Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial

Pediatric Research

Volumn 74, Issue 5, 2013, Pages 570-575

  Fairchild, Karen D ^a   Schelonka, Robert L ^b   Kaufman, David A ^a   Carlo, Waldemar A ^c   Kattwinkel, John ^a   Porcelli, Peter J ^d   Navarrete, Cristina T ^e   Bancalari, Eduardo ^e   Aschner, Judy L ^f   Walker, M Whit ^g   Perez, Jose A ^h   Palmer, Charles ⁱ   Lake, Douglas E ^a   O'Shea, T Michael ^d   Moorman, J Randall ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e JACKSON MEMORIAL HOSPITAL   (United States)

^f VANDERBILT UNIVERSITY   (United States)

^g GREENVILLE HOSPITAL SYSTEM   (United States)

^h Winnie Palmer Children's Hospital   (United States)

ⁱ PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONFIDENCE INTERVAL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEART RATE; HUMAN; INCIDENCE; INFANT; MAJOR CLINICAL STUDY; MONITORING; MORTALITY; NEWBORN; NEWBORN INTENSIVE CARE; PRIORITY JOURNAL; RISK FACTOR; SECONDARY ANALYSIS; SEPTICEMIA; VERY LOW BIRTH WEIGHT;

HEART RATE; HUMANS; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; INTENSIVE CARE UNITS, NEONATAL; LOGISTIC MODELS; MONITORING, PHYSIOLOGIC; SEPSIS;

EID: 84887438293     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2013.136     Document Type: Article

References (22)

1. Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285-91.
2. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B; Israel Neonatal Network. Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. Clin Infect Dis 2005;40:218-24.
3. Schlapbach LJ, Aebischer M, Adams M, et al.; Swiss Neonatal Network and Follow-Up Group. Impact of sepsis on neurodevelopmental outcome in a Swiss National Cohort of extremely premature infants. Pediatrics 2011;128:e348-57.
4. Stoll BJ, Hansen NI, Adams-Chapman I, et al.; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004;292:2357-65.
5. Raynor LL, Saucerman JJ, Akinola MO, Lake DE, Moorman JR, Fairchild KD. Cytokine screening identifies NICU patients with Gram-negative bacteremia. Pediatr Res 2012;71:261-6.
6. Ng PC, Ang IL, Chiu RW, et al. Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants. J Clin Invest 2010;120:2989-3000.
7. Brocklehurst P, Farrell B, King A, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med 2011;365:1201-11.
8. Carr R, Modi N, Dore C. G-CSF and GM-CSF for treating or preventing neonatal infections. Coch Database Syst Rev 2003;2003:CD003066.
9. Fairchild KD, OShea TM. Heart rate characteristics: physiomarkers for detection of late-onset neonatal sepsis. Clin Perinatol 2010;37:581-98.
10. Fairchild K, Aschner JL. HeRO monitoring to reduce mortality in NICU patients. Res Reports Neonatol 2012;2:65-76.
11. Griffin MP, Lake DE, Bissonette EA, Harrell FE Jr, OShea TM, Moorman JR. Heart rate characteristics: novel physiomarkers to predict neonatal infection and death. Pediatrics 2005;116:1070-4.
12. Griffin MP, OShea TM, Bissonette EA, Harrell FE Jr, Lake DE, Moorman JR. Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness. Pediatr Res 2003;53:920-6.
13. Moorman JR, Lake DE, Griffin MP. Heart rate characteristics monitoring for neonatal sepsis. IEEE Trans Biomed Eng 2006;53:126-32.
14. Griffin MP, Scollan DF, Moorman JR. The dynamic range of neonatal heart rate variability. J Cardiovasc Electrophysiol 1994;5:112-24.
15. Cao H, Lake DE, Griffin MP, Moorman JR. Increased nonstationarity of neonatal heart rate before the clinical diagnosis of sepsis. Ann Biomed Eng 2004;32:233-44.
16. Kovatchev BP, Farhy LS, Cao H, Griffin MP, Lake DE, Moorman JR. Sample asymmetry analysis of heart rate characteristics with application to neonatal sepsis and systemic inflammatory response syndrome. Pediatr Res 2003;54:892-8.
17. Lake DE, Richman JS, Griffin MP, Moorman JR. Sample entropy analysis of neonatal heart rate variability. Am J Physiol Regul Integr Comp Physiol 2002;283:R789-97.
18. Moorman JR, Carlo WA, Kattwinkel J, et al. Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial. J Pediatr 2011;159:900-6.e1.
19. Griffin MP, Moorman JR. Toward the early diagnosis of neonatal sepsis and sepsis-like illness using novel heart rate analysis. Pediatrics 2001;107: 97-104.
20. Griffin MP, Lake DE, Moorman JR. Heart rate characteristics and laboratory tests in neonatal sepsis. Pediatrics 2005;115:937-41.
21. Griffin MP, Lake DE, OShea TM, Moorman JR. Heart rate characteristics and clinical signs in neonatal sepsis. Pediatr Res 2007;61: 222-7.
22. Harrell FE. Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression and Survival Analysis. Berlin: Springer, 2001.