Deep brain stimulation (DBS) at the interface of neurology and psychiatry

Journal of Clinical Investigation

Volumn 123, Issue 11, 2013, Pages 4546-4556

  Williams, Nolan R ^a   Okun, Michael S ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPOLAR DEPRESSION; BIPOLAR DISORDER; BRAIN DEPTH STIMULATION; COGNITIVE THERAPY; ELECTROCONVULSIVE THERAPY; GILLES DE LA TOURETTE SYNDROME; HEALTH CARE QUALITY; HUMAN; IMPLANTATION; MAJOR DEPRESSION; NERVE DEGENERATION; OBSESSIVE COMPULSIVE DISORDER; PARKINSON DISEASE; PERSONALIZED MEDICINE; PLACEBO EFFECT; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVIEW; THERAPY EFFECT; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84887455518     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI68341     Document Type: Review

References (174)

1. Meyer FC, Chemali Z. On education: teaching the neurology-psychiatry interface using a flexible quadrant model [published online ahead of print 2013]. Clinical Neuropsychiatry. Epub code: CN100004.
2. Benabid AL. What the future holds for deep brain stimulation. Expert Rev Med Devices. 2007; 4(6):895-903.
3. Lozano AM, Lipsman N. Probing and regulating dysfunctional circuits using deep brain stimulation. Neuron. 2013;77(3):406-424.
4. FDA approves humanitarian device exemption for deep brain stimulator for severe obsessivecompulsive disorder [press release]. February 19, 2009. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm149529.htm. FDA Web site. Updated April 18, 2013. Accessed September 13, 2013.
5. Benabid AL, et al. Deep brain stimulation: BCI at large, where are we going to? Prog Brain Res. 2011; 194:71-82.
6. Ferrao YA, Diniz JB, Lopes AC, Shavitt RG, Greenberg B, Miguel E. [Resistance and refractoriness in obsessive-compulsive disorder]. Rev Bras Psiquiatr. 2007; 29(suppl 2):S66-S76.
7. Giacobbe P, Mayberg HS, Lozano AM. Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulation. Exp Neurol. 2009;219(1):44-52.
8. Sackeim HA. The definition and meaning of treatment-resistant depression. J Clin Psychiatry. 2001; 62(suppl 16):10-17.
9. Denny AP, Behari M. Motor fluctuations in Parkinson's disease. J Neurol Sci. 1999;165(1):18-23.
10. Abudy A, Juven-Wetzler A, Zohar J. Pharmacological management of treatment-resistant obsessive-compulsive disorder. CNS Drugs. 2011;25(7):585-596.
11. Porta M, Sassi M, Menghetti C, Servello D. The need for a proper definition of a "treatment refractoriness" in Tourette syndrome. Front Integr Neurosci. 2011;5:22.
12. Mink JW, et al. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Mov Disord. 2006; 21(11):1831-1838.
13. Defer GL, Widner H, Marie RM, Remy P, Levivier M. Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSITPD). Mov Disord. 1999;14(4):572-584.
14. Greenberg BD, et al. Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issues. Neurosurg Clin N Am. 2003;14(2):199-212.
15. Gaynes BN, Rush AJ, Trivedi MH, Wisniewski SR, Spencer D, Fava M. The STAR*D study: treating depression in the real world. Cleve Clin J Med. 2008; 75(1):57-66.
16. Lozano AM, Mayberg HS, Giacobbe P, Hamani C, Craddock RC, Kennedy SH. Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol Psychiatry. 2008;64(6):461-467.
17. Okun MS, et al. Do stable patients with a premorbid depression history have a worse outcome after deep brain stimulation for Parkinson disease? Neurosurgery. 2011;69(2):357-360.
18. Bernal-Pacheco O, et al. Taking a better history for behavioral issues pre- and post-deep brain stimulation: issues missed by standardized scales. Neuromodulation. 2012;16(1):35-39.
19. Houeto JL, et al. Subthalamic stimulation in Parkinson disease: intraoperative predictive factors. Arch Neurol. 2003;60(5):690-694.
20. Sauleau P, et al. Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson's disease. J Neurol. 2005;252(4):457-464.
21. Mayberg HS, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005; 45(5):651-660.
22. Okun MS, et al. What's in a "smile?" Intra-operative observations of contralateral smiles induced by deep brain stimulation. Neurocase. 2004;10(4):271-279.
23. Haq IU, et al. Smile and laughter induction and intraoperative predictors of response to deep brain stimulation for obsessive-compulsive disorder. Neuroimage. 2011;54(suppl 1):S247-S255.
24. Stewart CD, Eljamel S. Prediction of implantable pulse generator longevity in deep brain stimulation: limitations and possible solutions in clinical practice. Stereotact Funct Neurosurg. 2011;89(5):299-304.
25. Tykocki T, Nauman P, Koziara H, Mandat T. Microlesion effect as a predictor of the effectiveness of subthalamic deep brain stimulation for Parkinson's disease. Stereotact Funct Neurosurg. 2013; 91(1):12-17.
26. Hardesty DE, Sackeim HA. Deep brain stimulation in movement and psychiatric disorders. Biol Psychiatry. 2007;61(7):831-835.
27. Goodman WK, et al. Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design. Biol Psychiatry. 2010;67(6):535-542.
28. Schlaepfer TE, Bewernick BH, Kayser S, Mädler B, Coenen VA. Rapid effects of deep brain stimulation for treatment-resistant major depression. Biol Psychiatry. 2013;73(12):1204-1212.
29. Burdick AP, et al. Prevalence of Twiddler's syndrome as a cause of deep brain stimulation hardware failure. Stereotact Funct Neurosurg. 2010; 88(6):353-359.
30. Montuno MA, Kohner AB, Foote KD, Okun MS. An algorithm for management of deep brain stimulation battery replacements: devising a web-based battery estimator and clinical symptom approach. Neuromodulation. 2013;16(2):147-153.
31. Wagle Shukla A, Okun MS. Personalized medicine in deep brain stimulation through utilization of neural oscillations. Neurology. 2012;78(24):1900-1901.
32. Okun MS, Foote KD. Parkinson's disease DBS: what, when, who and why? The time has come to tailor DBS targets. Expert Rev Neurother. 2010; 10(12):1847-1857.
33. Van Essen DC, Ugurbil K. The future of the human connectome. Neuroimage. 2012;62(2):1299-1310.
34. Gutman DA, Holtzheimer PE, Behrens TE, Johansen-Berg H, Mayberg HS. A tractography analysis of two deep brain stimulation white matter targets for depression. Biol Psychiatry. 2009;65(4):276-282.
35. Henderson JM. "Connectomic surgery": diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks. Front Integr Neurosci. 2012;6:15.
36. Coenen VA, Allert N, Mädler B. A role of diffusion tensor imaging fiber tracking in deep brain stimulation surgery: DBS of the dentato-rubrothalamic tract (drt) for the treatment of therapyrefractory tremor. Acta Neurochir (Wien). 2011; 153(8):1579-1585
37. Johansen-Berg H, et al. Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression. Cereb Cortex. 2008;18(6):1374-1383.
38. Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Optical deconstruction of parkinsonian neural circuitry. Science. 2009; 324(5925):354-359.
39. Foutz TJ, McIntyre CC. Evaluation of novel stimulus waveforms for deep brain stimulation. J Neural Eng. 2010;7(6):066008.
40. Foutz TJ, Ackermann DM, Kilgore KL, McIntyre CC. Energy efficient neural stimulation: coupling circuit design and membrane biophysics. PLoS One. 2012; 7(12):e51901.
41. Chaturvedi A, Foutz TJ, McIntyre CC. Current steering to activate targeted neural pathways during deep brain stimulation of the subthalamic region. Brain Stimul. 2012;5(3):369-377.
42. Butson CR, McIntyre CC. Role of electrode design on the volume of tissue activated during deep brain stimulation. J Neural Eng. 2006;3(1):1-8.
43. Eusebio A, Cagnan H, Brown P. Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? Front Integr Neurosci. 2012;6:47.
44. Broadway JM, et al. Frontal theta cordance predicts 6-month antidepressant response to subcallosal cingulate deep brain stimulation for treatmentresistant depression: a pilot study. Neuropsychopharmacology. 2012;37(7):1764-1772.
45. Maling N, Hashemiyoon R, Foote KD, Okun MS, Sanchez JC. Increased thalamic gamma band activity correlates with symptom relief following deep brain stimulation in humans with Tourette's syndrome. PLoS One. 2012;7(9):e44215.
46. Okun MS, et al. A trial of scheduled deep brain stimulation for Tourette syndrome: moving away from continuous deep brain stimulation paradigms. JAMA Neurol. 2013;70(1):85-94.
47. Morrell MJ. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011;77(13):1295-1304.
48. Tang JK, et al. Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease. J Neurophysiol. 2007;98(2):720-729.
49. Okun MS. Deep-brain stimulation for Parkinson's disease. N Engl J Med. 2012;367(16):1529-1538.
50. Deuschl G, et al. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med. 2006; 355(9):896-908.
51. Williams A, et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol. 2010; 9(6):581-591.
52. Schuepbach WM, et al. Neurostimulation for Parkinson's disease with early motor complications. N Engl J Med. 2013;368(7):610-622.
53. Okun MS, et al. Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial. Ann Neurol. 2009;65(5):586-595.
54. Follett KA, et al. Pallidal versus subthalamic deepbrain stimulation for Parkinson's disease. N Engl J Med. 2010;362(22):2077-2091.
55. Weaver FM, et al. Randomized trial of deep brain stimulation for Parkinson disease: thirty-sixmonth outcomes. Neurology. 2012;79(1):55-65.
56. Odekerken VJ, et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurol. 2013; 12(1):37-44.
57. Oyama G, et al. GPi and STN deep brain stimulation can suppress dyskinesia in Parkinson's disease. Parkinsonism Relat Disord. 2012;18(7):814-818.
58. Rubin JE, McIntyre CC, Turner RS, Wichmann T. Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects. Eur J Neurosci. 2012; 36(2):2213-2228.
59. McNeely ME, et al. Effects of deep brain stimulation of dorsal versus ventral subthalamic nucleus regions on gait and balance in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2011;82(11):1250-1255.
60. Moscovich M, Morishita T, Foote KD, Favilla CG, Chen ZP, Okun MS. Effect of lead trajectory on the response of essential head tremor to deep brain stimulation. Parkinsonism Relat Disord. 2013; 19(9):789-794.
61. Butson CR, Cooper SE, Henderson JM, Wolgamuth B, McIntyre CC. Probabilistic analysis of activation volumes generated during deep brain stimulation. Neuroimage. 2011;54(3):2096-2104.
62. Frankemolle AM, et al. Reversing cognitive-motor impairments in Parkinson's disease patients using a computational modelling approach to deep brain stimulation programming. Brain. 2010; 133(pt 3):746-761.
63. Maks CB, Butson CR, Walter BL, Vitek JL, McIntyre CC. Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes. J Neurol Neurosurg Psychiatry. 2009;80(6):659-666.
64. Brocker DT, et al. Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease. Exp Neurol. 2013;239:60-67.
65. Porta M, et al. Thalamic deep brain stimulation for treatment-refractory Tourette syndrome: two-year outcome. Neurology. 2009;73(17):1375-1380.
66. Servello D, Porta M, Sassi M, Brambilla A, Robertson MM. Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. J Neurol Neurosurg Psychiatry. 2008;79(2):136-142.
67. Piedimonte F, et al. Behavioral and motor improvement after deep brain stimulation of the globus pallidus externus in a case of Tourette's syndrome. Neuromodulation. 2013;16(1):55-58.
68. Martinez-Torres I, Hariz MI, Zrinzo L, Foltynie T, Limousin P. Improvement of tics after subthalamic nucleus deep brain stimulation. Neurology. 2009; 72(20):1787-1789.
69. Viswanathan A, Jimenez-Shahed J, Baizabal Carvallo JF, Jankovic J. Deep brain stimulation for Tourette syndrome: target selection. Stereotact Funct Neurosurg. 2012;90(4):213-224.
70. Porta M, et al. Deep brain stimulation for treatment of refractory Tourette syndrome: long-term followup. Acta Neurochir (Wien). 2012;154(11):2029-2041.
71. Maciunas RJ, et al. Prospective randomized doubleblind trial of bilateral thalamic deep brain stimulation in adults with Tourette syndrome. J Neurosurg. 2007; 107(5):1004-1014.
72. Ackermans L, et al. Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome. Brain. 2011;134(pt 3):832-844.
73. Martinez-Fernandez R, et al. Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus. Mov Disord. 2011;26(10):1922-1930.
74. Cannon E, Silburn P, Coyne T, O'Maley K, Crawford JD, Sachdev PS. Deep brain stimulation of anteromedial globus pallidus interna for severe Tourette's syndrome. Am J Psychiatry. 2012; 169(8):860-866.
75. Makki MI, Govindan RM, Wilson BJ, Behen ME, Chugani HT. Altered fronto-striato-thalamic connectivity in children with Tourette syndrome assessed with diffusion tensor MRI and probabilistic fiber tracking. J Child Neurol. 2009;24(6):669-678.
76. Sachdev PS, Cannon E, Coyne TJ, Silburn P. Bilateral deep brain stimulation of the nucleus accumbens for comorbid obsessive compulsive disorder and Tourette's syndrome. BMJ Case Rep. 2012; 2012.pii: bcr2012006579.
77. Saleh C, Gonzalez V, Cif L, Coubes P. Deep brain stimulation of the globus pallidus internus and Gilles de la Tourette syndrome: Toward multiple networks modulation. Surg Neurol Int. 2012; 3(suppl 2):S127-S142.
78. Welter ML, et al. Internal pallidal and thalamic stimulation in patients with Tourette syndrome. Arch Neurol. 2008;65(7):952-957.
79. Kuhn J, et al. In vivo evidence of deep brain stimulation-induced dopaminergic modulation in Tourette's syndrome. Biol Psychiatry. 2012; 71(5):e11-e13.
80. Widge AS, Moritz CT. Rodent Proof of Concept for a Patient-Controllable Brain Stimulator (Closed-Loop Limbic Prosthesis). In 2013 Society of Biological Psychiatry Meeting, San Francisco, California, USA. May 16-18, 2013.
81. Oyama G, et al. Rescue leads: a salvage technique for selected patients with a suboptimal response to standard DBS therapy. Parkinsonism Relat Disord. 2011; 17(6):451-455.
82. Sturm V, et al. DBS in the basolateral amygdala improves symptoms of autism and related selfinjurious behavior: a case report and hypothesis on the pathogenesis of the disorder. Front Hum Neurosci. 2012;6:341.
83. Servello D, et al. De novo and rescue DBS leads for refractory Tourette syndrome patients with severe comorbid OCD: a multiple case report. J Neurol. 2009; 256(9):1533-1539.
84. Williams N, Simpson AN, Simpson K, Nahas Z. Relapse rates with long-term antidepressant drug therapy: a meta-analysis. Hum Psychopharmacol. 2009; 24(5):401-408.
85. Jimenez F, et al. A patient with a resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle. Neurosurgery. 2005;57(3):585-593.
86. Sartorius A, et al. Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient. Biol Psychiatry. 2010; 67(2):e9-e11.
87. Drevets WC, Ongur D, Price JL. Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders. Mol Psychiatry. 1998;3(3):220-226.
88. Holtzheimer PE, et al. Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch Gen Psychiatry. 2012; 69(2):150-158.
89. Haq IU, et al. A case of mania following deep brain stimulation for obsessive compulsive disorder. Stereotact Funct Neurosurg. 2010;88(5):322-328.
90. Riva-Posse P, Holtzheimer PE, Garlow SJ, Mayberg HS. Practical considerations in the development and refinement of subcallosal cingulate white matter deep brain stimulation for the treatment resistant depression. World Neurosurg. 2012; pii:S1878-8750(12)01436-2.
91. Rizvi SK, et al. Investigation of the targeted effects of deep brain stimulation on depressive symptom profiles: a pooled analysis. Society of Biological Psychiatry 68th Annual Scientific Convention, May 16-18, 2013. San Francisco, California, USA.
92. Lozano AM, et al. A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression. J Neurosurg. 2012; 116(2):315-322.
93. Mayberg, H. Optimizing subcallosal cingulate DBS for treatment resistant depression. Society of Biological Psychiatry 68th Annual Scientific Convention, May 16-18, 2013. San Francisco, California, USA.
94. Kennedy SH, et al. Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years. Am J Psychiatry. 2011;168(5):502-510.
95. Puigdemont D, et al. Deep brain stimulation of the subcallosal cingulate gyrus: further evidence in treatment-resistant major depression. Int J Neuropsychopharmacol. 2011:1-13.
96. Ramasubbu RA. Double-blind optimization of subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study. Society of Biological Psychiatry 68th Annual Scientific Convention, May 16-18, 2013. San Francisco, California, USA.
97. Malone DA, et al. Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol Psychiatry. 2009; 65(4):267-275.
98. Malone DA. Use of deep brain stimulation in treatment-resistant depression. Cleve Clin J Med. 2010; 77(suppl 3):S77-S80.
99. Rezai A. Deep brain stimulation (DBS) for treatment-resistant depression: a randomized controlled trial. 2012 ASSFN Biennial Meeting Abstracts - Oral Presentation. June 3-6, 2012. San Francisco, California, USA.
100. Schlaepfer TE, et al. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology. 2008; 33(2):368-377.
101. Bewernick BH, et al. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biol Psychiatry. 2010;67(2):110-116.
102. Bewernick BH, Kayser S, Sturm V, Schlaepfer TE. Long-term effects of nucleus accumbens deep brain stimulation in treatment-resistant depression: evidence for sustained efficacy. Neuropsychopharmacology. 2012;37(9):1975-1985.
103. Coenen VA, Panksepp J, Hurwitz TA, Urbach H, Madler B. Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression. J Neuropsychiatry Clin Neurosci. 2012; 24(2):223-236.
104. McGrath CL, et al. Toward a neuroimaging treatment selection biomarker for major depressive disorder. JAMA Psychiatry. 2013;70(8):821-829.
105. Downar J, Daskalakis ZJ. New targets for rTMS in depression: a review of convergent evidence. Brain Stimul. 2013;6(3):231-240.
106. Lujan JL, et al. Tractography-activation models applied to subcallosal cingulate deep brain stimulation. Brain Stimul. 2013;6(5):737-739.
107. Greenberg BD, et al. Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience. Mol Psychiatry. 2010;15(1):64-79.
108. Chabardes S, et al. Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target [published onlinea ahead of print March 30, 2012]. World Neurosurg. doi:10.1016/j. wneu.2012.03.010.
109. Fins JJ, et al. Misuse of the FDA's humanitarian device exemption in deep brain stimulation for obsessive-compulsive disorder. Health Aff (Millwood). 2011;30(2):302-311.
110. Huff W, et al. Unilateral deep brain stimulation of the nucleus accumbens in patients with treatmentresistant obsessive-compulsive disorder: Outcomes after one year. Clin Neurol Neurosurg. 2010; 112(2):137-143.
111. Denys D, et al. Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessivecompulsive disorder. Arch Gen Psychiatry. 2010; 67(10):1061-1068.
112. Abelson JL, et al. Deep brain stimulation for refractory obsessive-compulsive disorder. Biol Psychiatry. 2005; 57(5):510-516.
113. Greenberg BD, et al. Three-year outcomes in deep brain stimulation for highly resistant obsessivecompulsive disorder. Neuropsychopharmacology. 2006; 31(11):2384-2393.
114. Jimenez-Ponce F, et al. Preliminary study in patients with obsessive-compulsive disorder treated with electrical stimulation in the inferior thalamic peduncle. Neurosurgery. 2009; 65(6 suppl):203-209.
115. Mallet L, et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med. 2008;359(20):2121-2134.
116. Mian MK, Campos M, Sheth SA, Eskandar EN. Deep brain stimulation for obsessive-compulsive disorder: past, present, and future. Neurosurg Focus. 2010;29(2):E10.
117. Burbaud P, et al. Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder. Brain. 2013;136(pt 1):304-317.
118. Lipsman N, Neimat JS, Lozano AM. Deep brain stimulation for treatment-refractory obsessivecompulsive disorder: the search for a valid target. Neurosurgery. 2007;61(1):1-11.
119. Lujan JL, Chaturvedi A, McIntyre CC. Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders. Front Biosci. 2008;13:5892-5904.
120. Le Jeune F, et al. Decrease of prefrontal metabolism after subthalamic stimulation in obsessive-compulsive disorder: a positron emission tomography study. Biol Psychiatry. 2010;68(11):1016-1022.
121. Bourne SK, Eckhardt CA, Sheth SA, Eskandar EN. Mechanisms of deep brain stimulation for obsessive compulsive disorder: effects upon cells and circuits. Front Integr Neurosci. 2012;6:29.
122. Harrison BJ, et al. Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. Biol Psychiatry. 2013; 73(4):321-328.
123. van den Heuvel OA, et al. The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. Brain. 2009;132(pt 4):853-868.
124. Saleh C, Okun MS. Clinical review of deep brain stimulation and its effects on limbic basal ganglia circuitry. Front Biosci. 2008;13:5708-5731.
125. Fontaine D, et al. Effect of subthalamic nucleus stimulation on obsessive-compulsive disorder in a patient with Parkinson disease. Case report. J Neurosurg. 2004;100(6):1084-1086.
126. Hamani C, et al. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann Neurol. 2008;63(1):119-123.
127. Kosel M, et al. Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depression. J Psychiatr Res. 2007;41(9):801-803.
128. Damier P, et al. Bilateral deep brain stimulation of the globus pallidus to treat tardive dyskinesia. Arch Gen Psychiatry. 2007;64(2):170-176.
129. Mallet L, et al. Compulsions, Parkinson's disease, and stimulation. Lancet. 2002;360(9342):1302-1304.
130. Fimm B, Heber IA, Coenen VA, Fromm C, Noth J, Kronenbuerger M. Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease. Mov Disord. 2009;24(11):1613-1620.
131. Neuner I, Podoll K, Lenartz D, Sturm V, Schneider F. Deep brain stimulation in the nucleus accumbens for intractable Tourette's syndrome: followup report of 36 months. Biol Psychiatry. 2009; 65(4):e5-e6.
132. Neuner I, et al. Microstructure assessment of grey matter nuclei in adult tourette patients by diffusion tensor imaging. Neurosci Lett. 2011;487(1):22-26.
133. Stefurak T, et al. Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case study. Mov Disord. 2003; 18(12):1508-1516.
134. Moum SJ, et al. Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome. PLoS One. 2012; 7(1):e29768.
135. Chopra A, et al. Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. J Neuropsychiatry Clin Neurosci. 2012;24(1):102-110.
136. Burdick AP, et al. Do patient's get angrier following STN, GPi, and thalamic deep brain stimulation. Neuroimage. 2011;54(suppl 1):S227-S232.
137. Kirsch-Darrow L, Zahodne LB, Marsiske M, Okun MS, Foote KD, Bowers D. The trajectory of apathy after deep brain stimulation: from pre-surgery to 6 months post-surgery in Parkinson's disease. Parkinsonism Relat Disord. 2011;17(3):182-188.
138. Kluger BM, et al. The prevalence of fatigue following deep brain stimulation surgery in Parkinson's disease and association with quality of life. Parkinsons Dis. 2012;2012:769506.
139. Zahodne LB, et al. Binge eating in Parkinson's disease: prevalence, correlates and the contribution of deep brain stimulation. J Neuropsychiatry Clin Neurosci. 2011;23(1):56-62.
140. Voon V, et al. A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease. Brain. 2008;131(pt 10):2720-2728.
141. Dietz J, et al. Stimulation region within the globus pallidus does not affect verbal fluency performance. Brain Stimul. 2013;6(3):248-253.
142. Chopra A, et al. Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report. Biol Psychiatry. 2011; 70(2):e5-e7.
143. Campbell MC, et al. Mood response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2012; 24(1):28-36.
144. Okun MS, Green J, Saben R, Gross R, Foote KD, Vitek JL. Mood changes with deep brain stimulation of STN and GPi: results of a pilot study. J Neurol Neurosurg Psychiatry. 2003; 74(11):1584-1586.
145. Whiting DM, et al. Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism. J Neurosurg. 2013; 119(1):56-63.
146. Mantione M, van de Brink W, Schuurman PR, Denys D. Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report. Neurosurgery. 2010;66(1):E218.
147. Voges J, Müller U, Bogerts B, Münte T, Heinze HJ. Deep brain stimulation surgery for alcohol addiction [published online ahead of print July 21, 2012]. World Neurosurg. doi:10.1016/j. wneu.2012.07.011.
148. Kuhn J, et al. Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications? J Neurol Neurosurg Psychiatry. 2007;78(10):1152-1153.
149. Kuhn J, et al. Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction [published online ahead of print January 22, 2013]. Mol Psychiatry. doi:10.1038/mp.2012.196.
150. Müller UJ, et al. Deep brain stimulation of the nucleus accumbens for the treatment of addiction. Ann N Y Acad Sci. 2013;1282:119-128.
151. Shapira NA, et al. Panic and fear induced by deep brain stimulation. J Neurol Neurosurg Psychiatry. 2006; 77(3):410-412.
152. Kuhn J, Grundler TO, Lenartz D, Sturm V, Klosterkotter J, Huff W. Deep brain stimulation for psychiatric disorders. Dtsch Arztebl Int. 2010; 107(7):105-113.
153. Stetka BK, Kantor EM, Williams NR. A new psychiatry subspecialty? Medscape Psychiatry. May 30, 2013. http://www.medscape.com/viewarticle/804826. Accessed September 13, 2013.
154. Zahodne LB, et al. Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus. J Neurol. 2009;256(8):1321-1329.
155. Synofzik M, Schlaepfer TE. Electrodes in the brain-ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders. Brain Stimul. 2011;4(1):7-16.
156. Fins JJ, et al. Ethical guidance for the management of conflicts of interest for researchers, engineers and clinicians engaged in the development of therapeutic deep brain stimulation. J Neural Eng. 2011; 8(3):033001.
157. Christopher PP, Leykin Y, Appelbaum PS, Holtzheimer PE, Mayberg HS, Dunn LB. Enrolling in deep brain stimulation research for depression: influences on potential subjects' decision making. Depress Anxiety. 2012;29(2):139-146.
158. Fisher CE, et al. The ethics of research on deep brain stimulation for depression: decisional capacity and therapeutic misconception. Ann N Y Acad Sci. 2012; 1265:69-79.
159. Synofzik M, Fins JJ, Schlaepfer TE. A neuromodulation experience registry for deep brain stimulation studies in psychiatric research: rationale and recommendations for implementation. Brain Stimul. 2012;5(4):653-655.
160. Rabins P, et al. Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought. Arch Gen Psychiatry. 2009; 66(9):931-937.
161. Schlaepfer TE, George MS, Mayberg H. WFSBP Guidelines on Brain Stimulation Treatments in Psychiatry. World J Biol Psychiatry. 2010;11(1):2-18.
162. Riva-Posse P, Holtzheimer PE, Garlow SJ, Mayberg HS. Practical considerations in the development and refinement of subcallosal cingulate white matter deep brain stimulation for treatment resistant depression. World Neurosurg. 2012;pii:S1878-8750(12)01436-2.
163. Bell E, Mathieu G, Racine E. Preparing the ethical future of deep brain stimulation. Surg Neurol. 2009; 72(6):577-586.
164. Kringelbach ML, Green AL, Owen SL, Schweder PM, Aziz TZ. Sing the mind electric - principles of deep brain stimulation. Eur J Neurosci. 2010; 32(7):1070-1079.
165. Okun MS, et al. Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial. Lancet Neurol. 2012;11(2):140-149.
166. Odekerken VJ, et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurol. 2013; 12(1):37-44.
167. Goodman WK, et al. Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design. Biol Psychiatry. 2010;67(6):535-542.
168. Denys D, et al. Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessivecompulsive disorder. Arch Gen Psychiatry. 2010; 67(10):1061-1068.
169. Graff-Radford J, et al. Mood and motor effects of thalamic deep brain stimulation surgery for essential tremor. Eur J Neurol. 2010;17(8):1040-1046.
170. Kuhn J, et al. Observations on unaided smoking cessation after deep brain stimulation of the nucleus accumbens. Eur Addict Res. 2009;15(4):196-201.
171. Zhou H, Xu J, Jiang J. Deep brain stimulation of nucleus accumbens on heroin-seeking behaviors: a case report. Biol Psychiatry. 2011;69(11):e41-e42.
172. Valencia-Alfonso CE, et al. Effective deep brain stimulation in heroin addiction: a case report with complementary intracranial electroencephalogram. Biol Psychiatry. 2012;71(8):e35-e37.
173. Flaherty AW, et al. Deep brain stimulation of the anterior internal capsule for the treatment of Tourette syndrome: technical case report. Neurosurgery. 2005;57(suppl 4):E403; discussion E403.
174. Nuttin B, et al. Targeting bed nucleus of the stria terminalis for severe obsessive-compulsive disorder: more unexpected lead placement in obsessive-compulsive disorder than in surgery for movement disorders. World Neurosurg. 2012; S1878-S8750(12):01463-01465.