

1. Chen LF, Anderson DJ, Paterson DL. Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance. Infect Drug Resist 2012; 5:133-41.
2. P. Nordmann, M. Gniadkowski, C. G. Giske, L. Poirel, N. Woodford, V. Miriagou and the European Network on Carbapenemases* Identification and screening of carbapenemase-producing Enterobacteriaceae. Clin Microbiol Infect 2012; 18:432-38.
3. Hirsch EB, Tam VH. Detection and treatment options for Klebsiella pneumonia carbapenemases (KPCs): an emerging cause of multidrug-resistant infection. J Antimicrob Chemother 2010; 65:1119-25.
4. Ryan SA, Thom KR, Sharma S, Phillips M, Johnson JK, Morgan DJ. Emergence of Klebsiella pneumoniae Carbapenemase (KPC)-Producing Bacteria. South Med J 2011; 104:40-5.
5. Leavitt A, Chmelnitsky I, Ofek, Carmeli Y, Navon-Venezia S. Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain. J Antimicrob Chemother 2010; 65:243-8.
6. Warburg G, Hidalgo-Grass C, Partridge SR, Tolmasky ME, Temper V, Moses AE, Block C, Strahilevitz J. A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6′)-Ib. J Antimicrob Chemother 2012; 67:898-901.
7. Benenson S, Warburg G, Hidalgo-Grass C, Temper V, Moses AE, Block C, Strahilevitz J. Comparison of two carbapenem-resistant Klebsiella pneumoniae clones: from a contained outbreak in a paediatric population and from a national epidemic. J Antimicrob Chemother 2012; 67:1651-54.
8. Munoz-Price LS, Quinn JP. The spread of Klebsiella pneumoniae carbapenemases: a tale of strains, plasmids, and transposons. Clin Infect Dis 2009; 49:1739-41.
9. Livermore DM, Warner M, Mushtaq S, Doumith M, Zhang J, Woodford N. What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline. Int J Antimicrob Agents 2011; 37:415-9.
10. Giamarellou H, Poulakou G. Multidrug-resistant Gram-negative infections: what are the treatment options? Drugs 2009; 69:1879-901.
11. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase producing bacteria. Lancet Infect Dis 2009; 9:228-36.
12. Zarkotou O, Pournaras S, Voulgari E, Chrysos G, Prekates A, Voutsinas D, Themeli-Digalaki K, Tsakris A. Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: a matched case-control study. Clin Microbiol 2010; 48:2271-74.
13. Kontopoulou K, Protonotariou E, Vasilakos K, Kriti M, Koteli A, Antoniadou E, Sofianou D. Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 b-lactamase resistant to colistin. J Hosp Infect 2010; 76:70-73.
14. Samra Z, Ofir O, Lishtzinsky Y, Madar-Shapiro L, Bishara J. Outbreak of carbapenem-resistant Klebsiella pneumoniae producing KPC-3 in a tertiary medical centre in Israel. Int J Antimicrob Agents 2007; 30:525-29. (Pubitemid 350064465)
15. Suh JY, Son JS, Chung DR, Peck KR, Ko KS, Song JH. Non clonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. Antimicrob Agents Chemother 2010; 54:560-2.
16. Marchaim D, Chopra T, Pogue JM, et al. Outbreak of Colistin-Resistant, Carbapenem-Resistant Klebsiella pneumoniae in Metropolitan Detroit, Michigan. Antimicrob Agents Chemother 2011; 55:593-9.
17. Cantón R, Akóva M, Carmeli Y, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 2012; 18:413-21.
18. Bogdanovich T, Adams-Haduch JM, Tian GB, Nguyen MH, Kwak EJ, Muto CA, Doi Y. Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258. Clin Infect Dis 2011; 53:373-6.
19. Mezzatesta ML, Gona F, Caio C, Petrolito V, Sciortino D, Sciacca A, Santangelo C, Stefani S. Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals. Clin Microbiol Infect 2011; 17:1444-47.
20. Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S. Multilocus Sequence Typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 2005; 43:4178-82. (Pubitemid 41129719)
21. Klebsiella pneumoniae MLST Database. Paris: Institute Pasteur. [Accessed December 2011]. Available from: http://www.pasteur.fr/recherche/genopole/PF8/ mlst/Kpneumoniae.html
22. Santino I, Bono S, Borruso L, Bove M, Cialdi E, Martinelli D, Alari A. Kodamaea ohmeri isolate from two immunocompromised patients: first report in Italy. 2013; 56(2):179-81. Epub 2012 Aug 12.
23. Souli M, Galani I, Giamarellou H. Emergence of extensively drug-resistant and pandrug-resistant Gram-negative bacilli in Europe. Euro Surveill 2008; 13:19045.
24. Richter SN, Frasson I, Franchin E Bergo, Lavezzo E, Barzon L, Cavallaro A, Palù G. KPC-mediate resistance in Klebsiella pneumoniae in two hospitals in Padua, Italy, June 2009-December 2012: massive spreading of a KPC-3-encoding plasmid and involvement of non-intensive care units. Gut Pathog 2012; 4:7.
25. Capone A, Giannella M, Fortini D, et al. High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality. Clin Microbiol Infect 2013; 19:23-30.