In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release

Nature Medicine

Volumn 19, Issue 10, 2013, Pages 1232-1235

  Scheller, Richard H ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGRIN; BINDING PROTEIN; BOTULINUM TOXIN; BOTULINUM TOXIN E; CALCIUM CHANNEL; CHOLINERGIC RECEPTOR; N ETHYLMALEIMIDE SENSITIVE FACTOR; NORADRENALIN; SCAFFOLD PROTEIN; SNARE PROTEIN; SYNAPTOBREVIN 1; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNAPTOTAGMIN I; SYNTAXIN; SYNTAXIN 4; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

APLYSIA; CALCIUM TRANSPORT; CELL MEMBRANE; CELL MIGRATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DNA LIBRARY; EXOCYTOSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNOELECTRON MICROSCOPY; INTRACELLULAR MEMBRANE; MEMBRANE FUSION; MOLECULAR CLONING; NERVE ENDING; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; NORADRENALIN RELEASE; PC12 CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVIEW; SECRETORY PATHWAY; SYNAPTIC MEMBRANE; SYNAPTOSOME; TORPEDO CALIFORNICA; ANIMAL; METABOLISM; SYNAPTIC TRANSMISSION;

ANIMALS; MEMBRANE FUSION; NEUROTRANSMITTER AGENTS; SYNAPTIC TRANSMISSION;

EID: 84887443728     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3339     Document Type: Review

References (20)

1. Heuser, J.E. & Reese, T.S. Evidence for recycling of synaptic vesicle membrane during neurotransmitter release at the frog neuromuscular junction. J. Cell Biol. 57, 315-344 (1973)
2. Hooper, J.E., Carlson, S.S. & Kelly, R.B. Antibodies to synaptic vesicles purified from narcine electric organ bind a subclass of mammalian nerve terminals. J. Cell Biol. 87, 104-113 (1980)
3. Trimble, W.S., Cowan, D.M. & Scheller, R.H. VAMP-1: A synaptic vesicle-associated integral membrane protein. Proc. Natl. Acad. Sci. USA 85, 4538-4542 (1988)
4. Bennett, M.K., Calakos, N. & Scheller, R.H. Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science 257, 255-259 (1992)
5. Söllner, T. et al. SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324 (1993)
6. Söllner, T., Bennett, M.K., Whiteheart, S.W., Scheller, R.H. & Rothman, J.E. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell 75, 409-418 (1993)
7. Misura, K.M., Scheller, R.H. & Weis, W.I. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature 404, 355-362 (2000)
8. Lin, R.C. & Scheller, R.H. Structural organization of the synaptic exocytosis core complex. Neuron 19, 1087-1094 (1997)
9. Sutton, R.B., Fasshauer, D., Jahn, R. & Brunger, A.T. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution. Nature 395, 347-353 (1998)
10. Hay, J.C. & Martin T.F. Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins. J. Cell Biol. 119, 139-151 (1992)
11. Chen, Y.A., Scales, S.J., Patel, S.M., Doung, Y.C. & Scheller, R.H. SNARE complex formation is triggered by Ca2+ and drives membrane fusion. Cell 97, 165-74 (1999)
12. Südhof, T.C. A molecular machine for neurotransmitter release: synaptotagmin and beyond. Nat. Med. 19, 1227-1231 (2013)
13. Scales, S.J., Yoo, B.Y. & Scheller, R.H. The ionic layer is required for efficient dissociation of the SNARE complex by a-SNAP and NSF. Proc. Natl. Acad. Sci. USA 98, 14262-14267 (2001)
14. Hua, Y. & Scheller, R.H. Three SNARE complexes cooperate to mediate membrane fusion. Proc. Natl. Acad. Sci. USA 98, 8065-8070 (2001)
15. Bennett, M.K. et al. The syntaxin family of vesicular transport receptors. Cell 74, 863-873 (1993)
16. Hay, J.C., Chao, D.S., Kuo, C.S. & Scheller, R.H. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell 89, 149-158 (1997)
17. Bock, J.B., Matern, H.T., Peden, A.A. & Scheller, R.H. A genomic perspective on membrane compartment organization. Nature 409, 839-841 (2001)
18. Scales, S.J. et al. SNAREs contribute to the specificity of membrane fusion. Neuron 26, 457-64 (2000)
19. McNew, J.A. et al. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature 407, 153-159 (2000)
20. Bennett, M.K. & Scheller, R.H. The molecular machinery for secretion is conserved from yeast to neurons. Proc. Natl. Acad. Sci. USA 90, 2559-2563 (1993)