The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy

Reproductive Sciences

Volumn 20, Issue 12, 2013, Pages 1471-1477

  Grotegut, Chad A ^a   Gunatilake, Ravindu P ^b   Feng, Liping ^a   Heine, R Phillips ^a   Murtha, Amy P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

obesity; oxytocin; oxytocin receptor; pregnancy

Indexed keywords

ARTICLE; BODY MASS; CESAREAN SECTION; FEMALE; GENE; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; HYSTEROTOMY; MYOMETRIAL OXYTOCIN RECEPTOR GENE; MYOMETRIUM; OBESITY; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

OBESITY; OXYTOCIN; OXYTOCIN RECEPTOR; PREGNANCY;

BODY MASS INDEX; CESAREAN SECTION; FEMALE; GENE EXPRESSION REGULATION; GESTATIONAL AGE; HUMANS; LABOR, OBSTETRIC; LINEAR MODELS; MYOMETRIUM; OBESITY; PREGNANCY; RECEPTORS, OXYTOCIN; RNA, MESSENGER;

EID: 84887432962     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719113488446     Document Type: Article

References (38)

1. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012 ; 307 (5). 491-497
2. Kim SY, Dietz PM, England L, Morrow B, Callaghan WM. Trends in pre-pregnancy obesity in nine states, 1993-2003. Obesity (Silver Spring). 2007 ; 15 (4). 986-993 (Pubitemid 46740974)
3. Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The spread of the obesity epidemic in the United States, 1991-1998. JAMA. 1999 ; 282 (16). 1519-1522 (Pubitemid 29504044)
4. Baeten JM, Bukusi EA Lambe M. Pregnancy complications and outcmes among overweight and obese nulliparous womn. Am J Public Health. 2001 ; 91 (3). 436440 (Pubitemid 3217959)
5. Ovesen P, Rasmussen S, Kesmodel U. Effect of prepregnancy maternal overweight and obesity on pregnancy outcome. Obstet Gynecol. 2011 ; 118 (2 pt 1). 305-312
6. Roos N, Sahlin L, Ekman-Ordeberg G, Kieler H, Stephansson O. Maternal risk factors for postterm pregnancy and cesarean delivery following labor induction. Acta Obstet Gynecol Scand. 2010 ; 89 (8). 1003-1010
7. Verdiales M, Pacheco C, Cohen WR. The effect of maternal obesity on the course of labor. J Perinat Med. 2009 ; 37 (6). 651-655
8. Pevzner L, Powers BL, Rayburn WF, Rumney P, Wing DA. Effects of maternal obesity on duration and outcomes of prostaglandin cervical ripening and labor induction. Obstet Gynecol. 2009 ; 114 (6). 1315-1321
9. Chin JR, Henry E, Holmgren CM, Varner MW, Branch DW.. Maternal obesity and contraction strength in the first stage of labor. Am J Obstet Gynecol. 2012 ; 207 (2). e1 - e6
10. Halloran DR, Cheng YW, Wall TC, Macones GA, Caughey AB. Effect of maternal weight on postterm delivery. J Perinatol. 2012 ; 32 (2). 85-90
11. Caughey AB, Stotland NE, Washington AE, Escobar GJ.. Who is at risk for prolonged and postterm pregnancy?. Am J Obstet Gynecol. 2009 ; 200 (6). e1 - e5
12. Zhang J, Bricker L, Wray S, Quenby S. Poor uterine contractility in obese women. BJOG. 2007 ; 114 (3). 343-348
13. Higgins CA, Martin W, Anderson L, et al. Maternal obesity and its relationship with spontaneous and oxytocin-induced contractility of human myometrium in vitro. Reprod Sci. 2010 ; 17 (2). 177-185
14. Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z. The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents. Int J Endocrinol. 2011 ; 2011: 350546
15. Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG. Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. J Biol Chem. 2001 ; 276 (22). 19452-19460
16. Conti F, Sertic S, Reversi A, Chini B. Intracellular trafficking of the human oxytocin receptor: evidence of receptor recycling via a Rab4/Rab5 short cycle. Am J Physiol Endocrinol Metab. 2009 ; 296 (3). E532 - E542
17. Grotegut CA, Feng L, Mao L, Heine RP, Murtha AP. Rockman HA. β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration. Am J Physiol Endocrinol Metab. 2011 ; 300 (3). E468 - E477
18. Ku CY, Murtazina DA, Kim YS, Garfield RE, Sanborn BM. Changes in rat myometrial plasma membrane protein kinase A are confined to parturition. Reprod Sci. 2010 ; 17 (7). 696-704
19. Gilead R, Yaniv Salem S, Sergienko R, Sheiner E. Maternal isolated obesity and obstetric complications. J Matern Fetal Neona. 2012 ; 25 (12). 2579-2582
20. Arrowsmith S, Wray S, Quenby S. Maternal obesity and labour complications following induction of labour in prolonged pregnancy. BJOG. 2011 ; 118 (5). 578-588
21. Misra VK, Trudeau S. The influence of overweight and obesity on longitudinal trends in maternal serum leptin levels during pregnancy. Obesity (Silver Spring). 2011 ; 19 (2). 416-421
22. Moynihan AT, Hehir MP, Glavey SV, Smith TJ, Morrison JJ. Inhibitory effect of leptin on human uterine contractility in vitro. Am J Obstet Gynecol. 2006 ; 195 (2). 504-509 (Pubitemid 44142379)
23. Jie Z, Kendrick A, Quenby S, Wray S. Contractility and calcium signaling of human myometrium are profoundly affected by cholesterol manipulation: implications for labor?. Reprod Sci. 2007 ; 14 (5). 456-466 (Pubitemid 351168802)
24. Gimpl G, Fahrenholz F. Cholesterol as stabilizer of the oxytocin receptor. Biochim Biophys Acta. 2002 ; 1564 (2). 384-392
25. Wiegand V, Gimpl G. Specification of the cholesterol interaction with the oxytocin receptor using a chimeric receptor approach. Eur J Pharmacol. 2012 ; 676 (1-3). 12-19
26. Gimpl G, Reitz J, Brauer S, Trossen C. Oxytocin receptors: ligand binding, signalling and cholesterol dependence. Prog Brain Res. 2008 ; 170: 193-204 (Pubitemid 352010230)
27. Qiu Y, Wang Y, Law PY, Chen HZ, Loh HH. Cholesterol regulates micro-opioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts. Mol Pharmacol. 2011 ; 80 (1). 210-218
28. Arthur P, Taggart MJ, Zielnik B, Wong S, Mitchell BF. Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. J Physiol. 2008 ; 586 (pt 24). 6063-6076
29. Tattersall M, Engineer N, Khanjani S, et al. Pro-labour myometrial gene expression: are preterm labour and term labour the same?. Reproduction. 2008 ; 135 (4). 569-579 (Pubitemid 351578163)
30. Mesiano S, Chan EC, Fitter JT, Kwek K, Yeo G, Smith R. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab. 2002 ; 87 (6). 2924-2930 (Pubitemid 34655365)
31. Condon JC, Jeyasuria P, Faust JM, Wilson JW, Mendelson CR. A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc Natl Acad Sci U S A. 2003 ; 100 (16). 9518-9523 (Pubitemid 37033960)
32. Wathes DC, Borwick SC, Timmons PM, Leung ST, Thornton S. Oxytocin receptor expression in human term and preterm gestational tissues prior to and following the onset of labour. J Endocrinol. 1999 ; 161 (1). 143-151 (Pubitemid 29170201)
33. Helguera G, Eghbali M, Sforza D, Minosyan TY, Toro L, Stefani E. Changes in global gene expression in rat myometrium in transition from late pregnancy to parturition. Physiol Genomics. 2009 ; 36 (2). 89-97
34. Terzidou V, Sooranna SR, Kim LU, Thornton S, Bennett PR, Johnson MR. Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes. J Clin Endocrinol Metab. 2005 ; 90 (1). 237-246 (Pubitemid 40116664)
35. Ou CW, Chen ZQ, Qi S, Lye SJ. Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals. Biol Reprod. 1998 ; 59 (5). 1055-1061 (Pubitemid 28498914)
36. Havelock JC, Keller P, Muleba N, et al. Human myometrial gene expression before and during parturition. Biol Reprod. 2005 ; 72 (3). 707-719 (Pubitemid 40279850)
37. Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol. 1984 ; 150 (6). 734-741 (Pubitemid 15204655)
38. Blanks AM, Vatish M, Allen MJ, et al. Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. J Clin Endocrinol Metab. 2003 ; 88 (7). 3392-3400 (Pubitemid 36880841)